Farmatsevtichnii zhurnal最新文献

{"title":"Pharmacological justification of the composition of active ingredients in the composition of «Molozol» gel","authors":"Відомо, що, як агентів, із кератолітичними, ти речовини, шкіри, поліпшує вологозв’я, зувальні здібності, шкіри. Це, особливо корисно","doi":"10.32352/0367-3057.2.23.05","DOIUrl":"https://doi.org/10.32352/0367-3057.2.23.05","url":null,"abstract":"Today, in connection with the rapid increase in the number of skin diseases complicated by secondary microbial and fungal infection, the creation of new drugs with a complex dermatomycosis effect for their local use is gaining particular relevance. In modern dermatological practice, mostly soft dosage forms are used. The wide use of soft medicinal forms is due to the presence of some advantages: high local concentration in the skin, relative economy and manufacturability of these means. However, on the modern Ukrainian pharmaceutical market, the range of drugs with a complex dermatomycosis effect is limited. This makes it necessary to find new means for local application in dermatitis with complicated fungal pathology. \u0000The aim of our research is an experimental ground of rational composition of operating substances in a gael under the conditional name «Molozol» for treatment of dermatomycoses. Gel was prepared on general rules by preparations of soft medical forms. Taking into account physical and chemical properties of operating substances, in particular their solubility, sucking, salicylic and sorbic acid was entered as a solution in propylene glycol and entered in the basis procured in advance for gel. With the aim of ground of rational concentration milk, salicylic and sorbic acid in the combined gel of «Molozol», and also study of his biological activity were conducted microbiological and toxicological. \u0000Determination of the antibacterial properties of the gel was carried out by diffusion in agar using reference strains of microorganisms Staphylococcus aureus ATCC 25923, Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Candida albicans ATCC 885/653. \u0000The rational composition of the active substances of the gel under the conventional name «Molosol» for the treatment of dermatomycosis was experimentally substantiated. Based on the data of microbiological studies, the concentration of active substances – lactic acid, salicylic acid and sorbic acid in the composition of the gel «Molosol» was justified. With the combination of active substances salicylic acid 8%, lactic acid 10%, for sorbic acid concentration 0.5%, «Molosol» gel shows the most pronounced antimicrobial and fungicidal activity against the tested strains of microorganisms. \u0000The index of acute toxicity when applied to the skin of animals was determined, which proved that the developed soft drug «Molosol» in the form of a gel belongs to the IV class of low-toxic substances. \u0000The combined gel «Molosol» is promising for further research as an antimicrobial and antifungal agent with keratolytic properties.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46663332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative determination of 4-((5-(decylthio)-4-methyl-4-h-1,2,4-triazol-3-yl)methyl)morpholine in the soft medicinal form by spectrophotometric method","authors":"К. В. Хоменко, К. П. Мєдвєдєва, І. В. Бушуєва, С. О. Васюк, Ж. М. Полова","doi":"10.32352/0367-3057.2.23.03","DOIUrl":"https://doi.org/10.32352/0367-3057.2.23.03","url":null,"abstract":"Synthetic biologically active compounds are the active pharmaceutical ingredients of various dosage forms that are widely used in both human and veterinary medicine. Nowadays the development of new effective antimicrobial and antifungal drugs remains a actual problem. This fact has a reasoned explanation in connection with the increase in infectious diseases of microbial and fungal etiology and the ever-growing resistance of microorganisms and fungi to various drugs. \u0000The aim of this research was to develop and validate a new spectrophotometric method for the quantitative determination of 4-((5-(decylthio)-4-methyl-4-H-1,2,4-triazol-3-yl)methyl)morpholine in 7% ointment by intrinsic absorption. \u0000At the stage of development of the quantitative determination method, the solvent was selected based on the solubility of the active substance. According to the data provided, 4-((5-(decylthio)-4-methyl-4-H-1,2,4-triazol-3-yl)methyl)morpholine is insoluble in water, but soluble in ethanol, methanol, isopropanol, dioxane, and dimethyl sulfoxide. Ethanol was chosen as the most accessible and less toxic solvent for the development of this method. Studied 4-((5-(decylthio)-4-methyl-4-H-1,2,4-triazol-3-yl)methyl)morpholine