Journal of Regenerative Biology and Medicine最新文献

{"title":"Anti-inflammatory and Antifibrotic Effects of Plant Regulatory Peptides in Patients with Steatohepatitis and Cirrhosis: Opportunities of Primary Liver Cancer Prevention","authors":"S. Konovalenko","doi":"10.37191/mapsci-2582-385x-1(2)-009","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(2)-009","url":null,"abstract":"The pathogenesis of steatohepatitis, which develops on the background of non-alcoholic fatty liver disease and may be the cause of liver cirrhosis, is considered in the article. Also, the paper focuses on the prospects of using peptide drugs for the treatment of liver cirrhosis. The study found that the preparation of plant regulatory peptides GA-40 has pronounced hepatoprotective, anti-inflammatory and anti-fibrotic effects, which is confirmed by the elastometry data of the shear wave. The results of this work indicate that the use of the drug GA-40 was accompanied not only by the normalization of the inflammatory panel of the liver and triglycerides, but also by a likely decrease in the level of glypican-3 - the main factor that causes the development of primary liver cancer. Gene protector and immunocorrector GA-40, harmonizing metabolic processes in the liver, as well as suppressing inflammation and preventing excessive output of hepatocytes in apoptosis, has a positive effect on the prognosis of the disease. Reduced expression of glypican-3 in patients in the study group indicates that GA-40 is able to control the level of pro-oncogenic trigger proteins, thus reducing the risk of primary liver cancer.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116998060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Can IV Infusions Of Bone Marrow Derived Mesenchymal Stem Cell Extracellular Vesicles Be The Fountain Of Youth?","authors":"Maxwell Dordevic","doi":"10.37191/mapsci-2582-385x-1(2)-010","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(2)-010","url":null,"abstract":"There is increasing published literature to support the safety and efficacy of IV infusions of bone marrow-derived expanded allogeneic mesenchymal stem cells (MSCs) for the treatment of various auto-immune diseases. Frailty Syndrome was created to provide a way of objectively measuring aging with physical activity scales and bio-inflammatory markers. IV infusions of allogeneic MSCs have been reported to statistically significantly increase physical function and decrease inflammatory biomarkers in Frailty Syndrome. Replacing cellular allogeneic IV infusions with acellular bone marrow-derived MSC extracellular vesicle isolate products (EVIP) containing active growth factors (GFs) and exosomes has numerous advantages. Regenerative medicine researchers and clinicians now realize that living MSCs are not required to achieve clinical efficacy. The clinical efficacy of MSCs is due to their paracrine release of GFs and exosomes. Living MSCs are not required to accomplish the paracrinesignaling of GFs and exosomes. Acellular MSC EVIP containing active GFs and exosomes are the future of regenerative medicine.Acellular exosomesderived from bone marrow MSCs provide a consistent product that has extensive characterization, which includes advanced particle analysis, proteomic evaluation and USP<71> sterility assurance. The future “Fountain of Youth” will be the frequent (3 to 4 times per year) IV infusion of bio pharmacologic quality bone marrow-derived MSC EVIP. These active GF and exosome infusions will result in a continual down regulation of systemic inflammation and based on published research reverse many of the inflammatory effects of aging.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130490077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Future of Medicine - Biologics and Artificial Intelligence","authors":"G. Slater","doi":"10.37191/mapsci-2582-385x-1(2)-008","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(2)-008","url":null,"abstract":"The future of medicine is in biologics and artificial intelligence AI. With the advent of advancing and disruptive technologies, many traditional therapies are being replaced by new therapies such as: stem cell therapy,joint preservation,limb saving technologies and medical robotics. In countries where first world medicine is available, there will emerge new challenges in retraining for practitioners and confusion for patients as to what are the best treatment options. \u0000\u0000From the medical practitioners’ perspective, the challenge will be to stay up to date with the changing times and innovations. Some aspects of their practice may quickly become obsolete.As patients become more aware of symptoms of their conditions, self-diagnosis will be on the rise, and patients may often run the risk of misdiagnosing themselves, or experiencing conditions such as cyber phobia from information overload. Innovations such as Artificial Intelligence will emerge, to summarize the vast amount of information that is being published each day relevant to medical fields. Artificial Intelligence that will interact with the doctor, promoting plausible diagnoses and treatment options is already present. Embracing change will become the norm.