Digital Chinese Medicine最新文献

{"title":"Research status and prospect of tongue image diagnosis analysis based on machine learning","authors":"X.U. Jiatuo,&nbsp;J.I.A.N.G. Tao,&nbsp;L.I.U. Shi","doi":"10.1016/j.dcmed.2024.04.002","DOIUrl":"https://doi.org/10.1016/j.dcmed.2024.04.002","url":null,"abstract":"<div><p>Image-based intelligent diagnosis represents a trending research direction in the field of tongue diagnosis in traditional Chinese medicine (TCM). In recent years, machine learning techniques, including convolutional neural networks (CNNs) and Transformers, have been widely used in the analysis of medical images, such as computed tomography (CT) and nuclear magnetic resonance imaging (MRI). These techniques have significantly enhanced the efficiency and accuracy of decision-making in TCM practices. Advanced artificial intelligence (AI) technologies have also provided new opportunities for the research and development of medical equipment and TCM tongue diagnosis, resulting in improved standardization and intelligence of the tongue diagnostic procedures. Although traditional image analysis methods could transform tongue images into scientific and analyzable data, recognizing and analyzing images that capture complicated tongue features such as tooth-marked tongue, tongue spots and prickles, fissured tongue, variations in coating thickness, tongue texture (curdy and greasy), and tongue presence (peeled coating) continues posing significant challenges in contemporary tongue diagnosis research. Therefore, the employment of machine learning techniques in the analysis of tongue shape and texture features as well as their applications in TCM diagnosis is the focus of this study. In the study, both traditional and deep learning image analysis techniques were summarized and analyzed to figure out their value in predicting disease risks by observing the tongue shapes and textures, aiming to open a new chapter for the development and application of AI in TCM tongue diagnosis research. In short, the combination of TCM tongue diagnosis and AI technologies, will not only enhance the scientific basis of tongue diagnosis but also improve its clinical applicability, thereby advancing the modernization of TCM diagnostic and therapeutic practices.</p></div>","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"7 1","pages":"Pages 3-12"},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S258937772400020X/pdfft?md5=ea933f4c35060e5cb6d1f7b9d1bece79&pid=1-s2.0-S258937772400020X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141485184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective effects of ginseng total saponins on reward-directed operant conditioning in hindlimb suspension rats","authors":"Dong Lijinchuan ,&nbsp;Chen Ying ,&nbsp;Hu Qin ,&nbsp;Bao Yu ,&nbsp;Pan Ruile ,&nbsp;Zeng Guirong ,&nbsp;Peng Bo ,&nbsp;Liu Xinmin ,&nbsp;Shi Zhe","doi":"10.1016/j.dcmed.2024.01.005","DOIUrl":"10.1016/j.dcmed.2024.01.005","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the therapeutic effects of ginseng total saponins (GTSs) on cognitive impairments in astronauts caused by prolonged exposure to microgravity environment.</div></div><div><h3>Methods</h3><div>Fifty specific pathogen-free (SPF) male Wistar rats were randomized into control, hindlimb suspension (HLS), Huperzine A (HLS-Hup A 0.1 mg/kg), low-dose GTSs (HLS-GTSs 100 mg/kg), and high-dose GTSs (HLS-GTSs 200 mg/kg) groups, based on the completion time of reward-directed conditioning tasks. Except for rats in the control group, the others were subjected to HLS and treated with drugs (day 20 – 58), received reflex test under the condition of rewarding, and underwent Nissl body staining and Western blot detection on hippocampal.</div></div><div><h3>Results</h3><div>After modeling, rats in HLS group exhibited a reduction in the number of lever presses and an increase in the completion time of the reward-directed operant conditioning task Ⅰ (<em>P</em> &lt; 0.05) when compared with the control group, which were not substantially altered in the HLS-GTSs 100 and 200 mg/kg groups (<em>P</em> &gt; 0.05). In the reward-directed operant conditioning task Ⅱ, the HLS group rats demonstrated a marked decrease in the number of lever presses (<em>P</em> &lt; 0.05) and nose pokes (<em>P</em> &lt; 0.01) when compared with the control group rats; the HLS-GTSs 100 mg/kg showed a significant increase in the number of