Pigment InternationalPub Date : 2022-01-01DOI: 10.4103/pigmentinternational.pigmentinternational_2_20
N. Mittal, T. Kaur
{"title":"Role of oral corticosteroids, methotrexate, and azathioprine in patients with unstable vitiligo: A comparative study","authors":"N. Mittal, T. Kaur","doi":"10.4103/pigmentinternational.pigmentinternational_2_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_2_20","url":null,"abstract":"Background: There are several medical and surgical interventions for vitiligo but still the search for a definite cure is going on. The first goal of the therapy is to make the disease stable by preventing the appearance of new lesions. Drugs like oral corticosteroids, methotrexate, and azathioprine have been found effective in this phase. Objective: To compare the efficacy of oral corticosteroids, methotrexate, and azathioprine in patients with unstable vitiligo. Materials and Methods: It was a retrospective data analysis of 319 vitiligo patients, out of which 52 patients with unstable vitiligo who have received treatment in the form of 0.5 mg/kg oral corticosteroids on 2 consecutive days per week, 0.3 mg/kg methotrexate per week, and 1 to 1.5 mg/kg azathioprine daily were selected and were evaluated for the effect of drug for 12weeks. Results: There was no statistically significant difference in the appearance of new lesions in all 3 groups; however, methotrexate showed the early effect which plateaus after a few weeks whereas steroids as well as azathioprine showed a gradual and consistent effect. Conclusion: Methotrexate, steroids, and azathioprine all arrest the disease activity in vitiligo. Methotrexate can be used to arrest disease activity in fast-spreading vitiligo. Azathioprine can be used in patients with active vitiligo, wherever steroids are contraindicated.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"23 1","pages":"33 - 38"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87698885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-01-01DOI: 10.4103/pigmentinternational.pigmentinternational_13_22
Y. Bhat, Soumil Khare, Nahida Nabi
{"title":"Dermoscopy of disorders of hypopigmentation","authors":"Y. Bhat, Soumil Khare, Nahida Nabi","doi":"10.4103/pigmentinternational.pigmentinternational_13_22","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_13_22","url":null,"abstract":"Dermoscopy has traditionally been used to diagnose neoplasms and, more recently, to evaluate inflammatory conditions. Recent observational studies have suggested a role for dermoscopy in identifying and differentiating various hypopigmentary disorders. This comprehensive review will summarize the growing literature on the use of dermoscopy for hypopigmentary disorders.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"277 1","pages":"4 - 13"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75780630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2022-01-01DOI: 10.4103/pigmentinternational.pigmentinternational_47_21
M. Gupta, B. Doolan
{"title":"Pigmentary disorders: paradigms in a multicultural society","authors":"M. Gupta, B. Doolan","doi":"10.4103/pigmentinternational.pigmentinternational_47_21","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_47_21","url":null,"abstract":"","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"28 1","pages":"1 - 3"},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90678287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2021-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_77_20
R. Ramani, Hima Gopinath, N. Prabhakaran, T. Santosh
{"title":"A cautionary tale in skin lightening: chemical leukoderma","authors":"R. Ramani, Hima Gopinath, N. Prabhakaran, T. Santosh","doi":"10.4103/pigmentinternational.pigmentinternational_77_20","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_77_20","url":null,"abstract":"","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"26 1 1","pages":"120 - 122"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80385861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2021-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_50_21
S. Verma, R. Sarkar, B. Sahoo
{"title":"Study of contact sensitivity to cosmetic allergens in melasma","authors":"S. Verma, R. Sarkar, B. Sahoo","doi":"10.4103/pigmentinternational.pigmentinternational_50_21","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_50_21","url":null,"abstract":"Introduction: Melasma is a relatively common hypermelanotic disorder characterized by symmetrical light to gray-brown macules and patches involving photoexposed areas. Multiple factors have been implicated in the etiopathogenesis, including genetic factors, UV radiation, pregnancy, oral contraceptive pills (OCPs), thyroid dysfunction, and cosmetics. However, the role of cosmetics has not been well studied in melasma patients. The present study was designed to study the contact sensitivity to cosmetic allergens in patients with melasma. Material and Methods: Thirty patients with and thirty without melasma who visited Dermatology OPD between October 2015 and March 2017 were recruited according to selection criteria and were sequentially patch and photopatched with Indian cosmetic and fragrance series. Results: The mean age of melasma patients was 32.10 ± 6.62 years with female to male ratio of 1.72:1. Sixteen (53%) patients were found to show positive reactions on patch and photopatch testing with Indian cosmetic and fragrance series. Among 32 allergens tested, 15 allergens were found eliciting positive reaction. Thiomersol was the most common contact sensitizer eliciting positive reaction in six (38%) patients, followed by cetrimide, hexamine, and sorbitan each in three patients (19%). In the control group, only one (3.3%) subject showed positive contact allergy pattern. The results were significant (P < 0.001). Conclusion: A possible consideration of the pigmented cosmetic dermatitis and cosmetic contact sensitivity is recommended in the etiologic factors of melasma especially, in nonpregnancy/lactation induced melasma or when it is not associated with hormone therapy. Contact sensitizers might also have a role in melasma that is recalcitrant to all standard therapies.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"8 1","pages":"86 - 94"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89578842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2021-05-01DOI: 10.4103/Pigmentinternational.Pigmentinternational_27_20
Preema Sinha, Sunmeet Sandhu, R. Kothari, S. Neema
