World Journal of OtorhinolaryngologyHead and Neck Surgery最新文献

{"title":"Expression and clinical significance of the p53/SAT1/ALOX15 ferroptosis-associated proteins in sinonasal inverted papilloma.","authors":"Dan-Yang Li, Lin Wang, Ji-Sheng Zhang, Jia-Jia Zi, Han Chen, Zi-Hui Dong, Long-Gang Yu, Yan Jiang","doi":"10.1002/wjo2.213","DOIUrl":"10.1002/wjo2.213","url":null,"abstract":"<p><strong>Objectives: </strong>Sinonasal inverted papilloma (SNIP) is a benign tumor type that has been subject to growing levels of research interest owing to its potential for malignant transformation. However, there have been no studies to date of ferroptosis or related proteins in SNIP. Accordingly, this study was designed to examine correlative relationships between SNIP pathogenesis and the expression of proteins associated with ferroptotic activity, including p53, SAT1, and ALOX15.</p><p><strong>Methods: </strong>Samples were collected from 44 total SNIP patients, and control middle turbinate samples were obtained from 28 patients with deviated septums. The RNA and protein levels of p53, SAT1, and ALOX15 were compared between these samples via quantitative real-time PCR (qRT-PCR), Western blot analysis (WB), and immunohistochemistry (IHC). The expression of mRNA was further validated by interrogating the GSE193016 data set. The correlations among the expression levels of these three genes were also assessed. Then, the Krouse stage system was used to grade these patients and to explore differences in p53, SAT1, and ALOX15 expression among different stages of the disease. Lastly, we compared the differences in the expression of these genes in inverted papilloma and squamous cell carcinoma by qRT-PCR and IHC.</p><p><strong>Results: </strong>SNIP samples exhibited significantly higher p53, SAT1, and ALOX15 mRNA and protein levels than control samples, and strong correlations were observed between the levels of these three proteins. Furthermore, the expression levels of p53, SAT1, and ALOX15 were significantly higher in stage T4 compared to T2 in SNIP. p53 and SAT1 were significantly elevated in squamous carcinomas compared to inverted papilloma. However, the expression of ALOX15 tended to decrease in squamous carcinoma.</p><p><strong>Conclusion: </strong>These results support a potential role for the p53/SAT1/ALOX15 ferroptotic pathway proteins in SNIP pathogenesis, although future molecular biology-based studies will be essential to test this hypothesis.</p>","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"11 2","pages":"281-289"},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Author Guidelines.","authors":"","doi":"10.1002/wjo2.206","DOIUrl":"https://doi.org/10.1002/wjo2.206","url":null,"abstract":"","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"10 3","pages":"244-251"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11369789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142134018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Augmentation laryngoplasty: Results and decision plan.","authors":"Laura Tissot, Christol Fabre, Marie-Pierre Aboussouan, Paul F Castellanos, Ihab Atallah","doi":"10.1002/wjo2.212","DOIUrl":"10.1002/wjo2.212","url":null,"abstract":"<p><strong>Objectives: </strong>Augmentation laryngoplasty represents a therapeutic choice for patients who suffer from glottic insufficiency of different etiologies. There have been multiple injectables that have been proven effective. The present study examines the short-term effects of vocal fold augmentation on phonation, swallowing, and breathing in individuals with glottic insufficiency. In addition, a decision plan is also proposed.</p><p><strong>Methods: </strong>Data from medical records and operative notes were used to conduct a retrospective cohort study on patients with glottic insufficiency who underwent vocal fold augmentation from 2016 to 2023. Hyaluronic acid, calcium hydroxyapatite, and polydimethylsiloxane were the injectable materials that were used. An analysis was conducted on phonation, breathing, swallowing, and laryngoscopy findings both before and after vocal folds' augmentation.</p><p><strong>Results: </strong>Seventy-nine patients were included, which represents 97 injections. The median (IQR) preoperative Voice Handicap Index-10 (VHI-10) score improved from 21 (15-28) to 16 (9-25) postoperatively (<i>p</i> < 0.001). The GRBAS scale also significantly decreased (<i>p</i> < 0.001). The median (IQR) preoperative Dyspnea Index score improved from 6 (0-17) to 2 (0-10) postoperatively (<i>p</i> < 0.05). Laryngoscopic findings showed significant improvement in the bulk of the vocal folds. There was no significant change in swallowing.