Annals of Urologic Oncology最新文献

Clinical Features and Significance of Malignant Priapism 恶性尿崩症的临床特征和意义

Annals of Urologic Oncology Pub Date : 2024-07-18 DOI: 10.32948/auo.2024.07.15

Dilibe Ekowa, Austin J. Marrah, Justin D. Murray, M. Wakefield, Yujiang Fang

{"title":"Clinical Features and Significance of Malignant Priapism","authors":"Dilibe Ekowa, Austin J. Marrah, Justin D. Murray, M. Wakefield, Yujiang Fang","doi":"10.32948/auo.2024.07.15","DOIUrl":"https://doi.org/10.32948/auo.2024.07.15","url":null,"abstract":"Priapism is a disorder defined as a persistent erection maintained without an appropriate sexual stimulus lasting for longer than 4 hours. Priapism is generally classified into two categories, ischemic and non-ischemic. Ischemic priapism is considered a true urological emergency as prolongation of this subtype is often associated with loss of sinusoidal endothelial function, corporal fibrosis, and necrosis. Non-ischemic priapism is a type of priapism often caused by the formation of arteriovenous fistulas that create dysregulation of cavernosa blood flow. One less common cause of priapism includes malignancy. Malignancy, either primary or secondary, is considered a rare cause of priapism. During our review of malignant priapism, several etiologies have been identified as potential causes of malignant priapism. Pathologies such as chronic myelogenous leukemia, chronic lymphocytic leukemia, and myelodysplastic syndromes have been implicated in the development of priapism, most likely due to hyperleukocytosis. Metastasis from distal or regional tumors such as the lung, bladder, prostate have been shown to produce secondary tumors that can initiate the development of priapism. Thus, it is important to consider malignancy as a possible cause of a patients priapism. The clinical presentation and prognosis between patients vary greatly and modern treatment modalities have been shown to differ greatly in its efficacy. A comprehensive study that addresses the different forms of malignant priapism may benefit healthcare professionals by providing a better understanding of the complexities, etiologies, and early interventions that can be used for their patients.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":" 31","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141827308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progress on the Association between Obesity and Prostate Cancer 肥胖与前列腺癌关系的研究进展

Annals of Urologic Oncology Pub Date : 2024-07-12 DOI: 10.32948/auo.2024.07.17

Hang Xu, Yingshuang Tang, Xiaorui Zhang, Xian Zhang, Along Kang

{"title":"Research Progress on the Association between Obesity and Prostate Cancer","authors":"Hang Xu, Yingshuang Tang, Xiaorui Zhang, Xian Zhang, Along Kang","doi":"10.32948/auo.2024.07.17","DOIUrl":"https://doi.org/10.32948/auo.2024.07.17","url":null,"abstract":"The complex association between obesity and prostate cancer necessitates exploring how obesity impacts the incidence, progression, treatment response, and prognosis of prostate cancer. An analysis was conducted to determine the potential adverse effects of obesity on prostate cancer treatment, including changes in drug metabolism and surgical complications. It also discusses how obesity increases the risk of disease progression and recurrence. Further emphasis was provided to the importance of comprehensive interventions to reduce the risk of prostate cancer through lifestyle modifications (including healthy diet, moderate exercise, and maintaining normal weight), pharmacological treatments (such as potential drugs targeting obesity and prostate cancer-related mechanisms), and regular check-ups and screenings. Lastly, the work envisions future research directions, including exploring the specific mechanisms linking obesity and prostate cancer, designing more scientific clinical trials, and enhancing interdisciplinary cooperation. These opportunities and challenges aim to provide references and insights for future research and development.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"197 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141834359","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploration of Apoptosis in Histopathologies of Balkan Endemic Nephropathies with Both Urothelial Tumour and Atrophied Kidney 巴尔干地方性肾病组织病理学中的细胞凋亡与尿道肿瘤和萎缩肾的关系探讨

