Down Syndrome: Regenerative Medicine Taming the Over-Expressive Trisomy (Chromosome 21) Genes

Abstract

Trisomy silencing is an important factor in curing Down syndrome. As per a study in various experiments, XIST Transgene transforms chromosome 21 in stem cells. This Transgene normalizes cell function and development upon transformation and its induction in Transgene clones corrects the overproduction of meakayocytes, stemcells, iPS cells and erythrocytes keeping the balance of hemopoietic developments. Given all these to added knowledge, our study further advanced to CD4/CD43 progenitors cells demonstrating principle proof for epigenetic based investigative strategy in pathology. Chapter basic focuses on drug discovery, delivery of drugs, administration path, dosage and frequency of transplantation. Monitor tools of MRI, MSK and PET-CT scanners. Also,the cultivation of chromosome 21 cells trisomy to disomy is relevant without genetic manipulation, chemical treatment and exposure to irradiation. Disomy or diploid cells serve to the purpose of drug screening and raw material of regenerative medicine and cell-based therapy.