Research Progress on the Association between Obesity and Prostate Cancer

Abstract

The complex association between obesity and prostate cancer necessitates exploring how obesity impacts the incidence, progression, treatment response, and prognosis of prostate cancer. An analysis was conducted to determine the potential adverse effects of obesity on prostate cancer treatment, including changes in drug metabolism and surgical complications. It also discusses how obesity increases the risk of disease progression and recurrence. Further emphasis was provided to the importance of comprehensive interventions to reduce the risk of prostate cancer through lifestyle modifications (including healthy diet, moderate exercise, and maintaining normal weight), pharmacological treatments (such as potential drugs targeting obesity and prostate cancer-related mechanisms), and regular check-ups and screenings. Lastly, the work envisions future research directions, including exploring the specific mechanisms linking obesity and prostate cancer, designing more scientific clinical trials, and enhancing interdisciplinary cooperation. These opportunities and challenges aim to provide references and insights for future research and development.