2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)最新文献_第7页

A method for assessing the reliability of heart rates obtained from ambulatory ECG 一种评估动态心电图心率可靠性的方法

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399672

Christina Orphanidou, T. Bonnici, D. Vallance, Alexander Darrell, P. Charlton, L. Tarassenko

引用次数: 5

What are the symbols of Alzheimer? A permutation entropy based symbolic analysis for the detection of early changes of the electroencephalographic complexity due to mild Alzheimer 阿尔茨海默病的标志是什么?基于排列熵的符号分析检测轻度阿尔茨海默症早期脑电图复杂性变化

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399689

C. Frantzidis, A. Ladas, Maria D. Diamantoudi, A. Semertzidou, E. Grigoriadou, A. Tsolaki, Despoina Liapi, Anatoli Papadopoulou, F. Kounti, A. Vivas, M. Tsolaki, C. Pappas, P. Bamidis

{"title":"What are the symbols of Alzheimer? A permutation entropy based symbolic analysis for the detection of early changes of the electroencephalographic complexity due to mild Alzheimer","authors":"C. Frantzidis, A. Ladas, Maria D. Diamantoudi, A. Semertzidou, E. Grigoriadou, A. Tsolaki, Despoina Liapi, Anatoli Papadopoulou, F. Kounti, A. Vivas, M. Tsolaki, C. Pappas, P. Bamidis","doi":"10.1109/BIBE.2012.6399689","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399689","url":null,"abstract":"Alzheimer's disease (AD) is the most common type of dementia, greatly affecting cognitive functioning and independent living of elderly population. The lack of an available drug therapy that could prevent disease progression shifted the research interest towards the early detection of the neurodegeneration symptoms that affect the mature brain and impair the interaction between brain regions, thus partially causing functional disconnection. The notion of electroencephalographic complexity is a valid and reliable method of quantifying the degree of isolation of brain regions due to AD pathology. Recently permutation entropy, which is a methodology of transforming the signal data into symbolic sequences and then computing the frequency distribution of symbolic patterns, gained great attention and was applied in seizure detection and computation of consciousness. The current study aims to investigate whether this complexity marker would be suitable to be applied in dementia research towards the quantification of the degree of cognitive deterioration due to disconnection of brain regions. The promising results indicate that permutation entropy on posterior regions (parieto-occipital areas) abnormally increases during mild dementia and is negatively correlated with the level of cognitive dysfunction, as estimated by the Mini Mental State Examination. Therefore, it may be a fast, accurate and simple tool for screening elderly population prone in Alzheimer.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128758204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Model-based control of tumor progression 基于模型的肿瘤进展控制

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399772

M. Hadjiandreou, G. Mitsis

引用次数: 1

Relating postural synergies to low-D muscular activations: Towards bio-inspired control of robotic hands 将姿势协同作用与低d肌肉激活联系起来:迈向机器人手部的仿生控制

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399682

P. Katsiaris, P. Artemiadis, K. Kyriakopoulos

引用次数: 3

Investigation of network brain dynamics from EEG measurements in patients with epilepsy using graph-theoretic approaches 用图论方法研究癫痫患者脑电图测量的网络脑动力学

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399693

Manolis Christodoulakis, M. Anastasiadou, S. Papacostas, E. Papathanasiou, G. Mitsis

{"title":"Investigation of network brain dynamics from EEG measurements in patients with epilepsy using graph-theoretic approaches","authors":"Manolis Christodoulakis, M. Anastasiadou, S. Papacostas, E. Papathanasiou, G. Mitsis","doi":"10.1109/BIBE.2012.6399693","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399693","url":null,"abstract":"`Small-world' neuronal networks are characterized by strong clustering in combination with short path length, and assist the progress of synchronization and conceivably seizure procreation. In this article we aim to investigate if the brain networks display `small-world' features during seizures, by using graph-theoretic measures as well as scalp EEG recordings from patients with focal and generalized epilepsy. Specifically, we used linear cross-correlation to characterize patterns between nodes in scalp EEG recordings of 5 patients for 3 periods of interest: before, during and after seizure onset. For each period we reconstruct graphs from the linear cross-correlation calculations and use different network measures to characterize the graphs such as clustering coefficient, characteristic path length, betweenness centrality and network small-world-ness. In three (out of five) patients, our results suggest that shortly after seizure onset and in the early postictal period the brain network changes towards a more small-world structure, in agreement with earlier graph-theoretic based results related to epilepsy. However, for one patient the opposite was observed: small-worldness decreased after seizure onset. Finally, for one patient we could observe no differences in the network properties before and after the onset. These preliminary results suggest the potential use of graph-theoretic measures to quantify brain dynamics before and during seizures after further refinements.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121682305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies 基于相关医学本体识别临床试验资格标准的语义

