Iranian Journal of Diabetes and Obesity最新文献

The Transformative Role of Artificial Intelligence in Diabetes Treatment 人工智能在糖尿病治疗中的变革性作用

Iranian Journal of Diabetes and Obesity Pub Date : 2024-06-15 DOI: 10.18502/ijdo.v16i2.15705

Masoud Rostami, V. Anoosheh

引用次数: 0

A Comparison of Renal Effects between Empagliflozin and Linagliptin in Diabetic Patients with Chronic Kidney Disease: A Randomized Clinical Trial 慢性肾病糖尿病患者服用恩格列净和利拉利汀对肾脏影响的比较：随机临床试验

Iranian Journal of Diabetes and Obesity Pub Date : 2024-06-15 DOI: 10.18502/ijdo.v16i2.15706

Reza Zeinabadi Noghabi, Rojin Rouintan, Tahereh Sabaghian, Shayesteh Khalili

{"title":"A Comparison of Renal Effects between Empagliflozin and Linagliptin in Diabetic Patients with Chronic Kidney Disease: A Randomized Clinical Trial","authors":"Reza Zeinabadi Noghabi, Rojin Rouintan, Tahereh Sabaghian, Shayesteh Khalili","doi":"10.18502/ijdo.v16i2.15706","DOIUrl":"https://doi.org/10.18502/ijdo.v16i2.15706","url":null,"abstract":"Objective: The current study aimed to compare the renal effects of Empagliflozin with Linagliptin combined with Metformin in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease. combined with Metformin in patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease. \u0000Materials and Methods: We conducted a randomized clinical trial on diabetic patients aged over 18 years with chronic renal failure and an EGFR between 20 to 60 ml/minutes/1.73 m2 corrected with the MDRD equation. Between January and December 2023, a total of 150 cases in Imam Hossein Hospital were randomized into two study arms of 75 cases receiving Empagliflozin (10 mg/day) and metformin or Linagliptin (5mg/day) and metformin for 6 months. The primary outcome was a change in chronic kidney disease (CKD) stage, while serum creatinine, fasting blood sugar (FBS), proteinuria, and blood pressure were evaluated at baseline, 3 and 6 months later. \u0000Results: The mean age of participants was 62.20 (± 4.45) years and 50% of them were females. Study indices including serum creatinine (P: 0.001), estimated glomerular filtration rate (eGFR) (P: 0.001), FBS (P: 0.001), HgA1c (P: 0.001), proteinuria (P: 0.001), and blood pressure (P: 0.001) reduced significantly over time in both groups. After adjustment for potential confounders, Empagliflozin reduced the level of serum creatinine independent of other factors. \u0000Conclusion: Empagliflozin significantly reduces the level of serum creatinine compared to Linagliptin in patients with T2DM and chronic renal failure.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"1 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vildagliptin-Associated Bullous Pemphigoid: A Case Report 维达列汀相关大疱性丘疹：病例报告

Iranian Journal of Diabetes and Obesity Pub Date : 2024-06-15 DOI: 10.18502/ijdo.v16i2.15711

Debanjan Roy, Gunjan Gayen, S. Begum, Sandip Ghosh, Sucheto Talukder, Arisha Sarkar, S. Aich

{"title":"Vildagliptin-Associated Bullous Pemphigoid: A Case Report","authors":"Debanjan Roy, Gunjan Gayen, S. Begum, Sandip Ghosh, Sucheto Talukder, Arisha Sarkar, S. Aich","doi":"10.18502/ijdo.v16i2.15711","DOIUrl":"https://doi.org/10.18502/ijdo.v16i2.15711","url":null,"abstract":"Objective: Bullous pemphigoid is a rare autoimmune skin disorder characterized by blistering, urticarial lesions, which are sometimes associated with adverse drug reactions. Vildagliptin is an oral anti-diabetic agent that selectively inhibits the dipeptidyl peptidase-4 (DPP-4) enzyme \u0000Materials and Methods: A 75-year-old female with a known case of type 2 Diabetes Mellitus, hypertension, and hypothyroidism for the last 10 years presented with pruriginous tense bullous skin lesions over her both palms and soles. There was no mucosal involvement. Further interrogation revealed that she started taking Vildagliptin 5 days ago which was prescribed due to high levels of post-prandial blood sugar level despite already intake of Glimepiride-4 mg and Metformin-3 gm. \u0000Results: Vildagliptin was immediately advised to be stopped. She was treated with antihistamines, steroids, and conservative management which led to remission of the blisters \u0000Conclusion: Vildagliptin is the probable causative drug for developing bullous pemphigoid skin lesion which shows temporal association in this case as other concomitant drugs has no direct correlation. Therefore physicians must be aware of this rare life-threatening side effect of this medicine and advice patients to visit the hospital even the slightest cutaneous manifestation. Bullous pemphigoid can result in fatal life-threatening conditions if not treated early.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"8 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141335981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Predictors of Mortality among Intensive Care Unit (ICU) Hospitalized Diabetic Patients with COVID-19 重症监护室（ICU）住院糖尿病患者 COVID-19 死亡率的预测因素