lever presses and nose pokes (<em>P</em> &lt; 0.05), while the HLS-GTSs 200 mg/kg demonstrated a significant reduction in completion time and an elevation in the number of lever presses (<em>P</em> &lt; 0.05) when compared with the HLS group rats. In visual signal discrimination task, compared with the control group rats, the HLS group rats showed decrease in the indexes of the visual signal discrimination (<em>P</em> &lt; 0.01), while HLS-GTSs 100 and 200 mg/kg groups exhibited manifest increase in it (<em>P</em> &lt; 0.01). In reward extinction experiment, the number of lever presses in HLS rats significantly increased when compared with the control group (<em>P</em> &lt; 0.01); compared with the HLS group, HLS-GTSs 100 and 200 mg/kg groups demonstrated a marked descrease (<em>P</em> &lt; 0.05). The expressions of N-methyl-D-aspartic acid receptor 1 (NR1) and phosophorylated N-methyl-D-aspartic acid receptor 2B (p-NR2B) proteins were markedly decreased in rats in the HLS group (<em>P</em> &lt; 0.05 and <em>P</em> &lt; 0.01, respectively), while that of NR2B protein maintained the same (<em>P</em> &gt; 0.05). GTSs increased the expression levels of p-NR2B (<em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>GTSs improved the learning and memory ability of complex operations by regulating the NR1/NR2B phosphorylation pathways in rats.</div></div>","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"6 4","pages":"Pages 416-425"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143235719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Jiuhua hemorrhoid suppository plus diosmin for the treatment of hemorrhoid hemorrhage: a multicenter, randomized, and controlled trial","authors":"Rong Xinqi ,&nbsp;Wu Mingsheng ,&nbsp;Xin Xuezhi ,&nbsp;Zhang Bo ,&nbsp;Liu Dianwen ,&nbsp;Xiao Huirong ,&nbsp;Wang Zhenyi ,&nbsp;Cui Junhui ,&nbsp;Wang Jianping ,&nbsp;Wang Zhongcheng ,&nbsp;Fan Xiaohua ,&nbsp;Hu Ying ,&nbsp;Rong Yisheng ,&nbsp;Li Ying","doi":"10.1016/j.dcmed.2024.01.009","DOIUrl":"10.1016/j.dcmed.2024.01.009","url":null,"abstract":"<div><h3>Objective</h3><div>To compare the efficacy and safety of combining diosmin with Jiuhua hemorrhoid suppository versus diosmin alone for the treatment of hemorrhoid hemorrhage.</div></div><div><h3>Method</h3><div>The Jiuhua hemorrhoid suppository study was conducted in 10 medical centers across China from April 1, 2019 to June 30, 2020. Patients with hemorrhoid bleeding were randomized in a ratio of 1 : 1 to either receive Jiuhua hemorrhoid suppository and diosmin tablets (the study group) or diosmin tablets alone (the control group). The suppository was used once a day after defecation or at bedtime after rinsing the anus with warm water. Diosmin tablets were administered only once a day (0.9 g). The primary endpoint of the study was the assessment of hemorrhoid bleeding relief 7 ± 2 days after treatment, classified as “very effective” “effective” and “ineffective”. The secondary endpoint included the evaluation of pain alleviation using the visual analogue scale (VAS, with scores ranging from 0 to 10) and edema (with scores ranging from 0 to 3). The safety of the two treatment regimens was evaluated 14 ± 2 days after drug administration.</div></div><div><h3>Results</h3><div>The full analysis set (FAS) comprised 107 participants in the study group and 111 in the control group, while the per-protocol set (PPS) included 106 participants in the study group and 111 in the control group. In terms of hemorrhoid bleeding, the proportion of very effective and effective cases in the study group were significantly higher than that in the control group [106 (99.06 %) vs. 91 (81.98 %), <em>P</em> &lt; 0.0001] in the FAS, and the PPS results [105 (99.06 %) vs. 91 (81.98 %), <em>P</em> &lt; 0.0001] were comparable to the FAS results. The pain VAS scores at day 7 after treatment were comparable between the two groups (0.80 ± 1.17 vs. 0.80 ± 1.20, <em>P</em> = 0.2177). The majority of the participants in both groups had an edema score of 0 at day 7 after treatment [96 (89.72 %) vs. 99 (91.67 %), <em>P</em> = 0.3705]. Adverse events (AEs) occurred in 9 patients (8.4 %) in the study group and 3 patients (2.7 %) in the control group. In addition, 5 AEs in the study group and 1 AE in the control group were possibly in association with the study drug.