Clinical study on anorexia in patients with terminal cancer.

Fujita Medical Journal Pub Date : 2024-11-01 Epub Date: 2024-08-28 DOI:10.20407/fmj.2024-002

Miyo Murai, Masanobu Usui, Akihiro Ito, Akihiko Futamura, Kazuki Imai

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Abstract

Objectives: Patients with terminal cancer tend to have an increased frequency of a variety of clinical symptoms, including anorexia, at 1 month of life expectancy. This study examined clinical symptoms affecting anorexia in patients with terminal cancer.

Methods: Of 1068 patients with terminal cancer who died and were discharged from our hospital between April 2014 and March 2016, we included 471 patients whose clinical symptoms could be subjectively assessed within 4 weeks before death.Patients were evaluated subjectively on a scale of 0 to 10 (11-point scale) using the Numerical Rating Scale (NRS) once a week for nine major clinical symptoms: (1) pain, (2) general fatigue, (3) dyspnea, (4) depressed mood, (5) anorexia, (6) insomnia, (7) nausea, (8) constipation, and (9) dry mouth. Primary data within 4 weeks prior to death were used for analysis, and Spearman's rank correlation was used to examine clinical symptoms affecting anorexia.

Results: Spearman's rank correlation coefficients between anorexia and the following clinical symptoms were: pain, 0.186; general fatigue, 0.414; dyspnea, 0.15; depressed mood, 0.287; insomnia, 0.327; nausea, 0.297; constipation, 0.215; and dry mouth, 0.204. General fatigue was positively correlated with anorexia.

Conclusions: General fatigue may influence anorexia in patients with terminal cancer.

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癌症晚期患者厌食症的临床研究。

目的：癌症晚期患者在预期寿命的 1 个月内出现包括厌食在内的各种临床症状的频率往往会增加。本研究探讨了影响癌症晚期患者厌食的临床症状：在2014年4月至2016年3月间死亡并出院的1068名晚期癌症患者中，我们纳入了471名在死亡前4周内可对其临床症状进行主观评估的患者。患者每周一次使用数字评定量表（NRS）对以下九种主要临床症状进行主观评估，评分标准为 0 至 10 分（11 分制）：(1) 疼痛；(2) 全身乏力；(3) 呼吸困难；(4) 情绪低落；(5) 厌食；(6) 失眠；(7) 恶心；(8) 便秘；(9) 口干。死亡前 4 周内的主要数据用于分析，斯皮尔曼等级相关性用于研究影响厌食的临床症状：厌食症与以下临床症状之间的斯皮尔曼等级相关系数分别为：疼痛，0.186；全身疲劳，0.414；呼吸困难，0.15；情绪低落，0.287；失眠，0.327；恶心，0.297；便秘，0.215；口干，0.204。全身疲劳与厌食呈正相关：结论：全身疲劳可能会影响晚期癌症患者的厌食。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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