dissolved in ethanol is introduced into the ointment base as a solution. \u0000The quantitative content of substances subject to chemical control in soft dosage forms should be between 90% and 110% of the nominal content. On this basis, the maximum permitted analytical uncertainty can be determined, which is 3.20. \u0000During the procedure the main validation characteristics were determined, such as: linearity, precision, accuracy and robustness. \u0000Thus, a new sensitive, economical and easy-to-use spectrophotometric method for the quantitative determination of 4-((5-(decylthio)-4-methyl-4-H-1,2,4-triazol-3-yl)methyl)morpholine in a soft dosage form for external use (7% ointment) by the intrinsic absorption method was developed. According to the main validation characteristics (linearity, precision, accuracy and robustness), the proposed method is valid and meets the requirements of the State Pharmacopoeia of Ukraine.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49217325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of phenolic compounds in black walnut (Juglans nigra L.) fruit extract using high-performance liquid chromatography","authors":"Л. В. Еберле, А. О. Цісак, І. М. Радаєва, А. C. Казанцева","doi":"10.32352/0367-3057.2.23.06","DOIUrl":"https://doi.org/10.32352/0367-3057.2.23.06","url":null,"abstract":"Black walnut (Juglans nigra L.), which belongs to the Nut family (Juglandaceae), is a valuable raw material for the production of phytopreparations. The extract from the fruits of Juglans nigra L. has immunomodulating and antioxidant properties, which is primarily due to the presence of a large amount of phenolic compounds in the plant. But the phytochemical composition and pharmacological properties of Juglans nigra L. have not been sufficiently studied. \u0000The aim of our work was to study the optimal conditions for the extraction of Juglans nigra L. fruits, followed by the identification of its quantitative and qualitative composition. \u0000The main criterion for evaluating optimal extraction conditions was the quantitative content of phenolic compounds, which was determined spectrophotometrically by the Folin–Chocalteu method. The analysis of polyphenolic compounds was carried out by the method of high performance liquid chromatography. \u0000On the basis of experimental studies, the optimal conditions for extracting the fruits of Juglans nigra L. by maceration method conditions were selected. According to the results of the comparative analysis, it is shown that for the maximum extraction of phenolic compounds, it is advisable to use a 70% water-ethanol mixture as an extractant with a raw material to solvent ratio of 1:9. The method of high-performance liquid chromatography showed that the total content of phenolic compounds in the fruits of Juglans nigra L. is 2 327.09 μg/ml. Analysis of the extract of Juglans nigra L. by high-performance liquid chromatography method showed the presence of such phenolic compounds in plant material samples as catechins, catechin-like substances, flavonols (rutin, quercetin, myricetin), flavanones (naringin, naringenin) and phenolic acids. It should be noted, that the presence of such substances as chlorogenic acid, caffeic acid, kaempferol, hesperidin, genistein and daidzein glycosides, luteolin and apigenin glycosides, luteolin and apigenin in the extract of Juglans nigra L. was not detected. \u0000A high content of compounds of polyphenolic nature in the fruits of Juglans nigra L. was established. Therefore, this medicinal plant material is promising for further research, in particular, for the development of medicines based on the extract with potential anti-inflammatory, analgesic and antioxidant activity.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42357511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Study of the polyphenolic compounds accumulation in Thymus serpyllum L. herb during the flowering period","authors":"О. В. Мазулін, Л. А. Фуклева, Г. В. Мазулін","doi":"10.32352/0367-3057.2.23.07","DOIUrl":"https://doi.org/10.32352/0367-3057.2.23.07","url":null,"abstract":"The Thymus serpyllum L. is a widespread in the steppe bioсenosеs of southern and eastern Ukraine. It is well cultivated in specialized farms. A promising direction of modern phytochemical research of wild and cultivated Thymus L. species is the determination of the accumulation of biologically active polyphenolic compounds that exhibit pronounced biological activity. \u0000The purpose of the work is to determine the accumulation of polyphenolic compounds in Thymus serpyllum L. herb at the flowering using TLC and HPLC methods. \u0000The Thymus serpyllum L. herb was harvested in