Iranian Journal of Diabetes and Obesity Pub Date : 2024-06-15 DOI: 10.18502/ijdo.v16i2.15707

Mohsen Gholinataj Jelodar, S. Mirzaei, Majid Haji Maghsoudi

{"title":"Predictors of Mortality among Intensive Care Unit (ICU) Hospitalized Diabetic Patients with COVID-19","authors":"Mohsen Gholinataj Jelodar, S. Mirzaei, Majid Haji Maghsoudi","doi":"10.18502/ijdo.v16i2.15707","DOIUrl":"https://doi.org/10.18502/ijdo.v16i2.15707","url":null,"abstract":"Objective: Diabetic patients with COVID-19 are at the higher risk of clinical complications and intensive care unit (ICU) admission. There is limited information available on the risk factors of mortality in diabetic patients with COVID-19 admitted to the ICUs. The aim of this study was identifying the mortality risk factors in diabetic patients with COVID-19 who are admitted to the ICU. \u0000Materials and Methods: In this study, we conducted a descriptive-analytical observational analysis on 391 patients admitted to the ICU for 18 months. We assessed the demographic, clinical, pharmaceutical, laboratory and imaging data of diabetic patients and statistically analyzed them to identify mortality risk factors. \u0000Results: The study found 156 (39.89%) diabetic out of 391 patients. The group of diabetic patients had significantly higher rates of endotracheal intubation (P< 0.001), mortality (P< 0.001), and complications during hospitalization due to COVID-19, including secondary bacterial infections (P = 0.005), venous thrombosis (P = 0.008), and gastrointestinal bleeding (P = 0.011), compared to the nondiabetic patient. \u0000Conclusion: Patients with diabetes who also have COVID-19 tend to experience more severe clinical outcomes and a higher mortality rate when admitted to the intensive care unit. The likelihood of mortality in these patients is closely associated with factors such as stroke occurrence, oxygenation levels, and the presence of secondary infections at the time of admission.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genetic and Epigenetic Etiologies of Type 1 Diabetes Mellitus 1 型糖尿病的遗传学和表观遗传学病因

Iranian Journal of Diabetes and Obesity Pub Date : 2024-06-15 DOI: 10.18502/ijdo.v16i2.15712

T. Yahaya, Israel Obaroh, Umar Magaji, C. Obadiah, D. Anyebe, U. Shemishere

{"title":"Genetic and Epigenetic Etiologies of Type 1 Diabetes Mellitus","authors":"T. Yahaya, Israel Obaroh, Umar Magaji, C. Obadiah, D. Anyebe, U. Shemishere","doi":"10.18502/ijdo.v16i2.15712","DOIUrl":"https://doi.org/10.18502/ijdo.v16i2.15712","url":null,"abstract":"Numerous suspect genes associated with type 1 diabetes mellitus (T1DM) have been identified, suggesting a need to focus on the disease's causal genes and mechanisms. This necessitates an update to raise public awareness. This review articulates genes with mutations that predispose individuals to T1DM. We conducted a comprehensive search of academic databases, including Web of Science, Scopus, PubMed, and Google Scholar, for relevant materials. Available information indicates that at least 70 genes are suspected in the pathogenesis of T1DM. However, the most frequently implicated genes include human leukocyte antigen (HLA), insulin (INS), cytotoxic T lymphocyte-associated antigen 4 (CTLA-4), and protein tyrosine phosphatase non-receptor type 22 (PTPN22). Mutations or variants in these genes may lead to insulin insufficiency and, consequently, T1DM by tricking immune cells, such as T-cells and B-cells, into attacking self-antigens and triggering the autoimmunity of beta cells. Furthermore, this pathophysiology can be mediated through aberrant epigenetic modifications, including DNA methylation, histone post-translational modifications, and noncoding RNAs, in the mentioned genes. Some of these pathophysiologies are gene-specific and may have an epigenetic origin that is reversible. In the event of an epigenetic origin, a treatment for T1DM that addresses the causal genes or reverses epigenetic changes and their mechanisms could yield improved outcomes. Medical professionals are encouraged to design therapeutic regimens that specifically target the mentioned genes and address the identified epigenetic alterations in individuals expressing such etiologies.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"5 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141336830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Antibody Engineering to Enhancement of Ranibizumab Binding Affinity for the Prevention and Treatment of Diabetic Retinopathy 通过抗体工程增强雷珠单抗的结合亲和力以预防和治疗糖尿病视网膜病变