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399762

A. Bucur, J. V. Leeuwen, D. Pérez-Rey, R. Alonso-Calvo, B. Claerhout, Kristof de Schepper

{"title":"Identifying the semantics of eligibility criteria of clinical trials based on relevant medical ontologies","authors":"A. Bucur, J. V. Leeuwen, D. Pérez-Rey, R. Alonso-Calvo, B. Claerhout, Kristof de Schepper","doi":"10.1109/BIBE.2012.6399762","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399762","url":null,"abstract":"An important objective of the INTEGRATE project1 is to build tools that support the efficient execution of post-genomic multi-centric clinical trials in breast cancer, which includes the automatic assessment of the eligibility of patients for available trials. The population suited to be enrolled in a trial is described by a set of free-text eligibility criteria that are both syntactically and semantically complex. At the same time, the assessment of the eligibility of a patient for a trial requires the (machine-processable) understanding of the semantics of the eligibility criteria in order to further evaluate if the patient data available for example in the hospital EHR satisfies these criteria. This paper presents an analysis of the semantics of the clinical trial eligibility criteria based on relevant medical ontologies in the clinical research domain: SNOMED-CT, LOINC, MedDRA. We detect subsets of these widely-adopted ontologies that characterize the semantics of the eligibility criteria of trials in various clinical domains and compare these sets. Next, we evaluate the occurrence frequency of the concepts in the concrete case of breast cancer (which is our first application domain) in order to provide meaningful priorities for the task of binding/mapping these ontology concepts to the actual patient data. We further assess the effort required to extend our approach to new domains in terms of additional semantic mappings that need to be developed.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126292518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

A technical infrastructure to support personalized medicine 支持个性化医疗的技术基础设施

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399763

M. Tsiknakis, S. Sfakianakis, K. Marias, N. Graf

引用次数: 0

IcyHeart: Highly integrated ultra-low-power SoC solution for unobtrusive and energy efficient wireless cardiac monitoring: Research project for the benefit of specific groups (FP7, Capacities) IcyHeart:高度集成的超低功耗SoC解决方案，用于不引人注目和节能的无线心脏监测:为特定群体造福的研究项目(FP7，容量)

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399716

M. Milis, K. Michaelides, A. Kounoudes, G. Ansaloni, David Atienza Alonso, Frédéric Giroud, Pierre-François Ruedi, F. Masson

{"title":"IcyHeart: Highly integrated ultra-low-power SoC solution for unobtrusive and energy efficient wireless cardiac monitoring: Research project for the benefit of specific groups (FP7, Capacities)","authors":"M. Milis, K. Michaelides, A. Kounoudes, G. Ansaloni, David Atienza Alonso, Frédéric Giroud, Pierre-François Ruedi, F. Masson","doi":"10.1109/BIBE.2012.6399716","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399716","url":null,"abstract":"The objective of the IcyHeart project is to investigate and demonstrate a highly integrated and power-efficient microelectronic solution for remote monitoring of a subject's electrocardiogram (ECG) signals. A complete System-on-a-Chip (SoC) is being developed that embarks on a single chip an ultra-low-power signal acquisition front-end with analogue-to-digital converter (ADC) for ECG, a low-power digital signal processor (DSP) and a low-energy radio frequency (RF) transceiver. These features, for the first time, coexist on a single die. Energy efficient signal processing algorithms targeting ECG, and expandable to other bio-signals, are embedded and run on the on-chip DSP. The final IcyHeart product will consist of a tiny PCB embarking IcyHeart SoC and all the necessary discrete components and powering circuit. The outcome of the project is expected to generate high market value for the European SMEs developing novel cardio-monitoring products in home and professional environments, and to create high societal impact for several categories of European citizens requiring miniature, comfortable and easy-to-use wireless tele-healthcare solutions.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128389160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8

Clustering subjects in genetic studies with Self Organizing Maps 自组织图谱在遗传研究中的聚类主题

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399731

Aristos Aristodimou, A. Antoniades, C. Pattichis

引用次数: 2

GIDT — A tool for the identification and visualization of genomic islands in prokaryotic organisms GIDT -原核生物基因组岛的识别和可视化工具

2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399707

Haswanee D. Goodur, Vyasanand Ramtohul, S. Baichoo

引用次数: 1