Journal of Current Oncology最新文献

{"title":"Choosing Optimal Feeding Method in Head–Neck Cancer Patients Receiving Radiation: Percutaneous Endoscopic Gastrostomy Versus Nasogastric Tube—Is It Pertinent?","authors":"Shreyasee Karmakar-Mangaj, S. Laskar, K. Talapatra","doi":"10.1177/25898892231214586","DOIUrl":"https://doi.org/10.1177/25898892231214586","url":null,"abstract":"The current standard of care for locally-advanced head–neck cancer is multidisciplinary, using bimodality or trimodality therapy as appropriate. These patients are frequently malnourished either due to disease or due to treatment related toxicities. Both chemotherapy and radiotherapy are associated with acute and late toxicities which in turn exacerbate malnutrition in these patients. Malnutrition is found to be associated with poor survival outcomes. To maintain nutrition in such patients, enteral feeding can be done using either percutaneous endoscopic gastrostomy tube (PEG) or a nasogastric tube (NGT). Both PEG and NGT have been found effective in adequate maintenance of weight; however, both have their own set of advantages and disadvantages. Nutritional counselling forms an integral part of weight management during treatment and oral feeding should be encouraged in all unless contra-indicated.","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":" 97","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140384335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Survival Outcomes in Different Sino-nasal Malignancies: An Institutional Review","authors":"Umesh Preetha, Shamima Akhter, Tandon Sarthak, Ahlawat Parveen, Purohit Sandeep, Gairola Munish","doi":"10.1177/25898892241232746","DOIUrl":"https://doi.org/10.1177/25898892241232746","url":null,"abstract":"Objective: The purpose of this review is to comprehend the treatment outcome of different PNS cancer histologies and their survival. Materials and Procedures: A review of our institutional database from January 2010 to December 2022 included 122 sinonasal cancer patients. After exclusions, 84 patients whose data sets were complete underwent analysis. Overall survival (OS), loco-regional failure-free survival (LRFS), and distant metastases-free survival (DMFS) were the measured endpoints. Results: With a median follow-up time of 26 months, there was no correlation detected between histological type and OS, LRFS, or DMFS. It was discovered that the type of treatment technique was substantially related to LRFS. Surgery plus adjuvant radiation and/or chemotherapy had a minor tendency to be significant in terms of OS, with a median OS of 56 months (95% CI: 38.6–73.3). Conclusions: It showed that the use of different treatment modalities had an impact on LRFS, while the type of histology did not correlate with the effectiveness of the treatment.","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":"2006 8","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140246450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of CYP2D6, CYP2C9/19, CYP3A4, UGT, and SULT Variability on Tamoxifen Metabolism in Breast Cancer Treatment","authors":"Mariam Sidibe, A. Tazzite, Hassan Jouhadi, H. Dehbi","doi":"10.1177/25898892231223300","DOIUrl":"https://doi.org/10.1177/25898892231223300","url":null,"abstract":"In hormone-receptor-positive breast cancer, the main treatment is tamoxifen. Tamoxifen is a weak antiestrogen that requires prior activation to its most active metabolite, endoxifen, which has superior antiestrogenic activity. In the search for predictive biomarkers to optimize treatment and reduce tamoxifen resistance, studies have concluded that endoxifen concentrations are associated with CYP2D6 activity and that the concentration of endoxifen and other metabolites (whose activities are also linked to the activity of other pharmacogenes) may be associated with tamoxifen efficacy. The aim of this review is to highlight the evidence concerning the contribution of pharmacogenes (CYP2D6, CYP2C9/19, CYP3A4, UGT, and SULT) to tamoxifen metabolism and the effect of the genetic variation to which they are subject on the concentration of active tamoxifen metabolites.","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":"52 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140427618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aggressive Benign Lesion