</p><p><strong>Conclusions: </strong>In case of dysphonia secondary to glottic insufficiency, augmentation laryngoplasty using various injectable materials has proven to be an effective option across a range of different etiologies, as it results in significant improvements in voice quality. The choice of the injectable material depends upon the severity and the etiology of glottic insufficiency.</p>","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"11 2","pages":"232-240"},"PeriodicalIF":0.0,"publicationDate":"2024-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172133/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327035","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Response to concerns on \"Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China\".","authors":"Meng-Fan Liu, Rui-Xia Ma, Xian-Bao Cao, Jian-Feng Liu, Lei Cheng, Yu-Cheng Yang","doi":"10.1002/wjo2.210","DOIUrl":"10.1002/wjo2.210","url":null,"abstract":"","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"10 4","pages":"355-356"},"PeriodicalIF":0.0,"publicationDate":"2024-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830152","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recurrent nerve damage following thyroid surgery: What can I do?","authors":"Domenico Testa, Lucia Del Vecchio, Sergio Motta, Ludovica Castagna, Giovanni Conzo, Vincenza Carandente, Giovanni Docimo, Nicola Lombardo, Alessandra Conzo, Giovanni Motta, Ludovico Docimo","doi":"10.1002/wjo2.203","DOIUrl":"10.1002/wjo2.203","url":null,"abstract":"<p><strong>Objectives: </strong>Bilateral recurrent nerve damage still represents one of the main complications following thyroid surgery, even though the nerve intraoperative monitoring has allowed the decrease of this injury<b>.</b> This observational retrospective study aims to define the onset modalities and the recovery time of different clinical conditions that may occurs after thyroidectomy.</p><p><strong>Methods: </strong>From a total of 1417 patients who underwent total thyroidectomy for benign tumors between 2017 and 2022 in ENT Unit of University of Campania \"L. Vanvitelli,\" this study involved 30 patients with bilateral vocal folds motility deficit. These patients (28 F, 2 M), aged from 24 to 78 years old (average age 51.7), presented a bilateral vocal fold motility deficit. Five patients of the study developed an acute respiratory failure upon the awakening that required a nasotracheal prolonged safe extubation. The other 25 patients underwent 9 months diagnostic and therapeutic process, which started approximately 30 days after thyroid surgery.</p><p><strong>Results: </strong>Indeed, there are several outcomes of these complications, like functional laryngeal defects, which are mainly related to respiratory and phonatory activities. These clinical manifestations can evolve in different ways within a context of a wide range of possibilities, from the spontaneous bilateral or monolateral recovery to the necessity of a functional or surgical restoration.</p><p><strong>Conclusion: </strong>This study allowed the acquisition of useful information about prognostic indications and an adequate therapeutic process, based on the specific clinical characteristics.</p>","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"11 2","pages":"256-263"},"PeriodicalIF":0.0,"publicationDate":"2024-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172132/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Incidence and prognosis of olfactory and gustatory dysfunctions related to SARS-CoV-2 Omicron strain infection in China: Correspondence.","authors":"Hinpetch Daungsupawongm, Viroj Wiwanitkit","doi":"10.1002/wjo2.209","DOIUrl":"10.1002/wjo2.209","url":null,"abstract":"","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"10 4","pages":"353-354"},"PeriodicalIF":0.0,"publicationDate":"2024-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634741/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Phenotypic differences in airway obstruction as determined by VOTE score.","authors":"Andrew S Franklin, Paul M Putnam, Meghana C Chanamolu, Chad A Nieri, M Boyd Gillespie","doi":"10.1002/wjo2.202","DOIUrl":"10.1002/wjo2.202","url":null,"abstract":"<p><strong>Objective: </strong>The objective if this study was to investigate phenotypic differences in airway obstruction, as determined by VOTE score, in a cohort of patients with obstructive sleep apnea (OSA) undergoing drug-induced sleep endoscopy (DISE).