Journal of applied oral science : revista FOB最新文献

{"title":"Effects of CEACAM1 in oral keratinocytes on HO-1 expression induced by Candida β-glucan particles.","authors":"Miyuki Sakuma,&nbsp;Kouji Ohta,&nbsp;Shohei Fukada,&nbsp;Misaki Akagi,&nbsp;Hiroki Kato,&nbsp;Yoko Ishida,&nbsp;Takako Naruse,&nbsp;Masaaki Takechi,&nbsp;Hideo Shigeishi,&nbsp;Hiromi Nishi,&nbsp;Tomonao Aikawa","doi":"10.1590/1678-7757-2022-0158","DOIUrl":"https://doi.org/10.1590/1678-7757-2022-0158","url":null,"abstract":"<p><strong>Objective: </strong>Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a member of the carcinoembryonic antigen family. Although its expression has been found in chronic oral inflammatory epithelium, this study aimed to know whether CEACAM1 in oral keratinocytes participates in host immune response against Candida albicans .</p><p><strong>Methodology: </strong>We investigated CEACAM1 expression in oral keratinocytes induced by C. albicans as well as by Candida cell wall component β-glucan particles (β-GPs). Furthermore, the effects of CEACAM1 on β-GPs-induced heme oxygenase-1 (HO-1) expression and its related signals were examined.</p><p><strong>Results: </strong>Fluorescence staining showed CEACAM1 expression in oral keratinocytes (RT7) cells, whereas quantitative reverse transcription (RT)-PCR indicated that both live and heat-killed C. albicans increased CEACAM1 mRNA expression in RT7 cells. Examinations using quantitative RT-PCR and western blotting indicated that CEACAM1 expression was also increased by β-GPs derived from C. albicans . Specific siRNA for CEACAM1 decreased HO-1 expression induced by β-GPs from C. albicans as well as the budding yeast microorganism Saccharomyces cerevisiae . Moreover, knockdown of CEACAM1 decreased β-GPs-induced ROS activity in the early phase and translocation of Nrf2 into the nucleus.</p><p><strong>Conclusion: </strong>CEACAM1 in oral keratinocytes may have a critical role in regulation of HO-1 for host immune defense during Candida infection.</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e20220158"},"PeriodicalIF":2.7,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651918/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40689162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of the effects of three hydraulic calcium silicate cements on odontoblastic differentiation of human dental pulp stem cells: an in vitro study.","authors":"Hadi Assadian,&nbsp;Arash Khojasteh,&nbsp;Zahra Ebrahimian,&nbsp;Fereshteh Ahmadinejad,&nbsp;Helia Sadat Haeri Boroojeni,&nbsp;Mahboubeh Bohlouli,&nbsp;Mohammad Hossein Nekoofar,&nbsp;Paul Mh Dummer,&nbsp;Hanieh Nokhbatolfoghahaei","doi":"10.1590/1678-7757-2022-0203","DOIUrl":"https://doi.org/10.1590/1678-7757-2022-0203","url":null,"abstract":"<p><strong>Objective: </strong>The study aimed to compare the response of human dental pulp stem cells (hDPSCs) towards three hydraulic calcium silicate cements (HCSCs) by measuring cytotoxicity and expression of dentinogenic genes.</p><p><strong>Methodology: </strong>Dental pulps of five impacted mandibular third molars were extirpated as a source for hDPSCs. Next to culturing, hDPSCs were subjected to fluorescence-activated cell sorting after the third passage to validate stemness of the cells. Human DPSCs were exposed to diluted supernatants of OrthoMTA (OMTA), Biodentine (BD) and Calcium-Enriched Mixture (CEM) at concentrations 10, 25, 50 and 100% at the first, third and fifth day of culture. Then, cells were exposed to 10% concentrations supernatant of HCSCs to determine DSPP and DMP1 gene expression, using a quantitative polymerase-chain reaction. Data were analyzed using one-way and three-way ANOVA, followed by Tukey post hoc statistical tests.</p><p><strong>Results: </strong>Optimal cell proliferation was observed in all groups, regardless of concentration and time-point. HCSC supernatants were non-cytotoxic to hDPSCs at all three time-points, except for 100% Biodentine on day five. On day seven, OMTA group significantly upregulated the expression of DSPP and DMP1 genes. On day 14, expression of DMP1 and DSPP genes were significantly higher in BD and OMTA groups, respectively.</p><p><strong>Conclusion: </strong>Biodentine significantly upregulated DMP1 gene expression over 14 days, whereas CEM was associated with only minimal expression of DSPP and DMP1 .