Lipid Metabolism Pathway and Renal Tumor Therapy

Wenjun Wang, Chunyan Xin
{"title":"Lipid Metabolism Pathway and Renal Tumor Therapy","authors":"Wenjun Wang, Chunyan Xin","doi":"10.32948/auo.2023.12.30","DOIUrl":null,"url":null,"abstract":"Renal tumor remains as one of the common malignancy of the urinary system whose incidence and mortality is increasing over the years. Although the emergence of targeted drugs has greatly improved the prognosis of patients with advanced kidney cancer, the occurrence of drug resistance still brings huge treatment pressure to patients. Renal clear cell carcinoma (RCC), the most common pathological type of renal cancer, has been widely reported as a metabolic disease undergoing enormous metabolic reprogramming. This metabolic abnormality not only supports the synthesis of macromolecules such as proteins, lipids, and nucleic acids, but also promotes tumor progression. Changes in lipid metabolism, especially fatty acid metabolism, which is involved in the synthesis of biofilm components, provides energy for tumor progression, and regulates tumorigenesis. In this review, the key molecules of lipid metabolism pathway were systematically summarized, aiming to find potential therapeutic targets for RCC, and further elucidate the potential clinical application prospect of interfering with fatty acid metabolism pathway in the treatment of renal tumor.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"115 7","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Urologic Oncology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.32948/auo.2023.12.30","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

Abstract

Renal tumor remains as one of the common malignancy of the urinary system whose incidence and mortality is increasing over the years. Although the emergence of targeted drugs has greatly improved the prognosis of patients with advanced kidney cancer, the occurrence of drug resistance still brings huge treatment pressure to patients. Renal clear cell carcinoma (RCC), the most common pathological type of renal cancer, has been widely reported as a metabolic disease undergoing enormous metabolic reprogramming. This metabolic abnormality not only supports the synthesis of macromolecules such as proteins, lipids, and nucleic acids, but also promotes tumor progression. Changes in lipid metabolism, especially fatty acid metabolism, which is involved in the synthesis of biofilm components, provides energy for tumor progression, and regulates tumorigenesis. In this review, the key molecules of lipid metabolism pathway were systematically summarized, aiming to find potential therapeutic targets for RCC, and further elucidate the potential clinical application prospect of interfering with fatty acid metabolism pathway in the treatment of renal tumor.
脂质代谢途径与肾肿瘤治疗
肾肿瘤仍是泌尿系统常见的恶性肿瘤之一,其发病率和死亡率呈逐年上升趋势。虽然靶向药物的出现大大改善了晚期肾癌患者的预后,但耐药性的出现仍给患者带来巨大的治疗压力。肾透明细胞癌(RCC)是肾癌中最常见的病理类型,已被广泛报道为一种代谢性疾病,正在经历巨大的代谢重编程。这种代谢异常不仅支持蛋白质、脂类和核酸等大分子的合成,还促进了肿瘤的进展。脂质代谢的变化,尤其是脂肪酸代谢的变化,参与了生物膜成分的合成,为肿瘤的进展提供能量,并调节肿瘤的发生。本综述系统总结了脂质代谢通路的关键分子,旨在寻找RCC的潜在治疗靶点,进一步阐明干扰脂肪酸代谢通路治疗肾脏肿瘤的潜在临床应用前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
自引率
0.00%
发文量
5
审稿时长
4 weeks
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信