Farmatsevtichnii zhurnal最新文献

{"title":"Analysis of the range of rectal drugs used for the treatment of proctologic diseases in Ukraine","authors":"О. М. Глущенко","doi":"10.32352/0367-3057.1.23.02","DOIUrl":"https://doi.org/10.32352/0367-3057.1.23.02","url":null,"abstract":"Proctological diseases (acute and chronic hemorrhoids, anal fissure, proctitis) have frequent relapses, are characterized by a severe course and are common among broad strata of the working-age population. The leading clinical sign of this group of diseases is lesions of the mucous membrane of the rectum of varying degrees of severity which is accompanied by signs of inflammation, pain syndrome, deterioration of local circulation, involvement of secondary infection. It determines the use of complex products that combine anti-inflammatory, analgesic effects and promote the reparative processes of the mucous membrane. On the Ukrainian pharmaceutical market the number of such products is limited, most of them are foreign-made. \u0000The purpose of the work is to study the assortment of medicines for rectal use on the pharmaceutical market of Ukraine, to determine the feasibility and prospects of developing new combined soft medicines of domestic production. Methods of marketing, statistical and graphic analysis were used in the work from official sources of information: (The State Register of Medicinal Products of Ukraine and the ATC classification system). \u0000While researching the assortment of medicines for rectal use it was established that there are 34 names of medicines for rectal use in various forms of release on the domestic market, of which suppositories ‒ 55.9%, ointments ‒ 35.3%, creams ‒ 8.8%; the share of foreign-made medicines is 61.7% and domestic ‒ 38.3%. Complex synthetic medicines occupy 49.9% of the assortment and complex medicines of natural origin ‒ only 2.95%. \u0000In the production of soft medicines for rectal use, hydrophobic (40%), emulsion (40%) and diphilic bases (20%) are more often used. Solid fat (78.9%) is more often used in the production of suppositories. \u0000Considering the limited range of medicines for rectal use based on medicinal plant raw materials, it is advisable to develop new combined soft medicinal products which will include biologically active substances of plant origin.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47505089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of volatile compounds of Сalendula officinalis L. flowers by the method of gas chromatography with MAS detection","authors":"А. В. Гудзенко, О. П. Колядич, Т. М. Курапова, П. І. Середа, І. О. Гуртовенко, Т. К. Шураєва, Л. А. Бутко","doi":"10.32352/0367-3057.1.23.08","DOIUrl":"https://doi.org/10.32352/0367-3057.1.23.08","url":null,"abstract":"A promising direction for improving the procedure of standardization of multicomponent phytoremedies is the use of so-called marker compounds, or markers – substances whose presence is characteristic only for individual medicinal raw materials. The introduction of methods of qualitative and quantitative analysis based on the use of markers is not only of great practical importance, but also of significant scientific expediency. \u0000One of the most common components used to make complex herbal collections are the flowers of medicinal plants, which are successfully used in medical practice both in the form of mono preparations and in the form of components of over-the-counter medicinal product of herbal origin. \u0000The pharmacological activity of the flowers of marigolds is due to the presence in their composition of a complex of biologically active substances, in particular essential oils, the content of which is associated with such pharmacological properties of the plant as bactericidal, antioxidant, etc. That is why it was considered expedient to search on markers for plant standardization in mixtures among essential oil components. \u0000The aim of the work was to study the components of the essential oil of calendula flowers (Calendula officinalis L.) by the method of gas chromatography with mass detection \u0000The object of the study was marigold flowers in packs of 50 g (CJSC «Liktravy», series 80310). \u0000The study of volatile components was carried out using the method of gas chromatography with mass detection. Chromatographic study of the studied extracts was carried out on an Agilent 6890 gas chromatograph equipped with a mass spectrometric detector (model 5973). The identification of the studied components was carried out by mass spectra and the retention time of the components. \u0000As a result of the conducted research, using library spectra, 59 volatile components were identified in the extract of the flowers of Calendula officinalis L., 50 were recognized: monocyclic and bicyclic monoterpenoids, sesquiterpenoids, sesquiterpene alcohols, etc. \u0000The major volatile components of flowers of Calendula officinalis L. are the following substances: α-cadinol, δ-cadinene, α-muurolol and epi-α-cadinol, the content of which is equal to 417.2 mg/kg, 284.2 mg/kg, 92.4 mg/kg and 75.7 mg/kg of raw material, respectively. \u0000 The total content of all four major volatile compounds of the flowers of Calendula officinalis L. is 44.14% of the total amount of volatile compounds found in the object of research.