Folia Medica Indonesiana最新文献

{"title":"Selected Vegetables and Spices Improve DNA Quality and Histopathological Abnormalities in Roof Rats (Rattus rattus) Exposed to Cement Dust","authors":"T. Yahaya, T. Salisu, Mohammed N. Musa, A. Izuafa, Chidi Obi, Samuel S. Ribah, Suleiman Abubakar","doi":"10.20473/fmi.v59i2.42346","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.42346","url":null,"abstract":"Highlights:\u00001. This study identified feasible and affordable alternatives to ineffective conventional cement production pollution control strategies.2.M. oleifera, H. sabdariffa, T. occidentalis, and Z. officinale are effective as personal interventions to ameliorate the effects of cement pollution. \u0000Abstract\u0000Conventional pollution control strategies in the cement industry have proven ineffective. As a result, effective and targeted complementary interventions are necessary. This study used roof rats (Rattus rattus) inhabiting the premises of a cement plant in Sagamu, Ogun State, Nigeria, to evaluate the ameliorative effects of moringa (Moringa oleifera), roselle (Hibiscus sabdariffa), fluted pumpkin (Telfairia occidentalis), and ginger (Zingiber officinale) on cement dust exposure. A total of 42 rats were divided into seven groups, with each group consisting of six rats. Group 1 served as the negative control group and was not exposed to any substances, while group 2 served as the positive control group and received standard feed throughout the experiment. Meanwhile, groups 3, 4, 5, 6, and 7 served as the experimental group. Rats in these groups were fed with 400 mg/kg of ethanolic extracts of Z. officinale, M. oleifera, T. occidentalis, H. sabdariffa, and a mixture of the four extracts with a composition of 1:1:1:1, respectively, for 90 days. The plasma DNA concentrations, DNA purity, and lungs of the rats were examined before and after the experiment. Prior to the experiment, the exposed rats had higher plasma DNA concentrations and lower DNA purity, as well as severe fibrosis and congested alveoli in their lungs, compared to the unexposed rats. At the end of the experiment, the experimental groups showed a significant increase in DNA purity (p≤0.05) and a decline in plasma DNA concentrations compared to the positive control group. In addition, the experimental groups showed fewer histopathological abnormalities than the positive control group. The mixture of the extracts yielded the most favorable results, followed by the extracts of Z. officinale, M. oleifera, T. occidentalis, and H. sabdariffa, respectively. These findings suggested that the selected vegetables and spices have the properties to ameliorate the effects of cement dust exposure. Therefore, individuals residing in close proximity to cement plants are encouraged to consume these vegetables and spices.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43339031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Purple Sweet Potato (Ipomoea Batatas L.) Ethanol Extract on Bladder Urothelial Layer and Smooth Muscle Thicknesses in Menopausal Female Wistar Rats","authors":"Bismantara A. Putra, K. Santosa, W. Niryana, Nyoman Golden, Gede Wirya, Kusuma Duarsa, Ida Bagus, Made Suryawisesa","doi":"10.20473/fmi.v59i2.44621","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.44621","url":null,"abstract":"Highlights:\u0000\u0000Purple sweet potatoes cultivated in Bali, Indonesia, were found to be rich in phytoestrogen due to the high levels of anthocyanin-type flavonoids. \u0000The phytoestrogen in purple sweet potato ethanol extract demonstrated estrogenic activity and the potential to substitute hormone replacement therapy (HRT) as the treatment of lower urinary tract symptoms. \u0000\u0000Abstract\u0000Postmenopausal women experience estrogen hormone deficiency, which can cause thinning of the smooth muscle and urothelial layer of the bladder, leading to lower urinary tract symptoms (LUTS). Hormone replacement therapy (HRT) has been the primary choice for addressing these problems. However, long-term prescription of HRT can result in several adverse effects, including a higher risk of breast cancer and cardiovascular diseases. Phytoestrogen, an estrogen-like compound derived from plants such as purple sweet potatoes (Ipomoea batatas L.), contains anthocyanin that could serve as a better alternative to estrogen replacement therapy. This study aimed to demonstrate the effects of phytoestrogens in purple sweet potatoes on the histomorphology of the bladder in menopausal female Wistar rats (Rattus norvegicus). This experimental study used a posttest-only control group design. A total of 36 Wistar rats undergoing ovariectomy were randomly assigned into two groups, with 18 samples in each group. The experimental group received the purple sweet potato ethanol extract orally, while the control group received a placebo. The structures of the smooth muscle and urothelial layer of the bladder were observed using a microscope. Data were analyzed using an independent t-test to compare bladder smooth muscle and urothelial layer thickness between groups, with a significance of p<0.05. A normality test was performed to determine the normal distribution of the