</div></div><div><h3>Conclusion</h3><div>Compared with the administration of diosmin oral tablets alone, the addition of Jiuhua hemorrhoid suppository to the tablets demonstrates enhanced efficacy in addressing hemorrhoid bleeding, with satisfactory patient adherence and acceptable safety.</div></div>","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"6 4","pages":"Pages 467-476"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143234933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"2Long-read sequencing revealed alterations of microbial relationship between tongue coating and gastric mucosa in patients with gastric intestinal metaplasia","authors":"Wu Jianping ,&nbsp;Li Meifeng ,&nbsp;Hua Zhaolai ,&nbsp;Lu Bin ,&nbsp;Xiang Jiao ,&nbsp;Wu Zhenfeng ,&nbsp;Zhang Junfeng","doi":"10.1016/j.dcmed.2024.01.007","DOIUrl":"10.1016/j.dcmed.2024.01.007","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the microbial correlation between oral tongue coating (TC) and gastric mucosa (GM) in patients with gastric intestinal metaplasia (GIM).</div></div><div><h3>Methods</h3><div>The present study recruited 1360 volunteers for upper gastrointestinal cancer screening. The microbiota in TC and GM were profiled by long-read sequencing of full-length 16S rRNA gene. The microbial diversity, community structure, and linear discriminant analysis effect size (LEfSe) were analyzed by the software Visual Genomics. SparCC correlation analysis was used to construct the commensal network and the graphical display was conducted by R software.</div></div><div><h3>Results</h3><div>The population included 44 patients with precancerous GIM, and 28 matched controls with negative rapid urease test (RUT) and non-symptomatic chronic superficial gastritis (CSG). No significant difference in diversity was observed between GIM patients and controls in TC or GM microbiota (<em>P</em> &gt; 0.05). Patients had a higher percentage of 41 – 60 co-occurring operational taxonomic units (OTUs) between TC and GM than controls (34.1 % vs. 25.0 %) (<em>P</em> &lt; 0.05). The LEfSe showed that TC <em>Prevotella melaninogenica</em> and three gastric <em>Helicobacter species</em> (i.e., <em>Helicobacter pylori</em>, <em>Helicobacter pylori XZ274</em>, and <em>Helicobacter pylori 83</em>) were enriched in patients with GIM. Furthermore, GIM patients with positive RUT had a lower percentage of co-occurring OTUs over 20 (<em>P</em> &lt; 0.05), and lower abundances of gastric <em>Veillonella</em>, <em>Pseudonocardia</em>, and <em>Mesorhizobium</em> than those with negative RUT (<em>P</em> &lt; 0.05). The commensal network between TC and GM was more complex in GIM patients than in controls. GIM patients with positive RUT demonstrated more bacterial correlations between TC and GM than those with negative RUT. Finally, the serum ratio of PG-I/II was negatively correlated with three gastric <em>Helicobacter species</em> (<em>Helicobacter pylori</em>, <em>Helicobacter pylori XZ274</em>, and <em>Helicobacter pylori 83</em>) in patients with negative RUT (<em>P</em> &lt; 0.05), and negatively correlated with two TC species (<em>Fusobacterium nucleatum</em> subsp. <em>nucleatum</em> and <em>Campylobacter showae</em>) in patients with positive RUT (<em>P</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The development of GIM potentiated the commensal network between oral TC and GM, providing microbial evidence of the correlation between TC and the stomach.</div></div>","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"6 4","pages":"Pages 438-450"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143235718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of metabolites in different parts of Juandan Baihe (Lilium lancifolium) by UPLC-Q-TOF-MS and their hypoglycemic activities","authors":"Zhang Luoqin ,&nbsp;Wu Yizhen ,&nbsp;Wang Hong ,&nbsp;Xiang Sheng ,&nbsp;Wang Binghui ,&nbsp;Tan Xiaowen ,&nbsp;Li Zhongzheng","doi":"10.1016/j.dcmed.2024.01.006","DOIUrl":"10.1016/j.dcmed.2024.01.006","url":null,"abstract":"<div><h3>Objective</h3><div>To identify the main components in the extracts of different parts of Juandan Baihe (<em>Lilium lancifolium</em>) by ultra-high performance liquid chromatography quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS) technology and investigate their hypoglycemic activities.