</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e20220203"},"PeriodicalIF":2.7,"publicationDate":"2022-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651926/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40689163","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 incidence, severity, medication use, and vaccination among dentists: survey during the second wave in Brazil.","authors":"Rafael R Moraes,&nbsp;Marcos B Correa,&nbsp;Paulo R Martins-Filho,&nbsp;Giana S Lima,&nbsp;Flavio F Demarco","doi":"10.1590/1678-7757-2022-0016","DOIUrl":"https://doi.org/10.1590/1678-7757-2022-0016","url":null,"abstract":"<p><strong>Objective: </strong>This cross-sectional study with dentists in Brazil assessed the COVID-19 incidence and severity, its vaccination status, and the level of confidence in vaccines in May 2021 (COVID-19 second wave). The medications used to prevent or treat COVID-19, including controversial substances (vitamin D, ivermectin, zinc, and chloroquine), were analyzed.</p><p><strong>Methodology: </strong>Dentists were recruited by email and responded to a pretested questionnaire until May 31, 2021. Bivariate and multivariate regression analyses were performed (α=0.05). Prevalence ratios were calculated for the association between professional characteristics and two outcomes: SARS-CoV-2 infection and use of controversial substances.</p><p><strong>Results: </strong>In total, 1,907 responses were received (return rate of 21.2%). One third of dentists reported intermediate levels of confidence in the safety and efficacy of COVID-19 vaccines, but 96% had received at least one vaccine dose, mainly CoronaVac. The effect of the pandemic on dental practice was classified as lower/much lower, in comparison with the first wave, by 46% of participants. Moreover, 27% of dentists had already tested positive for SARS-CoV-2 and about 50% had relatives or friends who had been hospitalized or died from COVID-19. At least one medication was used by 59% of participants and 43% used two or more substances. Vitamin D (41%), ivermectin (35%), and zinc (29%) were the most frequent substances. More experienced dentists (≥21 years of professional experience) were 42% more likely to use controversial substances than less experienced dentists. The prevalence of use of controversial substances was 30% higher among dentists with residency or advanced training, such as postgraduate degrees, in comparison with participants holding MSc or PhD degrees. Participants with low confidence in vaccines were 2.1 times more likely to use controversial substances than participants with a very high confidence.</p><p><strong>Conclusion: </strong>The results of this study show the high severity of the COVID-19 pandemic in Brazil and raised questions about the use of scientific evidence by dentists in their decision to use controversial substances.</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e20220016"},"PeriodicalIF":2.7,"publicationDate":"2022-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33505088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of taxifolin on methotrexate-induced oxidative and inflammatory oral mucositis in rats: biochemical and histopathological evaluation.","authors":"Zeynep Bayramoglu,&nbsp;Behzad Mokhtare,&nbsp;Ali Sefa Mendil,&nbsp;Taha Abdulkadir Coban,&nbsp;Renad Mammadov,&nbsp;Seval Bulut,&nbsp;Zeynep Suleyman,&nbsp;Halis Suleyman","doi":"10.1590/1678-7757-2022-0115","DOIUrl":"https://doi.org/10.1590/1678-7757-2022-0115","url":null,"abstract":"<p><strong>Background: </strong>The role of oxidative stress, as well as inflammation in the pathogenesis of methotrexate (MTX)-induced oral mucositis, is a known fact. The anti-inflammatory, antitumor, antimicrobial, and antioxidant properties of taxifolin-the effect we tested against MTX-induced oral mucosal damage-are well known.</p><p><strong>Objective: </strong>Evaluating biochemically and histopathologically the effects of taxifolin on methotrexate-induced oral mucosal damage in rats.</p><p><strong>Methodology: </strong>In the taxifolin+MTX (TMTX) group, 50 mg/kg taxifolin was orally administered to rats by gavage. In the MTX and healthy (HG) groups, normal saline was applied to rats as solvent by the same method. One hour after administration of taxifolin and solvent, 5 mg/kg MTX was orally administered to rats in the MTX and TMTX groups. Taxifolin and methotrexate were administered once a day for 30 days. Macroscopic, biochemical, and histopathological evaluations were performed on the inner cheek and tongue tissues of rats. These parts were removed after rats were killed with a high-dose anesthesia.