Annals of Urologic Oncology最新文献_第2页

Research Progress of New Urine Markers in the Diagnosis of Bladder Cancer 诊断膀胱癌的新型尿液标记物研究进展

Annals of Urologic Oncology Pub Date : 2024-02-06 DOI: 10.32948/auo.2024.02.03

Rose Lamichhane

{"title":"Research Progress of New Urine Markers in the Diagnosis of Bladder Cancer","authors":"Rose Lamichhane","doi":"10.32948/auo.2024.02.03","DOIUrl":"https://doi.org/10.32948/auo.2024.02.03","url":null,"abstract":"Bladder cancer is the tenth most commonly diagnosed cancer worldwide and poses a great threat to human health. It has a high recurrence rate and requires long-term close monitoring and follow-up after surgery. At present, the most reliable method for the clinical diagnosis of bladder cancer is still cystoscopy and urine exfoliative cytology. However, cystoscopy is an invasive examination, which is often accompanied by complications such as infection, bleeding, pain and discomfort, and is cost ineffective. At the same time, the sensitivity of urine cytology for low-grade tumors is low, and the subjective factors of the examiners have a great impact on the test results. Urinary biomarkers have the advantages of non-invasive, safe, and simple detection, possessing clinical diagnostic value. At present, it has been found that many urine markers show higher sensitivity than urine exfoliative cytology in the detection of bladder cancer, but due to their poor specificity, they are not widely used in clinical practice. Therefore, there is an urgent need to find novel noninvasive and reliable method for the diagnosis of bladder cancer with high specificity and sensitivity. This article reviews the recent research progress of some new urine biomarkers in the diagnosis of bladder cancer.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139800417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Scrotal Leiomyomas, Unraveling the Mysteries of a Rare Tumor: A Case Report 探究阴囊线粒体瘤，揭开罕见肿瘤的神秘面纱：病例报告

Annals of Urologic Oncology Pub Date : 2024-01-30 DOI: 10.32948/auo.2024.01.28

Sana Sana Ahuja, Pooja Verma, Adil Aziz Khan, S. Zaheer

{"title":"Exploring Scrotal Leiomyomas, Unraveling the Mysteries of a Rare Tumor: A Case Report","authors":"Sana Sana Ahuja, Pooja Verma, Adil Aziz Khan, S. Zaheer","doi":"10.32948/auo.2024.01.28","DOIUrl":"https://doi.org/10.32948/auo.2024.01.28","url":null,"abstract":"Leiomyomas, originating from smooth muscle cells, are common in the uterus but rare in the scrotum, presenting a clinical challenge. Scrotal leiomyomas, first described in the 19th century, are characterized by benign pathology from the subcutaneous dartos muscle. We present two cases of middle-aged males with scrotal leiomyomas, detailing clinical presentations, histopathological findings, and immunohistochemistry results. The first involved a 48-year-old with a painless scrotal lump, excised to reveal well-circumscribed smooth muscle bundles. Immunohistochemistry confirmed vimentin, desmin, and smooth muscle actin (SMA) positivity, consistent with scrotal leiomyoma. The second case featured a 25-year-old with a painless scrotal swelling, histologically matching the features of scrotal leiomyoma. Accurate diagnosis is crucial for guiding appropriate management strategies. Clinicians often employ a combination of clinical evaluation, imaging studies, and histopathological examination to confirm the presence of scrotal leiomyomas. Ultrasound remains a valuable tool for assessing the size, location, and vascularity of the tumor, aiding in the formulation of a differential diagnosis. Definitive diagnosis, however, relies on histological examination, which typically reveals spindle-shaped smooth muscle cells arranged in interlacing bundles.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"187 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140485357","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid Metabolism Pathway and Renal Tumor Therapy 脂质代谢途径与肾肿瘤治疗

Annals of Urologic Oncology Pub Date : 2023-12-31 DOI: 10.32948/auo.2023.12.30

Wenjun Wang, Chunyan Xin

引用次数: 0

Measurement of Microvessel Density Using CD105 (Endoglin) as a Marker in Prostatic Adenocarcinoma 使用 CD105（内皮素）作为前列腺腺癌的标记物测量微血管密度