data. Normally distributed data were assessed to find the mean and standard deviation (SD). Significant differences were found in the mean thickness of the smooth muscle and urothelial layer between both groups (p=0.00), with both being thicker in the experimental group. In conclusion, phytoestrogens in purple sweet potatoes can influence the histomorphology of the bladder. Ovariectomized female Wistar rats that received purple sweet potato ethanol extract exhibited thicker smooth muscle and urothelial layer of the bladder. ","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48051873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improvement of Cadres' Skills and Knowledge to Provide Comprehensive Health Services for the Elderly","authors":"Lilik Djuari, Linda Dewanti, Sulistiawati, Natasya Nurvita Brilianti, Farhan Nurdiansyah, S. Prajitno","doi":"10.20473/fmi.v59i2.39896","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.39896","url":null,"abstract":"Highlights:\u0000\u0000Due to the increasing elderly population in Indonesia, this study must address the knowledge and skill gaps among health cadres in a number of Integrated Health Posts for the Elderly (Pos Layanan Terpadu Lanjut Usia/ Posyandu Lansia). \u0000Through this study, the health cadres increased their knowledge and skills, enabling them to provide comprehensive health services for the elderly. \u0000\u0000Abstract\u0000Numerous issues have arisen as a result of the large size and rapid growth of the elderly population, attesting to the need for serious efforts from all sectors to enhance their welfare. However, the health cadres at the Integrated Health Post for the Elderly (Pos Layanan Terpadu Lanjut Usia/ Posyandu Lansia) lacked the training that would have equipped them with the necessary knowledge and skills to carry out their duties. This study aimed to evaluate the significance of training for enhancing the cadres' knowledge and skills in providing comprehensive health services for the elderly. This study was quasi-experimental research with a pre-test and post-test design. The data analysis was performed using the Shapiro-Wilk test (p>0.05) and the Wilcoxon test (p<0.05). A total of 30 health cadres at Songgon Community Health Center were measured for their levels of knowledge and skills before and after the training. The training included filling out health evaluation charts, providing leaflets containing health counseling materials for the elderly, practicing exercise for the elderly, and singing an elderly marching song. Before filling out the health evaluation chart, the cadres had to measure the elderly's degree of independence as well as their mental, emotional, and nutritional status. The cadres also had to measure the weight, height, and blood pressure of the elderly. Prior to training, the cadres' knowledge of hospitalization referrals, independence, and physical exercise for the elderly was limited. The cadres' skills in filling out health evaluation charts, assessing mental, emotional, and nutritional status, measuring blood pressure, and instructing physical exercise were also inadequate. There was a significant difference in the knowledge and skills of the health cadres before and after training (p<0.05). In conclusion, there was an improvement in the health cadres' knowledge and skills regarding comprehensive health services for the elderly at the Posyandu Lansia.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44571507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Detection of Knockdown-Resistance Homozygous Mutant C1534C using Allele-Specific Polymerase Chain Reaction in Aedes Albopictus and Aedes Aegypti","authors":"Syananda Zahra Fadila, A. Setiawan, S. Fauziyah, Safira Madaniyah, Eryantika Cipta Dewi, S. E. Cahyaningrum, Tukiran, T. H. Sucipto, Teguh Hari, Sucipto","doi":"10.20473/fmi.v59i2.39802","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.39802","url":null,"abstract":"Highlights:\u0000\u0000 This research analyzed a previously understudied subject in Surabaya, Indonesia, and discovered knockdown resistance (kdr) mutations in Aedes albopictus.\u0000 The findings of this study can prompt further research, including bioassay testing and the development of more potent insecticides.\u0000\u0000Abstarct :\u0000Dengue hemorrhagic fever (DHF) has been endemic in Indonesia for decades. Insecticides are necessary to manage the transmission of the dengue virus. However, prolonged use of insecticides can lead to insecticide resistance. This study aimed to examine the genotype of mosquitoes using the allele-specific polymerase chain reaction (ASPCR) method. The ASPCR method was chosen for genotype detection due to its high sensitivity, affordability, and ease of design. Five mosquitoes were collected from human habitation in four different areas of Surabaya, Indonesia, namely Kranggan, Ulul Azmi Mosque, Ploso, and Kalijudan. Among them, three samples were identified as Aedes albopictus (A1, A2, and A5) and two samples were identified as Aedes aegypti (A3 and A4). The frequency of resistant alleles was analyzed using the Hardy-Weinberg package in RStudio version 2023.03.1. This study revealed that two mosquitoes carried homozygous mutant alleles with a band of 113 bp and three mosquitoes carried homozygous wild-type alleles with a band of 93 bp. Cysteine-to-cysteine (C/C) mutations and phenylalanine-to-phenylalanine (F/F) mutations at codon 1534 were observed in Aedes aegypti and Aedes albopictus mosquitoes. The homozygous mutant alleles were found in Kranggan, Surabaya, Indonesia. Further research is required to assess insecticide resistance and knockdown resistance (kdr)-like mutation by collecting more representative samples from larger areas within the region of Surabaya. Nevertheless, this study can be used as a reference for vector control and early prevention of dengue fever.