of Jaw in a Teenager: A Case Report","authors":"J. Goyal, Tamanna Khullar, Nitin Agarwal, S. Pasricha, Himanshu Rohela, Sunil Kumar Puri","doi":"10.1177/25898892231206006","DOIUrl":"https://doi.org/10.1177/25898892231206006","url":null,"abstract":"","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":"81 1","pages":"35 - 37"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139371867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Prognostic Impact of Log Odds of Positive Lymph Nodes on Survival of Patients With Early-stage Non-small Cell Lung Cancer: A Population Study Based on the Seer Database and a Chinese Cohort","authors":"K. Xi, Hui Yu, Zewei Huang","doi":"10.1177/25898892231196721","DOIUrl":"https://doi.org/10.1177/25898892231196721","url":null,"abstract":"Objective The purpose of this study was to investigate the prognostic value of log odds of positive lymph nodes (LODDS) in patients with early-stage non-small cell lung cancer (NSCLC). Methods Four hundred and eighty-seven NSCLC patients with pT2N0M0 who underwent radical resection from June 1999 to September 2009 at Sun Yat-Sen University Cancer Center and 8,702 patients from the Surveillance, Epidemiology, and End Results (SEER) were reviewed. According to the X-tile analysis, the patients were classified into two groups based on their log odds ratio [≤ –1.40 (group LODDS1) and > –1.40 (group LODDS2)]. Cox univariate and multivariate analyses were used to identify the prognostic factors for survival. Result Patients were divided into two groups according to the value of LODDS: ≤ – 1.40 (group LODDS1) and > – 1.40 (group LODDS2). For the development cohort, the 5-year CSS rate for patients was 79.6% and 69.3% in the group LODDS1 and LODDS2, respectively (P = .009). For the validation cohort, the 5-year CSS rate was 85.4% for patients in group LODDS1, compared with 82.5% for those in group LODDS2 (P = .006). In multivariate analysis, LODDS was associated with CSS significantly [hazard ratio (HR), 1.487; 95% confidence intervals (CI), 1.126–1.963] in the development cohort. The HR value of LODDS for CSS was 1.260 (95% CI,1.107–1.434) in the validation cohort. Conclusion LODDS was a strong independent prognostic factor for early-stage NSCLC.","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":"27 1","pages":"6 - 14"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139371738","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Grid Size and Statistical Uncertainty on the Accuracy of VMAT Plans Based on Dosimetric Parameters for Head and Neck Cancers","authors":"Asma Javid, J. Nagesh, Rajpal Singh, Senni Andavar S, Shambhavi C, Krishna Sharan, Preeti Kour","doi":"10.1177/25898892231196723","DOIUrl":"https://doi.org/10.1177/25898892231196723","url":null,"abstract":"Aim Grid size and Statistical Uncertainty (SU) settings have an impact on the efficiency and accuracy of the treatment plans. Hence, it is very important, to find an optimum combination of the two-dose calculation parameters for efficient treatment planning. This study aims to study the impact of Grid Size and SU on Head and Neck cancer plans which were planned using the Volumetric-Modulated Arc Therapy (VMAT) technique. Materials and Methods 15 patients were selected for this retrospective study who had undergone radiation therapy at KMC, Manipal for various Head and Neck cancers. VMAT plans were generated for each case in Monaco 5.11 Treatment Planning System (TPS) using the Monte Carlo algorithm. For each patient, nine plans were generated in which the Grid size values were taken as 2 mm, 3 mm, and 5 mm and for each Grid size, SU settings were varied as 1%, 2%, and 5%. The plans were analysed and evaluated using outcome measures such as the Homogeneity Index (HI) and the Conformity Index (CI). Results The plans were evaluated as per the ICRU guidelines. In all the plans, PTV coverage achieved was above 95% with the maximum coverage (97.009) achieved with the 3 mm/1% combination. Overall, the effect of varying Grid Size and SU was insignificant in the plans generated, but there were few variations in the dose calculation parameters. For 2 mm/1%, 2 mm/2%, 2 mm/5%, 3 mm/1%, 3 mm/2%, 3 mm/5%, 5 mm/1%, 5 mm/2%, 5 mm/5%, the mean values of HI were 1.073, 1.078,1.078, 1.075, 1.0805, 1.0805, 1.068, 1.079, 1.089, and the mean values of CI were 