The Antiglycation Ability of Typical Medicinal Plants, Natural and Synthetic Compounds: A Review

M. Sadeghi, M. Miroliaei
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引用次数: 1

Abstract

Given the prevalence of diabetes and the increasing number of diabetics, it is essential to find medicines to decrease the chronic complications of diabetes. Several studies have demonstrated that chronic hyperglycemia and its complications are directly related to protein glycation. Thus, identifying natural inhibitors to stop glycation of proteins may play a crucial role in managing the chronic complications of diabetes. Currently, various natural and synthetic compounds with anti-glycation attributes have been reported. The use of natural compounds in herbs (medicinal and non-medicinal) may be of particular importance due to fewer side effects and a wide range of therapeutic properties. Accordingly, this mini-review provides a list of common natural medicines and synthetic compounds with anti-glycation activity. As well, it provides brief information on the formation of advanced glycosylated end products (AGEs), their side effects, and glycation prevention mechanisms.
典型药用植物、天然和合成化合物的抗糖化能力综述
鉴于糖尿病的流行和糖尿病患者人数的增加,找到减少糖尿病慢性并发症的药物是至关重要的。多项研究表明,慢性高血糖及其并发症与蛋白糖化直接相关。因此,鉴定天然抑制剂来阻止蛋白质糖化可能在控制糖尿病的慢性并发症中起着至关重要的作用。目前,已经报道了各种具有抗糖基化属性的天然和合成化合物。在草药(药用和非药用)中使用天然化合物可能特别重要,因为副作用少,治疗特性广泛。因此,本综述提供了具有抗糖基化活性的常见天然药物和合成化合物的清单。此外,它还提供了关于晚期糖基化终产物(AGEs)的形成、其副作用和糖基化预防机制的简要信息。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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25
审稿时长
26 weeks
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