steppe biocenoses of southern and eastern Ukraine at the flowering, during the period of biologically active polyphenolic compounds maximum accumulation. For experimental studies, alcohol extracts from Thymus serpyllum L. herb (1:100) were used. The substances component composition was studied by TLC method Biostep CD 60 densitometer (Germany) and HPLC Agilent 1260 Infinity HPLC System Open LABCDS Software (Japan). \u0000TLC and HPLC methods revealed up to 25 polyphenolic compounds. Experimentally were determined 13 flavonoids and 12 hydroxycinnamic acids. All these biologically active compounds are well known in modern phytotherapy for their pronounced antimicrobial, anti-inflammatory and antioxidant activity. During the flowering period up to 25 polyphenolic compounds were identified and quantified in the ethanolic extract (1:100) obtained from Thymus serpyllum L. herbal raw material. Of these, 13 compounds were attributed to flavonoids with a defined total content (0.3 mg/100 mg) and 12 to hydroxycinnamic acids (0.9 mg/100 mg). The highest accumulation of hydroxycinnamic acids in the Thymus serpyllum L. herbal raw material were characterized by rosmarinic acid (12.77 + 1.19%), chlorogenic acid (8.55 + 0.79%) and p-coumaric acid (7.41 + 0.69%). Of flavonoids, the highest content were established for rutin (8.45 + 0.79%), luteolin (3.87 + 0.37%), luteolin-7-O-β-D-glucopyranoside (3.86 ± 0.33%), apigenin-7,4'-diglucoside (3.86 ± 0.32%), quercetin (3.85 ± 0.34%) and apigenin (3.81 ± 0.36%). \u0000The results obtained by TLC and HPLC methods indicate the perspective of polyphenolic compounds research for the purpose of determining the biological activity of extracts and carrying out the standardization of Thymus serpyllum L. herb. The study of the polyphenolic compounds accumulation in the Thymus serpyllum L. plant raw materials is important for this standardization and obtaining effective phytopreparations.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46812599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The problems of unifying information in the patient leaflets in Ukraine during the COVID-19 pandemic and wartime","authors":"Ю. В. Качерай, З. О. Заболотня, О. М. Заліська, І. Г. Мудрак, О. М. Кушта","doi":"10.32352/0367-3057.2.23.08","DOIUrl":"https://doi.org/10.32352/0367-3057.2.23.08","url":null,"abstract":"The information in the patient leaflets on the medicines must be unified, have a good structure and be clearly presented to the patient for prevent information asymmetry. We substantiated and worked a methodic of comparative analysis of antibiotic using for example of 74 instructions on the drug of one INN, which are registered on the markets of Ukraine, EU countries and Japan. Ways to unify information in to improve patient awareness of the correct use of drugs, especially antibiotics, are substantiated and presented. \u0000Aim – to conduct a comparative analysis of the patient leaflets for antibacterial medicines and determine the presence or absence of information asymmetry using the example of antibiotics of one INN that are registrated on the Ukrainian market or they received as a humanitarian aid from Europe in wartime, in order to establish inconsistencies in the information structure and data in the information leaflets. \u0000The objects were information leaflets for antibiotics: azithromycin, amoxiclav, amoxicillin, zinnate, cefazolin, cefatoxin. Methods were informational, comparative and content analysis. Methodology of information asymmetry analysis using the example of information leaflets for the medicine azithromycin from various manufacturers available on the market of Ukraine. \u0000As a result, significant differences were established in 3 sections: «Indications», «Peculiarities of use», suspension preparation, etc. Significant differences were found in the information leaflets for prescribing azithromycin for skin infections, which requires immediate unification in the information leaflets of data for correct prescribing by a doctor using an electronic prescription and good use for a treatment course. It was established that in the  for azithromycin from one manufacturer, which is on the market of Ukraine and EU countries, significant differences in information were found in 10 sections of the information leaflets, which requires the unification of information accordingly. \u0000We have reasoned that the information leaflets should contain information that is important for the correct use of the medicine, in order to prevent potentially dangerous consequences that may arise from incorrect preparation or dosage. We grounded the information leaflets should include a section on the disposal of expired or unused medicines to harmonize with the information leaflets іn the EU countries.