双氯芬钠对骨髓细胞和外周血分化机制的影响:文献综述

Yu. Bahmut, O. S. Ivanov, G. V. Tsapko
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引用次数: 0

摘要

造血系统是由许多细胞组成的群体,这些细胞在体内发挥某些功能。制药行业从非甾体抗炎药中创造出新药,但“黄金”标准仍然是药物双氯芬酸钠。在某些情况下,一个人被迫长期服用这种药物,有时甚至终生服用。长期给药条件下药物对骨髓细胞作用的机制尚不清楚。在分析文献的过程中,已经确定该药物的使用对血细胞和造血器官有毒性作用。毒性作用逐渐减少,但该药物对大鼠机体的长期作用有助于抑制骨髓红细胞和髓细胞芽的发育。最长10天的使用期是最佳的,然后寻找一种对身体更安全的药物是值得的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
EFFECT OF DICLOFENAС SODIUM ON MECHANISMS OF DIFFERENTIATION OF BONE MARROW CELLS AND PERIPHERAL BLOOD: A LITERATURE REVIEW
The hematopoietic system is a population of many cells that perform certain functions in the body. The pharmaceutical industry creates new drugs from the group of nonsteroidal anti-inflammatory drugs, but the “gold” standard remains the drug Diclofenac Sodium. In some conditions, a person is forced to take the drug for a long time, and sometimes all life. The mechanism of the drug effect on the bone marrow cells under the condition of long-term administration remains unclear. In the process of analyzing the literature, it has been established that the use of the drug has a toxic effect on the blood cells and blood-forming organs. Gradually, the toxic effect is reduced, but the long-term effect of the drug on the rat organism contributes to the inhibition of the development of erythrocyte and myelocytic sprouts of the bone marrow. A period of up to 10 days is optimal for use, and then it is worthwhile to look for a drug that is safer for the body.
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