dnshnmh Srm最新文献

{"title":"The effect of COVID-19 disease on sperm parameters and male fertility","authors":"J. amini mahabadi, F. Negaresh","doi":"10.52547/sjrm.5.2.58","DOIUrl":"https://doi.org/10.52547/sjrm.5.2.58","url":null,"abstract":"Backgrounds and aims: The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may have men at a risk of infertility. The direct influence of this virus on the male urogenital organs should be evaluated. As well as SARS-CoV, SARS CoV-2 uses the ‘Angiotensin Converting Enzyme-2’ (ACE2) as a receptor to enter human cells. It was found that ACE2, Angiotensin (1-7) and its MAS receptors are present, over in the lung, also in the testicles, in particular in Leydig and Sertoli cells. Also, the presence of proteases such as: TMPRSS2, TMPRSS11B, TMPRSS12 and furin are capable to promote viral fusion. Since the exact mechanism of the COVID-19 has not been fully elucidated and no specific drug or vaccine has been developed for it, control is mainly based on the interruption of the transmission cycle. There are symptoms of COVID-19 (e.g. fever) with the known andrological impacts that should be highlighted. Conclusion: the SARS-COV-2 may have the potential to infect the testis via and adversely reproductive it is essential to commence with targeted finding and studies to learn from this disease. The aim of this study was to evaluate the effect of COVID-19 disease on sperm parameters and male fertility.","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48040978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of molecular genetic techniques in COVID-19 diagnosis","authors":"Leila Javanparast Sheikhani, S. Taghizadeh, Tamouchin Moharrami, Golnoosh Goljah Rad, A. Mohammadpour, F. Behjati","doi":"10.52547/sjrm.5.1.1","DOIUrl":"https://doi.org/10.52547/sjrm.5.1.1","url":null,"abstract":"1 Sarem Fertility and Infertility Research Center (SAFIR), Sarem Women’s Hospital, Iran University of Medical Science (IUMS), Tehran, Iran Genetics Research Centre, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran. Background and aims: We have encountered many epidemics such as HIV, SARS and Middle East respiratory syndrome corona viruses, Ebola virus, Zika and recently SARS-Cov-2. All these epidemics resulted from an animal to human transmission, during all these epidemics, absence of rapid and accurate molecular diagnostic testing has threatened the public health. Most tests for early detection of SARSCOV-2 RNA rely on reverse transcription-polymerase chain reaction, but isothermal mediated amplification assays and CRISPER based methods are thriving alternatives. Identification of individuals who have activated antibodies to the SARS COV-2 virus requires serological tests including enzyme-linked immuno sorbent assay (ELISA) and lateral flow immunoassay and they can be used as complementary tests in complex cases. This report is an overview of current development in COVID 19 molecular genetic techniques and future improvement and innovation. Conclusion: There is an ongoing race to develop more efficient laboratory techniques and cost-effective, point-of-care test kits that can be used in large scale. While RT-PCR has been the dominant technique for detection of viral RNA, other nucleic acid assays such as isothermal amplification assays, hybridization microarray assays, amplicon-based metagenomics sequencing, and recently CRISPR-related technologies are also under development.","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44000441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of biofeedback and neuromuscular stimulation on increasing the endometrial thickness of patients with thin endometrial thickness during frozen embryo transfer","authors":"M. Nejat, F. Akbarian, Elahe Hematboland","doi":"10.52547/sjrm.5.1.27","DOIUrl":"https://doi.org/10.52547/sjrm.5.1.27","url":null,"abstract":"Faculty of Educational Sciences and Psychology, University of Tehran, Tehran, Iran. Nejat Sexual Disorders Center Iran University of Medical Science, Tehran, Iran. Sarem Fertility and Infertility Research Center (SAFIR), Sarem Women’s Hospital, Iran University of Medical Science (IUMS), Tehran, Iran. Objective: This study was performed to evaluate the effect of biofeedback and neuromuscular stimulation of pelvic floor muscles in improving endometrial thickness in women with thin endometrium. Methodology: Of 62 women with a thin endometrium (less than or equal to 6 mm) recommended for frozen embryo transfer, 32 underwent biofeedback and neuromuscular stimulation by a vaginal probe in addition to receiving routine treatment (as in the control group). Findings: The women included in this study were 31 and 32 in the control and intervention groups. In general, the results showed that the endometrial thickness increased in each group, but in the group treated with biofeedback and neuromuscular stimulation, the thickness increased more. There was a significant difference between pre-treatment and post-treatment in increasing thickness. There is also a significant difference in the success rate of frozen embryo transfer between the two groups, which is higher in the group treated with biofeedback and neuromuscular stimulation. On the other hand, more in the intervention group, their pregnancy test was positive after the transfer of frozen embryos. Conclusion: Treatment of functional electrical stimulation of the pelvic floor muscles can be effective in improving the increase in endometrial thickness.","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44984483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of clomiphene citrate therapy on fertility success rate in infertile patients with ovulatory factors in Sarem hospital 1394-1396","authors":"A. Nazempour, A. Saremi","doi":"10.52547/sjrm.5.2.75","DOIUrl":"https://doi.org/10.52547/sjrm.5.2.75","url":null,"abstract":"Aims: Ovarian factor is one of the most common causes of infertility in couples and various