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49303457","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experimental study of the transformation of 2-aminophenylacetic acid hexafluorosilicate into 2-oxindol under mild conditions","authors":"І. В. Литвинчук, М. С. Фонарь, В. Х. Кравцов, В. О. Гельмбольдт","doi":"10.32352/0367-3057.2.23.02","DOIUrl":"https://doi.org/10.32352/0367-3057.2.23.02","url":null,"abstract":"Currently, ammonium hexafluorosilicates are being actively studied as new anti-caries agents, which, according to the results of researches on rats, show a more significant caries-preventive effectiveness compared to sodium fluoride with a simultaneous significant improvement of the biochemical indicators of the dental pulp and the absence of hepatotoxic effects. Previously, we’ve synthesized 2-, 3-, 4-aminophenylacetic acid hexafluorosilicates (2-, 3-, 4-APhHFS); in an attempt to recrystallize the 2-APhHFS salt from ethanol, a red crystalline product was obtained. \u0000The purpose of the research – considering the potential prospects of 2-, 3-, 4-APhHFS, it is expedient to establish the composition and structure of the recrystallization product of 2-APhHFS. Mass spectra were recorded on MX-1321 and VG 7070 spectrometers (VG Analytical), X-ray structural analysis was carried out on an Xcalibur E diffractometer. \u0000As follows from the comparison of the external inspection of the original 2-APhHFS and its recrystallization product (RP) samples, they differ significantly: light brown amorphous 2-APhHFS and red crystalline RP. The characteristics of the mass spectra of 2-APhHFS and RP are also different. The structure of RP as 2-oxindole was objectively established by X-ray diffraction data. \u0000The recrystallization process of 2-APhHFS to obtain 2-oxindole does not require heating of the reaction mixture, i.e., it is carried out under extremely mild conditions. It is possible that it's connected with the participation of the protonated form of 2-aminophenylacetic acid in the composition of 2-APhHFS in chemical transformations. \u0000Thus, caution should be exercised in experiments with both solutions and, apparently, solid samples of 2-APhHFS during salt purification procedures or other manipulations. The high lability of 2-aminophenylacetic acid hexafluorosilicate limits the possibilities of using standard purification methods (sublimation, recrystallization) for this compound.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48947400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis and properties of 7-((6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)methyl)theophyllines","authors":"Х. Д. Бакумовська, А. С. Гоцуля","doi":"10.32352/0367-3057.1.23.06","DOIUrl":"https://doi.org/10.32352/0367-3057.1.23.06","url":null,"abstract":"The creation of new biologically active compounds is a promising area of modern medicinal chemistry. Heterocyclic systems play an important role in this process.Among them, it is necessary to note 1,2,4-triazole and xanthine, the presence of which in the structure of known medicines determines their pharmacological activity. The combination of these heterocycles within a single molecule can lead to the enhancement of the existing biological effect or the emergence of new useful properties. \u0000The aim of the work has been to synthesize new theophylline-containing 4-amino-1,2,4-triazole-3-thiol derivatives, study their physicochemical properties and predictive study of their biological potential. \u0000The research objects have been the 7-((6-aryl-[1,2,4]triazolo[3,4-b][1,3,4]-thiadiazol-3-yl)methyl)theophylline, which were obtained by condensation of the starting 7-((4-amino-5-mercapto-1,2,4-triazol-3-yl)methyl)theophylline with aromatic carboxylic acids (benzoic,2-methoxybenzoic, 3-methoxybenzoic, 2-bromo-5-methoxybenzoic,2-bromo-4-fluorobenzoic, 2-chloro-4-nitrobenzoic, 2-bromo-5-nitrobenzoic) in phosphorus oxychloride medium under heating. The structure of the intermediate 7-((4-amino-5-mercapto-1,2,4-triazol-3-yl)methyl)theophylline was formed by a multistep chemical transformation of 1,3-dimethylxanthine. The structure of the synthesized compounds has been confirmed by elemental analysis, 1H NMR and IR spectroscopy, their individuality has been established by chromatography-mass spectrometry. \u0000The feasibility of further biological research has been preliminarily assessed by an in silico method, in particular, molecular docking. Cyclooxygenase-2, lanosterol 14α-demethylase and anaplastic lymphoma kinase have been used as model enzymes. The most likely activity, which is quite probable in a number of synthesized compounds, is antifungal. In this context, 7-((6-(2-bromo-5-methoxyphenyl)-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-3-yl)methyl)theophylline looks particularly promising, as it exceeds ketoconazole in terms of the energy of intermolecular interactions with lanosterol 14α-demethylase.