Annals of Urologic Oncology Pub Date : 2024-07-04 DOI: 10.32948/auo.2024.06.25

Peter Mantle, Rohit Upadhyay, Diana Herman, Vecihi Batuman

{"title":"Exploration of Apoptosis in Histopathologies of Balkan Endemic Nephropathies with Both Urothelial Tumour and Atrophied Kidney","authors":"Peter Mantle, Rohit Upadhyay, Diana Herman, Vecihi Batuman","doi":"10.32948/auo.2024.06.25","DOIUrl":"https://doi.org/10.32948/auo.2024.06.25","url":null,"abstract":"There seems yet no satisfactory explanation for the mysterious endemic renal disease, known as Balkan endemic nephropathy (BEN), seen across rural parts of several Balkan countries in the last century although some have claimed aristolochic acid as the etiologic agent. Nearly half of the BEN patients develop urothelial cancers and unilateral nephrectomy may be temporary life-extending measure for some cases. Recent access to some tissues of archived Serbian unilateral nephrectomy specimens during the past century enabled description of unique tumour immuno-profiles. We also evaluated the role of apoptosis using a modern TdT-mediated dUTP Nick-End Labeling (TUNEL) assay. We found clear evidence of apoptosis in regions of several tumour specimens and adjacent healthy kidney tissues. These observations suggest a prominent role of apoptosis in the pathogenesis of BEN and the associated urothelial cancers and point to the need for systematic evaluation of apoptosis in other archived tissues from BEN patients. Here, we also present evidence of apoptosis in kidney sections of male rats treated with ochratoxin A. These observations suggest a prominent role of apoptosis in the pathogenesis of BEN and the associated urothelial cancers and point to the need for systematic evaluation of apoptosis in other archived tissues from BEN patients. Here, we also present evidence of apoptosis in kidney sections of male rats treated with ochratoxin A. Fungal metabolites such as ochratoxin A and alkaloids from the Aristolochia plants are nephrotoxic in both animals and humans, and experimental animal models could be helpful in understanding the pathophysiology of kidney disease and tumorigenesis in humans exposed to such agents.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":" 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141678900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The relationship between vitamin D, chronic kidney disease, and mineral and bone disorder: a complex interplay comprehensive review 维生素 D、慢性肾病与矿物质和骨骼紊乱之间的关系：复杂的相互作用综合评述

Annals of Urologic Oncology Pub Date : 2024-06-09 DOI: 10.32948/ajsep.2024.05.20

Abdul Ghaffar, Ghulam Mustafa, Abdul Wahid

引用次数: 0

Incidental Detection of Papillary Renal Cell Carcinoma in Nephrectomy Specimen for Chronic Pyelonephritis 在慢性肾盂肾炎肾切除术标本中意外发现乳头状肾细胞癌

Annals of Urologic Oncology Pub Date : 2024-06-09 DOI: 10.32948/auo.2024.06.01

S. Ahuja, A. Khan, S. Zaheer

引用次数: 0

Advancing Genomics in Urologic Tumors: Navigating Precision Therapeutic Pathways 推进泌尿系统肿瘤的基因组学研究：精准治疗路径导航

Annals of Urologic Oncology Pub Date : 2024-05-21 DOI: 10.32948/auo.2024.05.18

Fawad Inayat, Imad Tariq, Nabiha Bashir, Fawad Ullah, Hadiqa Aimen

{"title":"Advancing Genomics in Urologic Tumors: Navigating Precision Therapeutic Pathways","authors":"Fawad Inayat, Imad Tariq, Nabiha Bashir, Fawad Ullah, Hadiqa Aimen","doi":"10.32948/auo.2024.05.18","DOIUrl":"https://doi.org/10.32948/auo.2024.05.18","url":null,"abstract":"Urologic cancers, with bladder cancer as a pivotal subtype, pose substantial challenges to global health, necessitating a profound understanding of their molecular underpinnings. This article explores recent genomic research, with a focus on transitional cell carcinoma, the primary histological form of transitional cell carcinoma, aiming to elucidate the intricate molecular processes that underlie the onset and advancement of disease. Leveraging advanced genomic and transcriptomic analyses such as next-generation sequencing (NGS) and molecular subtyping techniques, this review delves into the diverse genetic and molecular subtypes inherent in bladder cancer. It emphasizes the critical role of molecular subtyping in guiding treatment decisions and refining patient stratification for precision medicine approaches. Furthermore, the review examines emerging diagnostic biomarkers such as methylation markers and single nucleotide polymorphism (SNP) sites, highlighting their potential in enabling early detection and targeted therapies. Their integration promises to enhance diagnostic accuracy and therapeutic monitoring in bladder cancer patients. Collaboration among multidisciplinary teams comprising clinicians, researchers, and bioinformaticians is paramount for unraveling the molecular complexities of urologic cancers and advancing personalized cancer care. This thorough review seeks to offer a detailed examination of the existing understanding on urologic oncology, offering valuable insights into the molecular intricacies of urothelial carcinoma and while also laying the groundwork for future research directions aimed at optimizing patient outcomes globally.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"65 5","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141114187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research Progression in the Mechanism of Bone Metastasis and Bone-Targeted Drugs in Prostate Cancer 前列腺癌骨转移机制和骨靶向药物的研究进展