{"title":"Uncommon presentation of methotrexate-induced toxic erythema of chemotherapy","authors":"Preema Sinha, Sunmeet Sandhu, R. Kothari, S. Neema","doi":"10.4103/Pigmentinternational.Pigmentinternational_27_20","DOIUrl":"https://doi.org/10.4103/Pigmentinternational.Pigmentinternational_27_20","url":null,"abstract":"Toxic erythema of chemotherapy (TEC) is a term used to describe the presence of erythema with or without edema often affecting the hands and feet, intertriginous areas such as axillary and inguinal areas and less frequently elbows, knees, and postauricular areas. Sometimes the lesions can be petechial or with sterile blisters. They are generally self-limiting and resolve with post-inflammatory hyperpigmentation. Here we describe one such rare case of Methotrexate-induced TEC involving uncommon sites like hairline, postauricular areas, and neck.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"22 1","pages":"117 - 119"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79403054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2021-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_36_21
C. Grover, S. Bansal
{"title":"Nail changes associated with pigmentary disorders","authors":"C. Grover, S. Bansal","doi":"10.4103/pigmentinternational.pigmentinternational_36_21","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_36_21","url":null,"abstract":"Salient nail unit changes serve as pointers toward systemic disease. On similar lines, salient nail changes are associated with pigmentary disorders, and can help toward diagnosis. Nail changes form a part of various physiologic pigmentary changes including racial pigmentation, pregnancy, or neonatal period. At the same time, a number of nail changes can be valuable clues toward disorders of pigmentation associated with genetic syndromes (Laugier–Hunziker syndrome, incontinentia pigmenti, and tuberous sclerosis), endocrine disorders, disorders of metabolism (alkaptonuria), infections (HIV-AIDS), internal malignancies, etc. Nail changes are especially useful if cutaneous pigmentary changes are suspected to be drug-induced based or associated mucosal and/or cutaneous hyperpigmentation. Various drugs that can cause cutaneous pigmentary alterations along with nail changes include cyclophosphamide, adriamycin, vincristine, docetaxel, paclitaxel, carboplatin, psoralens, hydroxyurea, bleomycin, etc. Nail changes are also associated with disorders of hypomelanosis, for example, vitiligo. Pigmentary changes due to endogenous and exogenous pigments are again diagnosable based on the nail changes they induce. This narrative review highlights the importance of nail changes in suspecting and diagnosing various disorders of pigmentation. It also points toward areas which need future research.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"26 1","pages":"76 - 85"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90826993","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2021-05-01DOI: 10.4103/Pigmentinternational.Pigmentinternational_10_20
S. Mondal, A. Panigrahi, D. Bhanja, Sayantani Chakraborty, A. Sil
{"title":"Serpentine Supravenous Hyperpigmentation Following Intravenous Docetaxel","authors":"S. Mondal, A. Panigrahi, D. Bhanja, Sayantani Chakraborty, A. Sil","doi":"10.4103/Pigmentinternational.Pigmentinternational_10_20","DOIUrl":"https://doi.org/10.4103/Pigmentinternational.Pigmentinternational_10_20","url":null,"abstract":"Serpentine supravenous hyperpigmentation is a rare, cutaneous sequela of intravenous chemotherapeutic agents, collagen vascular diseases (systemic sclerosis, systemic lupus erythematosus, and rheumatoid arthritis), and infections like leprosy and HIV. The condition manifests clinically as a peculiar, patterned eruption characterized by hyperpigmented streaks following the superficial venous network on the skin. Here, we report a case of a middle-aged lady with breast carcinoma, who developed serpentine supravenous hyperpigmentation after intravenous docetaxel.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"9 1","pages":"109 - 111"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76337193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2021-05-01DOI: 10.4103/Pigmentinternational.Pigmentinternational_60_20
M. Shankar, S. Murthy
{"title":"Bathing trunk naevus: a case report with dermoscopic findings in a brown child","authors":"M. Shankar, S. Murthy","doi":"10.4103/Pigmentinternational.Pigmentinternational_60_20","DOIUrl":"https://doi.org/10.4103/Pigmentinternational.Pigmentinternational_60_20","url":null,"abstract":"Giant congenital melanocytic naevus is a naevus measuring more than 20 cm in adulthood. Its incidence is 1:20,000 and is more common in girls. Bathing trunk naevus, a specific form of giant congenital melanocytic naevus is even rarer with incidence of 1:500,000. Giant congenital melanocytic naevus usually presents as a brown lesion, with flat or mamillated surface, well-defined borders and hypertrichosis. Dermoscopic examination of melanocytic naevi shows brown-blackish background, globules, reticular network and vascular structures. Although giant congenital melanocytic naevus is often diagnosed clinically, dermoscopy aids in detecting early changes of complications such as malignant melanoma. We report a case of bathing trunk naevus with multiple satellite lesions in a brown child with dermoscopic findings.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"9 1","pages":"112 - 114"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76350072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pigment InternationalPub Date : 2021-05-01DOI: 10.4103/pigmentinternational.pigmentinternational_24_21
V. Nielsen, S. Thomsen
{"title":"The role of the mast cell in pigmentation disorders","authors":"V. Nielsen, S. Thomsen","doi":"10.4103/pigmentinternational.pigmentinternational_24_21","DOIUrl":"https://doi.org/10.4103/pigmentinternational.pigmentinternational_24_21","url":null,"abstract":"The mast cell is a critical mediator of the inflammatory response by secreting histamine. While histamine is currently not regarded as a melanogen, recent studies have shown histamine release to induce melanogenesis, melanocyte proliferation and migration. Herein, we discuss the current evidence of the complex relationship between the mast cell and melanocyte, and its impact in pigmentation disorders.","PeriodicalId":32636,"journal":{"name":"Pigment International","volume":"112 1","pages":"73 - 75"},"PeriodicalIF":0.0,"publicationDate":"2021-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80830507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}