2007 IEEE Dallas Engineering in Medicine and Biology Workshop最新文献_第3页

Characterization of Polymer Coated Magnetic Nanoparticles for Targeted Treatment of Cancer 聚合物包被磁性纳米颗粒靶向治疗癌症的表征

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1109/EMBSW.2007.4454167

S. Nattama, M. Rahimi, A. Wadajkar, B. Koppolu, J. Hua, F. Nwariaku, K. Nguyen

引用次数: 6

Experimental Study of EEG and Bold Responses to Sinusoidal Contrast Modulation 正弦对比调制下脑电和脑电信号的实验研究

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1109/EMBSW.2007.4454161

T. Ferrée, Alex R. Wade, M. L. Calvisi, D. Liley, B. Inglis, A. Norcia

引用次数: 1

Resolution beyond Rayleigh's criterion: a modern resolution measure with applications to single molecule imaging 超越瑞利准则的分辨率:一种应用于单分子成像的现代分辨率测量

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1109/EMBSW.2007.4454186

S. Ram, P. Prabhat, J. Chao, E. Ward, R. Ober

{"title":"Resolution beyond Rayleigh's criterion: a modern resolution measure with applications to single molecule imaging","authors":"S. Ram, P. Prabhat, J. Chao, E. Ward, R. Ober","doi":"10.1109/EMBSW.2007.4454186","DOIUrl":"https://doi.org/10.1109/EMBSW.2007.4454186","url":null,"abstract":"Rayleigh's criterion, although extensively used, is well known to be based on heuristic notions that are inadequate for modern optical microscopy applications. This inadequacy has necessitated a reassessment of the resolution limits of optical microscopes. By adopting a stochastic framework and using the statistical theory concerning the Fisher information matrix, we have derived a new resolution measure that overcomes the limitations of Rayleigh's criterion. Here, we provide a brief overview of this and other related results published by our group. The new resolution measure predicts that there is no resolution limit, but that the resolvability depends on the number of detected photons. It has been experimentally verified that distances well below Rayleigh's limit can be measured from images of closely spaced single molecules with an accuracy as predicted by the new resolution measure. The stochastic framework used to obtain the new resolution measure is applicable to a wide variety of estimation problems encountered in optical microscopy. As an application, we have investigated the localization accuracy problem, which is concerned with how accurately the 2D/3D location of a microscopic object can determined from its image. One of the shortcomings of current microscopy techniques is that they suffer from poor depth discrimination and as a result they are not well adapted for 3D tracking of single molecules/particles. We have recently developed a novel imaging modality called multifocal plane microscopy (MUM) to overcome this limitation. Using the stochastic framework, we have shown that MUM has significantly improved depth discrimination, which in turn enables 3D single particle tracking at high axial localization accuracy.","PeriodicalId":333843,"journal":{"name":"2007 IEEE Dallas Engineering in Medicine and Biology Workshop","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115571817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Wavelet Decomposition Analysis for Ultra-high Temporal Resolution fMRI Time Series 超高时间分辨率fMRI时间序列的小波分解分析

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1109/EMBSW.2007.4454180

Feng Xu, Z. A. Valdez-Jasso, Hanzhang Lu

{"title":"Wavelet Decomposition Analysis for Ultra-high Temporal Resolution fMRI Time Series","authors":"Feng Xu, Z. A. Valdez-Jasso, Hanzhang Lu","doi":"10.1109/EMBSW.2007.4454180","DOIUrl":"https://doi.org/10.1109/EMBSW.2007.4454180","url":null,"abstract":"Functional magnetic resonance imaging (fMRI) is a powerful tool for human brain mapping. Previously, it has primarily been applied at low temporal resolution, i.e. repetition time >500 ms, and cannot resolve rapid neuronal and vascular function/dysfunction. Here we aim to achieve a ten-fold improvement in temporal resolution by localizing the brain coverage (i.e. single-slice) in combination with optimized MR acquisition schemes, e.g. using parallel imaging, reducing flip angle and reducing echo-time. A new challenge is that, at this resolution, physiologic noises become more pronounced and may mix with the true brain activation signals. We therefore applied wavelet decomposition to separate the MRI time-course into four components: fMRI signal, cardiac pulsation signal, respiratory fluctuation signal, and residual noise. In vivo experiments using flashing checkerboard visual stimulation revealed hemodynamic responses that are consistent with previous low-resolution data but with more detailed temporal features. Time-to-peak of the fMRI signal was determined in six healthy subjects and one patient with possible Alzheimer's disease. Measurement reproducibility of the proposed method was also evaluated in three of the subjects.","PeriodicalId":333843,"journal":{"name":"2007 IEEE Dallas Engineering in Medicine and Biology Workshop","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124399575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Novel Preparation of Degradable Scaffolds Using BSA Microbubbles as Porogen 以牛血清白蛋白微泡为成孔剂制备可降解支架的新方法

