CLINICAL SIGNIFICANCE OF THE INFLUENCE OF CELL WALL ANTIGENS OF STAPHYLOCOCCUS AUREUS ON PHAGOCYTIC CELLS OF THE PERIPHERAL BLOOD IN CHILDREN WITH PURULENT AND INFLAMMATORY DISEASES OF STAPHYLOCOCCAL ETIOLOGY

Abstract

The paper examines the features of oxygen-dependent metabolism of peripheral blood phagocytes and the nature of its exposure to peptidoglycan and teichoic acid of Staphylococcus aureus. The study included 86 children with purulent and inflammatory processes of staphylococcal etiology aged from 7 months to 12 years and 14 apparently healthy children. The results of the study showed that in most children at the onset of the disease, an increase in the intensity of the oxygen-dependent metabolism of neutrophil granulocytes and monocytes was observed, which was manifested by elevated indicators of the spontaneous HCT test of these cells compared to healthy children. During the period of clinical recovery in children with an acute course of the disease, a significant decrease in spontaneous HST-test indicators was observed. In addition to the spontaneous HCT test, we also studied the indicators of the oxygen-dependent metabolism of neutrophil granulocytes and monocytes after incubation of these cells with cell wall antigens of Staphylococcus aureus – peptidoglycans and teichoic acids. The results of the study showed that after incubation, no significant difference was found between them and the indicators of the spontaneous HCT test. In the period of convalescence in children with acute bronchopneumonia, acute purulent otitis media, acute tonsillitis, a decrease in indicators of oxygen-dependent metabolism was observed after incubation of monocytes with teichoic acids compared to spontaneous indicators. Thus, the effect of cell wall antigens of Staphylococcus aureus on the oxygen-dependent metabolism of neutrophil granulocytes and monocytes of peripheral blood was different. At the beginning of the development of the pathological process, reliable inhibition of the oxygen-dependent metabolism of phagocytes by antigens of the cell wall of Staphylococcus aureus was observed in all clinical groups. In the acute course at the beginning of the disease, the suppression of HST-test indicators was somewhat greater than in the exacerbation of the chronic process. During the recovery of patients with an acute purulent-inflammatory process, reliable inhibition of the oxygen-dependent metabolism of neutrophil granulocytes and monocytes by cell wall antigens of Staphylococcus aureus was not observed, and in children with an exacerbation of the chronic pathological process, the inhibition of the indicators of the HCT test of neutrophil granulocytes and monocytes remained reliably higher and almost did not change compared to the onset of the disease.