</div></div><div><h3>Methods</h3><div>The MS fragmentation pathways of the main types of compounds in Juandan Baihe (<em>Lilium lancifolium</em>) were studied, and the main components in the extracts were systematically identified using MS fragmentation pathways combined with MS mining technology. Based on the hyperglycemia male mouse model [specific pathogen free (SPF)-grade Kunming mice] induced by streptozotocin (intragastric administration of 80 mg/kg for 3 d), the hypoglycemic effects of extracts of Juandan Baihe (<em>Lilium lancifolium</em>) roots, stems, corms, leaves, and flowers were evaluated by measuring the changes of blood glucose, daily water consumption, daily food intake, and body weight.</div></div><div><h3>Results</h3><div>The MS fragmentation pathways of regalosides, dioscins, phenylpropanoids, flavonoids, and chlorogenic acids in Juandan Baihe (<em>Lilium lancifolium</em>) were clarified, and a mining method for compounds in this plant was constructed. A total of 58 compounds, including 6 chlorogenic acids, 14 regalosides, 13 phenylpropanoids, 5 flavonoids, and 20 dioscins, were identified from the roots, stems, corms, leaves, and flowers of Juandan Baihe (<em>Lilium lancifolium</em>). Among them, 30 compounds were reported for the first time from this plant. The root and corm extracts demonstrated significant hypoglycemic activities by reducing blood glucose levels from 23.76 ± 1.21 and 24.29 ± 1.35 mmol/L to 17.21 ± 1.23 and 18.78 ± 1.49 mmol/L, respectively (<em>P</em> &lt; 0.05). The roots and corms extracts could also attenuate the symptoms of polydipsia (<em>P</em> &lt; 0.01), polyphagia (<em>P</em> &lt; 0.05), and weight loss caused by diabetes.</div></div><div><h3>Conclusion</h3><div>This study clarifies that the roots of Juandan Baihe (<em>Lilium lancifolium</em>) are rich in regalosides and dioscins for the first time, and have significant hypoglycemic activities, providing the foundation for the comprehensive utilization of this plant and the development of hypoglycemic drugs.</div></div>","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"6 4","pages":"Pages 426-437"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142014096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current status and trends in the modernization of pulse diagnosis research: a bibliometric analysis based on CiteSpace and VOSviewer","authors":"Zhang Fenfen,&nbsp;Zhu Guoshuang,&nbsp;Chen Jiali,&nbsp;Zhang Jianhong,&nbsp;Dong Sihui,&nbsp;Cheng Shaomin","doi":"10.1016/j.dcmed.2024.01.004","DOIUrl":"10.1016/j.dcmed.2024.01.004","url":null,"abstract":"<div><h3>Objective</h3><div>To provide ideas for the modernization of pulse diagnosis in traditional Chinese medicine (TCM) by comparing and analyzing the current status and trends of modern research on pulse diagnosis in China and abroad, using bibliometric and visualization software.</div></div><div><h3>Methods</h3><div>Modern research literature on pulse diagnosis was searched in China National Knowledge Infrastructure (CNKI) database from the foundation to May 31, 2023, and in Science Citation Index Expanded (SCIE) from January 1, 2003, to May 31, 2023. After further screening, Microsoft Excel 2019 was used for statistical analysis of publication volume, and CiteSpace (6.1.R6) and VOSviewer (1.6.20) softwares were employed for visual analysis of journals, countries/regions, authors, institutions, keywords, etc.</div></div><div><h3>Results</h3><div>This study included a total of 764 articles in Chinese and 1 459 articles in English. The publication trend of pulse diagnosis research in SCIE database showed an overall fluctuating upward trend, while it exhibited a fluctuating downward trend after 2007 in CNKI database. The volume of English research literature has consistently exceeded that of Chinese literature since 2009. Publications on pulse diagnosis research involved 74 countries/regions. The related journals covered various disciplinary fields, including mathematics, physics, chemistry, and computer science. The most prolific author in CNKI database was WANG Yiqin (Shanghai University of Traditional Chinese Medicine), while the highest number of publications was attributed to ZHANG David (The Hong Kong Polytechnic University) in SCIE database. High-volume institutions in pulse diagnosis research in China and abroad were predominantly TCM research institutions. However, comprehensive universities and other research institutions also made noteworthy contributions. In recent years, hot topics in the modernization of pulse diagnosis research in China included pulse waves, sensors, and artificial intelligence. Foreign research focused on pulse diagnosis systems, sensors, pulse feature extraction, pulse signal analysis, pulse detection, and efficiency of use.