</p><p><strong>Results: </strong>Taxifolin with MTX prevented the increase in oxidant and pro-inflammatory parameters, such as malondialdehyde (MDA), tumor necrosis factor alpha (TNF-α), interleukin 1 beta (IL-1β), interleukin 6 (IL-6), on the inner cheek and tongue tissues of rats. Moreover, taxifolin antagonized the decrease in total glutathione (tGSH). Taxifolin decreased MTX-induced histopathological damage.</p><p><strong>Conclusion: </strong>These findings suggest that taxifolin may be useful to treat MTX-associated oral mucositis.</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e20220115"},"PeriodicalIF":2.7,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9484792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33468200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of lysyl oxidase-like protein 3 expression in the periodontium of diabetic rats.","authors":"Li Huang,&nbsp;Jun Chen,&nbsp;Yuling Zuo,&nbsp;Jinle Li,&nbsp;Yuan Yue,&nbsp;Min Wang,&nbsp;Liang Hao","doi":"10.1590/1678-7757-2022-0176","DOIUrl":"https://doi.org/10.1590/1678-7757-2022-0176","url":null,"abstract":"<p><strong>Objectives: </strong>Diabetes has been strongly associated with periodontal diseases. The periodontal ligament (PDL) has an abundant extracellular matrix (ECM). Lysyl oxidases (LOXs) are closely associated with various diseases caused by abnormal ECM functions, however, the role of LOXs in periodontal diseases induced by diabetes remains unclear.</p><p><strong>Methodology: </strong>In this study, 8-week-old Zucker diabetic fatty rats were used to establish a type 2 diabetes mellitus (T2DM) model. After 9 and 16 weeks, hematoxylin and eosin (H&E), Masson's trichrome, and immunohistochemical staining were performed.</p><p><strong>Results: </strong>After 9 weeks, loose collagen fibers were found in the interradicular area of the diabetic group, in opposition to the control group. There were no significant differences in LOX expression between the diabetic and control groups (p>0.05). However, after 16 weeks, the diabetic group presented a disordered arrangement of the PDL, showing decreased collagen content and significantly increased lysyl oxidase-like protein 3 (LOXL3) expression when compared with the control group (p<0.05). This suggests that LOXL3 plays a significant role in periodontal histopathological changes in diabetic rats.</p><p><strong>Conclusion: </strong>Our study showed elevated LOXL3 expression in the PDL of diabetic rats after 16 weeks, suggesting that LOXL3 may be involved in the occurrence and development of periodontal histopathological changes in diabetic rats. LOXL3 could be further used as an indicator for the early diagnosis of diabetic periodontitis in T2DM patients in clinical settings.</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e20220176"},"PeriodicalIF":2.7,"publicationDate":"2022-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9529203/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33468201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Autologous platelet concentrates for facial rejuvenation.","authors":"Marília Afonso Rabelo Buzalaf,&nbsp;Flávia Mauad Levy","doi":"10.1590/1678-7757-2022-0020","DOIUrl":"https://doi.org/10.1590/1678-7757-2022-0020","url":null,"abstract":"<p><strong>Background: </strong>Autologous platelet concentrates (APCs) are promising therapeutic agents in facial rejuvenation since they are a great source of cytokines, growth factors and other biologically active substances. Obtained from the patient's blood, they have the advantages of reducing immunological reactions, making the procedure safer, well tolerated, with minimal adverse effects and lower cost. Currently, they are used for facial rejuvenation both in combination with microneedling and in mesotherapy techniques, as well as to treat facial acne scars, melasma and wounds after laser ablative treatments. This review summarizes current knowledge on the use of APCs, ranging from basic concepts related to their composition and mechanisms of action to up-to-date information on their clinical efficacy.</p><p><strong>Methodology: </strong>MEDLINE (PubMed) was searched from inception through 2021 for English language publications on APCs for facial rejuvenation.</p><p><strong>Results: </strong>A total of 100 files were found. Based on the available literature, APCs for skin rejuvenation are safe and well tolerated. The most studied product is the first-generation material, platelet-rich plasma (PRP).