{"title":"Current management of <i>Staphylococcus aureus</i> bacteremia in a Japanese university hospital.","authors":"Shogo Hanai, Masashi Yokose, Yukinori Harada, Yohei Doi, Taro Shimizu","doi":"10.20407/fmj.2024-010","DOIUrl":"10.20407/fmj.2024-010","url":null,"abstract":"<p><strong>Objectives: </strong>Consultation with infectious disease specialists is associated with reduced patient mortality in the care of patients with <i>Staphylococcus aureus</i> bacteremia (SAB) through appropriate management of complications including infective endocarditis. This study aimed to determine the rates of confirmation of a negative blood culture, implementation of echocardiography, and administration of appropriate antibiotics in patients with SAB at a university hospital in Japan that provides general internal medicine and not an infectious disease consultation service.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study at Dokkyo Medical University Hospital in Japan. Patients eligible for inclusion in the study were ≥20 years of age with ≥1 positive blood culture for <i>S. aureus</i> identified in a clinical microbiology laboratory. The primary outcome was the proportion of patients with confirmation of a negative blood culture, implementation of echocardiography, and administration of appropriate antimicrobial agents.</p><p><strong>Results: </strong>A total of 109 patients with SAB were included in the analysis. Follow-up blood cultures were collected in 91 patients and negative results were documented in 88 patients. Follow-up blood culture collection was performed within 4 days of the initial blood culture collection in 49 patients. Echocardiography was performed appropriately in 40 patients. Appropriate antibiotic therapy was administered in 36 patients.</p><p><strong>Conclusions: </strong>Quality-of-care indicators were more commonly implemented in patients with SAB who received general internal medicine consultation than in those who did not.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 4","pages":"106-110"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528325/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fujita Medical JournalPub Date : 2024-11-01Epub Date: 2024-08-28DOI: 10.20407/fmj.2024-006
Yuka Sano, Junko Sugama, Hiroe Koyanagi, Ryoko Murayama, Takuma Ishihara, Masushi Kohta, Keiko Mano
{"title":"Prevalence of constipation and associated factors in university hospital inpatients.","authors":"Yuka Sano, Junko Sugama, Hiroe Koyanagi, Ryoko Murayama, Takuma Ishihara, Masushi Kohta, Keiko Mano","doi":"10.20407/fmj.2024-006","DOIUrl":"10.20407/fmj.2024-006","url":null,"abstract":"<p><strong>Objectives: </strong>We aimed to determine (1) the prevalence of constipation among inpatients, (2) the prevalence and symptoms of difficult defecation among constipated inpatients, and (3) the factors associated with constipation.</p><p><strong>Methods: </strong>We performed a retrospective cohort study over a single day at one university hospital. We analyzed the nursing records for inpatients who had been hospitalized for at least 3 days. The survey items included the symptoms associated with defecation difficulty and nutritional intake. The symptoms of difficult defecation were defined as (1) fewer than three spontaneous bowel movements per week; (2) lumpy or hard stools (Bristol stool form scale types 1-2); (3) straining during defecation; and (4) the sensation of incomplete evacuation during defecation, based on the Roma-IV diagnostic criteria. Constipation was defined as the presence of two or more symptoms of defecation difficulty. Univariate and multivariate analyses were performed to determine the constipation status of the patients.</p><p><strong>Results: </strong>The prevalence of constipation in the university hospital was 12.2%, and the department with the highest prevalence of difficulty with defecation was the Psychiatry Department (64.1%). Of the patients with constipation, 36.8% exhibited symptoms of defecation difficulty other than low frequency of defecation. The factor that was significantly associated with constipation after admission was pre-admission constipation (odds ratio=8.92, <i>p</i><0.01).</p><p><strong>Conclusions: </strong>Subjective assessment has limitations for the accurate determination of constipation status. In addition, patients with a history of constipation before admission require early interventions to aid defecation following their admission.