Rad51C在DNA损伤修复中的研究进展

Clinical Oncology and Cancer Research Pub Date : 2016-09-30 DOI:10.3969/J.ISSN.1000-8179.2016.18.502

X. Ding, Xiuli Chen, Ping Wang

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引用次数: 0

摘要

细胞毒性物质及电离辐射等易致细胞DNA损伤，真核生物中DNA双链断裂（double strand breaks，DSBs）修复的主要通路是同源重组（homologous recombination，HR）。Rad51C蛋白作为HR通路的关键因子，其表达异常可致DNA损伤修复的失调，引起基因组的不稳定，最终导致肿瘤的发生发展。近年来随着对Rad51C基因的研究，发现Rad51C可能会成为恶性肿瘤治疗的潜在靶点。本文就Rad51C在DNA损伤修复及放疗中作用的研究进展进行综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Research progress on Rad51C in DNA damage repair

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Clinical Oncology and Cancer Research

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