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吲哚胺-2 3-双加氧酶对血液系统肿瘤治疗与预后的意义 吲哚胺-2 3-双加氧酶对血液系统肿瘤治疗与预后的意义
Clinical Oncology and Cancer Research Pub Date : 2018-04-30 DOI: 10.3969/J.ISSN.1000-8179.2018.08.419
吴东维, Wu Dongwei, 吴凌, Wu-Ting Lin, 夏冰, Xia Bing, 张翼鷟, Zhang Yizhuo
{"title":"吲哚胺-2 3-双加氧酶对血液系统肿瘤治疗与预后的意义","authors":"吴东维, Wu Dongwei, 吴凌, Wu-Ting Lin, 夏冰, Xia Bing, 张翼鷟, Zhang Yizhuo","doi":"10.3969/J.ISSN.1000-8179.2018.08.419","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.2018.08.419","url":null,"abstract":"肿瘤免疫反应作为一种保护机制，在血液系统肿瘤形成时即自发产生。然而，在临床明确诊断肿瘤之前，活化的免疫细胞和效应细胞因子的存在已经引发多种免疫抑制途径，这些途径相互协同并导致肿瘤抗原特异性T细胞的功能障碍，最终使血液系统肿瘤处于耐受状态。吲哚胺-2，3-双加氧酶（indoleamine 2，3-dioxygenase，IDO）为上述免疫抑制途径的重要成员之一，IDO通过代谢色氨酸，引起反馈性调节，从而限制炎症反应和引起T细胞获得性耐受，最终抑制肿瘤免疫反应。IDO免疫抑制的作用使得IDO抑制剂成为治疗多种肿瘤的重要免疫治疗方法，特别是在血液系统肿瘤中的作用为近些年的研究热点。本文就IDO及其抑制剂在血液系统肿瘤中的治疗作用和预后意义进行综述。","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2018-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125687509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and diagnostic value of serum miR-26a/b in patients with gastric cancer 胃癌患者血清miR-26a/b的表达及诊断价值
Clinical Oncology and Cancer Research Pub Date : 2017-12-30 DOI: 10.3969/J.ISSN.1000-8179.2017.24.612
司怡然, S. Yiran, 张海洋, Z. Haiyang, 王艺, Wang Yi, 邓婷, Deng Ting, 白明, Bai Ming, 宁涛, Ni Tao, 张乐, Zhang Le, 巴一, B. Yi
{"title":"Expression and diagnostic value of serum miR-26a/b in patients with gastric cancer","authors":"司怡然, S. Yiran, 张海洋, Z. Haiyang, 王艺, Wang Yi, 邓婷, Deng Ting, 白明, Bai Ming, 宁涛, Ni Tao, 张乐, Zhang Le, 巴一, B. Yi","doi":"10.3969/J.ISSN.1000-8179.2017.24.612","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.2017.24.612","url":null,"abstract":"目的探讨胃癌患者血清miR-26a/b诊断胃癌的价值及其与临床病理特征的关系。 方法采用qRT-PCR法检测121例胃癌患者和116例正常人(对照组)血清miR-26a/b的表达量，分析miR-26a/b与胃癌临床病理特征的关系，构建受试者工作特征曲线(ROC)，分析miR-26a/b诊断胃癌的价值。 结果胃癌患者血清miR-26a和miR-26b相对表达水平均低于对照组(1.60±1.02 vs.5.35±0.44；1.44±0.71 vs.5.35±0.71；P 0.05)；miR-26a的ROC曲线下面积为0.828(95% CI：0.776~0.881)，灵敏度为73.3%，特异度为81.0%；miR-26b的ROC曲线下面积为0.853(95%CI：0.801~0.906)，灵敏度为68.1%，特异度为99.2%。 结论miR-26a/b在胃癌患者血清中表达显著降低，并且其表达水平与胃癌的临床分期、浸润深度及有无淋巴结转移相关，有着较高的诊断价值。","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131349020","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and significance of LAPTM4B-35 and MMP-9 in patients with gastric cancer 胃癌患者LAPTM4B-35、MMP-9的表达及意义
Clinical Oncology and Cancer Research Pub Date : 2017-12-30 DOI: 10.3969/J.ISSN.1000-8179.2017.24.822
张静怡, Zhang Jingyi, 单丽珠, Shan Lizhu, 张洁, Zhang Jie, 张仑, Z. Lun
{"title":"Expression and significance of LAPTM4B-35 and MMP-9 in patients with gastric cancer","authors":"张静怡, Zhang Jingyi, 单丽珠, Shan Lizhu, 张洁, Zhang Jie, 张仑, Z. Lun","doi":"10.3969/J.ISSN.1000-8179.2017.24.822","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.2017.24.822","url":null,"abstract":"目的本研究分析溶酶体相关4次跨膜蛋白B(lysosome-associated transmembrane protein 4β，LAPTM4B)-35和基质金属蛋白酶(matrix metalloproteinase，MMP)-9在胃癌中的表达及其与临床病理因素和预后的关系。 方法采用qRT-PCR法检测胃癌细胞株及正常胃黏膜细胞株中LAPTM4B-35和MMP-9 mRNA的表达，免疫组织化学分析胃癌石蜡标本LAPTM4B-35和MMP-9蛋白的表达，运用相关手段分析蛋白表达与临床相关性，Log-rank单因素分析和Cox多因素分析对预后进行研究。 结果LAPTM4B-35和MMP-9 mRNA在HGC-27、SGC7901和MGC803胃癌细胞株相对表达量明显高于GES-1胃黏膜细胞株；免疫组织化学结果显示LAPTM4B-35和MMP-9均在细胞质中表达，LAPTM4B-35阳性表达率为50.7%，MMP-9阳性表达率为36.8%；LAPTM4B-35的表达与MMP-9的表达呈正相关；相关分析显示Lauren's分型和肿瘤浸润T分期与LAPTM4B-35表达相关，肿瘤大小和淋巴结转移N分期与MMP-9表达密切相关，预后生存Cox多因素分析结果显示分化程度、淋巴结转移N分期、LAPTM4B-35表达与MMP-9表达是胃癌患者独立预后因素。 结论LAPTM4B-35和MMP-9在胃癌的侵袭和迁移中起着重要作用，其表达为胃癌预后独立因素，可作为胃癌预后指标。","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2017-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128414199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress on Rad51C in DNA damage repair Rad51C在DNA损伤修复中的研究进展
Clinical Oncology and Cancer Research Pub Date : 2016-09-30 DOI: 10.3969/J.ISSN.1000-8179.2016.18.502
X. Ding, Xiuli Chen, Ping Wang
