Iranian Journal of Diabetes and Obesity最新文献_第8页

Correlation Between Cytochrome P450, 5-alpha Reductase, and Androgen Receptor Levels in Patients with Type 2 Diabetes Mellitus 2型糖尿病患者细胞色素P450、5-α还原酶与雄激素受体水平的相关性

Iranian Journal of Diabetes and Obesity Pub Date : 2022-02-20 DOI: 10.18502/ijdo.v14i1.8738

Mustafa Ali Hasan Aljanabi, M. Homayouni Tabrizi, Vahid Pouresmaeil

{"title":"Correlation Between Cytochrome P450, 5-alpha Reductase, and Androgen Receptor Levels in Patients with Type 2 Diabetes Mellitus","authors":"Mustafa Ali Hasan Aljanabi, M. Homayouni Tabrizi, Vahid Pouresmaeil","doi":"10.18502/ijdo.v14i1.8738","DOIUrl":"https://doi.org/10.18502/ijdo.v14i1.8738","url":null,"abstract":"Objective: Type 2 diabetes mellitus (T2DM) is one of the most common chronic diseases. The CYP450 plays an important role in the biosynthesis of steroid hormones and the hormonal activity is mediated by the androgen receptor (AR) and the enzyme 5-alpha reductase (5αR). Therefore, this study aimed to investigate the relationship between these factors in T2DM. \u0000Materials and Methods: This case-control study was performed with 60 volunteers, including 30 diabetics and 30 healthy individuals. Demographic information of individuals was recorded and levels of CYP450, 5αR, and AR were measured in serum by ELISA. Data were analyzed by SPSS v.26 version and the significance level was less than 5%. \u0000Results: There were no significant difference between diabetics and healthy individuals in gender (P= 1), body mass index (P= 0.199), diastolic pressure(P= 0.466), uric acid(P= 0.202), creatinine(P= 0.627), low-density lipoprotein (P= 0.572), high-density lipoprotein(P=0.692); But there was a significant difference in systolic pressure(P= 0.034), triglyceride(P= 0.0001), and insulin(P= 0.003), between diabetics and healthy individuals. The distribution of CYP450, 5αR and AR in two groups shows that the level of all three factors is higher in diabetic people (P= 0.0001). Also, glycosylated hemoglobin and insulin have a direct relationship with CYP450 (P= 0.0001, R=0.494; P= 0.043, R=0.263), 5αR (P= 0.0001, R=0.808; P= 0.016, R=0.309) and with AR (P= 0.0001, R=0.836; P= 0.011, R=0.326). \u0000Conclusion: These results showed that there was a relationship between the levels of CYP450, 5αR, and ARs with T2DM which may explain hormonal changes in diabetic people and the different responses to treatment.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45686245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effect of Endurance Training on Expression of Autophagy Genes (Beclin-1, ULK-1) in the Heart Tissue of Male Rats with Experimental Diabetes 耐力训练对实验性糖尿病雄性大鼠心脏组织自噬基因Beclin-1、ULK-1表达的影响

Iranian Journal of Diabetes and Obesity Pub Date : 2022-02-20 DOI: 10.18502/ijdo.v14i1.8742