Annals of Urologic Oncology Pub Date : 2024-02-24 DOI: 10.32948/auo.2024.02.20

Sajjad Ahmad

{"title":"Research Progression in the Mechanism of Bone Metastasis and Bone-Targeted Drugs in Prostate Cancer","authors":"Sajjad Ahmad","doi":"10.32948/auo.2024.02.20","DOIUrl":"https://doi.org/10.32948/auo.2024.02.20","url":null,"abstract":"Prostate cancer is a particularly slow growing cancer, the early stage of the disease is not easy to detect, the some major clinical manifestations include low back pain, urgent and frequent urination, urinary pain, and other urethral symptoms. These symptoms are often experienced after surgical resection or drug castration treatment. Early-stage, prostate cancer is curable, and with disease progression many clinical symptoms become worse with high probability of metastasis. Bone is the most common site of advanced metastasis of prostate cancer. Bone metastasis is a continuous and complex pathological process regulated by tumor cells and bone microenvironment, in which epithelial-mesenchymal transformation, homing and dormancy, reactivation, and proliferation of tumor cells are closely related to its occurrence and development. Several cytokines such as Receptor activator of NF-κB ligand (RANK-L) is overexpressed in bone microenvironment and prostate cancer. RANKL, chemokine family, and integrins are involved in bone metastasis of prostate cancer through complex interaction mechanisms. A variety of bone-targeting drugs such as bisphosphonates, RANKL inhibitors (denosumab) and radiotherapy drugs (radium-223, strontium-89, samarium-153), tyrosine kinase inhibitors, integrin-targeted drugs, etc. are approved for the prevention and treatment of skeletal related events caused by bone metastasis in prostate cancer patients. In this review, the biological mechanism of bone metastasis in prostate cancer and the research progress of bone-targeting drugs are reviewed.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"36 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140433962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Regulatory Role of Autophagy and Glucose Metabolic Reprogramming in the Malignant Progression of Bladder Cancer: A Review 自噬和葡萄糖代谢重编程在膀胱癌恶性进展中的调控作用：综述

Annals of Urologic Oncology Pub Date : 2024-02-15 DOI: 10.32948/auo.2024.02.10

Wei Sun, Junxiong Peng, Sen Pan, Chuanlin Wang, Mengjuan Yuan

引用次数: 0

Regulatory Role of Autophagy and Glucose Metabolic Reprogramming in the Malignant Progression of Bladder Cancer: A Review 自噬和葡萄糖代谢重编程在膀胱癌恶性进展中的调控作用：综述

Annals of Urologic Oncology Pub Date : 2024-02-15 DOI: 10.32948/auo.2024.02.10

Wei Sun, Junxiong Peng, Sen Pan, Chuanlin Wang, Mengjuan Yuan

引用次数: 0

Research Progress of New Urine Markers in the Diagnosis of Bladder Cancer 诊断膀胱癌的新型尿液标记物研究进展

Annals of Urologic Oncology Pub Date : 2024-02-06 DOI: 10.32948/auo.2024.02.03

Rose Lamichhane

{"title":"Research Progress of New Urine Markers in the Diagnosis of Bladder Cancer","authors":"Rose Lamichhane","doi":"10.32948/auo.2024.02.03","DOIUrl":"https://doi.org/10.32948/auo.2024.02.03","url":null,"abstract":"Bladder cancer is the tenth most commonly diagnosed cancer worldwide and poses a great threat to human health. It has a high recurrence rate and requires long-term close monitoring and follow-up after surgery. At present, the most reliable method for the clinical diagnosis of bladder cancer is still cystoscopy and urine exfoliative cytology. However, cystoscopy is an invasive examination, which is often accompanied by complications such as infection, bleeding, pain and discomfort, and is cost ineffective. At the same time, the sensitivity of urine cytology for low-grade tumors is low, and the subjective factors of the examiners have a great impact on the test results. Urinary biomarkers have the advantages of non-invasive, safe, and simple detection, possessing clinical diagnostic value. At present, it has been found that many urine markers show higher sensitivity than urine exfoliative cytology in the detection of bladder cancer, but due to their poor specificity, they are not widely used in clinical practice. Therefore, there is an urgent need to find novel noninvasive and reliable method for the diagnosis of bladder cancer with high specificity and sensitivity. This article reviews the recent research progress of some new urine biomarkers in the diagnosis of bladder cancer.","PeriodicalId":33190,"journal":{"name":"Annals of Urologic Oncology","volume":"452 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139860090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0