Problemi ekologiyi ta meditsini最新文献

{"title":"CURCUMIN RESTORES THE BALANCE OF NO-SYNTHASES IN THE BRAIN HEMISPHERES OF RATS EXPOSED TO ROUND-THE-CLOCK LIGHT UNDER CONDITIONS OF A DIET HIGH IN FRUCTOSE AND FAT","authors":"Y.D. Frankel, V. Zyuzin, V. Cherno","doi":"10.31718/mep.2023.27.3-4.06","DOIUrl":"https://doi.org/10.31718/mep.2023.27.3-4.06","url":null,"abstract":"The aim of the study was to evaluate the effect of curcumin on the ratio of constitutive and inducible NOS isoforms in the cerebral cortex of rats under a round-the-clock lighting (RCL) with a high fructose and fat diet. The experiments were performed on 21 white Wistar rats weighing 235±20 g, divided into 3 groups. Animals in the first group (control) received a standard diet (energy value 2720 kcal/kg) and were exposed to an equal alternation of light and darkness. The rats of the second and third groups were kept in RCL conditions against the background of the administration of a high-calorie carbohydrate-lipid diet (HCCLD, 4477 kcal/kg). In addition, animals of the third group received curcumin daily through a gavage, intragastrically, at a dose of 200 mg/kg. The activity of total NOS and its constitutive isoforms (cNOS) in the cerebral homogenate was measured, inducible isoenzyme (iNOS) activity and cNOS coupling index were calculated. Curcumin administration significantly reduced the total and inducible activity of NOS in the cerebral homogenate– by 34 and 38%, respectively, compared with the values of the second group. At the same time, cNOS activity (2.3-fold) and its coupling index (3.8-fold) increased significantly compared with the data of the second group. It is concluded that the use of curcumin in metabolic disorders associated with pathogenic factors of the “Western lifestyle” – light disorders and the use of HCCLD restores the normal ratio of constitutive and inducible NOS isoforms, cNOS coupling in the rat cerebral hemispheres, which prevents the development of oxidative-nitrosative stress.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44693873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ANALYSIS OF THE ACTIVITY INDICATORS OF THE SPORTS MEDICINE SERVICE IN THE POLTAVA REGION FOR 2017-2022","authors":"M.V. Khorosh","doi":"10.31718/mep.2023.27.3-4.05","DOIUrl":"https://doi.org/10.31718/mep.2023.27.3-4.05","url":null,"abstract":"A healthy lifestyle includes many components, one of which is adequate physical activity. An important role in the formation of the habit of observing a normal regime of motor activity belongs to the formation of the habit of physical exertion, which is usually formed during sports. However, sports activities are accompanied by high physical exertion and may be the result of injuries or the occurrence of pathological processes. The service of sports medicine plays an important role in health control and timely identification of contraindications to sports. The aim of the study is to analyze the performance indicators of the sports medicine service in the Poltava region. The analysis was carried out on the basis of statistical reports of sports medicine institutions of the Poltava region. As a result of the processing of the materials, a decrease in the performance of the sports medicine service was determined. However, the pattern of the decrease is clearly visible depending on external factors: quarantine restrictions due to the COVID-19 epidemic and the consequences of Russia’s full-scale armed aggression against our country. Despite this, there is a stable load on the sports medicine service, the specific weight of appeals from the profile of sports medicine is increasing, and the level of preventive work is at a sufficient level.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41396284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFODEMIOLOGY: USING GOOGLE TRENDS AS A RESEARCH TOOL DURING THE COVID-19 PANDEMIC","authors":"H. Morokhovets, Yu. Lysanets, I. Kaidashev","doi":"10.31718/mep.2023.27.3-4.01","DOIUrl":"https://doi.org/10.31718/mep.2023.27.3-4.01","url":null,"abstract":"The paper examines the prognostic potential of the Google Trends resource as one of the infodemiological tools that allows collecting and analyzing the frequency of search queries on the Internet. The aim of the research is to analyze the Cyrillic search queries on Google to study the dynamics of the development of COVID-19 in Ukraine in 2020-2022. The time interval of the study from 15.03.2020 to 23.02.2022 was determined by available official information on the incidence of COVID-19 in Ukraine. The data obtained from Google Trends, normalized relative to the country of study and time interval, was downloaded in *.csv format. Correlation between quantitative indicators was assessed using the Spearman rank correlation coefficient. The authors proposed a new direction to study the dynamics of the development of COVID-19, which relies on the analysis of the search for symptoms and names of medications to predict the course of the disease. It has been shown that Google Trends is an effective tool for the rapid collection of information on the state of morbidity in the country. The use of keyword searches not only allows us to predict the development of the disease but can also be an effective tool of pharmacoeconomics. The revealed regularities can be used in international epidemiological studies, taking into account national characteristics, the geographical location of the country, the impact of preventive restrictions, etc.