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45692944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bacterial Profile and Antibiotic Use in Catheter-Associated Urinary Tract Infection Patients at a Tertiary Referral Hospital in Surabaya, Indonesia","authors":"Ahmad Veri Erianto, T. Asmarawati, Agung Dwi, Wahyu Widodo, Brian Eka","doi":"10.20473/fmi.v59i2.39919","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.39919","url":null,"abstract":"Highlights:\u0000\u0000 This study examined patients with catheter-associated urinary tract infections (CAUTI) to find the prevalent bacteria and the frequency of antibiotic use.\u0000 Extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli sensitive to amikacin was found to be the most common pathogen in CAUTI, while ceftriaxone was the most commonly used antibiotic.\u0000\u0000Abstract\u0000Catheter-associated urinary tract infection (CAUTI) is the most typical type of infection associated with healthcare. This infection constitutes a significant health problem due to its complications and frequent recurrence. The high annual incidence of CAUTI leads to infectious complications and a high cost of treatment. Antibiotic-resistant bacteria further complicate the problem because multiresistant pathogenic bacteria are often responsible for these infections. Moreover, the lack of a comprehensive case reporting system in Indonesia hinders the determination of CAUTI incidence. This study aimed to determine the bacterial profile and antibiotic use in CAUTI patients (n=22) at the Internal Medicine Inpatient Unit of Dr. Soetomo General Academic Hospital, Surabaya, Indonesia. This retrospective descriptive study collected data from patient medical records to describe the incidence, type of bacteria, sensitivity patterns, and antibiotic use in CAUTI patients. The data collection process included collecting medical records, recording information on data collection sheets, and recapitulating and analyzing the data. The criteria for CAUTI diagnosis were a bacterial count of ≥105 CFU/mL and a catheterization that lasted more than 48 hours. Samples were selected using non-probability sampling, also known as saturation sampling. Meanwhile, variables analyzed in this study were the type of pathogenic bacteria, antibiotics used, age, and sex. Descriptive analysis was employed to analyze the data. The findings suggested that the most common bacteria were Escherichia coli, with eight of nine bacteria showing extended-spectrum beta-lactamase (ESBL) production. Female patients aged 35–65 years were the majority of the CAUTI patients. Amikacin was the antibiotic with the highest sensitivity (90.9%), while ceftriaxone was the most common type of antibiotic administered to the patients. In addition, intravenous (IV) administration was the most common route of antibiotic administration, with an average therapy duration of seven days. In conclusion, identifying the type of pathogenic bacteria and performing antibiotic susceptibility testing can help minimize antibiotic resistance and prevent more severe complications in CAUTI patients. ","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45856440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Cabbage (Brassica oleracea var. capitata L.) Extract on Macrophage and Blood Vessel Counts in Clean Wound Tissue of Male Rats (Rattus norvegicus)","authors":"Nidya Ulfiana Tsania, Willy Sandhika, Sawitri","doi":"10.20473/fmi.v59i2.39922","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.39922","url":null,"abstract":"Highlights :\u0000\u0000 Cabbage extract application accelerates wound healing and has anti-inflammatory effect.\u0000 Cabbage extract serves as an affordable source material for wound healing and anti-inflammation.