</p><p><strong>Methods: </strong>Patients older than 18 years of age scheduled for DISE by one surgeon at a tertiary care center from July 2016 to July 2022 were included in a single-center retrospective cohort study. Patient demographics, body mass index (BMI), apnea-hypopnea index (AHI), and VOTE scores were extracted. Spearman correlation tests were utilized to determine the relationship between variables, and statistical analyses were performed using R.</p><p><strong>Results: </strong>The study included 165 patients (61.24 years, SD 11.57; BMI 31.04 kg/m², SD 6.05). Due to several significant relationships between VOTE scores and patient demographics, a cluster analysis was performed, in which two distinct clusters (phenotype 1 and phenotype 2) arose. Phenotype 1 patients had lower overall VOTE scores (<i>p</i> < 0.001), less obstruction at the velum (<i>p</i> < 0.001) and oropharynx (<i>p</i> < 0.001), significantly more tongue obstruction (<i>p</i> = 0.031), and a significantly lower BMI (<i>p</i> = 0.001). Though not reaching significance, phenotype 1 patients also had more epiglottic obstruction (<i>p</i> = 0.0841) and were older (<i>p</i> = 0.2775).</p><p><strong>Conclusions: </strong>Patients suffering from OSA may be categorized into one of two distinct phenotypes of clinical significance. Phenotype 1 patients who are nonobese and have less significant obstruction overall, with increased obstruction at the tongue, may benefit greatly from targeted surgical modalities. Conversely, phenotype 2 patients with worse obstruction on DISE and increased velum and oropharynx obstruction may represent a phenotype of OSA that is increasingly difficult to treat surgically, due to body habitus and severe, multi-level obstruction.</p>","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"11 2","pages":"213-219"},"PeriodicalIF":0.0,"publicationDate":"2024-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choanal atresia: A review of surgical outcomes in a tertiary medical center.","authors":"Sinan Dheyauldeen, Ketil Heimdal, Terje Osnes, Harriet Akre, Lars Olsson","doi":"10.1002/wjo2.196","DOIUrl":"10.1002/wjo2.196","url":null,"abstract":"<p><strong>Introduction: </strong>Choanal atresia (CA) is a congenital narrowing or obliteration of the posterior nasal aperture. The condition is rare with an incidence of approximately 1 in 5000 to 9000 live births.</p><p><strong>Objective: </strong>The aim of this work was to assess the results of treating this condition at the Otolaryngology Department in Oslo University Hospital-Rikshospitalet.</p><p><strong>Methods: </strong>Retrospective review of patients treated at Oslo University Hospital-Rikshospitalet between 2005 and 2015 were performed. The review consisted of surgical techniques and outcomes, types of atresia, uses of stent and mitomycin C, age at operation, laterality of atresia, and associated anomalies.</p><p><strong>Results: </strong>Thirty-one patients with CA were referred to Oslo University Hospital-Rikshospitalet during the mentioned observation period. Nine (29%) of the cases had bilateral CA and 22 (71%) had unilateral CA. Ten patients (32%) had bony atresia, 12 (39%) had membranous and eight (26%) had mixed type of atresia. Twenty-one patients (68%) needed revision surgery because of complete or partial restenosis after primary surgery. Stents were applied in 16 cases (52%) of patients and Mitomycin C was only used in the primary surgery of three patients. In the bilateral group, eight of the nine patients were operated on within the first 9 days of life. Sixteen patients (45%) had associated anomalies.</p><p><strong>Conclusions: </strong>According to the observations in our sample, the restenosis problem is expected more and may need more revisions in bilateral CA than the unilateral type. The presence of other anomalies is associated with higher incidence of restenosis. Stenting is not essential in preventing restenosis.</p>","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"11 2","pages":"207-212"},"PeriodicalIF":0.0,"publicationDate":"2024-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12172098/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144327037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sirt5 affects the metabolic remodeling of eosinophils by negatively regulating the level of succinylation modification of Pkm2 in eosinophilic chronic rhinosinusitis.","authors":"Shun-Yu Wu, Bo-Yu Cai, Zhi-Wen Cao, Tian-Yu Wang, Cai-Quan Liang, En-Hong Xu, Hu Peng, Jianchun-Liao, Huan-Hai Liu","doi":"10.1002/wjo2.186","DOIUrl":"10.1002/wjo2.186","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to investigate the role of Sirt5 in regulating eosinophil maturation and activation, specifically focusing on primary eosinophils in mice at the genetic level. Additionally, the study aims to elucidate the underlying mechanism of Sirt5 in eosinophilic inflammation metabolism and identify potential drug targets for the treatment of chronic sinusitis. The findings of this study will provide new insights and a solid theoretical basis for the development of novel therapeutic strategies for eosinophilic chronic rhinosinusitis (eCRS).