2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)最新文献

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Despeckle filtering in ultrasound video of the common carotid artery 颈总动脉超声影像的去斑滤波
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399756
C. Loizou, T. Kasparis, P. Christodoulides, Charoula Theofanous, M. Pantziaris, E. Kyriacou, C. Pattichis
{"title":"Despeckle filtering in ultrasound video of the common carotid artery","authors":"C. Loizou, T. Kasparis, P. Christodoulides, Charoula Theofanous, M. Pantziaris, E. Kyriacou, C. Pattichis","doi":"10.1109/BIBE.2012.6399756","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399756","url":null,"abstract":"Noise reduction is essential for increasing the visual quality or as a preprocessing step for further automated analysis in video sequences and video coding. The objective of this work was to investigate four different video despeckle filtering techniques and evaluate them using visual assessment by two medical experts, texture features analysis, and video quality evaluation metrics. The four proposed video despeckle filtering techniques were evaluated on 10 ultrasound videos of the common carotid artery (CCA). The filters were applied on the whole video frame and in a selected by the user region of interest (ROI) which included the atherosclerotic carotid plaque. The despeckle filters were based on linear filtering (DsFlsmv), hybrid median filtering (DsFhmedian), nonlinear filtering (DsFkuwahara) and speckle reducing anisotropic diffusion (DsFsrad) filtering. Our results showed that, the best video despeckle filtering methods were the linear filter DsFlsmv, followed by the hybrid median filter DsFhmedian. Both filters improved the visual perception evaluation by experts and gave better texture and video quality metrics. Further work on a larger number of videos and by employing additional despeckle filtering techniques is required for the evaluation of video despeckle filtering methods on ultrasound videos of the CCA.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115953406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Linked2Safety: A secure linked data medical information space for semantically-interconnecting EHRs advancing patients' safety in medical research Linked2Safety:一个安全的关联数据医疗信息空间,用于语义互连的电子病历,提高患者在医学研究中的安全性
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399767
A. Antoniades, Christos Georgousopoulos, N. Forgó, Aristos Aristodimou, F. Tozzi, Panagiotis Hasapis, K. Perakis, A. Bouras, D. Alexandrou, Eleni Kamateri, Eleni Panopoulou, K. Tarabanis, C. Pattichis
{"title":"Linked2Safety: A secure linked data medical information space for semantically-interconnecting EHRs advancing patients' safety in medical research","authors":"A. Antoniades, Christos Georgousopoulos, N. Forgó, Aristos Aristodimou, F. Tozzi, Panagiotis Hasapis, K. Perakis, A. Bouras, D. Alexandrou, Eleni Kamateri, Eleni Panopoulou, K. Tarabanis, C. Pattichis","doi":"10.1109/BIBE.2012.6399767","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399767","url":null,"abstract":"Electronic Health Records (EHRs) contain an increasing wealth of medical information. They have the potential to help significantly in advancing medical research, as well as improve health policies, providing society with additional benefits. However, the European healthcare information space is fragmented due to the lack of legal and technical standards, cost effective platforms, and sustainable business models. The vision of Linked2Safety is to advance clinical practice and accelerate medical research, by providing pharmaceutical companies, healthcare professionals and patients with an innovative secure semantic interoperability framework facilitating the efficient and homogenized access to anonymised distributed EHRs in an aggregate form that enables merging multiple data sources into a single analyses. In this paper a first public introduction to the project is provided along with a clear definition of the problems, and proposed architecture. Three usage scenarios are used to demonstrate the potential impact of the outcomes of the project.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"113 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128385775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Combining reflector focused and phased array beamforming for microwave diagnosis and therapy 反射聚焦与相控阵波束形成相结合的微波诊断与治疗
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399678
K. Karathanasis, I. Karanasiou
{"title":"Combining reflector focused and phased array beamforming for microwave diagnosis and therapy","authors":"K. Karathanasis, I. Karanasiou","doi":"10.1109/BIBE.2012.6399678","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399678","url":null,"abstract":"In this paper we continue our recently reported work on the exploitation of the focusing properties of a conductive ellipsoidal reflector in conjunction with directive phased antenna configurations in order to achieve diagnosis and therapy at the microwave frequency regime. Both aforementioned modules are parts of a hybrid microwave radiometry and hyperthermia system comprising a symmetrical axis ellipsoidal conductive wall cavity which ensures the necessary beamforming and focusing on the body/brain areas of interest. The proposed system operates in an entirely non-invasive contactless manner providing temperature and/or conductivity variations monitoring while it is also designed to provide hyperthermia treatment. Recently, the effect of the use of patch antennas as receiving or emitting elements on the system's focusing properties and specifically the use of two-element phased array setups to achieve scanning of the areas under measurement was investigated. In the present paper, four element antenna setups are used and extensive simulations to compute the electric field distributions inside the whole ellipsoidal reflector and inside two types of human head models were carried out. The results show that clear focusing (creation of “hot spots”) inside the head models is achieved at 1GHz. In the case of the four element antennas, the “hot spot” performs a linear scan around the brain area of interest while the phase values of the four antenna elements significantly affect the way the scanning inside the head model is achieved. The proposed setups enhance and increase the dimensions and scanning of the focusing area toward the acquisition of tomography images without the need of subject movement.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116930841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