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1109/EMBSW.2007.4454166

A. Nair, Jian Yang, Liping Tang

{"title":"A Novel Preparation of Degradable Scaffolds Using BSA Microbubbles as Porogen","authors":"A. Nair, Jian Yang, Liping Tang","doi":"10.1109/EMBSW.2007.4454166","DOIUrl":"https://doi.org/10.1109/EMBSW.2007.4454166","url":null,"abstract":"Biodegradable scaffolds play a key role in contemporary medicine for tissue replacement as well as regeneration. Many degradable scaffold fabrication techniques have been developed. However, these scaffolds often hamper the growth of cells due to material hydrophobicity and/or lack of biocompatible protein coating. To overcome the common problems, in this study, the use of protein microbubbles as a porogen and drug/protein carrier to produce polymeric scaffolds with good porosity was conceptualized. Albumin bubbles were produced by sonicating bovine serum albumin in the presence of nitrogen gas. PLGA scaffolds were then prepared by thermally induced phase separation with the incorporation of protein microbubbles as porogens. SEM and cryosectioning of scaffold revealed the presence of open interconnected pores measuring around 100 to 150 mum size, which is suitable for cell migration into scaffold. This novel technique provides two distinct advantages. First, microbubbles are made of biological materials which can provide biocompatible protein coating on the pores throughout the scaffold. Second, apart from having produced scaffolds with larger pores compared to conventional methods, our novel scaffold also has the potential to function as a delivery mechanism for delivering chemokines and drugs into the polymeric matrix.","PeriodicalId":333843,"journal":{"name":"2007 IEEE Dallas Engineering in Medicine and Biology Workshop","volume":"28 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127788136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Clustering Validation of Spinal Deformity Classification With Simplified 3-D Model and Principal Component Analysis 基于简化三维模型和主成分分析的脊柱畸形分类聚类验证

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1109/EMBSW.2007.4454163

Hong Lin

{"title":"Clustering Validation of Spinal Deformity Classification With Simplified 3-D Model and Principal Component Analysis","authors":"Hong Lin","doi":"10.1109/EMBSW.2007.4454163","DOIUrl":"https://doi.org/10.1109/EMBSW.2007.4454163","url":null,"abstract":"In this paper, the clustering validation of spinal deformity classification by principal component analysis is introduced for the visualization of high dimensional patterns of the scoliosis spinal deformity with their reduced two-dimensional clustering properties. King spinal deformity classification system was used for PCA cluster implementation. The dataset used for this study had 25 spinal deformity patterns. Such dataset was further divided into 5 subgroups. In each subgroup there were exactly 5 King deformity patterns. These 25 King spinal deformity classifications had been verified by artificial neural network with hold-out method. At the first step the simplified three-dimensional (3-D) spine model was constructed based on the coronal and sagittal X-ray images. The features of the central axis curve of the spinal deformity patterns in 3-D space were extracted by the total curvature analysis. The discrete form of the total curvature, including the curvature and the torsion of the central axis of the simplified 3-D spine model was derived from the difference quotients. The total curvature values of 17 vertebrae from the first thoracic to the fifth lumbar spine formed a Euclidean space of 17 dimensions. For the purpose of classification, each pattern of spinal deformity was labeled to identify it from others. Principal component analysis (PCA) was applied on the total curvature of these 25 spinal deformity patterns. By PCA dimensional reduction on these patterns, the 17-D pattern characters of spinal deformity were reduced into 2-D and the clustering property of spinal deformity classification can be visualized in a 2-D principal component plane.","PeriodicalId":333843,"journal":{"name":"2007 IEEE Dallas Engineering in Medicine and Biology Workshop","volume":"67 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2007-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121121903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

A Programmable DSP Development Platform for Automated Detection of Melanoma 用于黑色素瘤自动检测的可编程DSP开发平台

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1080/1931308X.2009.10644167

Y. Wu, E. Stotzer, J. Chen, X. Yuan, N. Mullani, G. Zouridakis

引用次数: 5

Real-time pitch detection on the PDA for cochlear implant applications 用于人工耳蜗的PDA实时音高检测

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1109/EMBSW.2007.4454181

R. Ramachandran, P. Loizou

引用次数: 1

Comparison Between Infrared and Electrical Nerve Stimualtion 红外线与电神经刺激的比较

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1109/EMBSW.2007.4454187

A.P. Keef

引用次数: 2

Comparison of Brain Masking Techniques in Functional Magnetic Resonance Imaging 功能磁共振成像中脑掩蔽技术的比较

2007 IEEE Dallas Engineering in Medicine and Biology Workshop Pub Date : 2007-11-01 DOI: 10.1109/EMBSW.2007.4454178

On Tsang, A. Gholipour, N. Kehtarnavaz, K. Gopinath, R. Briggs

引用次数: 9