Clinical Oncology and Cancer Research最新文献_第2页

Development of Ebpl in tumor proliferation and invasion Ebpl在肿瘤增殖和侵袭中的研究进展

Clinical Oncology and Cancer Research Pub Date : 2014-12-15 DOI: 10.3969/J.ISSN.1000-8179.20141418

Yuan Liu, Fei Zhang, R. Niu

引用次数: 0

Placement of laparoscopic jejunostomy for patients with esophageal cancer 腹腔镜空肠造口术在食管癌患者中的应用

Clinical Oncology and Cancer Research Pub Date : 2014-12-15 DOI: 10.3969/J.ISSN.1000-8179.20141717

Xiao Ma, hecheng li, Yiliang Zhang, W. Guo, Long-fei Ma, Jie Zhang, J. Xiang

引用次数: 1

Clinicopathological features and prognostic factors of male breast cancer 男性乳腺癌的临床病理特征及预后因素分析

Clinical Oncology and Cancer Research Pub Date : 2014-12-15 DOI: 10.3969/J.ISSN.1000-8179.20141237

Xinli Liu, Fangfang Liu, Yi Zheng, Beibei Shen, L. Fu

引用次数: 0

Mir-30 functions as a tumor suppressor by modulating CD90 in hepatocellular carcinoma Mir-30在肝细胞癌中通过调节CD90发挥抑癌作用

Clinical Oncology and Cancer Research Pub Date : 2014-11-30 DOI: 10.3969/J.ISSN.1000-8179.20141389

Pei Li, Lian Li, Yan Guo, Hong Zheng, F. Song, Ben Liu, Kexin Chen

引用次数: 0

Effect of Hesl on bone marrow CD34 + cells in acute myeloid leukemia Hesl对急性髓系白血病患者骨髓CD34 +细胞的影响

Clinical Oncology and Cancer Research Pub Date : 2014-11-30 DOI: 10.3969/J.ISSN.1000-8179.20141339

C. Tian, Yongsheng Jia, D. Hu, Yizhuo Zhang

{"title":"Effect of Hesl on bone marrow CD34 + cells in acute myeloid leukemia","authors":"C. Tian, Yongsheng Jia, D. Hu, Yizhuo Zhang","doi":"10.3969/J.ISSN.1000-8179.20141339","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20141339","url":null,"abstract":"Objective: To determine the effect of Hes1 on bone marrow CD34 cells in acute myeloid leukemia (AML). Methods: Bone marrow mononuclear cells were isolated by using Ficoll. Then, the proportion and cell cycle of CD34+ cells were analyzed by using fluorescence-activated cell sorting (FACS). CD34 cells were cultured in vitro for colony-forming cells (CFC). The expression of Hes1 in CD34 cells was evaluated by using real-time polymerase chain reaction. After upregulating the expression of Hes1 in CD34 cells, the cell cycle was analyzed through FACS, and the colony formation of CD34Hes1 cells was analyzed by CFC. Results: The ratio of CD34 cells in the bone marrow was lower in the AML group than in the control group. In addition, more CD34 cells underwent quiescence in the AML group than in the control group. In vitro assay showed that the colony formation of CD34 cells was lower in the AML group than in the control group. The expression of Hes1 was higher in the CD34 cells from the AML patients than that in the CD34 + cells from normal donors. After Hes1 transduction, more CD34 + cells underwent quiescence and showed weak proliferation. Conclusion: The proportion of CD34 cells in the bone marrow was lower in AML patients than in normal donors. A large proportion of CD34+ cells underwent quiescence, which was related to Hes1, in AML patients.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"65 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122246642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of tumor microenvironment on culture and identification of breast cancer stem cell-like microspheres 肿瘤微环境对乳腺癌干细胞样微球培养及鉴定的影响

Clinical Oncology and Cancer Research Pub Date : 2014-11-30 DOI: 10.3969/J.ISSN.1000-8179.20141062

Yufen Zhu, Meijing Ren, Feng Gu, L. Fu

引用次数: 0

Prognostic value of post-mastectomy radiation therapy in node-positive breast cancer patients treated with breast conservation therapy 乳腺切除术后放射治疗对淋巴结阳性乳腺癌患者保乳治疗的预后价值

Clinical Oncology and Cancer Research Pub Date : 2014-11-15 DOI: 10.3969/I.ISSN.1000-8179.20131848

Ying Zheng, Qinanqian Chen, Miaomiao Jia, Zhijie Liang, Xuchen Cao

引用次数: 0

Development of target therapy for advanced gastric cancer 进展期胃癌靶向治疗的进展

Clinical Oncology and Cancer Research Pub Date : 2014-11-15 DOI: 10.3969/J.ISSN.1000-8179.20140171

Dingzhi Huang, B. A. Yi

引用次数: 0

Research progress on effects of TFPI-2 on proliferation, apoptosis, and metastasis of malignant tumors cells TFPI-2对恶性肿瘤细胞增殖、凋亡和转移影响的研究进展

Clinical Oncology and Cancer Research Pub Date : 2014-11-15 DOI: 10.3969/J.ISSN.1000-8179.20141336

Xi-yin Wei, F. Zang, Baocun Sun

{"title":"Research progress on effects of TFPI-2 on proliferation, apoptosis, and metastasis of malignant tumors cells","authors":"Xi-yin Wei, F. Zang, Baocun Sun","doi":"10.3969/J.ISSN.1000-8179.20141336","DOIUrl":"https://doi.org/10.3969/J.ISSN.1000-8179.20141336","url":null,"abstract":"Tissue factor pathway inhibitor-2 (TFPI-2), a member of the Kunitz-type family, is a broad-spectrum serine proteinase inhibitor. The expression of TFPI-2 is inversely related to increasing degree of malignancy, suggesting a role of TFPI-2 in the mainte- nance of tumor stability and inhibition of the growth of neoplasma. Aberrant methylation of TFPI-2 promoter cytosine-phosphorothio- ate- guanine (CpG) islands has been widely documented to be responsible for diminished expression of TFPI-2 mRNA and protein dur- ing cancer progression. TFPI-2 expression is significantly up-regulated by the ERK1/2 and JNK signaling pathways and modestly in- creased by VEGF, TNF-alpha, and fibroblast growth factor in time- and dose-dependent manners. TFPI-2 can maintain the stability of the tumor environment and inhibit invasiveness and growth of neoplasms. TFPI-2 has also been shown to regulate proliferation, apopto- sis, and vasculogenic mimicry of tumor cells, which may contribute significantly to tumor growth inhibition. Restoration of TFPI-2 ex- pression in tumor tissue inhibits tumor growth and metastasis, which creates a novel possibility of cancer patient treatment. This review focuses on the expression and the molecular regulation mechanisms of TFPI-2 in malignant tumors that control the functions of TFPI-2 in proliferation, apoptosis, and angiogenesis. Insight into these processes will improve our understanding of TFPI-2 and provide new ap- proaches for rational treatment strategies.","PeriodicalId":314105,"journal":{"name":"Clinical Oncology and Cancer Research","volume":"12 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2014-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123593928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of T-lymphocyte subpopulations in peripheral blood on disease-free survival of patients with different molecular subtypes of breast cancer 外周血t淋巴细胞亚群对不同分子亚型乳腺癌患者无病生存的影响

Clinical Oncology and Cancer Research Pub Date : 2014-11-15 DOI: 10.3969/J.ISSN.1000-8179.20141221

W. Ji, Yan Zhou, R. Niu

引用次数: 0