treatment methods have been adopted to treat it. Clomiphene drug is one of the safest, least expensive and most effective methods in these people. The drug is used with or without gonadotropins and IUI (Intra uterine insemination) method in infertile and subfertile couples with ovarian factors and health in the hypothalamic-pituitary-ovarian axis. The aim of this study was to evaluate the success rate of this drug in infertile women with ovarian factor that leads to a positive result. Positive results include pregnancies with a confirmed βhCG test, vaginal ultrasound, and a pregnancy sac seen inside the uterine cavity. Therefore, the results of this study can be effective and useful in the physician's decision to continue treatment. Methods: This study is a retrospective cross-sectional study that the results of treatment with clomiphene with or without IUI in 785 patients referred to the IVF clinic of Sarem subspecialty hospital with ovarian factor during 2015 to 1396 has been reviewed. Hormones level such as thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), and antimalarial hormone (AMH) were measured on the third day of menstruation and then clomiphene was prescribed. In all patients, spermogram test were performed twice, which was normal after the spermation process (Capacitation). Findings: The results showed that there was no significant relationship between the type of menstruation and treatment protocol used for the patients (P=0.109). Also, there was no significant relationship between the presence of acne and hirsutism in patients and the type of treatment protocol (P=0.281 and P=0.232, respectively). In this study, there was no significant relationship between the type of clomiphene treatment or clomiphene with IUI and the levels of LH (P=0.783), FSH (P=0.516), AMH (P=0.679) and PRL (P=0.345) and also there was no significant relationship between body mass index (BMI) with the type of patient treatment (P=0.584). Clomiphene treatment alone did not have a significant effect on the success of pregnancy outcomes, but in the clomiphene and IUI treatment protocol, there were 127 positive pregnancies, which 3% of them were ectopic pregnancies, and 5% of them was led to abortion. Finally, 124 cases resulted in the birth of a live baby, which based on the results of statistical analysis showed a significant relationship (P=0.036). Conclusion: Clomiphene as a drug with low complication, low cost and available can be used as a suitable option in the treatment of infertile patients with ovarian factor in combination with IUI treatment method.","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47840315","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A rare case of duodenal atresia with severe gastric bleeding, treated by vagotomy","authors":"S. Seyedi, Seyed Arsalan Seyedi, M. Samet, S. Mortazavi, Mohammad Reza Nateghi (MD, MPH), Maryam Sanaye Naderi","doi":"10.52547/sjrm.5.1.48","DOIUrl":"https://doi.org/10.52547/sjrm.5.1.48","url":null,"abstract":"to the operating room. In the operating room, due to severe bleeding and hypotension, with great effort by the anesthesiologist, the infant was intubated and subsequently, the infant underwent gastrotomy and blood clots were removed. There was oozing of blood from the mucosal surface. Then, duodenodenodenostomy surgery was performed, which continued after bleeding into the stomach, so in these conditions, several solutions such as total gastrectomy, pacing, and vagotomy were proposed. The infant underwent anterior-posterior truncal vagotomy. Gastric bleeding was controlled immediately after vagotomy. Because vagotomy can cause the pyloric constriction, gastrojejunostomy is also performed on the baby. The infant was discharged in good general condition without any complications after spending time in the neonatal intensive care unit. Conclusion: Severe gastrointestinal bleeding is a very rare occurrence in duodenal atresia. In this situation, a gastrectomy can be considered and performed, which will be associated with many problems in the future. In adults, a vagotomy with a vascular contraction mechanism is used to control gastric bleeding. However, no case has been reported in the control of gastrointestinal bleeding in infants. In this case, for the first time, neonatal vagotomy was performed despite special technical subtleties, which was also accompanied by excellent therapeutic results.","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49630069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous appearance of Dermoid cyst and Endometrioma in one ovary","authors":"M. Rasekhi, Mohammad Amin Zaeim Yekeh","doi":"10.52547/sjrm.5.2.82","DOIUrl":"https://doi.org/10.52547/sjrm.5.2.82","url":null,"abstract":"","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48515250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of differences in post-cesarean section infection following a three-dose prophylactic antibiotic regimen and no prescription of antibiotics, a randomized clinical trial","authors":"Mojghan Karamnia Far, A. Saremi, Mohammad Reza Nateghi (MD, MPH), Maryam Sanaye Naderi","doi":"10.52547/sjrm.5.1.42","DOIUrl":"https://doi.org/10.52547/sjrm.5.1.42","url":null,"abstract":"Aims: Inappropriate administration of antibiotics, in addition to increasing costs and drug reactions, can lead to the spread of resistant bacterial infections. Some studies have suggested that preoperative antibiotics are effective in reducing surgical infection. Other studies have shown that there is no difference between prescribing one-dose and three-dose antibiotics after surgery. Due to the lack of agreement on the use or non-use of antibiotics after surgery, the present study was performed to determine the effectiveness of antibiotics after elective cesarean section in reducing the rate of infection. Material and methods: In this randomized clinical trial, 63 patients who were candidates for elective cesarean section