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49621812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"EVALUATION OF THE FUNCTIONAL STATE AND MORPHOLOGY OF THE RETINA IN PATIENTS WITH RHEGMATOGENOUS RETINAL DETACHMENT AFTER SUBTOTAL VITRECTOMY","authors":"I.S. Olefir, V. V. Ryadnova, L. K. Voskresenskaya","doi":"10.31718/mep.2023.27.3-4.03","DOIUrl":"https://doi.org/10.31718/mep.2023.27.3-4.03","url":null,"abstract":"The article examines the functional state and morphology of the retina in patients with rhegmatogenous retinal detachment after subtotal vitrectomy. The aim of the research is to evaluate and compare perimetry data of the central retinal zone on postoperative functional results after closed subtotal vitrectomy for retinal detachment. The article presents a retrospective study of 36 patients who underwent closed subtotal vitrectomy for retinal detachment. The average age of the examined patients was 58±2.3 years. Patients were divided into 2 groups depending on changes in the macular zone of the retina. Operative interventions were performed by one surgeon, on one phacomachine (Constellation vision system). When evaluating the morphology of the retina in patients of both groups, it was found that thickening of the macular area occurs in almost all patients after surgical treatment within 1 month after surgery (р ≤ 0.05). A statistically significant thinning of the retina was also noted at the three-month follow-up (p ≤ 0.05). The study found that the dynamics of functional changes in the retina is more significant in patients with macular detachment of the retina. In this group of patients, lower functional results according to Visus indicators, significant thickening of the macular area of the retina in the early postoperative period, significant changes in retinal photosensitivity and more pronounced retinal atrophy were observed, especially of the optic zone after 3 months of observation. It was found that even a successfully performed surgery for rhegmatogenous retinal detachment can have low functional results, involving not only visual acuity.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42519149","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PECULIARITIES OF POSTOPERATIVE PAIN IN THE ELDERLY AND SENILE PATIENTS AT DIFFERENT STAGES OF NOCICEPTION","authors":"V.O. Telegan, K.V. Tarasenko","doi":"10.31718/mep.2023.27.3-4.04","DOIUrl":"https://doi.org/10.31718/mep.2023.27.3-4.04","url":null,"abstract":"According to modern concepts, the process of nociception includes transduction, transmission, modulation, and perception. However, at this stage of the development of modern medicine, not enough studies have been devoted to the issue of specific clinical and laboratory indicators of different stages of nociception in the elderly and older age, which may be related to both the aging process of the causes and the consequences of concomitant pathology. Therefore, the aim of our study was to evaluate the peculiarities of the state of the nociceptive system at the stages of transmission, modulation, and perception in older, elderly, and young people. We conducted a clinical study, which was organized based on the communal enterprise \"3rd City Clinical Hospital of the Poltava City Council\" in 2018-2020. The study included 201 patients who were in the postoperative period, regardless of the type of intervention and nosology. All examined patients were divided into 3 groups according to age: group 1 (n=82) – elderly people, group 2 (n=21) – older people, and control group (n=98) – young people. The study of neurophysiological indicators of the conductivity of sensory fibers was carried out by measuring the speed of propagation of the nerve impulse along the sensory fibers of the lower and upper extremities using stimulation electroneuromyography. The nociceptive flexor reflex was measured to assess the stage of modulation of nociception. We recorded the reflex threshold and the subjective pain threshold, as well as their content. To objectify the strength of the pain sensation, pressor algometry was used, which took place several times in the measurement of the subjective assessment of pain, with the appearance of painful stimuli increasing in intensity. We did not find any statistically significant differences in the sensory speed of recovery along fibers n. ulnaris and n. medianus between the right and left sides, as well as between patients of different groups in the early