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The Palliative Management of A Cancer Patient With Giant Retinoblastoma of The Left Eye 1例左眼巨大视网膜母细胞瘤的姑息治疗
Journal of Regenerative Biology and Medicine Pub Date : 2021-06-01 DOI: 10.37191/MAPSCI-2582-385X-3(3)-068
S. Bittmann
{"title":"The Palliative Management of A Cancer Patient With Giant Retinoblastoma of The Left Eye","authors":"S. Bittmann","doi":"10.37191/MAPSCI-2582-385X-3(3)-068","DOIUrl":"https://doi.org/10.37191/MAPSCI-2582-385X-3(3)-068","url":null,"abstract":"We report of a young African child with a giant retinoblastoma originating from the left orbital space. The mother and the child left Cameroon seeking medical support at the Department of Pediatrics. To date of arrival, the extensive tumor was exulcerating and not curable. Only palliative support was possible.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"29 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132572217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucormycosis: A Black Fungus- Post Covid Complications 毛霉病:一种黑色真菌-感染后并发症
Journal of Regenerative Biology and Medicine Pub Date : 2021-04-03 DOI: 10.37191/mapsci-2582-385x-3(4)-078
P. Kr
{"title":"Mucormycosis: A Black Fungus- Post Covid Complications","authors":"P. Kr","doi":"10.37191/mapsci-2582-385x-3(4)-078","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-3(4)-078","url":null,"abstract":"Human to human transmitted disease is the game of coronavirus disease (COVID-19) transmission and it had been declared an emergency global pandemic that caused major disastrous in the respiratory system to more than five million people and killing more than half a billion deaths across the globe. Besides lower acute respiratory syndrome, there is damage to the alveolar with severe inflammatory exudation. COVID-19 patients often have lower immunosuppressive CD4+ T and CD8+ T cells and most patients in intensive care units (ICU) need mechanical ventilation, hence longer stay in hospitals. These patients have been discovered to develop fungal co-infections. COVID-19 patients develop what is known as mucormycosis a black fungal infection that is deadly leading to loss of sight and hearing and eventually death. This chapter will focus on mucormycosis, a black fungus caused during post covid complications.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"6 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115025901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
Editor Note- Journal of Regenerative Biology and Medicine Volume 3 Issue 2 《再生生物学与医学杂志》第三卷第2期
Journal of Regenerative Biology and Medicine Pub Date : 2021-02-02 DOI: 10.37191/mapsci-2582-385x-3(2)-063
Ottorino Del Foco
{"title":"Editor Note- Journal of Regenerative Biology and Medicine Volume 3 Issue 2","authors":"Ottorino Del Foco","doi":"10.37191/mapsci-2582-385x-3(2)-063","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-3(2)-063","url":null,"abstract":"As a new editorial board member of the Journal of Regenerative Biology and Medicine, I would like to introduce myself, outline some aspects of my clinical background and emphasize the challenges we face shortly regarding stem cell therapy in vascular surgery.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132755065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Alice in Wonderland Syndrome: An Update of Present Data With A Special View to Body Position, Traumatic and Genetic Aspects 爱丽丝梦游仙境综合症:当前数据的更新与身体位置，创伤和遗传方面的特殊观点
Journal of Regenerative Biology and Medicine Pub Date : 2020-12-15 DOI: 10.37191/MAPSCI-2582-385X-2(6)-049
S. Bittmann
{"title":"Alice in Wonderland Syndrome: An Update of Present Data With A Special View to Body Position, Traumatic and Genetic Aspects","authors":"S. Bittmann","doi":"10.37191/MAPSCI-2582-385X-2(6)-049","DOIUrl":"https://doi.org/10.37191/MAPSCI-2582-385X-2(6)-049","url":null,"abstract":"Alice in Wonderland Syndrome (AIWS) was named after the description of Lewis Carroll in his novel. In 1955, John Todd, a psychiatrist described this entity for the first time and results in a distortion of perception. Todd described it as „Alice's Adventures in Wonderland“ by Lewis Carroll. The author Carroll suffered from severe migraine attacks. Alice in Wonderland Syndrome is a disorienting condition of seizures affecting visual perception. AIWS is a neurological form of seizures influencing the brain, thereby causing a disturbed perception. Patients describe visual, auditory, and tactile hallucinations and disturbed perceptions. The causes of AIWS are still not known exactly. Cases of migraine, brain tumors, depression episodes, epilepsy, delirium, psychoactive drugs, ischemic stroke, depressive disorders, and EBV, mycoplasma, and malaria infections are correlating with AIWS like seizures. Often no EEG correlate is found. Neuroimaging studies reveal disturbances of brain regions including the temporoparietal junction, the temporal and occipital lobe as typical localization of the visual pathway. A decrease of perfusion of the visual pathways could induce these disturbances, especially in the temporal lobe in patients with AIWS. Other theories suggest distorted body illusions stem from the parietal lobe. The concrete origin of this mysterious syndrome is to date not clearly defined.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129441169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Overall Analysis Of Covid-19 Pandemic In Germany 德国新冠肺炎大流行总体分析