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"16 3","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114133269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Articular Injection of an Extracellular Vesicle Isolate Product to Treat Hip Labral Tears","authors":"Maxwell Dordevic","doi":"10.37191/mapsci-2582-385x-1(1)-006","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(1)-006","url":null,"abstract":"Diarthrodial joints, such as the knee, hip, and shoulder consist of articular cartilage, a synovial capsule, and a fibrocartilaginous structure to increase the stability of the joint.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117167676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effectiveness of Amoxicillin and Cefalexin in Two Species from Staphylococcus and Bacillus Isolated from Bovine Mastitis in Sudan","authors":"R. R. M. Salih","doi":"10.37191/mapsci-2582-385x-1(1)-004","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(1)-004","url":null,"abstract":"In this study 60 milk samples collected from mastitic cows to isolates and identify bacterial agents. The percentage of isolates was as follows: Staphylococcus spp 52%, Bacillus spp 26%, Enteroccocispp 3%; microccus 3%, Nesseria 2%, Branhamella 3%, Clostridium 1%, Bordetella 2%, Enterobacteria 3%, Aeromonas 4%, Fusobacterium 1%. In sensitivity tests used two antibiotics Amoxicillin and Cephalexin against two highest isolates in this study (Staph spp and Bacillus spp and found: Staph. aureus and Staph. hyicus were resistant to Amoxicllin and cephlaxin relatively, Bacillus coagulans and Bacillus cereus were susceptible to Amoxicllin and cephlaxin.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133999767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioethics Human Papillomavirus and HPV Vaccine","authors":"C. Davies","doi":"10.37191/mapsci-2582-385x-1(1)-002","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(1)-002","url":null,"abstract":"This paper will discuss what the Human Papillomavirus (HPV) is. Ethical questions posed are “Should the HPV (Human Papillomavirus) vaccine be required? If yes at what age and should it be required for both boys and girls? During the paper another ethical question that will be discussed is, “On what basis should parents be permitted to refuse and be exempt from the mandate”? An analysis of the Human papillomavirus will explain what is HPV, how it is passed between people, any symptoms that could occur, and information about treatment, vaccines, and prevention. The role and responsibilities of the Family Nurse Practitioner, clinical aspects, scientific evidence, conflicts, social issues, contextual facts and stakeholders will all be discussed. In addition bioethical principles autonomy, informed consent, beneficence, non-malfeasance, and justice will be discussed that are relevant and applicable to the ethical issues associated with the Human papillomavirus and HPV vaccine.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126614339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Foetal Healing Cascade - Can We Duplicate It In Adults?","authors":"G. Slater","doi":"10.37191/mapsci-2582-385x-1(2)-007","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(2)-007","url":null,"abstract":"The scientific study of medicine is all about the science of healing. Whether the focus be on the mind or body, the fascination with prolonging life, improving the quality of life, and generating new life is a theme that will perpetuate the human experience. Organisms are self-contained growth and healing mechanisms. Science has marvelled for years on how these healing processes work, so that they can be engineered into the right circumstances to restore anything from joint cartilage, ligaments, blood vessels, muscles and bone","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"111 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-08-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132401996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Overview of Current Regulatory Practices, Challenges & Guidance for Regulation of Stem Cells and Stem Cell Derived Products in India","authors":"K. Deb","doi":"10.37191/mapsci-2582-385x-1(1)-001","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-1(1)-001","url":null,"abstract":"Stem Cell Science/Regenerative Medicine is perhaps the most important “pillar” out of the four pillars of modern medicine. Use and abuse of the “Stem Cells and Stem Cell derived Products” as therapeutic measure for treatment of several untreatable diseases has come to the fore in recent times. The “stem cells” are drugs as discussed below. In the realm of clinical trials, to be approved by FDA, just as a “drug” undergoes trials, successively via phase I, phase II and phase III trials, likewise stem cells, which are “drugs” per se has to be channeled through the same three phases of clinical trials. \u0000\u0000There are some evolving regulations in place for regulating stem cell research and its prospective human application in clinical trials which is in place, as per the guidelines of ICSSR 2016. Each and every country, including India has