Iranian Journal of Diabetes and Obesity Pub Date : 2024-06-15 DOI: 10.18502/ijdo.v16i2.15710

Fateme Sefid, Kimia Monshizadeh, G. Azamirad, Mohammad Yahya Vahidi Mehrjardi

{"title":"Antibody Engineering to Enhancement of Ranibizumab Binding Affinity for the Prevention and Treatment of Diabetic Retinopathy","authors":"Fateme Sefid, Kimia Monshizadeh, G. Azamirad, Mohammad Yahya Vahidi Mehrjardi","doi":"10.18502/ijdo.v16i2.15710","DOIUrl":"https://doi.org/10.18502/ijdo.v16i2.15710","url":null,"abstract":"Objective: The VEGF function blockage effectively reduces the progression of diabetic retinopathy. Ranibizumab and bevacizumab are some anti-VEGF monoclonal antibodies (mAb). Considering the importance of affinity maturation of ranibizumab, we aimed to find the essential amino acids of the ranibizumab antibody (Ab). \u0000Materials and Methods: We tried to find the important amino acids of this antibody via Paratome, Meta-PPISP, and the WESA web server. Subsequently, these amino acids were mutated to improve the binding affinity of the Ab variants to antigen (Ag). In this regard, the ranibizumab anti-VEGF-A was mutated. The structural docking prediction of the ranibizumab-VEGF-A complex was used for the design and validation of ranibizumab with a higher affinity for binding to VEGF-A. Finally, we measured the binding affinity of Ab variants to Ag by computational docking. \u0000Results: Bioinformatic analyzes such as molecular docking and dynamics showed that several mutant variants successfully improved the properties of Ab binding compared to the wild-type Ab. \u0000Conclusion: Consistent with the use of anti-VEGF monoclonal antibodies in the treatment of diabetic retinopathy, the mutant variants of ranibizumab may be potential candidates for stronger affinity binding to VEGF, which may affect the specificity and sensitivity of the antibody.","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141337542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Review About the Role of Spiritual Health in Type 2 Diabetes Mellitus People 精神健康在 2 型糖尿病患者中的作用综述

Iranian Journal of Diabetes and Obesity Pub Date : 2024-03-28 DOI: 10.18502/ijdo.v16i1.15243

Mohammad Hasan Lotfi, Mohammad Mehdi Ahmadi Faraz, Nasim Namiranian, Roohollah Arab, Maesomeh Dashtabadi, Hasan Zare Khormizi

引用次数: 0

Effects of Self-Care Training Combined with Stress Management on Treatment Adherence in Type 2 Diabetes People 自我护理训练与压力管理相结合对 2 型糖尿病患者坚持治疗的影响

Iranian Journal of Diabetes and Obesity Pub Date : 2024-03-28 DOI: 10.18502/ijdo.v16i1.15235

Amineh Jalali, Reza Pourhosein, Ahmad Alipour, Gholam Ali Afrooz

{"title":"Effects of Self-Care Training Combined with Stress Management on Treatment Adherence in Type 2 Diabetes People","authors":"Amineh Jalali, Reza Pourhosein, Ahmad Alipour, Gholam Ali Afrooz","doi":"10.18502/ijdo.v16i1.15235","DOIUrl":"https://doi.org/10.18502/ijdo.v16i1.15235","url":null,"abstract":"\u0000 \u0000 \u0000Objective: Diabetes is a chronic metabolic disorder that can be exacerbated by stress, poor compliance and self-care practices. This study investigated the effects of self-care training combined with stress management on treatment adherence in type 2 diabetes mellitus (T2DM) people. \u0000Materials and Methods: This is a randomized clinical trial with repeated measures. The study sample included 30 T2DM who were purposively selected among the eligible members of the Kerman Diabetes Association. The participants were randomized to the experimental group (stress management based on cognitive-behavioral therapy and self-care training) (n=15) and the control group (no intervention) (n=15). Both groups completed the Medanlo Treatment Adherence Questionnaire at the pretest, posttest, and follow-up time points. Data were analyzed statistically using ANOVA. \u0000Results: The post-test and follow-up mean scores of treatment adherence significantly increased in the experimental group compared with the control group (P< 0.001). In addition, the results demonstrated that treatment adherence improved in follow-up (P< 0.001). \u0000Conclusion: According to the study results, psychological training should be integrated with self-care training to achieve long lasting treatment adherence in T2DM people. \u0000 \u0000 \u0000","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"103 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140370783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effectiveness of Mindfulness Group Training Based on Stress Reduction on Emotional Self-Regulation and Self-Care in Diabetes Type 2 基于减压的正念小组培训对 2 型糖尿病患者情绪自我调节和自我护理的效果