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46295189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Attributes of pharmacy's educational activities according to good pharmacy practice standards from the perspective of patients with diabetes","authors":"І. О. Власенко, Л. Л. Давтян","doi":"10.32352/0367-3057.1.23.04","DOIUrl":"https://doi.org/10.32352/0367-3057.1.23.04","url":null,"abstract":"According to the Good Pharmaceutical Practice (GPP) Standards of Quality of Pharmacy Services, pharmacists should participate in preventive measures to improve the health of the population and prevent disease. The problem of diabetes is becoming increasingly relevant due to its prevalence and a significant number of undiagnosed cases. Patients with diabetes are frequent visitors to pharmacies and have specific needs for treatment. \u0000The purpose of the study was to determine the attributes of pharmaceutical educational activities in pharmacies according to the standards of GPP from the perspective of patients with diabetes, as well as to compare the obtained results with similar ones in other countries. \u0000The objects of the study were information sources regarding the involvement of pharmacists in the strategy of preventing diabetes in other countries, using literature review and analytical methods. To study the perspective of patients with diabetes, a semi-structured in-depth interview of patients with diabetes who use insulin therapy was applied. \u0000Based on research using the semi-structured in-depth interview method, attributes of educational activities were identified in providing pharmaceutical care to patients with diabetes according to GPP standards: identifying individuals with risk factor of diabetes  and people with undiagnosed diabetes; group training of diabetes patients in self-management control; and recommendations flu vaccination in the pre-epidemic period. The availability of diabetes risk factor detection and blood glucose testing in pharmacies contributes to early diagnosis and motivates patients to change their lifestyles. Training people with diabetes by qualified specialists are important for diabetes patients. The organasing of the «diabetes self management school» in pharmacies will increase the accessibility of training for diabetes patients and at the same time enhance the role of pharmacists in clinical practice and the social image of the pharmacy. To promote flu vaccination among patients with diabetes, pharmacists should be actively involved in providing information and promoting vaccination. \u0000The identified attributes of educational activities in providing pharmaceutical care according to GPP standards have already been implemented in many countries of the world and have demonstrated their high efficiency for the health care system.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49529970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"International experience of using report forms for hospital-based health technology asssessment","authors":"О. М. Філінюк, М. М. Бабенко","doi":"10.32352/0367-3057.1.23.03","DOIUrl":"https://doi.org/10.32352/0367-3057.1.23.03","url":null,"abstract":"Hospital-based health technology assessment (HB-HTA) is one of the components of public management and support hospital managers to science-based decision-making regarding the implementation of new and innovative health technologies (HT). HB-HTA includes the processes and methods used to make HTA reports in and for hospitals. Ukraine has already started implementing hospital-based HTA, but a number of steps are still needed to fully implement HTA at the hospitals. One of them is the choice of HB-HTA report form, which will be appropriate to use in the practical activities of hospitals in Ukraine. \u0000The purpose of the study is to analyse the international experience of using different HB-HTA report form with the aim of selecting the optimal HB-HTA report form for hospitals in Ukraine. There were analysed different forms of HTA reports in Ukraine regulatory framework, international scientific literature, the AdHopHTA handbook, which included the following countries: Norway, Finland, Turkey, Spain, Austria, Italy, Estonia, Denmark, Switzerland, in international HTA database INAHTA, Canadian and Kazakhstan report databases. The methods of content analysis, systematization and generalization were used. \u0000Making managerial decisions about investment or disinvestment in health technology requires information that meets the hospital stakeholders needs. Such scientifically based information is provided by HB-HTA report form. \u0000There are a wide range of HB-HTA reports forms in terms of content, subject matter, structure and resources (time and staff). Each is based on the EUnetHTA HTA core model. For introducing a hospital-based HTA, the countries of the world most often choose the mini-HTA form. Mini-HTA supports hospital managers to make science-based strategic decisions of the introduction of new treatment methods, new indications for the use of existing technology, medical equipment, medical devices, or stopping the usage of health technology. The choice between performing a mini-HTA or a more comprehensive hospital-based HTA often requires a balance between the quality and thoroughness and the necessary speed of assessment in a specific situation. \u0000From the authors' point of view, the most applicable to Ukrainian context is the mini-HTA form. Adapting mini-HTA and approving it as a recommended report form at the state level will provide an opportunity to more widely HTA usage by hospitals in Ukraine.