Virology & Immunology Journal最新文献_第3页

Polymorphism of KIR Genes in Women with Human Papillomavirus Infection 人乳头瘤病毒感染女性患者KIR基因多态性研究

Virology & Immunology Journal Pub Date : 2023-07-07 DOI: 10.23880/vij-16000319

García Ng

{"title":"Polymorphism of KIR Genes in Women with Human Papillomavirus Infection","authors":"García Ng","doi":"10.23880/vij-16000319","DOIUrl":"https://doi.org/10.23880/vij-16000319","url":null,"abstract":"Molecular biology screening techniques for early detection of human papillomavirus (HPV) infection in the National CervicalUterine Cancer Program in Cuba provide the opportunity to treat premalignant lesions and prevent progression to cervicaluterine cancer. Objectives: To identify 14 high-risk HPV genotypes in women aged 30 to 50 with negative previous cytology and to identify the polymorphism of killer immunoglobulin-like receptor (KIR) genes in a subsample of HPV-positive women. Methods: HPV screening tests were performed on 3,115 women using the COBAS 4800 system with the HPV COBAS kit (Roche, Germany). For KIR gene typing, 60 randomly selected HPV-positive women were analyzed using a molecular method based on hybridization probes on a LUMINEX flow analyzer with the LIFECODES KIR-SSO typing kit (Immucor, USA). Results: 295 (9.5%) women tested positive for one of the 14 high-risk genotypes. The highest percentage of positive women was found among those aged 30 to 39 years (12.0%). Fourteen women had coinfection with HPV16 or HPV18 along with another highrisk genotype. There was a high frequency of genes encoding activating receptors such as KIR 2DL1 (98.3%), KIR 2DL3 (98.3%), and KIR 2DS4*all full length (93.3%). Conclusions: The prevalence of HPV in Cuban women with normal cytology is lower than the global average, with activating KIR genes predominating among positive cases.","PeriodicalId":334586,"journal":{"name":"Virology & Immunology Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130560483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Molecular Docking and Dynamic Analyses of 3',5-Dihydroxy4',6,7-Trimethoxyflavanone, Isovitexin-2'-O-Rhamnoside, Solafuranone, (R)-5,3'-Dimethyl hesperidin, Phloretin 3',5'-Di-C -glucoside, Isomargaritene, Margaritene and Clemomandshuricoside B for Potential COVID-19 Therapy 3',5-Dihydroxy4',6,7-Trimethoxyflavanone, Isovitexin-2'-O-Rhamnoside, Solafuranone, (R)-5,3'-Dimethyl hesperidin, Phloretin 3',5'-Di-C -glucoside, Isomargaritene, Margaritene 和 Clemomandshuricoside B 的分子对接和动态分析，用于潜在的 COVID-19 疗法

Virology & Immunology Journal Pub Date : 2023-07-07 DOI: 10.23880/vij-16000326

Serap Yalcin

{"title":"The Molecular Docking and Dynamic Analyses of 3',5-Dihydroxy4',6,7-Trimethoxyflavanone, Isovitexin-2'-O-Rhamnoside, Solafuranone, (R)-5,3'-Dimethyl hesperidin, Phloretin 3',5'-Di-C -glucoside, Isomargaritene, Margaritene and Clemomandshuricoside B for Potential COVID-19 Therapy","authors":"Serap Yalcin","doi":"10.23880/vij-16000326","DOIUrl":"https://doi.org/10.23880/vij-16000326","url":null,"abstract":"Covid-19 (SARS-CoV-2), a new type of coronavirus, first appeared in the Chinese city of Wuhan in December 2019 and has become the main cause of the pandemic today. Although molecular studies continue, vaccination studies are not sufficient. In this Covid-19 process, which provides further increase in antiviral drug discoveries, we perform ligand-protein interactions in order to find an antiviral active substance with this study, Autodock. We present the analyzes based on the comparison of 8 different ligands(3',5-Dihydroxy-4',6,7-trimethoxyflavanone, Isovitexin-2'-O-rhamnoside, Solafuranone, (R)-5,3'-Dimethyl hesperidin, Phloretin 3',5'-Di-C-glucoside, Isomargaritene, Margaritene and Clemomandshuricoside B) based on the 6LU7 protein. It was observed that the molecules were bound by interacting with the main protease of Covid-19. Thus, we aim to be a reference with you in this article for further studies that enable ligands to create drug potential. Our results will serve as a reference for this molecular docking study","PeriodicalId":334586,"journal":{"name":"Virology & Immunology Journal","volume":"30 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139361635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Power of Viruses The COVID-19-Pandemic: A Harbinger of a Disastrous Geopolitics 病毒的力量 COVID-19 大流行：灾难性地缘政治的先兆

Virology & Immunology Journal Pub Date : 2023-07-07 DOI: 10.23880/vij-16000329

Vogt Pr

引用次数: 0

Targeting Spike Protein: Modified Antibody for Broad-Spectrum Binding to Coronaviruses: An In Silico Study 靶向尖峰蛋白：用于与冠状病毒广谱结合的改良抗体：硅学研究