0.968, 0.967, 0.967, 0.968, 0.958, 0.96, 0.954, 0.946, 0.948, respectively. Among all the combinations, the results for 5 mm/1% yielded more homogeneity, whereas 2 mm/1% and 3 mm/1% combinations resulted in better conformity. The 3 mm/1% combination gave maximum target coverage and quite fewer Monitor Units (MU) as well. Conclusion 3 mm Grid Size and 1% SU is suggested for the Head and Neck carcinomas planned using the VMAT technique.","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":"77 1","pages":"15 - 21"},"PeriodicalIF":0.0,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139371963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Step-by-Step Stereotactic Radiotherapy Planning of Glomus Jugulare: A Guide to Radiation Oncologists—Dr Kanhu’s ROSE (Radiation Oncology from Simulation to Execution)","authors":"K. Patro, A. Avinash, Chitta Kundu, P. Bhattacharyya, V. Pilaka, M. Rao, A. Prabu, AyyalasomayajulaAnil Kumar, Srinu Aketi, P. Prasad, Mohanapriya Atchaiyalingam, Keerthiga Karthikeyan, Kaviya Lakshmi Radhakrishnan","doi":"10.1177/25898892221145209","DOIUrl":"https://doi.org/10.1177/25898892221145209","url":null,"abstract":"Background Glomus jugulare is a rare, slow-growing tumor that arise within the jugular foramen of the temporal bone. In the past, surgery was the primary modality of treatment for glomus Jugulare, but it leads to many complications and increased mortality. Radiotherapy was indicated in adjuvant setting in post-operative residual disease. But, with the advent of highly conformal radiation planning, stereotactic radiosurgery (SRS), is now one of the main modalities of radiation treatment in glomus jugulare. Objective To describe the procedural steps for radiation planning of SRS of glomus jugulare. Methods The step-by-step procedure for stereotactic planning of glomus jugulare has been described using a clinical scenario of glomus jugulare. Results The stereotactic radiation planning of glomus jugulare starts with the basic history and relevant clinical evaluation, that is, visual testing. Computed tomography (CT) scan and magnetic resonance imaging (MRI) of the brain is the imaging modality of choice. The radiation planning of glomus jugulare starts with CT simulation. MRI of brain should be done in the prescribed format to achieve uniformity in radiation planning. After CT and MRI image fusion, contouring of target, organs at risk (OAR) and radiation planning should be done. The plan evaluation includes target and OAR coverage index, conformity, homogeneity and gradient index, and beam arrangement. After radiation plan evaluation, treatment is delivered after quality assurance and dry run. Conclusion The paper highlights the sequential process of radiation planning for SRS in glomus jugulare—starting from simulation, planning, evaluation of plan, and treatment.","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":"79 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116836770","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Role of Radiotherapy in Thyroid-Related Ophthalmopathy: A Case Series","authors":"B. Ravishankar, Bellala Venkata Madhvi, T. Tyagi, Vishy Srivastava, A. Kuppusamy, B. Prithviraj, Bellala Rishik","doi":"10.1177/25898892221145218","DOIUrl":"https://doi.org/10.1177/25898892221145218","url":null,"abstract":"Purpose To explore the role of radiotherapy (RT) in management of moderate to severe thyroid-related eye disease in terms of efficacy, treatment outcome, and response. Material and methods A case series of 5 patients with moderate to severe Graves Ophthalmopathy treated with orbital RT between July 2020 and March 2021. Patient symptoms and ophthalmic findings prior to RT and after 6 months post RT were analyzed. Computed tomography was performed before and after RT to compare orbital (muscles) volume change. Endpoints including improvement in ocular symptoms such as diplopia, proptosis, extraocular movement were compared. Acute and long-term complications were documented to assess its safety and treatment response. Results Addition of RT improved diplopia, visual acuity, proptosis, and color vision significantly. RT also decreased upper lid edema, optic nerve compression, and reduced intraocular muscle bulk. Extraocular muscles diameter reduced significantly. Patients experienced relief of symptoms and significant