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49161927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of the cost-effectiveness of early diagnosis and pharmacotherapy of pulmonary arterial hypertension","authors":"І. С. Даценко","doi":"10.32352/0367-3057.1.23.05","DOIUrl":"https://doi.org/10.32352/0367-3057.1.23.05","url":null,"abstract":"Over the past decades, health policy makers have focused on early diagnosis to introduce targeted and innovative treatments. Early diagnosis of pulmonary arterial hypertension (PAH) is associated with improved long-term survival, so screening high-risk groups is a reasonable strategy to improve outcomes in PAH treatment. \u0000Today, screening is an important part of preventive medicine, with the goal of detecting disease at an early and pre-symptomatic stage. \u0000All healthcare systems have limited resources and face opportunity costs; this means that any investment in a screening tool will come at the expense of other healthcare services, to the detriment of those patients who would otherwise be treated. \u0000By recognizing opportunity costs, health systems can require that health interventions be both clinically and cost-effective to be considered for implementation. \u0000The objective of the paper –to conduct a cost-effectiveness analysis of early diagnosis and pharmacotherapy of pulmonary arterial hypertension. \u0000Our analysis of the cost-effectiveness of early diagnosis and pharmacotherapy of pulmonary arterial hypertension is based on a cost‒utility model that estimates patient survival, which is significantly improved by reducing the delay in diagnosis of PAH and indicates the prevention of premature death of undiagnosed patients. The analysis of input data was conducted using systematic review, documentary, informational and graphical research methods. \u0000The results of the study showed that the choice of the target population and the level of diagnostic coverage of this risk group is critical for the cost-effectiveness of the implementation of PAH diagnostic screening. A decrease in these indicators leads to a decrease in the maximum allowable cost of diagnostic screening, and thus to a decrease in its profitability in real medical practice. The introduction of new treatments and the corresponding increase in the utility of PAP detection have the most positive effect on the profitability of the PAP diagnostic screening program. \u0000This cost-effectiveness analysis is the first attempt to evaluate the economic value of reducing the delay in PAH diagnosis compared to its benefits to the health care system and society as a whole.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48624193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reimbursement of combined antihypertensive medicenes in Ukraine: aspects of inclusion and external reference pricing","authors":"А. О. Гончар, Н. В. Шолойко, О. О. Комаріда","doi":"10.32352/0367-3057.6.22.06","DOIUrl":"https://doi.org/10.32352/0367-3057.6.22.06","url":null,"abstract":"Cardiovascular diseases (CVD), in particular arterial hypertension (AH), are the main causes of morbidity and mortality, Ukraine is on the 1st place in Europe for mortality from these diseases. Modern clinical guidelines emphasize the use of combined antihypertensive drugs, and improving the accessibility of these medicines for Ukrainian patients with hypertension is relevant. In Ukraine, at the end of 2022, there were no combined antihypertensive drugs in the List of reimbursed drugs. Therefore, there is a need to develop scientific and practical approaches to improve the «Affordable Medicines» reimbursement program in accordance with modern trends in the treatment of hypertension. \u0000The aim of the study is to formulate scientific and practical proposals for the inclusion of combined antihypertensive drugs in the state reimbursement program «Affordable Medicines» and to improve external reference pricing. \u0000Оbjects of the study were Orders of the Ministry of Health of Ukraine, national and international clinical guidelines, WHO ATC/DDD methodology guidelines. The study used content analysis, methods of comparative and logical analysis. \u0000At the 1st stage of the study, it was found that the current legislation of Ukraine does not prohibit the inclusion of combined antihypertensive drugs in the National List of Essential Medicines, and it is not limited solely to WHO recommendations. In the second stage of the study, it is proposed to use the data of pharmacoepidemiological studies and data of studies of actual consumption of combinated antihypertensive drugs in Ukraine, for further state HTA assessment and inclusion in the National List of Essential Medicines and «Affordable Medicines» program. The third and fourth stages of the study showed that the mechanism of external reference pricing needs to be improved and an algorithm for conducting external reference pricing for combined antihypertensive drugs, consisting of five consecutive stages, was developed and proposed. \u0000The current regulatory framework of Ukraine provides the possibility of including combined antihypertensive drugs in the state program «Affordable Medicines», and the initiation of the inclusion of medicines is within the competence of the Ministry of Health and the NHSU. A scientific and practical approach to the use of pharmaco-epidemiological research data to identify the most used doses of combined antihypertensive drugs as potential candidates for inclusion in the «Affordable Medicines» program is proposed. A scientific and practical algorithm for external reference pricing for combinated antihypertensive drugs was developed, considering current regulatory and methodological aspects.