received a dose of antibiotics (Cefazolin, 2g, intravenous injection) one hour before surgery. They were then randomly divided into two groups. The intervention group (n=37) received three doses of antibiotics (Cefazolin, 2g every 6h, intravenous injection), while the control group (n=26) did not receive any postoperative antibiotics. Patients were followed up for 40 days after surgery and the effectiveness of these two methods in preventing infection was investigated. Results: There was no statistically significant difference between the intervention group and the control group in any of the parameters of age, weight, height and body mass index. Also, there was no significant difference between the rate of infection after cesarean section between the group receiving antibiotics and the control group ( P> 0.05 ). Conclusion: Findings of this study showed that receiving antibiotics after the cesarean section has no effect on the prevention of surgical infection. According to the results of this study, as well as the increase in microbial resistance to antibiotics and treatment costs, antibiotics can be discontinued after elective cesarean section.","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43183171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effectiveness of functional electrical stimulation - biofeedback with sexual cognitive-behavioral therapy in the treatment of grade 3 and 4 Lamont vaginismus and pregnancy rate of treated individuals.","authors":"M. Nejat, Elahe Hemmat boland, Mahshid Tarzimoghadam","doi":"10.52547/sjrm.5.2.67","DOIUrl":"https://doi.org/10.52547/sjrm.5.2.67","url":null,"abstract":"2 Background and Purpose: Vaginismus is an involuntary muscle spasm of the outer third of the vagina that makes it impossible to penetrate the vagina and causes discomfort. Based on the Lamont rating, it has 4 degrees, which are 3 and 4 degrees of severity. The aim of this study was to determine the effectiveness of functional electrical stimulation-biofeedback combined with cognitive-behavioral therapy in the treatment of grade 3 and 4 vaginismus based on the Lamont scale and pregnancy success of treated individuals. Method: 113 women with grade 3 and 4 Lamont vaginismus referred to Nejat Sexual Disorders Clinic and Sarem Hospital participated in this study. The patients enrolled in this study had primary severe vaginismus sexual dysfunction according to diagnostic and statistical criteria and the Lamont questionnaire (Grade 3 and 4). Patients underwent gynecological examinations and clinical interviews related to sexual function before and after treatment. After diagnosis of vaginismus, women underwent biofeedback, neuromuscular inhibitory stimulation, and sexual cognitive-behavioral therapy twice a week for 4 weeks. After treatment, the grade of the disease was calculated based on the Lamont scale and the progress of treatment was considered. Findings: After 8 sessions of treatment, there was a significant difference in the improvement of vaginismus and 77.9% of the subjects were reduced to grade zero and 8% of the subjects were reduced to grade one of Lamont scale. 52.8% of people who planned to become pregnant became success after two months. Conclusion: Biofeedback and muscular inhibitory stimulation along with cognitive-behavioral therapy are effective and short-term therapies for patients with vaginismus.","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43515046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-occurrence of Left Ovarian Torsion and Right Fallopian Tube Ectopic Pregnancy in One Patient: A Case Report","authors":"Mahboobeh Rasekhi Kumle, Mohammad Amin Zaemi Yeke","doi":"10.52547/sjrm.5.2.95","DOIUrl":"https://doi.org/10.52547/sjrm.5.2.95","url":null,"abstract":"completely treat her/him. Simultaneous ectopic pregnancy and ovarian torsion are rare but do occur. Therefore, early diagnosis is important to maintain future fertility and the ovaries, which can prevent unwanted complications in these patients with appropriate treatment.","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45895229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Lorazepam on Ovary and Ovulation of Balb/C adult Female Mouse","authors":"Z. Karami, P. Torabzadeh, J. amini mahabadi","doi":"10.52547/sjrm.5.1.34","DOIUrl":"https://doi.org/10.52547/sjrm.5.1.34","url":null,"abstract":"Aims: The usage of antidepressants and sedatives such as lorazepam can cause side effects, including temporary or permanent infertility. The aim of this study was to evaluate the effect of lorazepam on the ovaries and ovulation of adult female Balb/C mice. Methods: 75 adult female mice were studied in 5 groups and 15 mice in each group. Lorazepam drug injection was done intraperitoneally (IP) by selecting a fixed dose of 2 mg/kg.bw for three groups at three different times. The study groups were included: the first experimental group for 5 days, the second experimental group for 10 days and the third experimental group for 15 days’ injection, sham group (distilled water injection) and control group (without injection). The day after the last injection, the mice were carefully dissected and their ovaries were removed for tissue examination. Results: Parameters such as animal weight, high and small diameter of ovary, the follicles number of primary, secondary, growing and graph and corpus luteum were significantly decreased by duration increasing of drug injection in experimental groups in compared with control group (P<0.05). There was a significant increase in parameters such as the number of destructive follicles and folded zona pellucida compared to the control group. Conclusion: In general, it can be concluded that the use of lorazepam for a long time had a destructive effect on female mice ovaries.","PeriodicalId":33200,"journal":{"name":"dnshnmh Srm","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43447658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}