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48466549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of maitake mushrooms thick extract on the state of antioxidant system in rats with DMH-induced colon carcinogenesis","authors":"І. І. Герасимець, Л. С. Фіра, І. І. Медвідь","doi":"10.32352/0367-3057.1.23.09","DOIUrl":"https://doi.org/10.32352/0367-3057.1.23.09","url":null,"abstract":"Colorectal cancer is a dangerous oncological disease that requires serious complex treatment. This type of oncopathology occurs due to atypical growth of the epithelium of the mucous layer that lines the intestinal walls. Colon cancer is characterized by slow development, so prevention and timely diagnosis are a priority. \u0000The main advantage of using oncoprotectors based on natural raw materials in clinical practice is their low toxicity and the possibility of long-term use without significant side effects. That is why the development and study of such drugs are relevant. \u0000The aim of the research was to study indicators of oxidative processes and antioxidant systems in rats with chemically induced colon carcinogenesis against the background of maitake mushrooms thick extract use. \u0000The study was performed on 120 white male rats weighing 190–210 g. Adenocarcinoma of the colon was modeled by administering 1,2-dimethylhydrazine (DMH) hydrochloride for 30 weeks (1 time per week). A thick extract from maitake mushrooms was administered intragastrically daily at a dose of 150 mg/kg of animal body weight. Blood and liver samples were taken for research monthly. The state of the pro- and antioxidant systems was studied by the content of oxidative modification of proteins products neutral and alkaline character, superoxide dismutase and catalase activity, contents of reduced glutathione and ceruloplasmin. \u0000It was found that DMH-induced colon carcinogenesis in rats is accompanied by an increase in the activity of free radical oxidation processes. It is evidenced by a decrease in superoxide dismutase activity, catalase activity, a significant reduction in the content of reduced glutathione, an increase in the content of ceruloplasmin and products of oxidative modification of proteins in the blood serum and liver of animals. The effectiveness of maitake mushrooms thick extract and its positive influence on the activity of the studied enzymes and the content of OMP products in investigated tissues was experimentally proved. \u0000The use of maitake mushrooms thick extract under conditions of DMH-induced colon carcinogenesis in rats led to the normalization of antioxidant protection indicators and a significant decrease in the indicators of oxidative modification of proteins, which testifies to the suppression of oxidative stress in animals with an oncological process.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43495593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Theoretical and experimental substantiation of receiving a pharmaceutical composition in the form of a cryogel with lidocain hydrochloride and decametoxin","authors":"А. М. Соломенний, А. О. Дроздова","doi":"10.32352/0367-3057.1.23.07","DOIUrl":"https://doi.org/10.32352/0367-3057.1.23.07","url":null,"abstract":"Modern medicines for the treatment of wounds are developed on the basis of knowledge about their phase healing. The main principle of wound treatment is the creation and maintenance of a moist environment, stable temperature, absorption of excess exudate, minimization of the risk of sensitization, increased intervals between dressings, easy removal of coatings from the surface of the wound. The implementation of this principle is the basis of our research on the creation of a cryogel – a supermacroporous hydrogel that is formed at subzero temperatures by polymerization of monomers or cryogel formation of oligomers without the use of toxic organic solvents and with controlled textural and structural characteristics. A comprehensive study of cryogels has like theoretical as practical interest, because they can serve as a perspectiving new material in pharmacy for obtaining new medicines. \u0000The purpose of our research was to substantiate the composition of the cryogel with lidocaine hydrochloride and decamethoxine based on the conducted pharmacotechnological, physicochemical and biopharmaceutical research methods. Model samples (№№ 1–10) with