2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)最新文献_第6页

An appendix to embedded designs of QRS detectors QRS探测器的嵌入式设计附录

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399717

R. Stojanovic, S. Knezevic, D. Karadaglic

{"title":"An appendix to embedded designs of QRS detectors","authors":"R. Stojanovic, S. Knezevic, D. Karadaglic","doi":"10.1109/BIBE.2012.6399717","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399717","url":null,"abstract":"The Wavelet Transform in its discrete form has been widely applied in the field of biomedical signals. Typically, its calculation is performed off-line and calculation systems usually suffer from limited autonomy, bulkiness and obtrusiveness. A noticeable surge in industrial, research and academic interest into telemedicine and medical embedded systems, has been happening recently, where miniature, low-cost, autonomous and ultra-low-power devices play a major role. Such devices are usually based on Microcontrollers (MCs) or Field Programmable Gate Arrays (FPGAs), and in addition to other tasks they need to perform signal processing, very often in real-time. This paper presents a methodology to perform on-line QRS detector on MC's and FPGA's platforms. After the theoretical considerations on wavelets and their optimization in term of integer arithmetic, the computation architectures for both technologies are described. At the end, the presentation of obtained results during intensive tests on real signals is given. Similar approach can be applied to other signals, where the embedded implementation of wavelets can be of a benefit.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"70 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132873649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An adaptive multiscale AM-FM texture analysis system with application to hysteroscopy imaging 自适应多尺度AM-FM纹理分析系统及其在宫腔镜成像中的应用

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399760

I. Constantinou, M. Pattichis, V. Tanos, M. Neofytou, C. Pattichis

引用次数: 4

Mathematical modeling of the interactions between cellular programs in response to oncogene inactivation: Incorporation of both cell intrinsic and cell extrinsic (Immune mediated) effects 响应癌基因失活的细胞程序之间相互作用的数学建模:细胞内在和细胞外在(免疫介导)效应的结合

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399720

Chinyere Nwabugwu, K. Rakhra, D. Felsher, D. Paik

{"title":"Mathematical modeling of the interactions between cellular programs in response to oncogene inactivation: Incorporation of both cell intrinsic and cell extrinsic (Immune mediated) effects","authors":"Chinyere Nwabugwu, K. Rakhra, D. Felsher, D. Paik","doi":"10.1109/BIBE.2012.6399720","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399720","url":null,"abstract":"Some tumors' addiction to the over-expression of a single oncogene provides a weakness for a molecularly targeted therapy to exploit. A number of targeted therapy drugs (e.g., imatinib, erlotinib, etc.) produce dramatic tumor regression but are often eventually followed by tumor relapse. Understanding the complex interaction of mechanisms behind the tumor's overall response to oncogene inactivation is key to preventing tumor relapse. It is becoming clear that there is a general sequence of cellular responses and that the latter immune-mediated steps are key to eliminating residual disease. What is still unclear is exactly how these mechanisms work together to produce the overall tumor regression response. We have built a novel integrative computational model that includes the various cellular response mechanisms of tumors to oncogene inactivation. This consists of cell intrinsic programs (e.g., apoptosis, proliferation, differentiation, dormancy) and immune-mediated cell extrinsic programs (e.g., senescence, inhibition of angiogenesis). Our model unifies these different response programs in order to allow for predictions of the time-course of events following oncogene inactivation and their impact on tumor burden. Eventually, we will use this model to make and validate predictions of the effect of various therapeutic strategies and interventions (e.g., adjunct chemotherapy, immune system modulation). These predictions will be validated in vivo using conditional expression transgenic mouse models of MYC-induced lymphoma, osteosarcoma, and hepatocellular carcinoma.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129104367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Automatic localization of the optic disc in retinal fundus images using multiple features 基于多特征的眼底图像视盘自动定位

