Problemi ekologiyi ta meditsini最新文献_第10页

EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW 双氯芬钠对骨髓细胞和外周血分化机制的影响：文献综述

Problemi ekologiyi ta meditsini Pub Date : 2018-12-26 DOI: 10.31718/MEP.2018.22.5-6.05

Yu. Bahmut, O. S. Ivanov, G. V. Tsapko

引用次数: 0

ENGLISH VERSION: OBESITY AS A TOPICAL MEDICAL PROBLEM OF THE 21ST CENTURY: A MODERN VIEW ON THE DISEASE OF THE HUMANITY 肥胖是21世纪的一个热门医学问题：人类疾病的现代视角

Problemi ekologiyi ta meditsini Pub Date : 2018-12-26 DOI: 10.31718/MEP.2018.22.5-6.07

V. Prymachenko

引用次数: 1

THE IFN-Α SYNTHESIS MONITORING ON LOCAL AND GENERAL LEVELS IN PATIENTS WITH HERPES SIMPLEX VIRUS INFECTION 单纯疱疹病毒感染患者局部和全身IFN-α合成监测

Problemi ekologiyi ta meditsini Pub Date : 2018-12-26 DOI: 10.31718/mep.2018.22.5-6.01

N. Horbal, K. E. Ishcheykin, G. Potemkina, I. Gaiduchok, I. Kril, V. Chopyak

引用次数: 0

PATHOGENETIC ROLE OF THROMBOCYTES IN THE DEVELOPMENT OF AUTOIMMUNE PATHOLOGY OF THE THYROID GLAND 血小板在甲状腺自身免疫病理发展中的病理作用

Problemi ekologiyi ta meditsini Pub Date : 2018-12-26 DOI: 10.31718/MEP.2018.22.5-6.02

I. Y. Bahmut, O. Halmyz, S. Hramatiuk, A. Titkova

引用次数: 0

METHODS OF EFFECTIVE TEACHING BIOINFORMATICS IN MEDICAL ACADEMIC SETTING 医学院校生物信息学教学的有效方法

Problemi ekologiyi ta meditsini Pub Date : 2018-10-30 DOI: 10.31718/mep.2018.22.3-4.05

H. Morokhovets, Y. Lysanets

引用次数: 1

SUBCUTANEOUS ADIPOSE TISSUE IN FEMALE PATIENTS WITH IRON DEFICIENCY ANEMIA AND OBESE WOMEN DOES NOT DIFFER IN THE EXPRESSION OF IKBΑ* 女性缺铁性贫血患者和肥胖女性皮下脂肪组织中ikbΑ *的表达没有差异

Problemi ekologiyi ta meditsini Pub Date : 2018-10-30 DOI: 10.31718/MEP.2018.22.3-4.04

V. M. Nedoborenko, O. Shlykova, O. Izmailova, K. Ishcheikin, I. Kaidashev

{"title":"SUBCUTANEOUS ADIPOSE TISSUE IN FEMALE PATIENTS WITH IRON DEFICIENCY ANEMIA AND OBESE WOMEN DOES NOT DIFFER IN THE EXPRESSION OF IKBΑ*","authors":"V. M. Nedoborenko, O. Shlykova, O. Izmailova, K. Ishcheikin, I. Kaidashev","doi":"10.31718/MEP.2018.22.3-4.04","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.3-4.04","url":null,"abstract":"Prerequisites and objective: Abdominal obesity is a common metabolic disease characterized by excessive accumulation of white adipose tissue, with excessive production of inflammatory mediators that activate transcriptional nuclear factors, in particular the nuclear factor kB. Hepcidin is the main hormone in the systemic regulation of iron. Its expression increases with elevated level of pro-inflammatory cytokines, as a result of which the concentration of iron in the blood plasma decreases, which reliably results in the activation of NF-kB. Therefore, the aim of the research was to determine the level of expression of ІКβα in subcutaneous adipose tissue in iron deficiency anemia concurrent with obesity. Methods: The study included 40 female women. Hemogram parameters, parameters of iron metabolism (serum iron, ferritin, hepcidin, total iron binding ability of serum, saturation of transferrin by iron) in serum and level of expression of the IkBα gene in subcutaneous adipose tissue were evaluated. Research results. The examined women had an average age of 40.3 ± 7.59 years. In the distribution of patients due to the cause and degree of severity of IDA, there was no reliable difference between the groups. The control group consisted of 10 obese women without IDA. Expression of IkBα by subcutaneous adipose tissue in female patients with IDA with and without obesity compared with the control group did not display a significant difference between the groups (p <0.05). In the course of correlation analysis, the expression of IkBα by subcutaneous adipose tissue to BMI, iron and hemogram rates did not have a correlated significance. Conclusion. Subcutaneous adipose tissue in women with iron deficiency anemia with and without obesity compared with obese women has no difference in expression of IkBα.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43254800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE DEVELOPMENT OF MEMBRANOUS PATHOLOGY OF HEPATOCYTES THE INFLUENCE OF INTOXICATION 肝细胞膜性病理的发展及中毒的影响

Problemi ekologiyi ta meditsini Pub Date : 2018-10-30 DOI: 10.31718/mep.2018.22.3-4.06