Annals of Urologic Oncology Pub Date : 2023-12-10 DOI: 10.32948/auo.2023.12.31

S. Azad, Garima Sharma, M. Kochhar, Saqib Ahmed, Seema Acharya, Sadaf Khan

{"title":"Measurement of Microvessel Density Using CD105 (Endoglin) as a Marker in Prostatic Adenocarcinoma","authors":"S. Azad, Garima Sharma, M. Kochhar, Saqib Ahmed, Seema Acharya, Sadaf Khan","doi":"10.32948/auo.2023.12.31","DOIUrl":"https://doi.org/10.32948/auo.2023.12.31","url":null,"abstract":"Introduction Angiogenesis has been proposed as a promising prognostic marker in a variety of tumours. Microvessel density (MVD) measurement is the most reliable method for the semiquantitative evaluation of angiogenesis. Endoglin (CD105) is a recognised marker of proliferating endothelium and is expressed in intra-tumoral as well as peri-tumoral vessels. It is upregulated in various cancers including prostate cancer, therefore, it is an upcoming prime marker for prognosis, tumour imaging and antiangiogenesis therapy. Aim The study was done to evaluate microvessel density (MVD) by using CD105 (endoglin) as an IHC marker in prostatic adenocarcinoma and to find its relationship with Gleason score and grade groups. Materials and methods This was an observational cross-sectional study under which a total of 31 histopathologically diagnosed cases of prostatic adenocarcinoma on TURP chips were included and were graded according to Gleason score and grades.IHC using endoglin (CD105) was done to detect the highest-density areas of stained vessels (hot spots). The highest value obtained in three hot spot fields was reported as microvessel density (MVD) and its relationship with Gleason score and grade groups was analysed. Results Most common age group was 71-80 years (48.39% cases). Maximum cases (45.16%) had a Gleason score of 9. The maximum mean MVD CD105 score was found in the Gleason grade group 5 (45.32%) while the minimum was in grade group 1 (24%). Comparison of mean MVD CD105 scores in different Gleason grade groups revealed a significant association of MVD CD105 with Gleason grade groups. Conclusion Endoglin measures microvessel density and its expression correlated with Gleason score and grade group. Hence it can be used as a potential prognostic marker in adenocarcinoma prostate.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"60 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139184684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on the Mechanism of Androgen Receptor Signaling Pathway in Castration-Resistant Prostate Cancer 雄激素受体信号通路在去势抵抗性前列腺癌中的作用机制研究进展

Annals of Urologic Oncology Pub Date : 2023-11-11 DOI: 10.32948/auo.2023.11.09

Na Cui, Mingjie Li

引用次数: 0

Diagnosis and Treatment of Adrenal Metastasis in Modern Era 现代肾上腺转移的诊断与治疗

Annals of Urologic Oncology Pub Date : 2023-11-11 DOI: 10.32948/auo.2023.11.07

Sarah E. Matusofsky, Paris M. Fang, Ellie R. Ellie R. Monnette, Austin M. Kim, Mark R. Mark R. Wakefield

引用次数: 0

Diet, Physical Activity, and Smoking in Patients Living with Non-Muscle Invasive Bladder Cancer 非肌肉浸润性膀胱癌患者的饮食、身体活动和吸烟

Annals of Urologic Oncology Pub Date : 2023-11-02 DOI: 10.32948/auo.2023.10.26

Elizabeth Y. Wang, Manuel Armas-Phan, Maxwell V. Meng, Sima P. Porten, Stacey A. Kenfield

{"title":"Diet, Physical Activity, and Smoking in Patients Living with Non-Muscle Invasive Bladder Cancer","authors":"Elizabeth Y. Wang, Manuel Armas-Phan, Maxwell V. Meng, Sima P. Porten, Stacey A. Kenfield","doi":"10.32948/auo.2023.10.26","DOIUrl":"https://doi.org/10.32948/auo.2023.10.26","url":null,"abstract":"Background Modifiable lifestyle factors have been implicated in bladder cancer outcomes. Further study is warranted to inform future strategies in patients with non-muscle invasive bladder cancer (NMIBC). Objective We aim to describe modifiable behaviors (smoking, diet, and physical activity) in a cohort of patients with NMIBC. Methods We conducted an observational cross-sectional study in patients undergoing surveillance for NMIBC. A comprehensive survey comprised of validated measures of physical activity, diet, and mutagen consumption was administered. We assessed a “healthy lifestyle score” consisting of body mass index (BMI) <25, smoking status, and physical activity (aerobic exercise minutes). We examined differences in lifestyle factors by stage, grade, recurrence, BMI, age, gender, and education level. Results In a cohort of 113 NMIBC patients, median age was 67 years (IQR: 59, 73) and median time since initial diagnosis was 26 months (IQR: 9, 42). Low levels of healthy habits are common among patients with NMIBC. Those with a BMI of ≥25 has greater red and processed meat intake, higher mutagen intake, and lower physical activity. Older patients reported more supplement use and lower physical activity. Low education level was associated with a less healthy lifestyle (higher processed meat consumption, higher Meiqx mutagen consumption, and lower physical activity). Conclusions In patients undergoing surveillance for NMIBC, 25% had all three components reflecting a healthy lifestyle. Older age, lower education, and higher body mass index were associated with fewer healthy habits. Education on healthy lifestyle changes should be a key component in NMIBC survivorship care.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"8 4","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135875718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Value of Immunological Biomarkers in Early Prediction of Bacillus Calmette-Guerin Failure in High-Risk Non-muscle-invasive Bladder Cancer 免疫生物标志物在高危非肌浸润性膀胱癌卡介苗- guerin衰竭早期预测中的价值