postoperative period. There are no age differences in the stage of pain impulse transmission in the upper limbs in the early postoperative period. However, a statistical value was established below the speed of recovery by sensory fibers of the lower extremities in the early postoperative period, in particular by n.peroneus superficialis and n. suralis, in the elderly. The ratio of the pain threshold to the reflex threshold showed differences in all groups. The higher threshold in the private control group was higher than group 2 and did not differ from group 1. A statistically lower pain tolerance was noted in groups 1 and 2 relative to the control group, but no difference was found between the elderly and older age groups. Thus, it was found that elderly patients have differences in various stages of nociception, in particular, transmission, modulation, and perception, which complicates the treatment of pain syndrome in the postoperative period and requires further research with f","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43693125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"THE RELATIONSHIP OF BREAST CANCER, BIOMINERALIZATION DISORDERS AND BONE METASTASES: A BIBLIOGRAPHICAL ANALYSIS","authors":"І. Starchenko, A. Korobchanska, B. М. Fylenko, N. Roiko, V. V. Cherniak","doi":"10.31718/mep.2023.27.3-4.08","DOIUrl":"https://doi.org/10.31718/mep.2023.27.3-4.08","url":null,"abstract":"Bone metastases are the most common and hard-to-treat complication of BC. About 70% of patients with metastatic BC have distant bone relapses during the disease. BC always leads to the death of patients within 5-10 years, and this statistic has not changed in the last 2-3 decades. The work aims to carry out a bibliometric analysis of the interrelationships of BC, processes of biomineralization (calcification), and metastases of BC to bone tissue. The authors searched electronic databases such as PubMed, Scopus, Web of Science, and Google Scholar for the period 1973-2023 using key terms such as \"breast cancer,\" \"calcification,\" and \"bone metastases.\" For bibliometric analysis, an online platform for monitoring and analyzing international scientific research using visualization tools and current citation metrics SciVal (Scopus), and a tool for building and visualizing bibliometric networks VOSviewer, were used. The authors used Scopus database bibliometric tools to analyze the year, source, type of study, subject area, and country of the publication. The VOSviewer system from the University of Leiden (https://www.vosviewer.com/download) was used to generate and visualize the bibliometric network. We found and examined 103 publications in the Scopus database using the keywords \"breast cancer,\" \"calcification,\" and \"bone metastases\" for the period 1973-2023. The results of the bibliometric analysis indicate that the number of publications on the specified subject has grown significantly (with small fluctuations) over the past 20 years, indicating scientists' interest in the problem and ways to solve it. The complex relationship between pathological biomineralization, breast cancer, and bone metastases is being actively studied by scientists, mainly from the United States of America, Germany, and Italy. Using the tool for building and visualizing bibliometric networks VOSviewer of publication activity for the period 1973-2023 in the researched topics of BC with calcification, we identified four chronological stages, which include: 1) radiological and biochemical research methods, 2) research on the effectiveness of diagnostics and treatment, including .h pathomorphological assessment of pathology, 3) fundamental studies of bone and mineral metabolism, 4) a practically oriented period of research. We also divided the identified publications into six thematic clusters: 1) application of radiological methods, 2) bone and mineral metabolism in conditions of pathology, 3) clinical diagnosis and prediction of the course of related pathology, 4) biomaterials and nanotechnology, 5) chemotherapy of oncopathology and its consequences, 6) fundamental molecular genetic research.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44605141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CLINICAL SIGNIFICANCE OF THE INFLUENCE OF CELL WALL ANTIGENS OF STAPHYLOCOCCUS AUREUS ON PHAGOCYTIC CELLS OF THE PERIPHERAL BLOOD IN CHILDREN WITH PURULENT AND INFLAMMATORY DISEASES OF STAPHYLOCOCCAL ETIOLOGY","authors":"R.B. Aliev, N.V. Stryzhak, A. S. Shapovalova, S. Abuvatfa, O.S. Kunytska, P.G. Kovalenko","doi":"10.31718/mep.2023.27.3-4.02","DOIUrl":"https://doi.org/10.31718/mep.2023.27.3-4.02","url":null,"abstract":"The paper examines the features of oxygen-dependent metabolism of peripheral blood phagocytes and the nature of its exposure to peptidoglycan and teichoic acid of Staphylococcus aureus. The study included 86 children with purulent and inflammatory processes of staphylococcal etiology aged from 7 months to 12 years and 14 apparently