</p><p><strong>Methods: </strong>Our study investigated the role of Sirt5 gene expression in both non-eCRS and eCRS. We examined the correlation between Sirt5 gene expression and disease severity as well as eosinophil infiltration. Additionally, we utilized a mouse model of eCRS to assess the impact of Sirt5 gene deletion on the disease. To further understand the underlying mechanisms, we conducted experiments at the single-cell level using bone marrow-derived eosinophils. We validated our findings through in vitro culture of eosinophils and intervention experiments. Through these experiments, we aimed to elucidate how Sirt5 regulates target proteins and reshapes their related metabolic pathways.</p><p><strong>Results: </strong>There is a positive correlation between the severity of eCRS and the expression level of Sirt5 in nasal mucosa. Inhibiting Sirt5 expression can effectively alleviate the abnormal activation of eosinophils and the resulting inflammatory response in eCRS-affected nasal mucosa. Sirt5 exerts its influence on eosinophil metabolism by negatively regulating the succinylation level of pkm2, a critical gene in the amino acid biosynthesis pathway.</p><p><strong>Conclusions: </strong>The severity of eCRS is closely associated with the expression level of Sirt5. Sirt5 plays a negative regulatory role in the succinylation level of Pkm2 in eosinophils, thereby influencing metabolic remodeling and functional activation in eCRS. Investigating Sirt5 and its downstream metabolic pathways could offer valuable insights into the disease's pathogenesis and facilitate the development of targeted therapeutic strategies. This research holds significant implications for clinical practitioners involved in the diagnosis and treatment of patients with eCRS.</p>","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"11 1","pages":"86-101"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agent Orange and head and neck cancer: A systematic review and meta-analysis.","authors":"Neil P Monaghan, Kelsey A Duckett, Shaun A Nguyen, Jason G Newman, Alexandra E Kejner, W Greer Albergotti","doi":"10.1002/wjo2.198","DOIUrl":"10.1002/wjo2.198","url":null,"abstract":"<p><strong>Objective: </strong>To assess the incidence of head and neck cancer in patients exposed to Agent Orange and related dioxins.</p><p><strong>Methods: </strong>Studies were identified through CINAHL, PubMed, and Scopus. Primary studies were identified through April 2023. Articles were included reporting incidence of head and neck cancer and/or deaths due to head and neck cancer in participants exposed to Agent Orange. Meta-analysis of proportions was conducted to calculate incidence and mortality by primary site in those who were exposed to Agent Orange and for control groups. A comparison of proportions was used to compare rates in exposed and control groups.</p><p><strong>Results: </strong>Of 1530 unique abstracts screened, 13 studies were included in the systematic review. Of the exposed patients with reported subsites, oral cavity (31.2%), and larynx (14%) were the most common. Of the exposed patients with reported deaths and subsites, oropharynx (0.25%) was the most common primary site in patients who died. The most common subsites of those who were not exposed, oropharynx (0.13%), and larynx (0.16%). Head and neck cancer of all subsites was more common in those exposed to Agent Orange than in unexposed controls (difference 0.061%; 95% confidence interval: 0.04%-0.08%, <i>p</i> < 0.0001).</p><p><strong>Conclusions: </strong>Our findings suggest that head and neck cancer is more common in those who were exposed to Agent Orange than those who were not. Additionally, individuals exposed to Agent Orange were more likely to die from head and neck cancer. Further investigation is warranted to evaluate subsite-specific outcomes given the limitations of our study design.</p>","PeriodicalId":32097,"journal":{"name":"World Journal of OtorhinolaryngologyHead and Neck Surgery","volume":"11 1","pages":"138-146"},"PeriodicalIF":0.0,"publicationDate":"2024-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11891274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143606557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}