Masoumeh Hosseinzadeh, A-S Taheri

{"title":"The Effect of Endurance Training on Expression of Autophagy Genes (Beclin-1, ULK-1) in the Heart Tissue of Male Rats with Experimental Diabetes","authors":"Masoumeh Hosseinzadeh, A-S Taheri","doi":"10.18502/ijdo.v14i1.8742","DOIUrl":"https://doi.org/10.18502/ijdo.v14i1.8742","url":null,"abstract":"Objective: This study aimed to investigate the effect of six weeks of endurance training on the expression of autophagy-related genes (Beclin-1, ULK-1) in the heart tissue (Myocardium) of rats with diabetes. \u0000Materials and Methods: Twenty male wistar rats (weight: 204±11.3g), (age= 8 weeks) were divided into four groups including: 1) diabetic type1 training, group 2) diabetic type1 control, group 3) healthy training group, and 4) healthy control group. They developed diabetes by intraperitoneal injection of streptozotocin (STZ) (45 mg / kg). The endurance training was performed with a moderate intensity (50-55% vo2max) of 5 days a week for 6 weeks. The expression level of autophagy-related genes (ULK-1, Beclin-1) was measured by real-time technique. One-way analysis of variance and Tukey's post hoc test were used for statistical analysis. \u0000Results: The expression of autophagy genes (Beclin-1: diabetic type1 control group: 2.49 (±0.53), and healthy control group: 1 (±0.21)), (ULK-1; diabetic type1 control group: 2.56 (±1.02), and healthy control group: 1 (±0.35)) in heart tissue in diabetic rats was significantly higher than in the healthy control group (P: 0.001). After six weeks of endurance training, the expression of these genes in heart tissue was significantly lower in the diabetic training group, healthy training and healthy control than in the diabetic control group. (P: 0.001). \u0000Conclusion: The present study results showed that endurance training by reducing autophagy factors in the heart of male rats with diabetes could be helpful as a preventive and non-pharmacological agent in the treatment of diabetic patients.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43477810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effects of the Combination of the Herbal Compound Against Inflammation Related to Obesity and Colitis Induced by Diet in Mice 复方中药对小鼠饮食性肥胖及结肠炎相关炎症的保护作用

Iranian Journal of Diabetes and Obesity Pub Date : 2022-02-20 DOI: 10.18502/ijdo.v14i1.8740

Fatemeh Azizian-Farsani, Navid Abedpoor, M. Derakhshan, M. Nasr-Esfahani, M. Sheikhha, K. Ghaedi

{"title":"Protective Effects of the Combination of the Herbal Compound Against Inflammation Related to Obesity and Colitis Induced by Diet in Mice","authors":"Fatemeh Azizian-Farsani, Navid Abedpoor, M. Derakhshan, M. Nasr-Esfahani, M. Sheikhha, K. Ghaedi","doi":"10.18502/ijdo.v14i1.8740","DOIUrl":"https://doi.org/10.18502/ijdo.v14i1.8740","url":null,"abstract":"Objective: High-fat diet (HFD) rises the susceptibility of both obesity and consequently Inflammatory Bowel Disease (IBD). We designed a study to investigate the improving effects of herbal extract (HE, the combination of turmeric, ginger, boswellia, and cat’s claw extract) on the risk of high AGEs-fat diet 60% (HFD) mice induced colitis and obesity. \u0000Materials and Methods: Four-week-old C57BL/6 male mice after 2 weeks adaptation with normal diet were fed with either HFD or normal diets. After 6 weeks of being on diet, animals received HE for 16 weeks. Obesity index markers were determined as well as histological studies using H&E (Hematoxylin-eosin) staining. Colonic expression of IL-1β was determined. Data analysis was performed by utilizing Kruskal-Wallis and Mann-Whitney test for post-hoc comparisons, and SPSS (version 17.0) and GraphPad Prism Software (Version 8.0, USA). \u0000Results: HE decreased histological scores (by 6-fold) in HFD diet-fed mice, and reduced myeloperoxidase activity (by 2.2-fold), and ratio of colon weight to length (by 4-fold) in HFD diet-fed mice. Moreover, HE prevented intestinal permeability through the restoration of ZO-1 (by 4-fold) and immune homeostasis by modulation of IL-1β (by 2.4-fold) expression. \u0000Conclusion: HFD induced obesity-associated colitis. HE decreased the colitis symptoms in HFD diet-fed mice, with the reduction of inflammation.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47121826","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Mediation Role of Parental Nutrition Style in Relation with Parental Coping Strategies and Pediatric Obesity in Shiraz, 2019 Shiraz，2019，父母营养风格在父母应对策略和儿童肥胖关系中的中介作用