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47562746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacological activity cream of extract Salix alba and zinc for allergic contact dermatitis","authors":"Л. М. Малоштан, В. В. Підгайна","doi":"10.32352/0367-3057.6.22.08","DOIUrl":"https://doi.org/10.32352/0367-3057.6.22.08","url":null,"abstract":"Allergic dermatitis  is the most common skin disease, manifested by classic factors in response to the external environment. Solving the problem of global prevalence and intensive growth of the frequency of allergic dermatitis requires improving the medical supply of the population of Ukraine with drugs for the effective treatment of allergic skin diseases. According to the literature, preparations based on white willow bark have a wide range of biological effects, which exhibit anti-inflammatory, anti-allergic, anti-pruritic, analgesic activity and have a positive effect on the immune system and are promising for the treatment and prevention of allergic dermatitis. Zinc takes part in metabolism and stabilization of cell membranes, is part of the main enzymes that take part in antioxidant biochemical reactions. The trace element has a regenerating effect, ensures the transmission of nerve impulses, promotes the synthesis of cortisol.          \u0000The purpose of our work was to study the effect of a cream based on white willow and Zn antigen-specific link of immune protection of animals on 3 experimental allergic dermatitis.           \u0000The study was conducted on сavia porcellus. Allergic contact dermatitis was modeled using 2,4-dinitrochlorobenzene. Phagocytic activity of granulocytic neutrophils in a suspension of leukocytes is determined for assessment of the activity of factors of non-specific immunity. \u0000It is important to determine the status of antigen-specific factors of immune protection, which are directly involved in all doses of the immune response. To assess the activity of factors of nonspecific immunity, the phagocytic activity of granulocytic neutrophils was determined in the suspension of leukocytes obtained from heparinized blood. \u0000The obtained data on the increase of F1 and F4 indicators in animals against the background of experimental dermatitis indicate the presence of a natural protective defense aimed at neutralizing the allergen and its subsequent removal from the body. In comparison with reference drugs it was found distinct antigen-specific effect, which exceeds Psoricap and is equal Fladex. \u0000On the model of allergic contact dermatitis in Cavia porcellus, the researched cream showed a pronounced immunotropic activity relative to a decrease in the phagocytic activity of cell.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47223789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodological approach to the pharmaceutical development of solutions for injection in polymer packaging","authors":"В. О. Шевченко, О. С. Шпичак, С. М. Ролік-Аттіа","doi":"10.32352/0367-3057.6.22.07","DOIUrl":"https://doi.org/10.32352/0367-3057.6.22.07","url":null,"abstract":"Medicines in the form of solutions for injections are the most effective in terms of dosage accuracy and speed of pharmacological action. Pharmaceutical development of drugs is one of the key stages of their life cycle, which main task is to create a high-quality medicine during the production process. \u0000The aim of the work is to develop a methodological approach to the pharmaceutical development of parenteral drugs, namely solutions for injections in polymer packaging. \u0000The objects of the study were sources of scientific literature, regulatory documents, manuals, textbooks and reports of the pharmaceutical development of medicinal products, documents of the registration dossier, reports of regulatory authorities on the examination of medicinal products. Informational and empirical research methods are used in the work by studying, summarizing and comparing documentary data. \u0000Compositions and technologies for the production of solutions for injections of domestic manufacturing based on medicinal substances of different chemical nature and their concentrations have been developed, taking into account data from scientific sources regarding their stability in aqueous solutions and the results of research into the chemical and technological properties of substances. The popular opinion about the inertness of auxiliary substances in the composition of the dosage form has been shown is not entirely reliable; since their appropriate and rational choice has a significant impact to the quality of the final product in the manufacture of solutions for injection. Therefore, in order to ensure the stability and safety of active pharmaceutical ingredients, as well as to improve the physicochemical parameters during the production of solutions for injections, it was necessary to introduce auxiliary substances into their composition. The methodological role of the stage of choosing the primary packaging with a comprehensive research of its properties in the production of specific solutions for injections was outlined. \u0000A methodological approach to the pharmaceutical development of solutions for injections in polymer packaging has been developed. As a result of the analysis of literary sources devoted to the theory and practice of creating medicinal forms and based on general methodological approaches to the development of medicinal products, as well as on the basis of practical work experience; an improved methodological approach to the creation of high-quality, effective and safe solutions for injections has been proposed.