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 4","pages":"98-105"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528326/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Phosphate overload via the type III Na-dependent Pi transporter represses aortic wall elastic fiber formation.","authors":"Yasumasa Yoshino, Tomoka Hasegawa, Shukei Sugita, Eisuke Tomatsu, Naoya Murao, Izumi Hiratsuka, Sahoko Sekiguchi-Ueda, Megumi Shibata, Takeo Matsumoto, Norio Amizuka, Yusuke Seino, Takeshi Takayanagi, Yoshihisa Sugimura, Atsushi Suzuki","doi":"10.20407/fmj.2023-004","DOIUrl":"10.20407/fmj.2023-004","url":null,"abstract":"<p><strong>Objectives: </strong>Phosphate (Pi) induces differentiation of arterial smooth muscle cells to the osteoblastic phenotype by inducing the type III Na-dependent Pi transporter Pit-1/solute carrier family member 1. This induction can contribute to arterial calcification, but precisely how Pi stress acts on the vascular wall remains unclear. We investigated the role of extracellular Pi in inducing microstructural changes in the arterial wall.</p><p><strong>Methods: </strong>Aortae of Pit-1-overexpressing transgenic (TG) rats and their wild-type (WT) littermates were obtained at 8 weeks after birth. The thoracic descending aorta from WT and TG rats was used for the measurement of wall thickness and uniaxial tensile testing. Structural and ultrastructural analyses were performed using light microscopy and transmission electron microscopy. Gene expression of connective tissue components in the aorta was quantified by quantitative real-time polymerase chain reaction.</p><p><strong>Results: </strong>Aortic wall thickness in TG rats was the same as that in WT rats. Uniaxial tensile testing showed that the circumferential breaking stress in TG rats was significantly lower than that in WT rats (<i>p</i><0.05), although the longitudinal breaking stress, breaking strain, and elastic moduli in both directions in TG rats were unchanged. Transmission electron microscopy analysis of the aorta from TG rats showed damaged formation of elastic fibers in the aortic wall. Fibrillin-1 gene expression levels in the aorta were significantly lower in TG rats than in WT rats (<i>p</i><0.05).</p><p><strong>Conclusions: </strong>Pi overload acting via the arterial wall Pit-1 transporter weakens circumferential strength by causing elastic fiber malformation, probably via decreased fibrillin-1 expression.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 4","pages":"87-93"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effects of speech tracking method using hearing aids for hearing disorder in older people.","authors":"Erina Ito, Saiko Sugiura, Koki Kawamura, Yasue Uchida, Hirokazu Suzuki, Mariko Shimono, Kazuyo Mise, Hitoshi Kagaya","doi":"10.20407/fmj.2024-001","DOIUrl":"10.20407/fmj.2024-001","url":null,"abstract":"<p><strong>Objectives: </strong>Speech tracking is defined as a complex act or task of listening in which the learner tracks the speech heard and repeats it as accurately as possible while paying attention to incoming contextual information. This ability involves auditory input, speech output, repetition, and divided attention. In this small-scale study, we aimed to use a speech-tracking method to train older adults with hearing loss and examine its effects on hearing loss from multiple perspectives, including hearing handicap, frailty, and neuropsychological testing.</p><p><strong>Methods: </strong>Auditory rehabilitation was provided to older patients who purchased hearing aids at the clinic and wanted to engage in rehabilitation. The Hearing Handicap Inventory for the Elderly, Nursing Home Hearing Handicap Index, speech-tracking rate, Token Test, Communication Activities of Daily Living, Kihon Checklist, Mini-Mental State Examination, Digit Symbol Substitution Test, symbol search, and word recall were used for assessments before and after rehabilitation using the speech-tracking method. Changes in scores of each assessment item and sub-item were examined using Wilcoxon's signed-rank test, and changes per question were examined using the sign test.</p><p><strong>Results: </strong>The speech tracking rate (<i>p</i><0.001), Token Test score (<i>p</i><0.001), and Mini-Mental State Examination score (<i>p</i>=0.035) improved significantly after the training. Notably, the speech-tracking rate improved for 31 of the 33 participants, with a maximum increase of 19.6 phrases per minute.</p><p><strong>Conclusions: </strong>The combination of a hearing aid and the speech-tracking method improved auditory comprehension.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 4","pages":"81-86"},"PeriodicalIF":0.0,"publicationDate":"2024-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11528328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fujita Medical JournalPub Date : 2024-08-01Epub Date: 2024-05-29DOI: 10.20407/fmj.2023-018