more or less similar rules and regulations which conform to the rules/regulations as proposed by ICSSR and followed by FDA, although many countries has done individual modifications in the same. The role of NAC-SCRT, ICMR, IEC, IC-SCR, DCGI are clearly defined and it has been clearly stated in NGSCR that approval for stem cell application in patients, (Autologous, allogenic, homologous or non-homologous) only within the confines of “clinical trials” and therapy based on Stem Cells and Stem Cell derived Products (SCDP) should be informed in a proper format to the regulatory concern and done through the proper channel. \u0000\u0000All laboratories and institutes coming under the umbrella of NGSCR should have GMP, GLP and GCP compliant. Appropriate clean room classification shall be followed for stem cell isolation, culturing or manipulation in their respective lab/institutes. The safety and efficacy concerns regarding animal and human applications, uniformity in batch production, strengthening of scientific knowhow should definitely be in line with the cutting edge technological advancements globally. Conformity with international guidelines, and peer reviewed publications are a must for getting approval for clinical trials and marketing options. \u0000\u0000The review as a whole may not be comprehensive enough to include all the points in relation to the regulatory domain for approving SCDP in our country but an attempt has been made to identify the important points keeping in mind that this domain will evolve and rules and regulations will change with the passage of time.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"30 1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131087276","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth Factors and Articular Cartilage Rejuvenation: Where are we up to with reversing OA?","authors":"G. Slater","doi":"10.37191/mapsci-2582-385x-2(1)-013","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-2(1)-013","url":null,"abstract":"Osteoarthritis has eluded a curative/disease modifying treatment despite extensive research over the last century. This is largely due to the extremely slow metabolic turnover of articular cartilage in an essentially avascular environment, along with a pro-catabolic inflammatory cascade that is induced by damage to the healthy cartilage structure. There has been promising data emerging whereby this poor chondrocyte healing process can be improved by applying autologous stem cell populations (harvested from marrow/adipose tissue) that have been programmed to undergo rapid and sustained chondrogenesis with the assistance of numerous chondrogenic growth factors. Here we aim to provide a comprehensive review article about the growth factors employed for the purpose of articular cartilage rejuvenation. Disease modifying agents incorporating chondrogenic growth factors have been extensively researched in the last 2 decades, and it has been identified that the likely chondrogenic growth factor families of most therapeutic value are the Transforming Growth Factor beta (TGF-B superfamily), Fibroblastic Growth Factor (FGF - specifically FGF-18) and Insulin Growth Factor (IGF) in combination with many of the aforementioned factors. There is still a need for consensus on appropriate dosing and long-term studies should be performed to assess the durability of current therapies over many years. The application of growth factor enriched stem cell populations to osteoarthritic cartilage appears to be very near to effective therapeutic use.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"132 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126284620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relentless Regeneration","authors":"U. Ryan","doi":"10.37191/mapsci-2582-385x-3(4)-079","DOIUrl":"https://doi.org/10.37191/mapsci-2582-385x-3(4)-079","url":null,"abstract":"Regenerative Medicine is a branch of medicine holding promise for the repair of cells, tissues, and organs to effective function. Much of the field has been developed in response to damage sustained by injury and disease. However, the body is under constant maintenance with a natural ebb and flow of dying and renewing cells. In addition, cells, tissues, and organs are constantly responding to routine demands to accommodate great variations in signals and responses. Remarkable examples are the cells composing the blood vessels and airways of the lungs. The ability to regulate, maintain and respond to changes in blood pressure and gas exchange across the blood-air interface illustrates the relentless ability of our bodies to self-adjust and self-renew throughout life. Likewise, the earth in which we live is under constant change and remodeling. Natural disasters such as volcanic eruptions and earthquakes, with time, recover and become incorporated into the rhythm of daily life. Initial recovery may be brutal but in both cases, the body and the earth have an amazing power to heal.","PeriodicalId":325610,"journal":{"name":"Journal of Regenerative Biology and Medicine","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131563838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}