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399726

T. Qureshi, Hassan Amin, M. Hussain, R. Qureshi, B. Al-Diri

{"title":"Automatic localization of the optic disc in retinal fundus images using multiple features","authors":"T. Qureshi, Hassan Amin, M. Hussain, R. Qureshi, B. Al-Diri","doi":"10.1109/BIBE.2012.6399726","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399726","url":null,"abstract":"Accurate optic disc localization is an essential step for a reliable retinal screening system. Existing methods for the optic disc localization may fail when encountering distractors such as imprecise boundaries, deceptive edge features and inconsistent contrast in retinal images. This paper presents an algorithm (Multi-Scheme method) for localization of the optic disc. The algorithm involves prior domain knowledge such as the optic disc size, cup-to-disc ratio (CDR) and vessel convergence feature to evaluate the confidence level for the candidate region(s) at each thresholding level. Based on the confidence level, the algorithm heuristically decides whether or not to opt for multi-scheme policy for a given image. For optimization, the Computed Response (CR) from variant versions of the same image is calculated in parallel and fits a contour to the optic disc through an iterative process of updating the location of the centre of the contour. The proposed approach has been validated using dataset ONHSD [3] and diaretdb0 [16]; and the results show the robustness and reliability of the proposed method even in the presence of distractors.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"108 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127948090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 13

Experiences in designing a distributed service-oriented platform for in-silico biomarker discovery and validation 具有设计面向服务的分布式芯片生物标志物发现和验证平台的经验

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399710

I. Muntean, Bogdan Rotaru, Ramona Suharoschi, C. Iuga

引用次数: 0

Security issues in research projects with patient's medical data 使用患者医疗数据的研究项目中的安全问题

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399771

N. Forgó, M. Góralczyk, C. Rex

引用次数: 3

Design rules for cancer nanomedicines 癌症纳米药物的设计规则

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399769

T. Stylianopoulos, Konstantinos Soteriou, D. Fukumura, R. Jain

引用次数: 2

A Gaussian Mixture Model to detect suction events in rotary blood pumps 用于检测旋转血泵吸入事件的高斯混合模型

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399661

A. Tzallas, G. Rigas, E. Karvounis, M. Tsipouras, Y. Goletsis, K. Zieliński, L. Fresiello, D. Fotiadis, M. Trivella

引用次数: 9

Lung capacity estimation through acoustic signal of breath 利用呼吸声信号估计肺活量

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399655

Ahmad Abushakra, M. Faezipour

{"title":"Lung capacity estimation through acoustic signal of breath","authors":"Ahmad Abushakra, M. Faezipour","doi":"10.1109/BIBE.2012.6399655","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399655","url":null,"abstract":"Breathing disorders are generally associated with the lung cancer disease. Through daily treatment, lung cancer patients often use a traditional spirometer to measure their lung capacity. However, the use of a spirometer device for accurate measurement requires some sort of training and adjustment, which may be inconvenient for certain groups of patients, especially the elderly. In addition, the spirometer readings can become unreliable if the measurements are not taken as instructed. On the other hand, a microphone, say the microphone on a hand-held device such as a smart-phone, can easily capture the acoustic signal of breath without certain instructions. This signal can then be processed to estimate the lung capacity. In this paper, we propose a methodology through the simply recorded acoustic signal of breath, splitting the breathing cycle to inhale, pause, exhale and pause phases to measure the depth of the breath along with the time duration and signal energy of the breathing phases. We show how these computed parameters are used to estimate the lung size with a high degree of accuracy. This work is part of a virtual reality platform embedded within a smart-phone to assist lung cancer patients regulate their breath. Furthermore, the lung capacity estimation methodology proposed in this paper can also be used to aid patients with other breathing disorders.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"36 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115455509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 18

Development of a reflectance photoplethysmographic sensor used for the assessment of perfusion of free jejunum flaps: A case report 用于评估游离空肠瓣灌注的反射式光容积脉搏波传感器的研制:1例报告

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399642

T. Zaman, P. Kyriacou, A. Belhaj, R. Langford, H. D. L. Patel

引用次数: 1