Miho Miyamoto, Satoko Yanagisawa, Junko Fukada, Rumi Seko
{"title":"Comparison of characteristic competencies of public health nurses working at a community general support center and health and welfare in public administration in Japan.","authors":"Miho Miyamoto, Satoko Yanagisawa, Junko Fukada, Rumi Seko","doi":"10.20407/fmj.2023-018","DOIUrl":"10.20407/fmj.2023-018","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the characteristic competencies of public health nurses working for the older adult's health and welfare in public administration (\"PA\") with those at community general support centers (\"CGSC\") in Japan.</p><p><strong>Methods: </strong>We conducted a questionnaire survey by mail for PA and CGSC public health nurses. A competency list that was developed to compare three groups (PA, CGSC experts with ≥5 years of experience, and CGSC newcomers with ≤2 years of experience) was used. The following characteristics were examined: (1) competencies acquired early after arriving at the CGSC, (2) competencies acquired through a certain amount of CGSC experience, (3) common competencies, (4) competencies that even experts lacked, and (5) competencies that the newcomers lacked.</p><p><strong>Results: </strong>We examined the responses of 171 PA nurses, 185 CGSC expert public health nurses, and 165 CGSC newcomer public health nurses. The results of comparison of the three groups showed that (1) had no applicable items; (2) had nine items for individual support associated with preventive care management; (3) had 14 items including teamwork among three professionals (social workers, senior care manager, public health nurse)/other professionals and self-improvement; (4) had three items for community development, (5) had two items for individual support and 16 items for community development.</p><p><strong>Conclusion: </strong>Initiatives for preventive care and coordination of care teams should be supported and suggested as characteristic competencies for CGSC public health nurses.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 3","pages":"75-80"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288718/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical feasibility of duodenum-preserving pancreatic head resection for neuroendocrine tumors of the pancreatic head as an intermediate procedure between enucleation and pancreaticoduodenectomy.","authors":"Masahiro Shimura, Hiroyuki Kato, Yukio Asano, Hidetoshi Nagata, Yuka Kondo, Satoshi Arakawa, Daisuke Koike, Takayuki Ochi, Hironobu Yasuoka, Toki Kawai, Takahiko Higashiguchi, Hiroki Tani, Yoshiki Kunimura, Kazuma Horiguchi, Yutaro Kato, Masahiro Ito, Tsunekazu Hanai, Akihiko Horiguchi","doi":"10.20407/fmj.2023-017","DOIUrl":"10.20407/fmj.2023-017","url":null,"abstract":"<p><strong>Objective: </strong>This study was performed to demonstrate the clinical application of duodenum-preserving pancreatic head resection (DPPHR) as a surgical treatment for pancreatic neuroendocrine tumors (PNETs) in terms of both curability and maintenance of postoperative quality of life.</p><p><strong>Methods: </strong>Seven patients diagnosed with PNETs underwent DPPHR from January 2011 to December 2021 at our institution. We investigated the clinical relevance of DPPHR based on the patients' clinicopathological findings.</p><p><strong>Results: </strong>The median operative time was 492 min, and the median blood loss was 302 g. Postoperative complications were evaluated according to the Clavien-Dindo classification, and postoperative intra-abdominal bleeding was observed in one patient. Pathological examination revealed a World Health Organization classification of G1 in six patients and G2 in one patient. Microvascular invasion was observed in two patients (29%); however, no patients developed lymph node metastasis or recurrence during the follow-up period. A daughter lesion was observed near the primary tumor in one patient. All patients achieved curative resection, and no tumor specimens showed positive margins.</p><p><strong>Conclusions: </strong>DPPHR facilitates anatomical resection of the pancreatic head in patients with PNETs as well as detailed pathological evaluation of the resected specimen. Therefore, this surgical procedure is an acceptable alternative to pancreaticoduodenectomy or enucleation for patients with PNETs.