</div></div><div><h3>Conclusion</h3><div>Chinese scholars have shown notable participation and emphasis in the modernization research of pulse diagnosis, involving a wide range of disciplinary fields and indicating a characteristic of multidisciplinary cross-fusion development. The hotspots and trends in the modernization of pulse diagnosis research primarily concentrate on the study of pulse condition and signal acquisition, the integration, development, and optimization of various algorithms with pulse diagnosis equipment, and the practical application research of existing objectified outcomes of pulse diagnosis.</div></div>","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"6 4","pages":"Pages 405-415"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143235720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Differential expression profiles analysis of DNA methylation between “disease” and “syndrome” in coronary heart disease-induced unstable angina patients with Qi deficiency and blood stasis syndrome","authors":"Wu Huaying ,&nbsp;Hu Hongchun ,&nbsp;Liu Yufeng ,&nbsp;Li Liang ,&nbsp;Li Jing ,&nbsp;Han Yuming ,&nbsp;Xiao Changjiang ,&nbsp;Peng Qinghua","doi":"10.1016/j.dcmed.2024.01.008","DOIUrl":"10.1016/j.dcmed.2024.01.008","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To explore the differential expression profiles of DNA methylation sites/regions and potential molecular mechanisms in the peripheral blood of coronary heart disease (CHD)-induced unstable angina pectoris patients with or without Qi deficiency and blood stasis syndrome, and to provide scientific evidence for the conbination of disease and syndrome.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;According to the pre-determined inclusion and exclusion criteria, the study subjects were enrolled and divided into two groups namely CHD-induced unstable angina group (G group) and healthy control group (J group) to conduct “disease” analysis, while G group was further divided into Qi deficiency and blood stasis syndrome group (case group) and non-Qi deficiency blood stasis syndrome group (control group) to perform “syndrome” analysis. The general data and clinical information of the study subjects were collected. The peripheral venous blood was extracted on an empty stomach, and the Illumina Infinium MethylationEPIC BeadChip (850K methylation chip) was used to detect the differential expression profiles of DNA methylation in each group, ChAMP software (V 2.14.0) was used for the differential methylation data analysis, with a threshold of the adjusted &lt;em&gt;P&lt;/em&gt; value (adj.&lt;em&gt;P.&lt;/em&gt;val) &lt; 0.01. Gene Ontology (GO) and Kyoto Encyclopedia of Genomes (KEGG) were employed for the functional and pathway enrichment analyses of related mapped genes.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 263 differentially methylated CpG positions (DMPs) were screened out between G and J groups, including 191 hypermethylated positions such as cg05845204 and cg08906898, and 72 hypomethylated positions such as cg26919182 and cg13149459. These positions were mainly mapped to 148 genes encompassing RNA binding motif protein 39 (&lt;em&gt;RBM39&lt;/em&gt;)&lt;em&gt;,&lt;/em&gt; acetyl-CoA acyltransferase 2 (&lt;em&gt;ACAA2&lt;/em&gt;)&lt;em&gt;,&lt;/em&gt; protein phosphatase 1 regulatory subunit 12B (&lt;em&gt;PPP1R12B&lt;/em&gt;)&lt;em&gt;,&lt;/em&gt; and the dual-specificity tyrosine phosphorylation-regulated kinase 2 (&lt;em&gt;DYRK2&lt;/em&gt;). GO functional enrichment analysis revealed that the genes of the DMPs were primarily enriched in protein localization to chromosomes, regulation of cell morphogenesis, negative regulation of calcium-mediated signals, etc. KEGG pathway analysis suggested that the genes were mainly enriched in fatty acid metabolism and endocytosis pathways. In addition, a total of 23 differential methylation regions (DMRs) were identified, with overlapping genes such as transmembrane protein 232 (&lt;em&gt;TMEM232&lt;/em&gt;), ribosomal protein large P1 (&lt;em&gt;RPLP1&lt;/em&gt;), peroxisomal biogenesis factor 10 (&lt;em&gt;PEX10&lt;/em&gt;), and forkhead box N3 (&lt;em&gt;FOXN3&lt;/em&gt;) recognized. It was found that GO functions were mainly