Journal of Current Research in Scientific Medicine最新文献

{"title":"A child with respiratory distress and chocolate brown arterial blood","authors":"Fanny Amalraj, P. Jose, S. Ponnarmeni, Peter Prasanth Kumar Kommu","doi":"10.4103/jcrsm.jcrsm_87_22","DOIUrl":"https://doi.org/10.4103/jcrsm.jcrsm_87_22","url":null,"abstract":"Methemoglobinemia is a hemoglobinopathy that occurs when the heme is oxidated. Ferric iron in oxidized heme cannot bind and transport oxygen. Hence, when the concentration exceeds 15%, symptoms start with cyanosis, distress, and tachypnea, and may progress to seizure, unconsciousness, and even death as the concentration increases. Congenital methemoglobinemia is rare and often clinically missed but responds well with medications. Here, the case of a 12-year-old girl with respiratory distress and no cyanosis is being reported. The diagnosis was made based on a chocolate brown-colored arterial blood sample taken for analysis. The importance of considering this condition as a differential diagnosis in a case of respiratory distress of unknown etiology is being discussed here.","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"199 1","pages":"72 - 74"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81081588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Revisiting the use of antenatal corticosteroids for late preterm and early term infants: An observational analytical study","authors":"Shiny Rugmini, Femitha Pournami, A. Prithvi, Anand Nandakumar, Jyothi Prabhakar, Naveen Jain","doi":"10.4103/jcrsm.jcrsm_75_22","DOIUrl":"https://doi.org/10.4103/jcrsm.jcrsm_75_22","url":null,"abstract":"Background: Guidelines from prominent policymakers on the use of antenatal steroids (ANS) in “late preterm deliveries and early term casearian deliveries” (LET) are nonuniform. This descriptive study compared LET infants born during two-time epochs: Retrospective: ANS exposed (ANSE) (when institute practice was to administer ANS to all LET mothers), and prospective – ANS unexposed (ANSU) (after the policy was revised in May 2021). Methodology: All antenatal mothers of anticipated late-preterm and early-term cesarean deliveries were being administered ANS before May 2021. Following the revision of hospital policy, this practice was discontinued. Comparative analysis for respiratory morbidity (RM) and other clinically relevant outcomes were conducted in infants born during two-time epochs (ANSE vs. ANSU). Results: Among 379 included infants, those with RMs were comparable between groups: 33 (17.5%) in ANSE; 31 (16.4%) in ANSU – Odds ratio (OR) 1.08; 95% confidence interval (CI) (0.61–1.92), P = 0.78. No difference was noted in hypoglycemia events: 23 (12.2%) in ANSE; 22 (11.6%) in ANSU, OR = 1.05 95% CI (0.56–1.96), P = 0.87. Conclusion: ANS in LET did not seem to reduce the risk of RM. It may be appropriate to audit individual unit practices and relevant outcomes before blanket recommendations are made.","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"18 1","pages":"24 - 28"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88379459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Journal of Current Research in Scientific Medicine: Past, present and future","authors":"Parthasarathy Ramamurthy, R. Kanungo","doi":"10.4103/jcrsm.jcrsm_29_23","DOIUrl":"https://doi.org/10.4103/jcrsm.jcrsm_29_23","url":null,"abstract":"","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"53 1","pages":"1 - 4"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76466668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of I-gel™ versus Baska mask® on oropharyngeal sealing pressure in patients receiving general anesthesia under spontaneous ventilation: A randomized controlled trial","authors":"Bhimala Ramya, S. Dav, S. Segaran, D. Sivaramakrishnan, M. Zachariah, R. Ranjan","doi":"10.4103/jcrsm.jcrsm_84_22","DOIUrl":"https://doi.org/10.4103/jcrsm.jcrsm_84_22","url":null,"abstract":"Background: Baska mask® is a newer third-generation supraglottic airway device (SAD) having a self-sealing membranous cuff that does not require inflation. Oropharyngeal sealing pressure (OSP) is used to quantify the efficacy of airway sealing in SAD. Our primary objective was to compare OSP between Baska mask® and I-gel™ in patients receiving general anesthesia on spontaneous ventilation. The secondary objectives were to determine the ease, duration, number of attempts during insertion, hemodynamic responses, and perioperative complications. Methodology: Fifty patients scheduled for a variety of surgical procedures lasting up to 90 min under general anesthesia were randomly allocated to one of the two groups, Group B (Baska mask®) and Group I (I-gel™). Data were collected and entered into an Excel sheet. Statistical analysis was performed using SPSS. Statistical tests used were Student's unpaired t-test, Mann–Whitney U-test, and Fisher's exact test. P < 0.05 was considered statistically significant. Results: The OSP was significantly higher in Group B than in Group I (29.4 ± 6.01 vs. 26.32 ± 4.26 cmH2O, respectively) (P = 0.042). The number of attempts, mean duration, and grade of ease of insertion in both groups had no statistical difference. Hemodynamic parameters were not significantly different between both groups. No postoperative complications were noticed in either group. Conclusion: Baska mask® offers a superior airway sealing pressure compared to I-gel™ without significant hemodynamic changes, with equal first-pass success rate and postoperative complications.","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"84 1","pages":"36 - 41"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85969394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Loss to follow-up of cervical cancer screening program beneficiaries at Rural Health Training Center in South India – An explanatory mixed method study","authors":"Subalakshmi Subramaniyan, R. Sindhuri, Reena