A distributed software package for global sensitivity analysis of biological models 用于生物模型全局敏感性分析的分布式软件包
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399724
Q. Thai, S. Yu, Yongseong Cho
{"title":"A distributed software package for global sensitivity analysis of biological models","authors":"Q. Thai, S. Yu, Yongseong Cho","doi":"10.1109/BIBE.2012.6399724","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399724","url":null,"abstract":"Mathematical modeling is a vital tool for studying biological systems. Due to the system complexity and technical challenges in molecular level measurement, it is commonly the case that a large number of model parameters have uncertain values. Analyzing model dynamics from a single estimated parameter set is insufficient and liable for misleading results. Global sensitivity analysis (GSA) has been recommended as a must-have step in the process of developing reliable models. However, the technique comes at high computation costs as it is based on Monte Carlo simulation which requires a large number of model evaluations and manipulating on massive data for sensitivity estimation. In this work, we develop a software package for global sensitivity estimation of biological models. The software is deployed on KISTI high performance computing (HPC) cluster environment to provide web-service to system biology modelers.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"11 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114410335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Combining unobtrusive electrocardiography and ballistography for more accurate monitoring of sleep 结合不显眼的心电图和弹道图,更准确地监测睡眠
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399674
A. Vehkaoja, M. Peltokangas, J. Verho, J. Lekkala
{"title":"Combining unobtrusive electrocardiography and ballistography for more accurate monitoring of sleep","authors":"A. Vehkaoja, M. Peltokangas, J. Verho, J. Lekkala","doi":"10.1109/BIBE.2012.6399674","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399674","url":null,"abstract":"We propose an unobtrusive bed integrated system for monitoring physiological parameters during sleep. Our system uses textile electrodes attached on the bed sheet for measuring multiple channels of electrocardiogram from which one at a time is selected for RR-interval detection and force sensors located under a bed post for detecting breathing and movements. The movement information is also used to assist in heart rate detection. We tested the system with six subjects in one hour recordings and achieved an average of 94 % detection coverage and 99 percentile absolute error of 2.86 ms for the RR-interval signal. Mean absolute error of the detected respiration cycle lengths was 0.24 seconds.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121653173","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Enabling data protection through PKI encryption in IoT m-Health devices 在物联网移动健康设备中通过PKI加密实现数据保护
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399701
C. Doukas, Ilias Maglogiannis, Vassiliki Koufi, F. Malamateniou, G. Vassilacopoulos
{"title":"Enabling data protection through PKI encryption in IoT m-Health devices","authors":"C. Doukas, Ilias Maglogiannis, Vassiliki Koufi, F. Malamateniou, G. Vassilacopoulos","doi":"10.1109/BIBE.2012.6399701","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399701","url":null,"abstract":"Ambient Assisted Living (AAL) aims at providing unobtrusive support to frail and elderly people for their daily life based on their context and situation. To this end, systems and services are required which are user-centric and adaptable towards the needs and capabilities of the people in need of care. The continuous integration of leading-edge technologies, such as cloud and wireless communication technologies, in the context of the Internet of the Things (IoT), can meet this requirement by enabling a new form of communication between frail and elderly people, their environment and relevant groups of care givers. However, for IoT-based systems to reach their full potential, sound answers need to be provided to the important security questions arisen, particularly those regarding authentication of entities (people and environmental objects) and data privacy. This paper presents a system based on Gateways (GW) that aggregate health sensor data and resolve security issues through digital certificates and PKI data encryption.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"14 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134148930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 98
Image guided mechanically scanned and co-registered localized optical and MR spectroscopies 图像引导机械扫描和共同注册的局部光学和磁共振光谱
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399738
A. E. Sonmez, A. Webb, N. Tsekos