Annals of Urologic Oncology Pub Date : 2023-10-05 DOI: 10.32948/auo.2023.10.03

Mohamed Mohamed G.A. El-Gazzar, Hassan Abol-Enein, Amira Amira Awadalla3, Ahmed Ahmed El-Assmy, Ahmed Ahmed El-Assmy, Mohamed S. El-Ghreb S. El-Ghreb, Lamiaa A.A. Barakat, Lamiaa A.F. Abdel-Aziz

{"title":"Value of Immunological Biomarkers in Early Prediction of Bacillus Calmette-Guerin Failure in High-Risk Non-muscle-invasive Bladder Cancer","authors":"Mohamed Mohamed G.A. El-Gazzar, Hassan Abol-Enein, Amira Amira Awadalla3, Ahmed Ahmed El-Assmy, Ahmed Ahmed El-Assmy, Mohamed S. El-Ghreb S. El-Ghreb, Lamiaa A.A. Barakat, Lamiaa A.F. Abdel-Aziz","doi":"10.32948/auo.2023.10.03","DOIUrl":"https://doi.org/10.32948/auo.2023.10.03","url":null,"abstract":"Objectives To investigate the predictive value of different immunological markers on treatment outcomes after bacillus Calmette-Guerin (BCG) induction in high-risk non-muscle-invasive bladder cancer (NMIBC). Patients and Methods Patients who underwent transurethral resection of bladder tumors for NMIBC were assessed for study eligibility. Urine and blood samples were taken from patients at baseline (immediately before the first dose of induction). Urine samples were evaluated for interleukin (IL)-6, IL-8, IL-10, IL-11, and interferon- γ by solid-phase enzyme-linked immunosorbent assay (ELISA). Blood samples were evaluated for epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor-2 (HER2) using quantitative reverse transcriptase-polymerase chain reaction analysis. Each marker was assessed in relation to tumor recurrence. Results Between June 2016 and December 2019, 160 patients were included. Tumor recurrence occurred in 47 (29.38%) patients over a median (IQR) follow-up of 24 (12: 49) months. Using univariate analysis, the following urinary cytokines were associated with higher recurrence: urinary IL-6, 8, 10, 11, and interferon-γ. Also, serum EGFR and HER2 were associated with higher recurrence. On multivariate Cox regression analysis, significant variables include HER2 [HR (95%CI): 2.675 (1.367-5.233), p= 0.004], and IL-11 [HR (95%CI): 0.889 (0.825-0.957), p= 0.002]. Conclusions Serum HER2 and urinary IL-11 could be applied in clinical practice to predict BCG failure in patients with high-risk NMIBC, so those patients could be offered other modalities (radical cystectomy) early with better survival. Further studies are recommended to establish their exact role.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134947930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress of Abnormal DNA Methylation in the Development, Diagnosis, and Treatment of Prostate Cancer 异常DNA甲基化在前列腺癌发生、诊断和治疗中的研究进展

Annals of Urologic Oncology Pub Date : 2023-09-30 DOI: 10.32948/auo.2023.09.30

Zhen Zhen Ren, Ming Ming Yu, Yi Xia

引用次数: 0

Primary Extra Renal Papillary Renal Cell Carcinoma Masquerading as A Metastatic Carcinoma: A Unique Case with Dual Malignancies 伪装成转移癌的原发性肾外乳头状肾细胞癌:一个独特的双重恶性肿瘤病例

Annals of Urologic Oncology Pub Date : 2023-09-16 DOI: 10.32948/auo.2023.09.10

Sivaranjani Selvaraj, Akkamahadevi Akkamahadevi Patil, Champaka G, Usha Usha Amirtham

引用次数: 0