\u0000\u0000Abstract \u0000Cabbage is a widely consumed vegetable known for its health benefits due to its rich nutrients and phytochemicals, especially phenolic compounds, which are known to have potent anti-inflammatory and antioxidant effects. This study aimed to investigate the effects of cabbage extract on wound healing by observing inflammatory responses in wound tissue. A total of 24 male rats were divided into four groups, with six rats in each group. The experiment was conducted for five days by administering cabbage extract to the treatment group and distilled water to the control group. Skin wound tissues were collected from all rats for histological observation by counting the number of macrophages and blood vessels. The results of the observation were analyzed statistically using an independent sample t-test with p<0.05. The results showed that the number of macrophages and blood vessels in the treatment group was significantly higher than the control group on the third day and significantly lower on the fifth day. In conclusion, the administration of cabbage extract can accelerate the inflammatory and proliferative phases of wound healing by promoting the migration of cells, including macrophages, resulting in accelerated angiogenesis. In addition, the decreased number of macrophages and blood vessels during the proliferative phase showed that the healing phase had reached a more advanced stage. ","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46448393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Moringa oleifera Leaf Extract on the Liver of Experimentally-Induced Diabetic Wistar Rats","authors":"Wahyu Ikhsan, S. Suryono, A. Purwandhono","doi":"10.20473/fmi.v59i2.37526","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.37526","url":null,"abstract":"Highlights:\u0000\u0000 This study examined the antioxidant flavonoid compounds derived from naturally sourced Moringa oleifera leaves.\u00002. Moringa oleifera leaf extract was able to prevent tissue fibrosis and liver cirrhosis in diabetic rat models through the nonalcoholic fatty liver disease (NAFLD) pathway.\u0000\u0000Abstract:\u0000Diabetes mellitus is known as a risk factor for nonalcoholic fatty liver disease (NAFLD) which can progress to nonalcoholic steatohepatitis (NASH) and eventually lead to hepatocellular carcinoma (HCC) through various stages, including necro-inflammatory fibrosis, cirrhosis, and hepatitis. M. oleifera leaves contain flavonoid antioxidants, which inhibit reactive oxygen species (ROS) and oxidative stress in diabetes mellitus. This study aimed to investigate the potential of M. oleifera leaf extract at a dosage of 1,000 mg/kgbw to inhibit liver tissue fibrosis in diabetic rats. This study used a true experimental method with a post-test-only control group design. This study was conducted at the Faculty of Medicine, Universitas Jember, Jember, Indonesia, from November 2021 to January 2022 on 27 male Wistar rats that were divided into three groups of nine rats. The rats were induced with streptozotocin and M. oleifera leaf extract at a dosage of 1,000 mg/kgbw. Masson's trichrome staining and the Meta-analysis of Histological Data in Viral Hepatitis (METAVIR) scoring system were used to measure liver tissue fibrosis. Data were analyzed using the Kruskal-Wallis and Mann-Whitney tests to examine significant differences between groups. The results showed a significant difference in the degree of liver tissue fibrosis between the control and diabetes groups (p=0.00) as well as the diabetes and treatment groups (p=0.003). However, the results did not show any significant differences between the control and treatment groups (p=0.270). These findings suggested that administering M. oleifera leaf extract at a dosage of 1,000 mg/kgbw can inhibit liver tissue fibrosis. In conclusion, this study provides evidence that administering M. oleifera leaf extract can inhibit liver tissue fibrosis in diabetic rats. ","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46524944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Workload Indicators of Staffing Need (WISN) for the Required Estimation of Nursing Staff in a Hemodialysis Unit","authors":"Feli Clarisa, Winvi Sri, Lestari Ramadhani, Nasution, Chrismis Novalinda, Ginting, Sri Lestari, Ramadhani Nasution","doi":"10.20473/fmi.v59i2.42309","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.42309","url":null,"abstract":"Highlights:\u0000\u0000This article presents an understudied topic of nursing workloads in a hemodialysis unit and concludes that directly and indirectly productive activities occupied the majority of the nurses' working time. \u0000An analysis using the Workload Indicators of Staffing Need produced a general report that may prompt re-evaluation of nursing staff requirements and policy-making for workload distribution. \u0000\u0000Abstract\u0000The number of hemodialysis patients continues to increase almost every month, while the number of nurses in the Hemodialysis Unit at Rasyida Renal Specialist Hospital, Medan, Indonesia, remains constant. This situation has increased the nurses' workload and responsibilities. Therefore, it is necessary to examine the balance between the workload and the number of required nursing staff in the Hemodialysis Unit at Rasyida Renal Specialist Hospital. This study aimed to identify the optimal number of nursing staff required in the Hemodialysis Unit at the hospital in 2022. This study used a mixed-methods approach using the Workload Indicators of Staffing Need (WISN) method. This study included 44 nurses working in the Hemodialysis Unit at Rasyida Renal Specialist Hospital. Primary data included questionnaires, observations, and interviews during working hours, while secondary data included document reviews and staffing data. WISN calculations showed that the Hemodialysis Unit required a total of 65 nursing staff. In other words, an addition of 21 nursing staff