Iranian Journal of Diabetes and Obesity Pub Date : 2024-03-28 DOI: 10.18502/ijdo.v16i1.15234

Mohammad Reza Aqebati, Jafar Shabani

{"title":"Effectiveness of Mindfulness Group Training Based on Stress Reduction on Emotional Self-Regulation and Self-Care in Diabetes Type 2","authors":"Mohammad Reza Aqebati, Jafar Shabani","doi":"10.18502/ijdo.v16i1.15234","DOIUrl":"https://doi.org/10.18502/ijdo.v16i1.15234","url":null,"abstract":"\u0000 \u0000 \u0000Objective: This study was conducted to investigate the effectiveness of mindfulness group training based on stress reduction on emotional self-regulation and self-care in type 2 diabetes people - Esfrain 2023. \u0000Materials and Methods: This is an experimental research with a pre-test and post-test method and a control group. The statistical society included all type 2 diabetes people in Esfrain city, of whom 36 people were selected as the study sample. The participants were simple random placed in an experimental group and a control group. The experimental group received mindfulness group education based on stress reduction during eight 2-h sessions over 8 weeks, whereas the control group received no education. Before and after the education sessions, the two groups completed Hoffman and Kashdan’s (2010) emotional self-regulation questionnaire and Tobert and Glasso’s (2000) self-care questionnaire. Data were analyzed using the multivariate analysis of covariance test. \u0000Results: The results showed that mindfulness group training based on stress reduction can improve emotional self-regulation scores and life expectancy in patients with type 2 diabetes(P: 0.0005). \u0000Conclusion: According to the results of the research, mindfulness training based on stress reduction is suggested to diabetic patients as a complementary treatment with the aim of improving the level of emotional self-regulation and self-care. \u0000 \u0000 \u0000","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"14 6","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140369024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of High-Intensity Interval Training on TCF7L2 Gene Expression in Hepatocytes of Obese Rats 高强度间歇训练对肥胖大鼠肝细胞中 TCF7L2 基因表达的影响

Iranian Journal of Diabetes and Obesity Pub Date : 2024-03-28 DOI: 10.18502/ijdo.v16i1.15237

Akbar Karimy, Yaser Kazemzadeh, M. Eizadi, Saeid Sedaghaty, Sepideh Ghotnian

{"title":"Effect of High-Intensity Interval Training on TCF7L2 Gene Expression in Hepatocytes of Obese Rats","authors":"Akbar Karimy, Yaser Kazemzadeh, M. Eizadi, Saeid Sedaghaty, Sepideh Ghotnian","doi":"10.18502/ijdo.v16i1.15237","DOIUrl":"https://doi.org/10.18502/ijdo.v16i1.15237","url":null,"abstract":"\u0000 \u0000 \u0000Objective: Hepatic glucose release is greatly increased in the presence of obesity and related diseases. The research objective was to explore the impact of high intensity interval training (HIIT) on TCF7L2 gene expression in hepatocytes of obese rats. \u0000Materials and Methods: Out of 21 male Wistar rats aged 10 weeks years (220±10 g), obesity was induced in 14 rats by 8-week high-fat diet. The rats were then divided into normal (n=7), obese control (n=7), and HIIT obese (n=7) groups. Rats in the HIIT group completed 8 weeks of HIIT/5 days weekly, whereas the other groups were inactive. After intervention, TCF7L2 gene expression in hepatocytes, insulin resistance and glucose compared using ANOVA /Tukey’s post hoc test between groups by SPSS-22. \u0000Results: Obesity induction led to a significant decrease in TCF7L2 gene expression (P: 0.011) and an increase in blood glucose (P: 0.009) and insulin resistance (P: 0.019) compared with the normal group (P< 0.001). On the other hand, interval training led to a significant increase in TCF7L2 gene expression (P: 0.029) and a decrease in blood glucose (P< 0.001) and insulin resistance (P< 0.001) in the obese group compared with the control group. \u0000Conclusion: The observed enhancement in fasting blood glucose levels among obese rats could be linked to increased TCF7L2 gene expression in liver cells, which appears to be a response to interval training intervention. Nevertheless, understanding the main mechanisms responsible for observed changes requires further studies in this field. \u0000 \u0000 \u0000","PeriodicalId":33205,"journal":{"name":"Iranian Journal of Diabetes and Obesity","volume":"132 42","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140369858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0