healthy children. The results of the study showed that in most children at the onset of the disease, an increase in the intensity of the oxygen-dependent metabolism of neutrophil granulocytes and monocytes was observed, which was manifested by elevated indicators of the spontaneous HCT test of these cells compared to healthy children. During the period of clinical recovery in children with an acute course of the disease, a significant decrease in spontaneous HST-test indicators was observed. In addition to the spontaneous HCT test, we also studied the indicators of the oxygen-dependent metabolism of neutrophil granulocytes and monocytes after incubation of these cells with cell wall antigens of Staphylococcus aureus – peptidoglycans and teichoic acids. The results of the study showed that after incubation, no significant difference was found between them and the indicators of the spontaneous HCT test. In the period of convalescence in children with acute bronchopneumonia, acute purulent otitis media, acute tonsillitis, a decrease in indicators of oxygen-dependent metabolism was observed after incubation of monocytes with teichoic acids compared to spontaneous indicators. Thus, the effect of cell wall antigens of Staphylococcus aureus on the oxygen-dependent metabolism of neutrophil granulocytes and monocytes of peripheral blood was different. At the beginning of the development of the pathological process, reliable inhibition of the oxygen-dependent metabolism of phagocytes by antigens of the cell wall of Staphylococcus aureus was observed in all clinical groups. In the acute course at the beginning of the disease, the suppression of HST-test indicators was somewhat greater than in the exacerbation of the chronic process. During the recovery of patients with an acute purulent-inflammatory process, reliable inhibition of the oxygen-dependent metabolism of neutrophil granulocytes and monocytes by cell wall antigens of Staphylococcus aureus was not observed, and in children with an exacerbation of the chronic pathological process, the inhibition of the indicators of the HCT test of neutrophil granulocytes and monocytes remained reliably higher and almost did not change compared to the onset of the disease.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42099773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"INFLUENCE OF EXO- AND ENDOGENOUS FACTORS ON THE MORPHOLOGICAL AND FUNCTIONAL STATE OF THE SPLEEN AS AN IMPORTANT MEDICAL AND SOCIAL PROBLEM OF THE HEALTH CARE SYSTEM","authors":"O. Mamai, S. Bilash, R.M. Grinko","doi":"10.31718/mep.2023.27.3-4.07","DOIUrl":"https://doi.org/10.31718/mep.2023.27.3-4.07","url":null,"abstract":"Over the past century, since the rapid development of mankind as a civilization, the state of the environment and the conditions of everyday human existence have undergone significant changes. Diseases of the spleen play an important role in the system of pathologies of the human internal organs. The spleen is often considered a “forgotten organ” among clinicians and radiologists. Nevertheless, the spleen can be involved in a variety of congenital and acquired diseases, which makes it important to study the influence of exogenous and endogenous factors on its morphological and functional state. The aim is to analyze the literature data of modern studies published in the scientific and metric databases Scopus, Web of Science, and Google Scholar in English and Ukrainian and to summarize the results to identify key gaps in the known data. We found that the spleen’s functions are focused on systemic circulation, so it has no afferent lymphatic vessels. Spleen architectural features have been described in aging, chronic stress, sleep deprivation, under the influence of electromagnetic radiation, radiation exposure, sodium glutamate, sodium nitrite, and sodium fluoride. In forensic practice, trauma is considered the most common pathology of the spleen. Changes in the spleen are also known to occur in the setting of death from anaphylaxis, drowning, and sepsis. Autopsy of the spleen plays an important role in toxicological research. In clinical practice, spleen diseases are usually considered in the structure of other disease syndromes, but the main clinical changes are considered to be asplenia, splenomegaly, and hypersplenism. Thus, modern literature sources indicate a significant role of the spleen not only in the processes of immune regulation but also in maintaining the body’s homeostasis through participation in hematopoiesis and the body’s response to stress. At the same time, numerous studies have been conducted that indicate the vulnerability of the spleen to exogenous and endogenous factors, which is manifested by asplenia, splenomegaly, and hypersplenism. In particular, sodium glutamate and sodium nitrite have a significant effect on the spleen, but no data on their combined effect, as well as on the effect of Ponceau 4R on the spleen, have been found, which indicates the relevance of studying the effect of sodium glutamate, sodium nitrite, and Ponceau 4R in combination.