{"title":"Research progress on Rad51C in DNA damage repair","authors":"X. Ding, Xiuli Chen, Ping Wang","doi":"10.3969/J.ISSN.1000-8179.2016.18.502","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.2016.18.502","url":null,"abstract":"细胞毒性物质及电离辐射等易致细胞DNA损伤，真核生物中DNA双链断裂（double strand breaks，DSBs）修复的主要通路\u0000是同源重组（homologous recombination，HR）。Rad51C蛋白作为HR通路的关键因子，其表达异常可致DNA损伤修复的失调，引起\u0000基因组的不稳定，最终导致肿瘤的发生发展。近年来随着对Rad51C基因的研究，发现Rad51C可能会成为恶性肿瘤治疗的潜在\u0000靶点。本文就Rad51C在DNA损伤修复及放疗中作用的研究进展进行综述。","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"69 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2016-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121285228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Expression and significance of PARP1 and PAR in triple-negative breast cancer PARP1和PAR在三阴性乳腺癌中的表达及意义
Clinical Oncology and Cancer Research Pub Date : 2014-12-30 DOI: 10.3969/J.ISSN.1000-8179.20141138
Huilan Li, Shuai Li, L. Zhai, L. Fu
{"title":"Expression and significance of PARP1 and PAR in triple-negative breast cancer","authors":"Huilan Li, Shuai Li, L. Zhai, L. Fu","doi":"10.3969/J.ISSN.1000-8179.20141138","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20141138","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"216 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123385324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal to epithelial transition in malignant mesenchymal tumors 恶性间质肿瘤中间质向上皮的转化
Clinical Oncology and Cancer Research Pub Date : 2014-12-30 DOI: 10.3969/J.ISSN.1000-8179.20141559
Jilong Yang, Xiaoling Du, Guo-wen Wang, Yun Yang
{"title":"Mesenchymal to epithelial transition in malignant mesenchymal tumors","authors":"Jilong Yang, Xiaoling Du, Guo-wen Wang, Yun Yang","doi":"10.3969/J.ISSN.1000-8179.20141559","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20141559","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"57 2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133975803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Clinical features and prognosis of patients with carcinomatous change of fibroadenoma: A report of 18 cases 纤维腺瘤癌变的临床特点及预后:附18例报告
Clinical Oncology and Cancer Research Pub Date : 2014-12-30 DOI: 10.3969/J.ISSN.1000-8179.20141024
Limei Chen, L.-Q. Zhnag, Y. Zhnag, Lin Gu
{"title":"Clinical features and prognosis of patients with carcinomatous change of fibroadenoma: A report of 18 cases","authors":"Limei Chen, L.-Q. Zhnag, Y. Zhnag, Lin Gu","doi":"10.3969/J.ISSN.1000-8179.20141024","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20141024","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"68 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126323309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in lymphoma maintenance therapy with rituximab 利妥昔单抗淋巴瘤维持治疗的进展
Clinical Oncology and Cancer Research Pub Date : 2014-12-30 DOI: 10.3969/J.ISSN.1000-8179.20141313
X. Bi, Tingchao Chen, Wenjing Jiang
{"title":"Advances in lymphoma maintenance therapy with rituximab","authors":"X. Bi, Tingchao Chen, Wenjing Jiang","doi":"10.3969/J.ISSN.1000-8179.20141313","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20141313","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"54 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131856323","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Research progress on the role of hedgehog signaling pathway in gastric cancer hedgehog信号通路在胃癌中的作用研究进展
Clinical Oncology and Cancer Research Pub Date : 2014-12-15 DOI: 10.3969/J.ISSN.1000-8179.20141392
B. Ke, Ning Liu, H. Liang
{"title":"Research progress on the role of hedgehog signaling pathway in gastric cancer","authors":"B. Ke, Ning Liu, H. Liang","doi":"10.3969/J.ISSN.1000-8179.20141392","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20141392","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128051947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Research progress in the postoperative nutritional support of esophageal carcinoma 食管癌术后营养支持的研究进展
Clinical Oncology and Cancer Research Pub Date : 2014-12-15 DOI: 10.3969/J.ISSN.1000-8179.20141718
Zhentao Yu
{"title":"Research progress in the postoperative nutritional support of esophageal carcinoma","authors":"Zhentao Yu","doi":"10.3969/J.ISSN.1000-8179.20141718","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20141718","url":null,"abstract":"","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"2015 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127705126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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