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43939333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development conceptual of pharmacoeconomic model of technology for early diagnosis and pharmacotherapy of pulmonary arterial hypertension","authors":"І. С. Даценко","doi":"10.32352/0367-3057.6.22.04","DOIUrl":"https://doi.org/10.32352/0367-3057.6.22.04","url":null,"abstract":"Pulmonary arterial hypertension (PAH) is a rare, progressive disease with a poor prognosis in the absence of timely diagnosis and appropriate therapy. Despite significant advances in the treatment of PAH, many patients remain undiagnosed years after the onset of the disease. Evaluation of the implementation of early diagnostic technologies for PAH is increasingly being used to develop economic evidence for health care at the early stages of diagnosis. The development of models of early diagnosis technology for LAH is highly relevant and can be used in the development and management of new medical technologies, as well as to reduce the perceived risks during the implementation of screening programs for LAH diagnosis. \u0000The objective of the paper: Conceptual development of a pharmacoeconomic model of the technology of early diagnosis and pharmacotherapy of PAH. \u0000Our pharmacoeconomic analysis is based on the «cost–effectiveness» model, which reflects the effectiveness and associated costs of implementing diagnostic screening for early detection of patients with PAH. The analysis of input data of the existing health care system was conducted using systematic review, documentary, informational and graphical research methods. \u0000The presented pharmacoeconomic model describes not only the structure of the incidence of PAH in the studied risk group or at the level of the entire population, but also takes into account the pharmacoeconomic evaluation of the complex technology of timely medical care for patients with PAH based on diagnostic screening. \u0000A pharmacoeconomic model of the technology of early diagnosis and pharmacotherapy of pulmonary arterial hypertension was developed, which covered a horizon of 10 years and was conducted from the point of view of the existing health care system, showed that for patients with delayed diagnosis of PAH, the modeling determined the average life expectancy at the level of 4.13 years and 2.08 QALYs. \u0000It has been determined that a diagnostic screening strategy for PAH would be cost–effective compared to no screening at different thresholds of diagnostic cost. However, other factors such as public awareness and acceptance of the screening programme and availability of human resources should be considered.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48883203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research оn healthcare oxygen measures during the COVID-19 pandemic: latest trends and current priorities","authors":"О. П. Баула, О. О. Салій, А. Г. Галстян, Т. В. Пазерська","doi":"10.32352/0367-3057.6.22.02","DOIUrl":"https://doi.org/10.32352/0367-3057.6.22.02","url":null,"abstract":"Medical oxygen is a critically needed medicine in the treatment of coronavirus disease. During out breaks of the COVID-19 pandemic, the needs of health care institutions for medical oxygen increase by 5-6 times. The issue of the reliable functioning of the oxygen supply system of health care institutions during the COVID-19 pandemic is extremely urgent and requires systematic research. \u0000The purpose of the work was to conduct research on measures to provide oxygen to health care facilities during the COVID-19 pandemic, to establish risk factors in its production and supply, and to determine priority directions for guaranteeing the ability to provide medical assistance in the treatment of coronavirus disease. \u0000The methods of systematic approach, bibliographic, information search, marketing analysis, as well as generalization and analysis were used during the research. \u0000The study showed that medical use of oxygen as a medicine, oxygen produced by medical devices, and technical oxygen was allowed at the state level. Domestic manufacturers produce medical oxygen that meets all regulatory requirements for medicinal products. In Ukraine, 36 drugs based on medical oxygen are registered, the production of which is carried out by 26 enterprises that have licenses for the production of medicinal products. During the pandemic, it was allowed for medical use of technical oxygen, which should meet the quality indicators of medical oxygen. The use of oxygen, which is produced by medical devices, which include oxygen generators and oxygen concentrators, which must meet the requirements of the Technical Regulations, became a significant measure for the expansion of oxygen therapy. \u0000During the implementation of all measures to provide oxygen, there are risks of a national and branch nature, as well as specific risks associated with the characteristics of different types of oxygen (oxygen as a medicine, oxygen produced by medical devices, technical oxygen). The identified list of risks and their analysis in the provision of oxygen to health care facilities during the COVID-19 pandemic will provide an opportunity to develop the concept of general risk assessment and risk management processes to guarantee the ability to provide adequate medical care in the treatment of coronavirus disease.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46879718","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}