胃癌患者血清miR-26a/b的表达及诊断价值

Clinical Oncology and Cancer Research Pub Date : 2017-12-30 DOI:10.3969/J.ISSN.1000-8179.2017.24.612

司怡然, S. Yiran, 张海洋, Z. Haiyang, 王艺, Wang Yi, 邓婷, Deng Ting, 白明, Bai Ming, 宁涛, Ni Tao, 张乐, Zhang Le, 巴一, B. Yi

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引用次数: 0

摘要

目的探讨胃癌患者血清miR-26a/b诊断胃癌的价值及其与临床病理特征的关系。方法采用qRT-PCR法检测121例胃癌患者和116例正常人(对照组)血清miR-26a/b的表达量，分析miR-26a/b与胃癌临床病理特征的关系，构建受试者工作特征曲线(ROC)，分析miR-26a/b诊断胃癌的价值。结果胃癌患者血清miR-26a和miR-26b相对表达水平均低于对照组(1.60±1.02 vs.5.35±0.44；1.44±0.71 vs.5.35±0.71；P 0.05)；miR-26a的ROC曲线下面积为0.828(95% CI：0.776~0.881)，灵敏度为73.3%，特异度为81.0%；miR-26b的ROC曲线下面积为0.853(95%CI：0.801~0.906)，灵敏度为68.1%，特异度为99.2%。结论miR-26a/b在胃癌患者血清中表达显著降低，并且其表达水平与胃癌的临床分期、浸润深度及有无淋巴结转移相关，有着较高的诊断价值。

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Expression and diagnostic value of serum miR-26a/b in patients with gastric cancer

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Clinical Oncology and Cancer Research

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