enriched in the negative regulation of Ras protein signal transduction, small GTPase-mediated signal transduction, negative regulation, etc. A total of 1 703 differential methylation sites were screened out betwe","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"6 4","pages":"Pages 451-466"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143234729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence and acupoint combinations in acupuncture for functional dyspepsia: an overview of systematic review and data mining study","authors":"Zou Menglong ,&nbsp;Hu Zhuoyu ,&nbsp;Long Dan ,&nbsp;Sun Haoxian ,&nbsp;Zhu Ying","doi":"10.1016/j.dcmed.2024.01.001","DOIUrl":"10.1016/j.dcmed.2024.01.001","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Objective&lt;/h3&gt;&lt;div&gt;To evaluate the methodological quality of papers that performed meta-analyzed and systematically reviewed acupoint selections for the treatment of functional dyspepsia (FD) and to identify the ideal acupoint combinations for FD.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Chinese databases including China National Knowledge Infrastructure (CNKI), China Science and Technology Journal Database (VIP), China Biology Medicine (CBM), and Wanfang Database, as well as English databases including PubMed, Embase, and Cochrane Library were searched to retrieve papers about meta-analysis and systematic literature reviews on acupuncture for FD. The time span for the paper retrieval was set from the foundation of the databases to April 30, 2022. The Veritas scores of the papers based on their publication year, study type, Assessment of Multiple Systematic Reviews 2 (AMSTAR2), Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), heterogeneity, and publication bias were rated to assess the methodological quality of the included studies. Then, randomized controlled trials (RCTs) were extracted from those meta-analysis papers or systematic literature reviews for analyzing acupoints frequency, meridian frequency, and association rules with the use of R software (V 4.3.1).&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Eight meta-analysis papers were included in the study after screening. The mean Veritas scores of the papers based on publication year, type of study, AMSTAR2, PRISMA, heterogeneity, and publication bias were 4.50, 8.00, 4.63, 4.63, 4.50, and 6.13, respectively. The analysis of the scores revealed insufficiencies in the reviews pertaining to the methodology, comprehension of the research strategy, detailed list of excluded studies, sources of funding, assessment of potential bias risks impact on meta-analysis results in each study, explanation of heterogeneity, and identification of potential conflicts of interest. Furthermore, a total of 85 RCTs were obtained from the eight meta-analysis papers involving 85 acupuncture prescriptions and 67 acupoints for subsequent data mining. The most commonly used meridian was Stomach meridian of Foot-Yangming (ST). Zusanli (ST36), Neiguan (PC6), Zhongwan (CV12), Taichong (LR3), Tianshu (ST25), Gongsun (SP4), Weishu (BL21), Pishu (BL20), Neiting (ST44), and Yinlingquan (SP9) topped the list of frequently selected acupoints. Additionally, a total of 28 association rules were identified, including 10 second-order, 15 third-order, and 3 fourth-order association rules. The top-ranking association rules in each order were “Neiguan (PC6) → Zusanli (ST36)” “Zhongwan (CV12) + Neiguan (PC6) → Zusanli (ST36)” and “Zhongwan (CV12) + Taichong (LR3) + Neiguan (PC6) → Zusanli (ST36)”, respectively.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;Acupuncture could alleviate the clinical symptoms of FD. However, the quality of methodology applied in the meta-analysis papers on the subject needs to be imp","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"6 4","pages":"Pages 369-380"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143234844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and safety of Qili Qiangxin Capsule in the adjuvant treatment of ischemic cardiomyopathy with heart failure: a systematic review and meta-analysis","authors":"Yin Ziwei ,&nbsp;Zheng Huizhen ,&nbsp;Guo Zhihua","doi":"10.1016/j.dcmed.2024.01.003","DOIUrl":"10.1016/j.dcmed.2024.01.003","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the efficacy and safety of Qili Qiangxin Capsule (QLQXC) combined with western medicine in patients with ischemic cardiomyopathy (ICM) comorbid with heart failure (HF) for clinical application.