Virology & Immunology Journal Pub Date : 2023-07-07 DOI: 10.23880/vij-16000324

Rai Rc

{"title":"Targeting Spike Protein: Modified Antibody for Broad-Spectrum Binding to Coronaviruses: An In Silico Study","authors":"Rai Rc","doi":"10.23880/vij-16000324","DOIUrl":"https://doi.org/10.23880/vij-16000324","url":null,"abstract":"An antibody-mediated immune response against the Spike protein is one of the potential ways to target the SARS-CoV-2 virus. The discovery of a highly effective vaccine or an antiviral drug that specifically targets the viral entry or its replication pathway, are commonly pursued as a way to combat COVID-19-like situation. The SARS-CoV-2 virus has RNA as its genetic material, which is known for its high mutation rate. This makes the efficiency and efficacy of the vaccine against it suboptimal later due to the continuous mutations in the epitope region of the virus. This was evident in the case of the spread of the Omicron (B.1.1.529) variant. Here we tested an in-silico approach towards finding an antibody that has the potential to recognise and bind against the Spike protein of the virus across most of the variants. We achieved this by altering the sequences of the VDJ region in the heavy and light chains of the natural human antibody against the Spike protein of the SARS-CoV-2 virus (Wuhan, PDB ID: 7BWJ). This was one of the first antibodies to be studied and published along with a crystal structure during mid2020, and known to have the ability to bind and neutralize the Wuhan isolate. Iterative substitutions were induced in the 7BWJ antibody sequence in different combinations. After 28 iterations, a potential antibody was found to bind across the variants with a comparatively higher docking score. This antibody also showed the potential to target the Spike protein of many members of Coronaviruses.","PeriodicalId":334586,"journal":{"name":"Virology & Immunology Journal","volume":"8 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139362096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

AstraZeneca Covid-19 Vaccine Reaction after a Second Dose Administration: A Case Study in Eldoret, Kenya 阿斯利康Covid-19疫苗第二次注射后的反应:肯尼亚埃尔多雷特的案例研究

Virology & Immunology Journal Pub Date : 2023-07-07 DOI: 10.23880/vij-16000315

Kwena Avm

引用次数: 0

The Complicated Relationship between Cancer Disease and Viral Infection: Facts and Understanding 癌症疾病与病毒感染的复杂关系:事实与认识

Virology & Immunology Journal Pub Date : 2023-04-03 DOI: 10.23880/vij-16000313

Hassan Bar

引用次数: 0

Inhibiting the Fusion of Enveloped Viruses 抑制包膜病毒的融合

Virology & Immunology Journal Pub Date : 2023-04-03 DOI: 10.23880/vij-16000312

Jacobs A

引用次数: 0

Undetermined Implications of Islamic Veil Practicing for COVID-19 Diagnosis and Treatment 伊斯兰面纱实践对COVID-19诊断和治疗的影响尚不确定

Virology & Immunology Journal Pub Date : 2023-04-03 DOI: 10.23880/vij-16000314

Rastmanesh R

引用次数: 0

Dengue- A Global Threat; Need to be Halted with Sound Scientific Measures to Stop its Rapid Devastation throughout the World 登革热——全球威胁;需要采取合理的科学措施制止其在世界各地的迅速破坏

Virology & Immunology Journal Pub Date : 2023-01-04 DOI: 10.23880/vij-16000309

S. Sh

引用次数: 0

Evaluation of Antibody Response in COVID-19 Recovered Population of Swat Kp, Pakistan 巴基斯坦斯瓦特Kp地区COVID-19康复人群抗体反应评估

Virology & Immunology Journal Pub Date : 2023-01-04 DOI: 10.23880/vij-16000308

K. I

{"title":"Evaluation of Antibody Response in COVID-19 Recovered Population of Swat Kp, Pakistan","authors":"K. I","doi":"10.23880/vij-16000308","DOIUrl":"https://doi.org/10.23880/vij-16000308","url":null,"abstract":"A novel coronavirus disease now known as the Coronavirus disease 2019 (COVID-19) is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It poses a huge challenge to the society, economy, and public health worldwide. At present, the antibody responses to SARS-CoV-2 remain largely unknown especially in remote regions of developing countries. The objective of the study was to evaluate the antibody response in COVID-19 recovered patients and vaccinated individuals of district Swat. COBAS-511 machine was used for quantitative detection of COVID-19 antibodies in 3 cc venous blood collected from selected patients and was stored in collection tubes followed by subsequent centrifugation to separate the serum. Further to ensure the variable factors does not affect the accuracy of the study, 95 questionnaires were distributed where the participants were asked to disclose basic information (name, age, gender, address, area, COVID-19 test, vaccinated or nonvaccinated, signs and symptoms, antibiotics/antivirals used during the infection time) since it is important to confirm patients' health status and to clearly determine whether they can donate plasma. Participant’s age ranging from 15 to 63 were involved in these studies. As per findings of this study, people aged 45 to 55 years had high levels of antibodies against COVID-19. In age wise antibody response level women were found to have higher antibody levels than men. Among the variable factors, the most common pre-complications were heart disease and diabetes, such individuals had higher levels of anti-COVID-19 antibodies than those with no prior health complications. The level of antibodies was significantly higher in patients that received anti-COVID-19 vaccines post recovery as compared to those that did not receive vaccine. However further study will be required to validate these preliminary observations.","PeriodicalId":334586,"journal":{"name":"Virology & Immunology Journal","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114298423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Virology &amp; Immunology Journal最新文献

Virology & Immunology Journal最新文献