Journal of Regenerative Biology and Medicine Pub Date : 2020-07-10 DOI: 10.37191/mapsci-2582-385x-2(4)-0039
Bittmann S
{"title":"Overall Analysis Of Covid-19 Pandemic In Germany","authors":"Bittmann S","doi":"10.37191/mapsci-2582-385x-2(4)-0039","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(4)-0039","url":null,"abstract":"What The COVID-19 pandemic has been present in Germany since 27 January 2020, it is the spread of the respiratory disease COVID-19, which first appeared at the end of 2019 and broke out worldwide at the beginning of 2020, triggered by infection with the coronavirus SARS-CoV-2.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126632488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Down Syndrome: Regenerative Medicine Taming the Over-Expressive Trisomy (Chromosome 21) Genes 唐氏综合症:再生医学驯服过度表达的三体(21号染色体)基因
Journal of Regenerative Biology and Medicine Pub Date : 2020-06-07 DOI: 10.37191/mapsci-2582-385x-2(5)-040
Prithiv K R Kumar
{"title":"Down Syndrome: Regenerative Medicine Taming the Over-Expressive Trisomy (Chromosome 21) Genes","authors":"Prithiv K R Kumar","doi":"10.37191/mapsci-2582-385x-2(5)-040","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(5)-040","url":null,"abstract":"Trisomy silencing is an important factor in curing Down syndrome. As per a study in various experiments, XIST Transgene transforms chromosome 21 in stem cells. This Transgene normalizes cell function and development upon transformation and its induction in Transgene clones corrects the overproduction of meakayocytes, stemcells, iPS cells and erythrocytes keeping the balance of hemopoietic developments. Given all these to added knowledge, our study further advanced to CD4/CD43 progenitors cells demonstrating principle proof for epigenetic based investigative strategy in pathology. Chapter basic focuses on drug discovery, delivery of drugs, administration path, dosage and frequency of transplantation. Monitor tools of MRI, MSK and PET-CT scanners. Also,the cultivation of chromosome 21 cells trisomy to disomy is relevant without genetic manipulation, chemical treatment and exposure to irradiation. Disomy or diploid cells serve to the purpose of drug screening and raw material of regenerative medicine and cell-based therapy.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129001567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The Role of TMPRSS2 and TMPRSS2- Inhibitors in Cell Entry Mechanism of COVID-19 TMPRSS2和TMPRSS2抑制剂在COVID-19细胞进入机制中的作用
Journal of Regenerative Biology and Medicine Pub Date : 2020-06-01 DOI: 10.37191/mapsci-2582-385x-2(3)-026
S. Bittmann
{"title":"The Role of TMPRSS2 and TMPRSS2- Inhibitors in Cell Entry Mechanism of COVID-19","authors":"S. Bittmann","doi":"10.37191/mapsci-2582-385x-2(3)-026","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(3)-026","url":null,"abstract":"The enzymes trypsin, furine and other proprotein convertases, cathepsin, transmembrane proteases (TMPRSS) and elastases play a role in the cell entry of coronaviruses (Coronaviridae). The proteases TMPRSS2 and TMPRSS11a, which are abundant in the respiratory tract and expressed on cell surfaces, promote the entry of SARS-CoV-1 viruses. For the TMPRSS protease TMPRSS11d - also known as human airway trypsin-like protease (HAT) - a proteolytic activation of the S- protein of SARS-CoV-1 was demonstrated. TMPRSS2, in turn, complexes with the ACE2 receptor, which allows efficient penetration of the virus directly at the cell surface. TMPRSS2 and TMPRSS11D activate the S protein by cleaving it into the S1 and S2 subunits, thus allowing endosome-independent cell entry at the cell membrane. Virus-based therapies include monoclonal antibodies, antiviral peptides that dock to the S protein of viruses, viral nucleic acid synthesis inhibitors and inhibitors for docking to other viral structures and accessory proteins.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115420390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
COVID-19: ACE-2 Receptor, TMPRSS2, Cathepsin-L/B and CD-147 Receptor COVID-19: ACE-2受体、TMPRSS2、组织蛋白酶- l /B和CD-147受体
Journal of Regenerative Biology and Medicine Pub Date : 2020-06-01 DOI: 10.37191/mapsci-2582-385x-2(3)-031
S. Bittmann