reduction in diplopia clinically. Conclusion External beam radiation is a safe and effective intervention in thyroid ophthalmopathy. Our study demonstrated that radiation is effective in decreasing inflammatory signs, symptoms, and muscle bulk. This treatment modality is well tolerated, and long-term complications are tolerable.","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":"15 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127062195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Scrototesticular Irradiation in Primary Testicular Lymphoma: A Guide for Scrotal Simulation (Dr Kanhu’s Burger Technique)","authors":"K. Patro, A. Avinash, Keerthiga Karthikeyan, Chitta Kundu, P. Bhattacharyya, V. Pilaka, M. Rao, A. Prabu, AyyalasomayajulaAnil Kumar, Srinu Aketi, P. Prasad, Mohanapriya Atchaiyalingam, Kaviya Lakshmi Radhakrishnan","doi":"10.1177/25898892221147123","DOIUrl":"https://doi.org/10.1177/25898892221147123","url":null,"abstract":"Primary testicular lymphoma (PTL) is a rare variant of non-Hodgkin’s lymphoma that is predominant in old age group. Painless testicular swelling is the most common presentation. The standard of care is surgery in the form of radical orchiectomy followed by adjuvant chemotherapy and central nervous system prophylaxis. Because of blood-testis barrier, contralateral testis acts as a sanctuary site for chemotherapy to act and hence scrototesticular radiation is advocated in order to reduce the chance of testicular relapse. Due to lack of any consensus simulation procedure, we propose here a step-by-step procedure for simulation of a case of PTL using a case scenario.","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114112170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound-Guided Isolated Recurrent Neck Nodal Interstitial Brachytherapy Following Radical Chemo Radiation of Head and Neck Cancer: A Case Report","authors":"S. Mohanty, Debadipti Pradhan, Nishant Madhani, Chandni Shah, Divya Kantesaria, Heena Ashar, Vimal Hothi, Dhandapani Varadhacharry, Vijay Kumar Gupta","doi":"10.1177/25898892221145085","DOIUrl":"https://doi.org/10.1177/25898892221145085","url":null,"abstract":"Background Therapeutic options are limited for unresectable isolated recurrent cervical lymph node (LN). There are different methods of salvaging the recurrent nodes such as surgery, reirradiation by fractionated external beam radiation therapy, stereotactic body radiotherapy, and interstitial brachytherapy. However, interstitial brachytherapy method is very less commonly used. We highlighted a treated case of oropharyngeal cancer with isolated recurrent neck node treated with interstitial brachytherapy under ultrasound guidance. Methods and materials One 60-year-old male patient diagnosed with case of squamous cell carcinoma vallecula with left level II LN, cT2N1M0, was given 70 Gy in conventional fractionation to the gross primary and node and 59 Gy and 56 Gy to the intermediate and low-risk volumes, respectively. Post chemoradiation, we achieved complete metabolic and morphological response of the primary and neck node as well. However, he developed a recurrent fluorodeoxyglucose avid level II LN of size 3×2 cm after 7 months which was fixed. Positron emission tomography (PET) scan showed a PET avid recurrent node abutting the great vessels in the left side. We treated by computed tomography (CT)-based high-dose-rate interstitial brachytherapy using Ir-192. High-risk clinical target volume was defined as 1.5 cm margin around the gross tumor volume, trying to achieve 100% volume with 95% dose prescribing 35 Gy/10 fractions @ 350cGy/# to HRCTV using Oncentra treatment planning system. Result He developed complete metabolic response after 3 month of nodal brachytherapy confirmed by PET CT and remained disease free for 30 months till the last follow-up. Conclusion Ultrasonography-guided interstitial nodal brachytherapy is a valid option and feasible in previously irradiated patients with isolated recurrent neck node of head and neck cancers. However, more number of patients needed to be done by similar fashion for adequate data generation and proper conclusion.","PeriodicalId":315168,"journal":{"name":"Journal of Current Oncology","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131630728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}