</p><p><strong>Conclusions: </strong>The results are in general favorable, but the quality of the studies is low. The second and third generation products, platelet-rich fibrin (PRF) and injectable platelet-rich fibrin (i-PRF), respectively, are easier to be obtained and, at least in vitro , seem to induce greater collagen production than PRP, especially under lower relative centrifugation forces, but to date only a few clinical trials evaluating these products exist. More high-quality trials with appropriate follow-up are necessary to provide adequate evidence that may help to improve the treatment regimens with APCs. Many aspects should be considered when designing clinical trials to evaluate APCs, such as the patients' characteristics that best predict a favorable response, the optimal number of sessions and the interval between them, the characteristics of the studies and the development of better instruments to evaluate skin aging.</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e20220020"},"PeriodicalIF":2.7,"publicationDate":"2022-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444188/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ginsenoside Rd inhibits migration and invasion of tongue cancer cells through H19/miR-675-5p/CDH1 axis.","authors":"Lu Chang,&nbsp;Dongxu Wang,&nbsp;Shaoning Kan,&nbsp;Ming Hao,&nbsp;Huimin Liu,&nbsp;Zhijing Yang,&nbsp;Qianyun Xia,&nbsp;Weiwei Liu","doi":"10.1590/1678-7757-2022-0144","DOIUrl":"https://doi.org/10.1590/1678-7757-2022-0144","url":null,"abstract":"<p><strong>Objective: </strong>Tongue squamous cell carcinoma (TSCC) is an oral cancer, with high malignancy and frequent early migration and invasion. Only a few drugs can treat tongue cancer. Ginsenoside Rd is a ginseng extract with anti-cancer effects. Many noncoding RNAs are abnormally expressed in tongue cancer, thus influencing its occurrence and development. H19 and miR-675-5p can promote cancer cell growth. This study aimed to analyze the regulation effect of ginsenoside Rd on H19 and miR-675-5p in tongue cancer.</p><p><strong>Methodology: </strong>We used CCK8 and flow cytometry to study the growth and apoptosis. Transwell assay was used to assess invasion; wound-healing assay to assess migration; and colony formation assays to test the ability of cells to form colonies. H19, miR-675-5p, and CDH1 expressions were analyzed by qPCR. E-cadherin expression was detected using western blot. CRISPR/cas9 system was used for CDH1 knockout.</p><p><strong>Results: </strong>Ginsenoside Rd inhibited the growth and increased the apoptosis of SCC9 cells. Ginsenoside Rd also inhibited the migration and invasion of SCC9 cells. H19 and miR-675-5p were highly expressed, while CDH1 and E-cadherin expressions were low. H19 and miR-675-5p promoted SCC9 metastasis. In contrast, CDH1 and E-cadherin inhibited the metastasis of SCC9 cells. Bioinformatics analysis showed that miR-675-5p was associated with CDH1. H19 and miR-675-5p expressions decreased after ginsenoside Rd treatment, while CDH1 and E-cadherin expressions increased.</p><p><strong>Conclusions: </strong>Ginsenoside Rd inhibits tongue cancer cell migration and invasion via the H19/miR-675-5p/CDH1 axis.</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e20220144"},"PeriodicalIF":2.7,"publicationDate":"2022-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9444189/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33449178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ERRATUM.","authors":"","doi":"10.1590/1678-7757-2022er002","DOIUrl":"https://doi.org/10.1590/1678-7757-2022er002","url":null,"abstract":"<p><p>[This corrects the article doi: 10.1590/1678-7757-2022-0161].</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e2022er002"},"PeriodicalIF":2.7,"publicationDate":"2022-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9390723/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40411573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laboratory study of tissue repair of resin-based endodontic sealers in critical surgical defects.","authors":"Guilherme Ferreira da Silva,&nbsp;Letycia Accioly Simões Coelho,&nbsp;Vanessa Abreu Sanches Costa,&nbsp;Letícia Citelli Conti,&nbsp;Ana Carolina de Almeida Lima,&nbsp;Gabriela Cristina de Santi Sodré,&nbsp;Mateus Rinaldi Lucio Martins,&nbsp;Marco Antonio Hungaro Duarte,&nbsp;Rodrigo Ricci Vivan","doi":"10.1590/1678-7757-2022-0108","DOIUrl":"https://doi.org/10.1590/1678-7757-2022-0108","url":null,"abstract":"<p><strong>Objective: </strong>Filling materials should be restricted to the root canal space. However, sometimes it is impossible to control the apical extrusion, in this case, the fate of the filling material and the result of the treatment will depend on its physicochemical properties and biocompatibility. To evaluate the tissue response and bone repair capacity of endodontic sealers that were implanted in the calvaria of Wistar rats, forming the groups (n=16): AH Plus and Sealer Plus, compared to the clot group.