was needed to meet the current workload. In conclusion, the current human resources available are not sufficient, and the workload is beyond the capacity of the nursing staff at the hospital. ","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48172309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress Levels and Seborrheic Dermatitis in the Class of 2020 Medical Students at a University in Indonesia","authors":"Eldy, Hari Darmawan","doi":"10.20473/fmi.v59i2.41208","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.41208","url":null,"abstract":"Highlights:\u00001. This research investigated a previously unexplored relationship between stress levels and seborrheic dermatitis in Indonesia.2. It has been shown that a significant proportion of medical students are susceptible to sleep problems, which can negatively impact their academic performance and mental health.3. This recent study found that seborrheic dermatitis affects men on average more frequently than women.\u0000 \u0000Abstract :\u0000Seborrheic dermatitis is a common skin disease in the form of superficial inflammation with a papulosquamous morphology that often occurs in sebaceous gland-rich areas. Emotional stress is one of the contributing factors to the susceptibility of individuals to seborrheic dermatitis, while lack of sleep is associated with its exacerbation. This study aims to investigate the relationship between stress levels and seborrheic dermatitis cases among the class of 2020 students at the Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia. This study used an analytical-observational approach with a cross-sectional design. The sampling technique used was simple random sampling. The samples were from 114 medical students from the class of 2020 at Universitas Tarumanagara. The data were collected using an online Google Forms questionnaire and a dermatological assessment. The data were analyzed through statistical software, IBM SPSS Statistics for Windows, version 26.0 (IBM Corp., Armonk, N.Y., USA), using the Chi-square hypothesis test. The results showed a significant relationship between sex and seborrheic dermatitis cases (p=0.000). However, there was no significant relationship between stress levels and seborrheic dermatitis cases among the respondents (p=0.591). In conclusion, factors other than stress levels might contribute to the development or exacerbation of seborrheic dermatitis among the participants. Further research is needed to explore the potential underlying mechanisms and additional factors influencing the development and progression of seborrheic dermatitis. ","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46413752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Calciferol Status and Clinical Outcomes in Children with Congenital Heart Disease after Heart Surgery","authors":"Zulham Effendy, Tri Yanti Rahayuningsih, Fachrul Razi, Hendra Kurniawan, Azmi, Farhan Marzuki, Herdianta, Rovy Pratama","doi":"10.20473/fmi.v59i2.44534","DOIUrl":"https://doi.org/10.20473/fmi.v59i2.44534","url":null,"abstract":"Highlights:\u0000\u0000Calciferol has cardioprotective properties, and a severe deficiency of calciferol is associated with septic shock, a longer duration of mechanical ventilation and treatment in the intensive care unit, and mortality. \u0000The role of calciferol in critical conditions has been described in several research reports, but relatively little is known about its function in pediatric cardiac surgery. \u0000\u0000Abstract\u0000Calciferol is a micronutrient and a secosteroid hormone that plays a role in maintaining the health of bones and soft tissues in the body, such as the myocardium, as well as the immune system. Hypovitaminosis D has been reported to be associated with poor clinical outcomes and child mortality in pediatric intensive care units. Children with congenital heart disease (CHD) are vulnerable to critical conditions and require early intervention due to heart failure. This study aimed to investigate the influence of calciferol status on the clinical outcomes of pediatric CHD patients who underwent heart surgery. A systematic literature review was conducted using the electronic databases from PubMed, Elsevier, and Cochrane. This study included observational and randomized control studies that assessed the calciferol status of pediatric CHD patients undergoing cardiac surgery. From a total of 168 studies, 8 studies were selected for review. The preoperative and postoperative calciferol status as well as clinical outcomes following pediatric cardiac surgery were reviewed. According to the findings, most pediatric CHD patients suffered from calciferol deficiency prior to corrective heart surgery, which further decreased postoperatively and was associated with clinical outcomes in the intensive care unit (ICU). Preoperative calciferol supplementation has been reported to enhance serum calciferol levels and is associated with good clinical outcomes in pediatric patients undergoing cardiac surgery.","PeriodicalId":32666,"journal":{"name":"Folia Medica Indonesiana","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42775836","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}