{"title":"COVID-19: ACE-2 Receptor, TMPRSS2, Cathepsin-L/B and CD-147 Receptor","authors":"S. Bittmann","doi":"10.37191/mapsci-2582-385x-2(3)-031","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(3)-031","url":null,"abstract":"COVID-19 shows an extremely rapid spreading pattern, classified as SARS-CoV-2, has become a worldwide health problem. Relating to biological characteristics of SARS-CoV-2, the new viral agent was comprehensively summarized in order to optimize the date research on this novel disease and make adequate therapeutic decisions. The structure of COVID-19 virus is partially similar to SARS-CoV and MERS-CoV and to date, the origin is not clearly ruled out in detail. COVID-19 in general shows, without any adequate measurement, an exponential reproductive rate, an incubation of nearly 14 days. The clinical appearance and the pandemic spread of COVID-19 were very similar to earlier SARS epidemics. The occurrence of SARS-CoV-2; previously provisionally referred to as novel coronavirus 2019 or 2019-nCoV (COVID-19) in China in late 2019, has induced a global spreading and is a worldwide public health problem. At the end of January 2020, the World Health Organization described COVID-19 as the sixth international public health emergency. SARS-CoV-2 is similar to severe corona viruses similar to acute respiratory syndrome of bat origin, bat-SL-CoVZC45 and bat-SL-CoVZXC21. The transmission is based on by human-to-human transmission via droplets or direct contact or stool, whereas the infection seems to have an incubation period of up to 14 days and a reproduction rate of 2.24-3.58. In patients with SARS-CoV-2-induced pneumonia, fever was the prominent symptom in these patients followed by cough. Currently, stopping the rapid spreading of SARS-CoV-2 is the primary intervention in health care management. However, health authorities should continue to monitor the situation closely.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129643163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
COVID-19 Cure through Stem Cells 通过干细胞治愈COVID-19
Journal of Regenerative Biology and Medicine Pub Date : 2020-05-05 DOI: 10.37191/mapsci-2582-385x-2(3)-034
Prithiv K R Kumar
{"title":"COVID-19 Cure through Stem Cells","authors":"Prithiv K R Kumar","doi":"10.37191/mapsci-2582-385x-2(3)-034","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(3)-034","url":null,"abstract":"Stem cells are the ultimate solution to treat any diseases. They help in giving solutions to the most deadly disease. The focus is on respiratory system because COVID-19 attracts that region, hence mesenchymal stem cells(MSC) is proposed to treat the disease. Clinical trials have already begun suggesting these therapeutics. They most probably will be helpful in preventing severe acute respiratory infection. A certain population of cells will get accumulated in the lungs after stem cell regeneration, to protect epithelial cells in the alveoli, cleanse the pulmonary artery and cure dysfunction in the lungs. In this review a new approach using mesenchymal stem cells has been taken into consideration for COVID cure. Currently, there seems little approach on basis of clinical trial on COVID patients. Stem cell therapy should show safe and highly effective method to cure COVID.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2020-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122730326","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Fast Food Consumption among Teenagers Aged Between (13 To 25) Years Old and Their Effect on Health in Derna-Libya 利比亚13 - 25岁青少年的快餐消费及其对健康的影响
Journal of Regenerative Biology and Medicine Pub Date : 2019-10-24 DOI: 10.37191/mapsci-2582-385x-1(1)-005
S. Eljamay
{"title":"Fast Food Consumption among Teenagers Aged Between (13 To 25) Years Old and Their Effect on Health in Derna-Libya","authors":"S. Eljamay","doi":"10.37191/mapsci-2582-385x-1(1)-005","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(1)-005","url":null,"abstract":"Background: Junk foods are rich in calories, salt and fats. Excess consumption of junk foods would lead rise to wide variety of health disorders.\u0000\u0000Objective: the purpose of this study is to find out about the fast food consumption of adolescent in age between 13-25 years old in Derna city and their effect on health\u0000\u0000Methods: the sample of this research included 100 adolescents from both sexes, a descriptive cross-sectional study of teenagers was conducted. The questionnaire was divided into two part: first part related to socio-demographic information and part two related to junk food pattern and influencing factors of junk food consumption and their effect on health. Data were analyzed using SPSS version 24. A value of P < 0.05 was interpreted as statistically significant. Results: The findings revealed that more girls (67.0%) consumed fast food than boys and approximately half (49.0%) of Participants were consumed fast food as an alternative to main meal and more than half of participants (63.0%) were consume soft drink every day, furthermore greater proportion of participants (42.0%) had urinary tract infection and that may related to chips and soft drink were the most attractive food items among Participants.\u0000\u0000Conclusion: adolescent consumed a greater amount of junk food which led to a majority of ill effects later on. It is recommended that the schools and community conduct and implement awareness programmers on fast food consumption and its ill effects.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"57 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115620426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 9
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