</p><p><strong>Methodology: </strong>On days 30 and 60, the animals were euthanized, the calvaria was removed and processed for hematoxylin-eosin, immunohistochemistry for collagen type I, Picrosirus red and microtomographic analysis. Data were subjected to ANOVA and Tuckey tests (p<0.05).</p><p><strong>Results: </strong>At 30 days, all groups showed an intense inflammatory reaction (p>0.05). At 60 days, the AH Plus and Sealer Plus maintained an intense inflammatory infiltrate compared to the clot group (p<0.05). We observed immunopositive areas for type I collagen in all groups at 30 days and 60 days (p>0.05). We observed more red collagen fibers for the Sealer Plus compared to the clot group at 30 days (p<0.05). Considering the total fibers, the clot group at 30 days compared to 60 days after surgery showed an increase in the amount of matrix (p<0.05). There were no statistical differences between groups for green and yellow fibers (p>0.05). Regarding morphometric parameters, at 30 days, the newly formed bone volume and number of bone trabeculae were higher in the groups with sealers compared to the clot group (p<0.05). At 60 days, AH Plus and Sealer Plus showed greater bone neoformation compared to the clot group (p<0.05).</p><p><strong>Conclusions: </strong>Despite AH Plus and Sealer Plus induced an intense inflammatory reaction, they can be considered biocompatible materials, since they allowed bone repair.</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e20220108"},"PeriodicalIF":2.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365338/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40579452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of risk factors on the long-term survival of oral rehabilitation with extra-narrow implants: a retrospective study.","authors":"Elcio Marcantonio Junior,&nbsp;Ivete Aparecida de Mattias Sartori,&nbsp;Camila Pereira Vianna,&nbsp;Roberta Schroder Rocha,&nbsp;Waleska Caldas,&nbsp;Larissa Carvalho Trojan","doi":"10.1590/1678-7757-2022-0089","DOIUrl":"https://doi.org/10.1590/1678-7757-2022-0089","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to retrospectively collect clinical data to evaluate the influence of possible risk factors on the long-term success of implant treatment with extra-narrow (2.9 mm diameter) implants in a daily dental practice setting.</p><p><strong>Methodology: </strong>Data were collected from records of patients who received at least one extra-narrow implant from 2012 to 2017, regarding implant survival, prosthesis survival, patient characteristics, and implant characteristics. The association between the dependent variables \"implant survival\", \"prosthesis survival,\" and \"adverse events\" related to patient and implant characteristics was statistically evaluated by chi-square tests. Moreover, implant and prosthesis survival were analyzed by Kaplan-Meier survival curves.</p><p><strong>Results: </strong>The sample was constituted of 58 patients (37 women and 21 men) with a mean age of 54.8 years old (SD: 12.5), followed up for up to eight years. In total, 86 extra-narrow implants were placed within this sample. Four implants were lost, resulting in an implant survival rate of 95.3%. A total of 55 prostheses were inserted and only one (1.8%) was lost, resulting in a prosthesis survival rate of 98.2%. The mean implant and prosthesis survival time was, respectively, 7.1 years and 6.3 years, according to the Kaplan-Meier survival analysis. A correlation was found between smoking and implant loss, which makes implant loss eight times more likely to occur in smokers than non-smokers. A significant association was also found between prosthesis loss and previous need of prosthesis repair. However, it was not considered clinically relevant. No association was found between the occurrence of adverse events and later implant or prosthesis loss.</p><p><strong>Conclusion: </strong>High implant and prosthesis survival rates were found in the long term for treatment with extra-narrow implants. Moreover, a significant correlation between smoking and implant loss was observed.</p>","PeriodicalId":321675,"journal":{"name":"Journal of applied oral science : revista FOB","volume":" ","pages":"e20220089"},"PeriodicalIF":2.7,"publicationDate":"2022-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9365337/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40579450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}