Iranian Journal of Diabetes and Obesity Pub Date : 2022-02-20 DOI: 10.18502/ijdo.v14i1.8739

Sara Jahandarpour, A. Davoodi

{"title":"Mediation Role of Parental Nutrition Style in Relation with Parental Coping Strategies and Pediatric Obesity in Shiraz, 2019","authors":"Sara Jahandarpour, A. Davoodi","doi":"10.18502/ijdo.v14i1.8739","DOIUrl":"https://doi.org/10.18502/ijdo.v14i1.8739","url":null,"abstract":"Objective: In obese children, there is a greater likelihood that they will become obese adults, and they will have negative physical and psychological outcomes. The aim of this study was to determine the mediating role of parental nutritional style in the relationship between parental coping styles and childhood obesity. \u0000Materials and Methods: The present study was descriptive and correlational. The statistical population of the study consisted of all obese children and their parents in 2019 in Shiraz. 160 children and their parents were selected and studied by multi-stage cluster sampling from the statistical population. Coping inventory for a stressful situation – short form (CISS) and parental feeding styles questionnaire (PFSQ), and body mass index (BMI) were used to collect data. After collecting and extracting data, participants' scores were analyzed using Pearson correlation coefficient and structural equations (path analysis) by means of SPSS 20 and AMOS 20 statistical software. \u0000Results: The results showed that the relationship between problem-oriented and emotion-oriented coping style with BMI was significant and negative (P= 0.01); furthermore, relationship between distraction style and social engagement style with BMI was significant and positive (P= 0.01). Moreover, there was a significant and positive the relationship between the subscale of emotional nutrition, instrumental nutrition, arousal, and encouragement to eat with BMI (P= 0.05). \u0000Conclusion: According to the findings, parents who urge their children to follow a healthy eating pattern have an essential moderating role in the interplay between coping techniques and childhood obesity.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45960186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Investigating the Relation between LCK Gene Expression with Type 2 Diabetes Patients in Yazd Diabetes Research Center 亚兹德糖尿病研究中心LCK基因表达与2型糖尿病患者关系的研究

Iranian Journal of Diabetes and Obesity Pub Date : 2022-02-20 DOI: 10.18502/ijdo.v14i1.8736

Zahra Rahvarzadeh, Mehran Dehghanian, Mohammad Yahya Vahidi Mehrjardi, M. Dehghani Ashkezari

引用次数: 0

Effectiveness of Motivational Interviewing based on the Ability, Information and Motivation Model on Adherence to Treatment and Glycosylated Hemoglobin in Females with Type 2 Diabetes Mellitus 基于能力、信息和动机模型的动机性访谈对女性2型糖尿病患者治疗依从性和糖化血红蛋白的影响

Iranian Journal of Diabetes and Obesity Pub Date : 2022-02-20 DOI: 10.18502/ijdo.v14i1.8741