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 3","pages":"69-74"},"PeriodicalIF":0.0,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11288719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141861130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparison of classical method and microdebrider technique for adenoidectomy in pediatric patients with obstructive sleep apnea.","authors":"Hiroya Inada, Masatoshi Hirata, Ayami Kimura, Satoshi Ito, Kazuki Shikano, Masamichi Kaneko, Takayuki Okano, Seiichi Nakata","doi":"10.20407/fmj.2023-009","DOIUrl":"https://doi.org/10.20407/fmj.2023-009","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate the safety and efficacy of microdebrider adenoidectomy on sleep-disordered breathing among pediatric patients with OSA.</p><p><strong>Methods: </strong>In the microdebrider group (Group I), there were 30 Japanese OSA patients consisting of 26 boys and 4 girls. For comparison, we had 15 children (13 boys and 2 girls) who underwent classical adenoidectomy (Group II). Patients in Group I were selected from a pool of 95 pediatric Japanese OSA patients and were matched by age, preoperative AHI, and Kaup index with those in Group II.Parameters such as the amount of residual adenoid tissue, bleeding, duration of the procedure, and sleep-related metrics were compared between the two groups.</p><p><strong>Results: </strong>A significant improvement in postoperative AHI was observed in Group I (<i>p</i><0.05). The prevalence of AHI <1 was significantly higher in Group I compared with Group II (<i>p</i><0.05). Additionally, the amount of postoperative residual adenoid was significantly less in Group I (3/30 of Grade 3 and 4 adenoid size) than in Group II (7/15, <i>p</i><0.05). Furthermore, a reduction in postoperative AHI was proportionally associated with a decrease in residual adenoid.</p><p><strong>Conclusions: </strong>The newly developed microdebrider adenoidectomy technique for pediatric OSA patients with adenotonsillar hypertrophy demonstrated greater accuracy and efficacy in ameliorating sleep apnea symptoms compared with the standard adenoidectomy approach.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 2","pages":"49-52"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11063575/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140855857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fujita Medical JournalPub Date : 2024-05-01Epub Date: 2024-02-15DOI: 10.20407/fmj.2023-016
Koji Ueoka, Tadashi Mizuguchi, Masayuki Horiguchi, Yasuki Ito
{"title":"Vitreoretinal interface abnormalities in fellow eyes of patients with a macular hole.","authors":"Koji Ueoka, Tadashi Mizuguchi, Masayuki Horiguchi, Yasuki Ito","doi":"10.20407/fmj.2023-016","DOIUrl":"https://doi.org/10.20407/fmj.2023-016","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine the incidence of bilateral macular holes (MHs), and to investigate the incidence and characteristics of retinal abnormalities in the fellow eyes, using high-definition optical coherence tomography (OCT).</p><p><strong>Methods: </strong>Medical records from 724 consecutive patients diagnosed with full-thickness MHs, who underwent surgery at Fujita Health University Hospital from May 2015 to March 2022, were retrospectively reviewed. Based on the exclusion criteria, 658 patients with idiopathic MHs were included. B-scan OCT images of the fellow eyes were used to identify vitreoretinal interface abnormalities, such as MHs, epiretinal membranes (ERMs), vitreomacular traction syndrome (VMTS) and lamellar macular holes (LMHs).</p><p><strong>Results: </strong>The mean age of the patients was 65.9±9.0 years. There were 292 males (44.4%) and 366 females (55.6%). There were 39 fellow eyes with MHs (5.9%), 77 with ERMs (11.7%), 32 with VMTS (4.9%) and 11 with LMHs (1.7%). Thirty-four fellow eyes (5.2%) could not be classified and 469 fellow eyes were normal (71.3%). Furthermore, the 39 bilateral MHs were divided into four stages according to the Gass classification, as follows: stage 1, 32 eyes (82.1%); stage 2, none (0%); stage 3, 5 eyes (12.8%); and stage 4, 2 eyes (5.1%).</p><p><strong>Conclusions: </strong>Vitreoretinal interface abnormalities, such as MHs, ERMs, VMTS and LMHs, are more common in the fellow eyes of patients with MHs than in the healthy population. The fellow eyes of patients with MHs should be carefully followed using OCT.