I. Bagmut, I. Kolisnyk, A. Titkova, Y. Rezunenko, O. Boiagina

{"title":"THE DEVELOPMENT OF MEMBRANOUS PATHOLOGY OF HEPATOCYTES THE INFLUENCE OF INTOXICATION","authors":"I. Bagmut, I. Kolisnyk, A. Titkova, Y. Rezunenko, O. Boiagina","doi":"10.31718/mep.2018.22.3-4.06","DOIUrl":"https://doi.org/10.31718/mep.2018.22.3-4.06","url":null,"abstract":"The study was performed at the Department of Clinical Pathophysiology, Topographical Anatomy and Operative Surgery at Kharkiv Medical Academy of Postgraduate Education as a part of research project \"Radiotoxins' pathochemical mechanisms and methods of early diagnostics and correction\", state registration No. 0117U000589. \u0000We studied the subtoxic effect of small doses of sodium fluoride on the activity of microsomal hepatocytes on 30 Wistar rats' populations in subacute experiment. The intensity of lipid peroxidation (LPO) in liver of rats which were administered sodium fluoride orally for a long time at doses of 1/10 and 1/100 LD50, was evaluated by the content of its molecular products - diene conjugates (DC), and MDA-reagents Schiff bases. We found that oral administration of sodium fluoride to rats at doses of 1/10 and 1/100 LD50 promotes a statistically significant increase (r≤0,002) relative to the control group of animals in DC content during the entire period of observation. At a dose 1/10 LD50 we observed the most significant increase in this indicator on the 10th day of the experiment - at 265%, and at a dose 1/100 LD50 – on the 20th day an average of 234%. In rats’ liver by the action of subtoxical dose of sodium fluoride at a dose of 1/10 LD50, starting from the 20th day, we detected a gradual increase (r≤0.001) of TBA-reagents relative to control - for 27, 41, 78, 133%. Secondary end products and lipid peroxidation, which are defined under the long-term of sodium fluoride, somehow contribute to the disruption of the microstructure of hepatocytes membranes, their permeability, reduce their division, regeneration and inhibition of mitochondrial respiratory chain enzymes and microsomal monooxygenase system.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46009816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

ПРИРОДНІ ПЕПТИДНІ КОМПЛЕКСИ ТИМУСА ТА НИРОК ПІДСИЛЮЮТЬ АПОПТОЗ ТРАНСФОРМОВАНИХ Т-КЛІТИН, АЛЕ НЕ ВПЛИВАЮТЬ НА ПРОЦЕСИ АПОПТОЗУ В-КЛІТИН 该团队的第一个上皮复合体是，神经正在从转化的T细胞中诱导细胞凋亡，除非它影响细胞的凋亡过程。

Problemi ekologiyi ta meditsini Pub Date : 2018-10-30 DOI: 10.31718/MEP.2018.22.3-4.07

Оксана Анатоліївна Шликова, Ольга Віталіївна Ізмайлова, Юлія Валеріївна Лисанець

{"title":"ПРИРОДНІ ПЕПТИДНІ КОМПЛЕКСИ ТИМУСА ТА НИРОК ПІДСИЛЮЮТЬ АПОПТОЗ ТРАНСФОРМОВАНИХ Т-КЛІТИН, АЛЕ НЕ ВПЛИВАЮТЬ НА ПРОЦЕСИ АПОПТОЗУ В-КЛІТИН","authors":"Оксана Анатоліївна Шликова, Ольга Віталіївна Ізмайлова, Юлія Валеріївна Лисанець","doi":"10.31718/MEP.2018.22.3-4.07","DOIUrl":"https://doi.org/10.31718/MEP.2018.22.3-4.07","url":null,"abstract":"Одним із найважливіших питань сучасної медицини є пошук методів регуляції програмованої загибелі клітин із метою розробки нових підходів до лікування, у тому числі раку та лейкемій. Гуморальна регуляція процесів апоптозу за допомогою цитокінів, гормонів, ростових факторів, пептидів посідає важливе місце серед механізмів регуляції апоптозу. Досліджено вплив природних пептидних комплексів тимусу та нирок на процеси апоптозу клітин HPB-ALL (гострий Т-клітинний лейкоз) та BJAB (лімфома Беркіта). Показано, що природні пептидні комплекси тимуса та нирок мають незначний стимулюючий вплив на апоптоз пухлинних В-клітин лінії BJAB у низьких концентраціях, а при збільшенні дози пептидів не впливають на процеси апоптозу; вірогідно підсилюють процеси елімінації трансформованих Т-клітин шляхом активації в них процесів апоптозу. При дії природного пептидного комплексу тимусу цей ефект має дозозалежний характер – зростає при збільшенні дози.","PeriodicalId":32911,"journal":{"name":"Problemi ekologiyi ta meditsini","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46037765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

THE STUDY OF PREVALENCE OF HYPERSENSITIVITY TO Β-LACTAM ANTIBIOTICS AMONG THE POPULATION OF UKRAINE 乌克兰人群对β-内酰胺类抗生素超敏反应的患病率研究

Problemi ekologiyi ta meditsini Pub Date : 2018-10-30 DOI: 10.31718/MEP.2018.22.3-4.03

A. V. Lavrenko, I. Kaidashev

引用次数: 0

ИЗУЧЕНИЕ РАСПРОСТРАНЕННОСТИ ГИПЕРЧУВСТВИТЕЛЬНОСТИ Β-ЛАКТАМНЫМ АНТИБИОТИКАМ СРЕДИ НАСЕЛЕНИЯ УКРАИНЫ 乌克兰人口对Φ-内酯抗生素过敏的研究

Problemi ekologiyi ta meditsini Pub Date : 2018-10-30 DOI: 10.31718/mep.2018.22.3-4.02

Анна Владимировна Лавренко, Игорь Петрович Кайдашев

引用次数: 0