{"title":"Image guided mechanically scanned and co-registered localized optical and MR spectroscopies","authors":"A. E. Sonmez, A. Webb, N. Tsekos","doi":"10.1109/BIBE.2012.6399738","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399738","url":null,"abstract":"Interrogation of tissue with combined molecular methods, such as light-induced fluorescence (LIF) and MR spectroscopy (MRS), may lead to new paradigms in assessing tissue malignancy in situ. The limited tissue penetration (LIF) or low sensitivity (MRS) of those modalities is usually addressed by local placement of the sensor via trans-needle or trans-catheter access. This work introduces a system and methodological approaches for mechanically scanning an area of interest with an MR-compatible manipulator that carries two sensors: an optical fiber for LIF and a miniature RF coil for MRS. Experimental studies on multi-compartment phantoms demonstrated dual-modality scanning and the generation of one-dimensional MRS/LIF scans inherently registered to MRI that was used to guide the scanning.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"75 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127364105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biodegradable encapsulation for inductively measured resonance circuit 用于电感测量谐振电路的可生物降解封装
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399644
T. Salpavaara, J. Lekkala, Saiful Khan, V. Ellä, M. Kellomäki
{"title":"Biodegradable encapsulation for inductively measured resonance circuit","authors":"T. Salpavaara, J. Lekkala, Saiful Khan, V. Ellä, M. Kellomäki","doi":"10.1109/BIBE.2012.6399644","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399644","url":null,"abstract":"The feasibility of biodegradable encapsulation for LC resonance circuits is studied. The used biodegradable polymers are polycaprolactone (PCL) and poly-L-lactide/caprolactone (PLCL). The encapsulated circuits are immersed in a phosphate buffer solution and the phase and magnitude responses are measured by using an inductive link during an 80-day test period. The features derived from the resonance curves are extracted and studied. The features change fast when the encapsulation absorbs water during the first days of immersion. After the initial water intake, there is a drift in the extracted estimates for the resonance frequency. The drift of the frequency of the resonance circuit in PLCL is faster compared with the drift of a circuit in PCL. The resonance curve of the PLCL specimen also diminished to undetectable after 72 days of immersion. The resonance curves of the sample in PCL were easily detectable throughout the test period. The achieved results promote further studies based on this concept in order to monitor biodegradable polymers and their properties.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"135 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131431374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 8
An innovative mathematical analysis of routine MRI scans in patients with glioblastoma using DoctorEye 使用DoctorEye对胶质母细胞瘤患者的常规MRI扫描进行创新的数学分析
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399773
Jonathan Zepp, N. Graf, H. Stenzhorn, W. Reith, Ioannis Karatzanis, Georgios C. Manikis, V. Sakkalis, K. Marias, G. Stamatakos
{"title":"An innovative mathematical analysis of routine MRI scans in patients with glioblastoma using DoctorEye","authors":"Jonathan Zepp, N. Graf, H. Stenzhorn, W. Reith, Ioannis Karatzanis, Georgios C. Manikis, V. Sakkalis, K. Marias, G. Stamatakos","doi":"10.1109/BIBE.2012.6399773","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399773","url":null,"abstract":"Improving the initial diagnosis and the assessment of response to treatment in malignant gliomas, while avoiding invasive methods as much as justifiable, is one major aspect actual research is focusing on. Imaging studies are used to calculate tumor volume and define vital, necrotic and cystic areas within a tumor. Though the visual interpretation of magnetic resonance (MR) images is based on qualitative observation of variation in signal intensity, a correlation of signal intensities with histological features of a tumor is not possible. Better methods are needed for a reliable interpretation of follow-up studies in single patients. Histograms of signal intensities might serve as a method adding quantitative data to the description of a tumor. Using DoctorEye software, tumors can be easily rendered and histograms of the signal intensities within a tumor as well as mean and median signal intensities are possible to calculate. Our results in glioblastoma suggest that these histograms are an innovative method of gaining new tumor-specific information without performing additional investigations in a patient. It can be an additional diagnostic tool in differentiating various intracranial lesions from each other, as well as in assessing response to treatment or progression of malignant glioma.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"161 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122046701","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Genome-wide search for coaxial helical stacking motifs 全基因组搜索同轴螺旋堆叠基序
2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE) Pub Date : 2012-11-11 DOI: 10.1109/BIBE.2012.6399685
K. Byron, J. Wang, Dongrong Wen
{"title":"Genome-wide search for coaxial helical stacking motifs","authors":"K. Byron, J. Wang, Dongrong Wen","doi":"10.1109/BIBE.2012.6399685","DOIUrl":"https://doi.org/10.1109/BIBE.2012.6399685","url":null,"abstract":"Motif finding in DNA, RNA and proteins plays an important role in life science research. In this paper, we present a computational approach to searching for RNA tertiary motifs in genomic sequences. Specifically, we describe a method, named CSminer, and show, as a case study, the application of CSminer to genome-wide search for coaxial helical stackings in RNA 3-way junctions. A coaxial helical stacking motif occurs in an RNA 3-way junction where two separate helical elements form a pseudocontiguous helix and provide thermodynamic stability to the RNA molecule as a whole. Experimental results demonstrate the effectiveness of our approach.","PeriodicalId":330164,"journal":{"name":"2012 IEEE 12th International Conference on Bioinformatics & Bioengineering (BIBE)","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124277510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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