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 2","pages":"64-68"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11063577/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140852404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Relationship between size of pharyngeal and palatine tonsils and apnea-hypopnea index in pediatric obstructive sleep apnea.","authors":"Masamichi Kaneko, Masatoshi Hirata, Ayami Kimura, Hiroya Inada, Kazuki Shikano, Satoshi Ito, Takayuki Okano, Hiroshi Yatsuya, Seiichi Nakata","doi":"10.20407/fmj.2023-011","DOIUrl":"https://doi.org/10.20407/fmj.2023-011","url":null,"abstract":"<p><strong>Objective: </strong>To determine whether the combination of the pharyngeal tonsil grade and palatine tonsil grade results in differences in the apnea-hypopnea index (AHI) and to determine whether each parameter separately (pharyngeal tonsil grade and palatine tonsil grade) results in differences in severe obstructive sleep apnea (OSA).</p><p><strong>Methods: </strong>This cross-sectional study involved 107 children (mean age, 7.2 years; range, 4-12 years) suspected of having OSA because of snoring or sleep-related complaints. The patients underwent polysomnography, and their palatine and pharyngeal tonsils were graded.</p><p><strong>Results: </strong>In examining whether the palatine tonsils and pharyngeal tonsils could be risk factors for severe OSA, the adjusted odds ratios were 4.42 for palatine tonsil grade 4 versus 1-3 and 10.40 for pharyngeal tonsil grade 4 versus 1-3; both were highly statistically significant. We also found that the AHI when both the pharyngeal and palatine tonsils were grade 4 was higher than the AHI expected for the pharyngeal and palatine tonsils alone.</p><p><strong>Conclusions: </strong>The combination of grade 4 pharyngeal tonsils and grade 4 palatine tonsils resulted in an AHI much higher than the AHI of other combinations (pharyngeal tonsils grades 1-3 and 4, palatine tonsils grades 1-3 and 4). We believe that grade 4 pharyngeal tonsils and grade 4 palatine tonsils have a great influence on severe OSA and that grade 4 pharyngeal tonsils increase the AHI.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 2","pages":"60-63"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11063576/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140865915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Deglutition dynamics of patients with obstructive sleep apnea.","authors":"Satoshi Ito, Yoichiro Aoyagi, Masatoshi Hirata, Miho Ohashi, Hitoshi Kagaya, Hiroya Inada, Ayami Kimura, Kazuki Shikano, Masamichi Kaneko, Takayuki Okano, Seiichi Nakata","doi":"10.20407/fmj.2023-010","DOIUrl":"https://doi.org/10.20407/fmj.2023-010","url":null,"abstract":"<p><strong>Objectives: </strong>In the present study, we performed a detailed analysis of deglutitive dynamics during sleep in patients with obstructive sleep apnea (OSA) using a methodology developed by Sato et al. We hypothesized that the frequency of deglutition would decrease with increasing severity of OSA. The aim of this study is to clarify the involvement of deglutitive dynamics during sleep in OSA by investigating the correlations between deglutition and sleep parameters.</p><p><strong>Methods: </strong>This study included 30 adult patients with OSA. To analyze deglutition dynamics during sleep, surface electromyography recordings of the suprahyoid and thyrohyoid neck muscles, which are involved in deglutition, were performed simultaneous with conventional polysomnography. The \"index of deglutition\" was defined as the frequency of deglutition per hour of sleep. We examined correlations between this index and sleep parameters (apnea-hypopnea index [AHI], apnea index, hypopnea index, and lowest blood oxygen saturation).</p><p><strong>Results: </strong>By analyzing the obtained polysomnography and electromyography waveforms, we identified two deglutition patterns with and without respiratory arousal during sleep. We found a significant negative correlation between the index of deglutition in sleep stage 1 and the AHI, with a correlation coefficient of -0.48. (p=0.02).</p><p><strong>Conclusions: </strong>In the current study, we distinguished deglutition during sleep with and without arousal. In addition we discovered a significant negative correlation between the index of deglutition in sleep stage 1 and the AHI. This new finding will provide a platform for future research on OSA in aspiration pneumonia.</p>","PeriodicalId":33657,"journal":{"name":"Fujita Medical Journal","volume":"10 2","pages":"43-48"},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11063574/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140871438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}