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46901262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"IDIOMATIC POTENTIAL OF ANATOMICAL TERMINOLOGY AND ITS ROLE IN DEVELOPING ENGLISH LANGUAGE PROFICIENCY","authors":"Y. Lysanets, O. Bieliaieva","doi":"10.31718/mep.2023.27.1-2.06","DOIUrl":"https://doi.org/10.31718/mep.2023.27.1-2.06","url":null,"abstract":"The article examines the idiomatic features of anatomical terminology in modern English. The authors emphasize that understanding and correct use of idiomatic expressions is an indicator of in-depth knowledge of a foreign language and an important element in preparing for international English language exams, in particular, with the aim of recognizing implicit meanings (C1 – Advanced, C2 – Proficiency levels). It has been noted that mastering idiomatic expressions constitute one of the most difficult challenges for speakers of other languages, therefore it requires additional attention during the foreign language training of students. Based on the analysis and systematization of lexicographic sources (The Oxford Dictionary of Idioms, A Dictionary of 3800 Picturesque Idiomatic Expressions, and McGraw-Hill's Dictionary of American Idioms and Phrasal Verbs), it has been shown that anatomical terminology has significant idiomatic potential and is widely reflected in the figurative language of modern English. The study has revealed 628 idioms based on 52 anatomical terms, among which the lexemes “head”, “hand”, “eye”, “heart” and “foot” have the most productive idiomatic potential, forming the core of 75, 70, 53, 46 and 43 idioms respectively. The developed corpus of anatomical idioms has been organized for meaningful and accessible use in the educational process at a medical university. Familiarizing students with English anatomical idioms in the course of ESP training contributes to the development of student's interest and motivation in learning a foreign language, broadening their outlook, and ensuring an in-depth understanding of the mechanisms of English figurative language, which is the key to successfully passing international proficiency tests and communicating in a foreign language environment.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44214650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"BRAIN CHOLECYSTOKININ SYSTEM IN NEUROTIC PATHOLOGY","authors":"R. Lutsenko, A. Vakhnenko, G. Ostrovska, N. V. Moiseieva, O. Lutsenko","doi":"10.31718/mep.2023.27.1-2.01","DOIUrl":"https://doi.org/10.31718/mep.2023.27.1-2.01","url":null,"abstract":"Violation and discoordination of mental processes leads to changes in the ratio of the main neurotransmitters content and further to mental disorders. A significant role in such processes is played by neuropeptides, in particular anti-anxiety ones, which include cholecystokinin (CCK) and its receptors. It has been established that stimulation of CCK receptors modulates the mesolimbic system of reward, anxiety and satiety. CCK-1 (the intestine) and CCK-2 type receptors (the CNS and stomach) are isolated. In the central nervous system, the short O-sulfated form of CCK-8 and the non-sulfated form of CCK-5 predominate. It was shown that the effect of CCK on the corresponding receptors inhibits GABA-ergic receptors in the subcortical nuclei, which mediates the transmission of nerve signals from the endocannabinoid system. A significant number of CCK receptors, their agonists and antagonists were found in the body. Potentially, blockers of these receptors can be combined with other agents for the treatment of CNS diseases. In CCK, it was shown an anxiogenic effect, which was realized through the influence of a selective CCK-2 receptors agonist. There is information that CCK-4 causes anxiogenic effects due to its influence on other neurotransmitters, in particular, due to neuromodulation of the dopaminergic system, and can interact with other neurotransmission systems. In behavioral tests, the anxiolytic effect of CCK-2 receptor blockers is shown. The participation of this system in the pathogenesis of anxiety is confirmed by the influence of non-selective agonists of CCK receptors and agonists of CCK-2 receptors in the \"elevated cross-shaped maze\" test. At the same time, CCK-2 receptor blockers reduced anxiety in this test. In clinical studies, they suppressed panic when administered as a bolus. However, the problem of bioavailability of compounds remains unsolved. The significant diversity of CCK receptors and their expression in all parts of the brain also complicates their application greatly. So, the CCK system of the brain is involved in the development of the main manifestations of anxiety pathology, but there are prospects for the medical use of substances that regulate the functional activity of CCK receptors.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46992110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}