Role of Radiotherapy in Thyroid-Related Ophthalmopathy: A Case Series

B. Ravishankar, Bellala Venkata Madhvi, T. Tyagi, Vishy Srivastava, A. Kuppusamy, B. Prithviraj, Bellala Rishik
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Abstract

Purpose To explore the role of radiotherapy (RT) in management of moderate to severe thyroid-related eye disease in terms of efficacy, treatment outcome, and response. Material and methods A case series of 5 patients with moderate to severe Graves Ophthalmopathy treated with orbital RT between July 2020 and March 2021. Patient symptoms and ophthalmic findings prior to RT and after 6 months post RT were analyzed. Computed tomography was performed before and after RT to compare orbital (muscles) volume change. Endpoints including improvement in ocular symptoms such as diplopia, proptosis, extraocular movement were compared. Acute and long-term complications were documented to assess its safety and treatment response. Results Addition of RT improved diplopia, visual acuity, proptosis, and color vision significantly. RT also decreased upper lid edema, optic nerve compression, and reduced intraocular muscle bulk. Extraocular muscles diameter reduced significantly. Patients experienced relief of symptoms and significant reduction in diplopia clinically. Conclusion External beam radiation is a safe and effective intervention in thyroid ophthalmopathy. Our study demonstrated that radiation is effective in decreasing inflammatory signs, symptoms, and muscle bulk. This treatment modality is well tolerated, and long-term complications are tolerable.
放疗在甲状腺相关性眼病中的作用:一个病例系列
目的探讨放射治疗(RT)在中重度甲状腺相关性眼病治疗中的疗效、疗效和反应。材料与方法对2020年7月至2021年3月期间5例中重度Graves眼病患者进行眼眶RT治疗。分析患者在放疗前和放疗后6个月的症状和眼科检查结果。RT前后行计算机断层扫描比较眼眶(肌肉)体积变化。终点包括复视、眼球突出、眼外运动等眼部症状的改善。记录急性和长期并发症,以评估其安全性和治疗反应。结果RT治疗后复视、视敏度、视力、色觉均有明显改善。RT还可减少上眼睑水肿、视神经压迫和眼内肌肉体积。眼外肌直径明显减小。患者临床症状缓解,复视明显减少。结论外束放射治疗甲状腺性眼病是一种安全有效的治疗方法。我们的研究表明,辐射在减少炎症体征、症状和肌肉量方面是有效的。这种治疗方式耐受性良好,长期并发症是可以忍受的。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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