S. Rahmani, Mohsen Mansoobifar, Mohammad Reza Sirifi, H. Ashayeri, H. Bermas

{"title":"Effectiveness of Motivational Interviewing based on the Ability, Information and Motivation Model on Adherence to Treatment and Glycosylated Hemoglobin in Females with Type 2 Diabetes Mellitus","authors":"S. Rahmani, Mohsen Mansoobifar, Mohammad Reza Sirifi, H. Ashayeri, H. Bermas","doi":"10.18502/ijdo.v14i1.8741","DOIUrl":"https://doi.org/10.18502/ijdo.v14i1.8741","url":null,"abstract":"Objective: The aim of this study was to determine the effectiveness of motivational interviewing based on the ability, information, and motivation (AIM) model on adherence to treatment and glycosylated hemoglobin (HbA1c) in female patients with type 2 diabetes. \u0000Materials and Methods: In this randomized controlled clinical trial 60 women with type 2 diabetes were randomly selected from the 73 patients who referred to the endocrinology department of Imam Hossein Hospital in Tehran province from December 2018 to April 2019. The experimental group (n= 30) was treated with family empowerment therapy based on self-compassion for eight weekly 90-minute sessions while the control group (n= 30) received the usual hospital treatments. Data collection instrument was Morisky medication adherence scale and HbA1c measurements in three phases. Multivariate repeated measures analysis of variance was used to analyze the data. Data analysis was carried out using SPSS-21 software package. \u0000Results: The findings showed that the mean score of adherence to treatment in the group treated with motivational interviewing based on the AIM model was significantly higher than that of the control group (P= 0.001). In addition, women with diabetes in the experimental group had a significantly lower mean HbA1c score compared to the control group (P= 0.001). \u0000Conclusion: The results of this study showed that motivational interviewing based on the AIM model can be effective in improving adherence to treatment and reducing HbA1c in women with type 2 diabetes.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43805124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

The Antiglycation Ability of Typical Medicinal Plants, Natural and Synthetic Compounds: A Review 典型药用植物、天然和合成化合物的抗糖化能力综述

Iranian Journal of Diabetes and Obesity Pub Date : 2022-02-20 DOI: 10.18502/ijdo.v14i1.8743

M. Sadeghi, M. Miroliaei

引用次数: 1

The Effectiveness of Acceptance and Commitment Therapy on Resilience at Women with Type 2 Diabetes in Yazd City 接纳与承诺治疗对亚兹德市2型糖尿病妇女心理弹性的影响

Iranian Journal of Diabetes and Obesity Pub Date : 2022-02-19 DOI: 10.18502/ijdo.v14i1.8728

Elham Balooch Zadeh, Farzad Farhoodi, R. Azizi

{"title":"The Effectiveness of Acceptance and Commitment Therapy on Resilience at Women with Type 2 Diabetes in Yazd City","authors":"Elham Balooch Zadeh, Farzad Farhoodi, R. Azizi","doi":"10.18502/ijdo.v14i1.8728","DOIUrl":"https://doi.org/10.18502/ijdo.v14i1.8728","url":null,"abstract":"Objective: Introduction: Diabetes is a chronic disease that engages affected person for long time and endangers mental health of affected persons. Purpose of this paper is examining the effect of training courses of acceptance and commitment therapy (ACT) on resilience of women with type 2 diabetes mellitus (T2DM) in Yazd City. \u0000Materials and Methods: This research was a quasi-experimental study with two groups of experiment and control. In order to admit and reject the hypotheses, a resilience questionnaire has been used. Sample size was 30 females in 30-60 years old with T2DM that have participated in this research as available and they have been set in two groups. To analyze the data, SPSS version 16 and multivariate analysis of covariance statistical test have been used. \u0000Results: Findings showed a significant increase in experimental group in resilience scale in the post-test (P= 0.01). In quarterly follow-up step, this effect was persistent too (P< 0.05). \u0000Conclusion: Course of ACT can cause increasing resilience in T2DM women in Yazd City. So it can be used as an effective intervention.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44592467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

HbA1c in Polycystic Ovary Syndrome as the Cardiac Risk Assessment HbA1c在多囊卵巢综合征中的心脏风险评估

Iranian Journal of Diabetes and Obesity Pub Date : 2022-02-19 DOI: 10.18502/ijdo.v14i1.8732