different contents of lidocaine hydrochloride, decamethoxine, and auxiliary substances were selected as research objects. Pharmacotechnological, physicochemical and biopharmaceutical research methods were used. \u0000The technological and biopharmaceutical factors of development pharmaceutical composition in the form of a cryogel with lidocaine hydrochloride and decamethoxine were studied. Based on the results of the research, we found that samples (№№ 1–10) are homogeneous without signs of delamination, no changes are observed (aggregation of particles, sediment, odor). Samples №№ 3, 9 and 10 differ in the presence/absence of API. It was shown that APIs do not affect the absorption capacity of the studied samples. Comparative studies confirm our assumption that the presence of PG in the cryogel increases the absorption of liquid by the samples. The prolongation of the action in the composition depends on the presence of PG in the sample of composition. The prolonged effect of pharmaceutical composition was established. For further research, sample № 10 (lidocaine hydrochloride – 0.4; decamethoxine – 0.03; PVA 15% – 20.0; PG – 10.0) was chosen.","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48760615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drugs for the treatment of ulcerative colitis on the pharmaceutical market of Ukraine","authors":"Л. М. Пальчак, О. С. Кухтенко, В. М. Хоменко","doi":"10.32352/0367-3057.1.23.01","DOIUrl":"https://doi.org/10.32352/0367-3057.1.23.01","url":null,"abstract":"The prevalence of diseases of the digestive organs at the current stage of human development is extremely high, and their universally increasing incidence rate is estimated as an epidemic. In Ukraine, mortality from diseases of the digestive organs ranks fourth in the population mortality structure (after diseases of the circulatory system, neoplasms, and accidents). Among all diseases of digestive organs in the modern world, inflammatory bowel diseases are one of the most serious and unsolved problems in modern gastroenterology and coloproctology. In terms of morbidity, non-specific ulcerative colitis (UC) and Crohn's disease (CD) are inferior to other gastroenterological diseases, although in terms of the severity of the course, the frequency of complications and mortality, they occupy one of the leading places in the structure of diseases of the gastrointestinal tract.         Therefore, the goal of our work was the marketing analysis of drugs for the treatment of non-specific ulcerative colitis containing mesalazine as an active component. Obtaining data on the demand on the pharmaceutical market for medicinal products with mesalazine, determining trends in the use of dosage forms with this substance will allow predicting approaches to the development of a domestic effective medicinal product containing mesalazine. The objects of the study were medicinal products of local and systemic action, containing mesalazine in their composition. To achieve the goal, generally accepted research methods were used, which contributed to the objective assessment of the analysis of the pharmaceutical market. \u0000The analysis of the assortment of medicines with mesalazine presented on the domestic pharmaceutical market was carried out according to the data of the classification system of the ATС, the State Formulary of Medicines, the State Register of Medicines of Ukraine. The presence on the pharmaceutical market of Ukraine of drugs of the group A07E Intestinal antiinflammatory agents indicates that the leader in terms of assortment offers is drugs with mesalazine (5-ASA). As of February 2023, Ukraine has registration certificates for 19 medicinal products of five brands with the active ingredient mesalazine. According to the received data, no medicinal product of domestic production containing mesalazine has been registered on the pharmaceutical market of Ukraine. Several types of dosage forms with mesalazine are available on the pharmaceutical market of Ukraine (coated tablets, long-acting granules, suppositories, and rectal suspension). It should be noted the absence of combined medicines with mesalazine. Also, there is no such medicinal form as enteric-dissolving hard gelatin capsules on the pharmaceutical market of Ukraine. \u0000Taking into account the obtained data, approaches to the introduction into production of a domestic medicinal product for the treatment of non-specific ulcerative colitis containing mesalazine and medicinal plant raw materials are in d","PeriodicalId":32942,"journal":{"name":"Farmatsevtichnii zhurnal","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41719248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}