</div></div><div><h3>Methods</h3><div>We searched relevant references in Chinese databases including China National Knowledge Infrastructure (CNKI), China Scientific Journal Database (VIP), Wanfang Database, and China Biology Medicine (CBM), as well as English databases including PubMed and Embase, from the foundation of the database to January 8, 2023, without language restrictions. All statistical analyses, including subgroup and sensitivity analyses, were performed using the Review Manager (version 5.4) and Stata (version 15.0).</div></div><div><h3>Results</h3><div>QLQXC combined with western medicine significantly increased the endpoints of overall response rate (ORR) (<em>P</em> &lt; 0.000 01), left ventricular ejection fraction (LVEF) (<em>P</em> &lt; 0.000 01), the score of Minnesota Living with Heart Failure Questionnaire (MLHFQ) (<em>P</em> = 0.000 2), and 6-minute walking distance (6MWD) (<em>P</em> &lt; 0.000 01), decreased left ventricular end-diastolic diameter (LVEDD) (<em>P</em> &lt; 0.000 01), left ventricular end-systolic diameter (LVESD) (<em>P</em> = 0.03), and pro-brain natriuretic peptide (pro-BNP) (<em>P</em> &lt; 0.00001), and reduced the incidence of rehospitalization (<em>P</em> = 0.0003) and adverse events (AEs) (<em>P</em> = 0.000 6) compared with those under the conventional western therapy alone. Nonetheless, no significant difference was observed in reducing the mortality between the QLQXC combined with western medicine group and the western medicine group (<em>P</em> = 0.30).</div></div><div><h3>Conclusion</h3><div>The combination therapy of QLQXC with western medicine can potentiate cardiac function and raise the quality of life in patients with ICM comorbid with HF.</div></div>","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"6 4","pages":"Pages 393-404"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143234592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cardioprotective of Saffron (Crocus sativus L.) treatment in patients with type 2 diabetes mellitus: a systematic review and meta-analysis","authors":"Arlinda Silva Prameswari ,&nbsp;Viskasari Pintoko Kalanjati ,&nbsp;Tri Hartini Yuliawati ,&nbsp;Abdurachman ,&nbsp;Muhammad Miftahussurur","doi":"10.1016/j.dcmed.2024.01.002","DOIUrl":"10.1016/j.dcmed.2024.01.002","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the cardioprotective effect of Saffron (<em>Crocus sativus</em> L.) treatment as a potential supplement on patients with type 2 diabetes mellitus (T2DM).</div></div><div><h3>Methods</h3><div>Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were applied to analyze articles retrieved from PubMed, ScienceDirect, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI), and China Biology Medicine (CBM) with a publication time span from January 15, 2015 to March 20, 2023. The articles were published in English only, including randomized controlled trials (RCTs) on adult patients who were diagnosed with T2DM, and received either Saffron or placebo treatment. Meta-analysis was performed using Review Manager 5.4 software. The present study was registered on the International Prospective Register of Systematic Reviews (PROSPERO) with a registration number as CRD42023443180.</div></div><div><h3>Results</h3><div>Seven RCTs with 455 patients were included in the study. The data revealed that Saffron treatment significantly reduced tumor necrosis factor (TNF)-<em>α</em> (<em>P</em> = 0.008) and fasting blood glucose (FBG) (<em>P</em> = 0.04) levels compared with what placebo did in T2DM patients. No significant differences were shown in the levels of interleukin (IL)-6, malondialdehyde (MDA), high serum C-reactive protein (hs-CRP), lipid profile, blood pressure, and body mass index (BMI) between Saffron and placebo (<em>P</em> &gt; 0.05).</div></div><div><h3>Conclusion</h3><div>Saffron treatment has a cardioprotective effect in T2DM patients by reducing TNF-<em>α</em> and FBG levels. However, the potential anti-oxidant, anti-hypertensive, and anti-dyslipidaemia effects of the phytochemical need to be further investigated.</div></div>","PeriodicalId":33578,"journal":{"name":"Digital Chinese Medicine","volume":"6 4","pages":"Pages 381-392"},"PeriodicalIF":0.0,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143234845","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}