Mohan, K. Ganapathy, Jayasree Manivasakan","doi":"10.4103/jcrsm.jcrsm_97_22","DOIUrl":"https://doi.org/10.4103/jcrsm.jcrsm_97_22","url":null,"abstract":"Background: In India, routine Pap smear screening is an ongoing process for the detection of cervical cancer, but the follow-up component remains unaddressed. The objectives of the present study were to find out the proportion of abnormal Pap smear results among women aged 30 years screened through the cervical cancer screening program at RHTC, their follow-up status, and explore the reasons and solutions for loss to follow-up (LTFU). Methodology: An explanatory mixed-method study (quantitative: A record-based cohort study followed by qualitative: Five in-depth interviews with loss to follow-up patients and 14 key informant interviews with stakeholders who were purposively selected to identify barriers and possible solutions for LTFU using an interview guide) was conducted in RHTC over 3 months. Ethical principles were adhered to. Results: The results showed that 307 of the 1328 women screened had abnormal Pap smear results. Of the 31 women with precancerous lesions, 26 (83.9%) were on regular follow-ups, and 5 (16.1%) were on irregular follow-ups. Manual content analysis showed five broad categories as barriers to LTFU, namely: (1) general awareness and practical issues; (2) family-related issues; (3) economic issues; (4) cultural issues; and (5) healthcare-associated issues. Community-level awareness generation for capacity building through health education constantly; displaying creative health information models (information, education, and communication); a positive deviance approach; a family and partner-centered approach; the formation of support groups; proactive intervention; and an incentive-based follow-up approach were possible solutions to mitigate the rate of LTFU. Conclusion: Improper knowledge, socio-cultural myths, and a lack of support from partners and family members were the main barriers identified for LTFU. Hence, to strengthen the follow-up component after the initial screening test, periodical sensitization and initiating an incentive-based follow-up approach should be recommended.","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"22 1","pages":"53 - 60"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78008580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Spontaneous rupture of pyogenic splenic abscess in infective endocarditis","authors":"Prashant Ahlawat, Gautam Jesrani, S. Mukherjee, Monica Gupta","doi":"10.4103/jcrsm.jcrsm_19_23","DOIUrl":"https://doi.org/10.4103/jcrsm.jcrsm_19_23","url":null,"abstract":"Infective endocarditis (IE) has various cardiac and extracardiac complications, which include metastatic abscesses of the solid organs such as the liver, kidney, brain, and spleen. Splenic abscess in IE is an uncommon entity, and spontaneous rupture of a large abscess in a newly diagnosed patient with IE is infrequently described in the literature. A 42-year-old male presented to us with a fever and worsening pain in his left upper quadrant. A detailed evaluation led to the diagnosis of IE and a large pyogenic splenic abscess. The blood culture had a growth of Escherichia coli. He was managed initially with intravenous antibiotics, but an urgent laparotomy and splenectomy were undertaken as he deteriorated and developed shock. Unfortunately, despite a prompt surgical intervention, he succumbed to the illness due to persistent postoperative shock. The case describes the catastrophic complications of IE and broadens the understanding of its complication spectrum.","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"13 1","pages":"75 - 78"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81496743","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A cross-sectional study to assess the post-traumatic stress disorder among discharged coronavirus disease-19-infected individuals in Karnataka, Southern India","authors":"Kishore S. Gudegowda, Riya George, Iswarya Partheeban, Ranganath T Sobagaiah","doi":"10.4103/jcrsm.jcrsm_77_22","DOIUrl":"https://doi.org/10.4103/jcrsm.jcrsm_77_22","url":null,"abstract":"Background: Posttraumatic stress disorder (PTSD) is a mental disorder that may develop after exposure to a horrifying or traumatic event. India reported a high number of cases worldwide during the waves of the coronavirus disease-19 (COVID-19) pandemic. Even though a high prevalence of PTSD is expected among hospitalized COVID-19 patients, only a very few studies have addressed the issue till now. The objectives of the study were to assess the prevalence and risk factors associated with PTSD among discharged COVID-19-infected individuals from a designated COVID-19 hospital in Karnataka. Methodology: A cross-sectional study was conducted among a total of 120 patients who were discharged after recovery from a designated COVID-19 hospital in Karnataka. Multistage random sampling was done, and equal representation was ensured from all the zones as per the hospital protocol from April 2021 to June 2021. Telephonic interviews with the subjects were conducted; participants were evaluated for PTSD using a semi-structured, prevalidated questionnaire (impact of events scale-revised) after 1 month of discharge from the hospital. Results: The prevalence of PTSD was found to be 29.16%. PTSD was more commonly associated among the middle age group, presence of comorbidities, and with an increased number of days of hospitalization stay especially in ICU with the ventilator. Conclusions: Studying PTSD and its associated factors is necessary to inform about the COVID-19 prognosis. Physicians treating the patient and caretakers of patients should be aware of PTSD risk and should consider PTSD Screening.","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"1 1","pages":"29 - 35"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88697086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicomicrobiological profile of mycotic keratitis patients presenting at a tertiary care hospital of rural North India","authors":"Jyoti Sangwan, K. Lohan, Manpreet Kaur, Y. Kumar, Nishtha Saini, Prof. Vanita Mane, P. Singla, Sameena Khan","doi":"10.4103/jcrsm.jcrsm_64_22","DOIUrl":"https://doi.org/10.4103/jcrsm.jcrsm_64_22","url":null,"abstract":"Background: Mycotic keratitis (MK) or keratomycosis is an infection of corneal stroma caused by a variety of fungal species. It is a condition resulting in blindness if untreated seen, especially in tropical and subtropical countries. The identification of causative fungus is key to starting appropriate treatment. This study aimed to describe clinicomicrobiological profile along with associated demographic factors of MK patients presenting at a tertiary care hospital situated in rural North West India. Methodology: A cross-sectional study was conducted for 3 years from June 2018 to June 2021 at a tertiary care hospital situated in rural North India after obtaining ethics committee approval. After obtaining informed consent, a detailed history was taken from suspected MK patients. Then, corneal scrapings were taken under the slit lamp and processed in the microbiology laboratory for isolation and identification of causative agents. The results obtained were analyzed. Results: A total of 114 nonrepetitive samples were collected from patients suspected of keratomycosis during the study period. Eighty-one (71.1%) samples were found to be positive for fungal growth. Males were affected more than females (1.53:1). Individuals belonging to the age group of 21–40 years were involved the most. Farmers (48.1%) were affected most of all. The predominant fungal species isolated was Candida followed by Aspergillus and Fusarium. Conclusion: The present study highlights the different etiology of MK across different geographical regions. Candida spp. was the most common etiological agent observed in the study followed by Aspergillus and Fusarium spp. Its prevalence, risk factors, and causative agents involved vary with geographic variation, occupation, and local prevailing practices. Timely diagnosis can get an individual the right treatment and can save the vision.","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"7 1","pages":"42 - 47"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82314966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enhancing the interpretational skills of complete blood count reports by second year medical students using competency based learning method","authors":"R. Varghese, Niraimathi Manickam, A. Mohanraj","doi":"10.4103/jcrsm.jcrsm_21_23","DOIUrl":"https://doi.org/10.4103/jcrsm.jcrsm_21_23","url":null,"abstract":"Background: Competency-based learning can help improve the skills of medical students to interpret lab reports like complete blood counts (CBCs). The objectives of this study were to assess whether “hands-on training” on interpreting the CBC reports is useful and to evaluate the students' and faculty's feedback on their experience based on the Kirkpatrick four-level training model. Methodology: Second-year MBBS students were initially assessed on the knowledge they already had regarding the interpretation of CBC reports, which they had learned in Physiology (T1). They were then divided into two groups as study (S) and control (C) groups. Study group students alone were given “hands-on training” to interpret CBC reports. Then, both the groups were assessed using objectively structured practical examination (OSPE) (T2). The control group was given the same training on another day. Then, both the groups were assessed using OSPE 1 month later (T3). Both the pretraining and posttraining scores were analyzed using repeated measures analysis of variance. Results: The mean scores differed significantly over time points. In the study group (Group A), the scores from pretraining (T1) to posttraining (T2) (P = 0.001), pretraining (T1) to 1 month later (T3) (P = 0.001), pretraining (T1) to 1 month later (T3) (P = 0.001), and posttraining (T2) to 1 month later (T3) (P = 0.001) were significant. However, in the control group (Group B), the scores from pretraining (T1) to 1 month later (T3) (P = 0.001) and posttraining (T2) to 1 month later (T3) (P = 0.001) were significant, but not from pretraining (T1) to posttraining (T2). Between the study and control groups, the difference in scores at pretraining (P = 0.001) and posttraining (P = 0.001) was significant, but not for the test 1 month later (35.5 ± 11.6 vs. 37.2 ± 10.7). Conclusion: Competency-based learning enhanced the student's interpreting skills of CBC reports, which will be useful in their career as doctors.","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"84 1","pages":"48 - 52"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80826124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A One-Pot Synthesis of Sulfonyl Amidinesvia Three-Component Reaction Under Mild and Solvent-Free Conditions","authors":"Chiaa Adiche, D. El Abed","doi":"10.14302/issn.2766-8681.jcsr-21-3805","DOIUrl":"https://doi.org/10.14302/issn.2766-8681.jcsr-21-3805","url":null,"abstract":"A convenient one-pot synthetic protocol for the preparation of sulfonyl amidines has been developed. The procedure combines three-component reaction of sulfonyl azide, methyl propiolate and secondary cyclic amine coupling in one sequence without any solvent or catalyst and at room temperature. The reaction proceeds smoothly and a variety of desired sulfonyl amidines were obtained in moderate to good yields. This protocol has synthetic advantages in terms of low environmental impact and very short reaction time.","PeriodicalId":32638,"journal":{"name":"Journal of Current Research in Scientific Medicine","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81182387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}