Arati Adhe Rojekar, M. Rojekar, Swati Ghanghurde, Poonam Lalla

{"title":"HbA1c in Polycystic Ovary Syndrome as the Cardiac Risk Assessment","authors":"Arati Adhe Rojekar, M. Rojekar, Swati Ghanghurde, Poonam Lalla","doi":"10.18502/ijdo.v14i1.8732","DOIUrl":"https://doi.org/10.18502/ijdo.v14i1.8732","url":null,"abstract":"Objective: Polycystic ovary syndrome (PCOS) is an endocrine disorder associated with hyperandrogenism marked with hirsutism and ovarian dysfunction. These conditions may lead to the risk of insulin resistance (IR), type 2 diabetes, obesity, and cardiovascular disease. These conditions are related to PCOS complications hence our aim was to study and investigate the relationship between high-sensitivity C - reactive protein (hs-CPR) level and glycosylated hemoglobin (HbA1c) level in PCOS patients. \u0000Materials and Methods: Female patients visiting the obstetrics and gynecology outpatient department (OPD), aged between 19 and 45 years with a body mass index (BMI) of 25 to 29 kg/m2. The individuals fulfilling the National Institute of Health (NIH) criteria for PCOS; including amenorrhea or oligomenorrhea and had been clinically diagnosed with hyperandrogenism were served as subjects. \u0000Results: Two hundred and ten individuals with HbA1c of 5.4% have a higher risk of cardiovascular disorders. The study showed the association between increased cardiac risk as measured by hs-CRP and patients with normal HbA1c values with a sensitivity of 77.2% and specificity of 75.99%. The HbA1c cutoff value can be used in the PCOS patients to assess the cardiac risk due to association of HbA1c cut off value with false positivity rate of 15.24%. \u0000Conclusion: In PCOS patients with chronic low-grade inflammation, IR, and the degree of inflammation associated with HbA1c value was observed.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44204636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Access to Anti-Diabetic Medicines among Patients Attending Tertiary Health Facilities in Oyo State, Nigeria 尼日利亚奥约州三级医疗机构患者获得抗糖尿病药物的情况

Iranian Journal of Diabetes and Obesity Pub Date : 2021-12-12 DOI: 10.18502/ijdo.v13i4.7995

Oluwaseun Oladapo Akinyemi, Babatunde M. Ayeni, O S Ilesanmi, O. Owopetu

{"title":"Access to Anti-Diabetic Medicines among Patients Attending Tertiary Health Facilities in Oyo State, Nigeria","authors":"Oluwaseun Oladapo Akinyemi, Babatunde M. Ayeni, O S Ilesanmi, O. Owopetu","doi":"10.18502/ijdo.v13i4.7995","DOIUrl":"https://doi.org/10.18502/ijdo.v13i4.7995","url":null,"abstract":"Objective: The management of Diabetes Mellitus (DM) is long-term and can be expensive. This study aimed to describe access to anti-diabetic medicines among patients in tertiary health care facilities in Oyo State, Nigeria. \u0000Materials and Methods: This was a hospital-based cross-sectional study. The study sites were the University College Hospital (UCH), Ibadan, and Ladoke Akintola University Teaching Hospital, Ogbomosho. It was conducted among 366 diabetic patients who had been attending the endocrinology clinic of these two tertiary health institutions for at least one year. Data analysis was done with the Statistical Program for Social Sciences. \u0000Results: Female participants were 186 (50.8%) and 298 (85.6%) depended on close relatives to purchase their drugs. Those who had difficulties affording their anti-diabetic medications were 142 (38.8%) and 80 (56.3%) preferred buying a cheaper brand of anti-diabetic medication. Also, 136 (37.2%) respondents had missed their required drugs at some point due to insufficient funds. Males who were able to afford their anti-diabetic medication were 96 (53.3%) compared to 128 (68.8%) females (P-value= 0.002). Those with no formal education had the highest proportion of respondents who could not easily afford anti-diabetic drugs (60.9%), those with tertiary education had the highest proportion of respondents who could afford their medication (77.5%), (P-value=< 0.001). Among those in the 61-70 years age group, 78 (66.1%) achieved glycaemic control compared to 34 (42.5%) of those above 70 years (P-value=< 0.001). \u0000Conclusion: To improve affordability, subsidizing the cost of anti-diabetic medications and encouraging patients to enrol in the Health Insurance Scheme will be beneficial.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42814834","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0