Caspian Journal of Neurological Sciences最新文献_第8页

The Effect of Kaempferol on Autophagy and Nrf-2 Signaling in a Rat Model of Aβ1-42-induced Alzheimer’s Disease 山奈酚对a β1-42诱导的阿尔茨海默病大鼠模型自噬和Nrf-2信号传导的影响

Caspian Journal of Neurological Sciences Pub Date : 2022-01-01 DOI: 10.32598/cjns.8.28.179.2

A. Jafari, P. Babaei, K. Rohampour, Samira Rashtiani

{"title":"The Effect of Kaempferol on Autophagy and Nrf-2 Signaling in a Rat Model of Aβ1-42-induced Alzheimer’s Disease","authors":"A. Jafari, P. Babaei, K. Rohampour, Samira Rashtiani","doi":"10.32598/cjns.8.28.179.2","DOIUrl":"https://doi.org/10.32598/cjns.8.28.179.2","url":null,"abstract":"Background: Numerous pieces of evidence support that oxidative stress is a key factor in the pathogenesis of neurodegenerative diseases, like Alzheimer’s Disease (AD). Suppression of oxidative stress is an attractive strategy and flavonoids as potent natural antioxidants are extremely noticeable. Objectives: In this study, the effects of Kaempferol (KMP) were evaluated on passive avoidance memory, hippocampal Nrf-2, and beclin-1 expression in a rat model of Aβ1-42 –induced AD. Materials & Methods: Forty male Wistar rats weighing 200-250 g were divided into five groups (n=8); sham-operated, AD model, and KMP treatment (5, 7.5, 10 mg/kg, i.p. for three weeks). Animals received an intracerebroventricular injection of amyloid-beta (1-42) to establish an AD model. Passive avoidance memory of rats was evaluated using a shuttle box on day 21; Step-Through Latency (STL) and time spent in The Dark Compartment (TDC) were recorded. Then, hippocampus homogenates were used for biochemical and molecular analysis by real-time PCR, western blot, and ELISA. Results: It was found that KMP improved memory evidenced by increased STL (P≤0.05) and decreased TDC (p≤0.01). KMP also increased the levels of Total Antioxidant Capacity (TAC) in the hippocampus of rats (P≤0.05). In addition, KMP enhanced the expression of Nrf-2 mRNA (P≤0.001) and beclin-1 protein in the hippocampus tissues (P≤0.001). Conclusion: Overall, it is suggested that the memory-improving effect of KMP is mediated, at least in part, by enhancing Nrf-2 and TAC. KMP is also able to induce autophagy through the expression of beclin-1.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"23 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81598662","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

chHDAC11 mRNA Expression During Prenatal and Postnatal Chicken (Gallus gallus) Brain Development chHDAC11 mRNA在鸡产前和产后脑发育中的表达

Caspian Journal of Neurological Sciences Pub Date : 2022-01-01 DOI: 10.32598/cjns.8.28.306.1

Seyedeh Rezvaneh Moadabpour, Afsaneh Shokri, F. Mashayekhi, M. Sohani, F. Ajamian

{"title":"chHDAC11 mRNA Expression During Prenatal and Postnatal Chicken (Gallus gallus) Brain Development","authors":"Seyedeh Rezvaneh Moadabpour, Afsaneh Shokri, F. Mashayekhi, M. Sohani, F. Ajamian","doi":"10.32598/cjns.8.28.306.1","DOIUrl":"https://doi.org/10.32598/cjns.8.28.306.1","url":null,"abstract":"Background: Histone deacetylation plays an essential role in transcriptional regulation of cell cycle progression and other evolutionary processes. Several results confirm the importance of the latest found HDAC11 gene to deacetylate histone core in neurons and their supportive cells in developing the vertebrate Central Nervous System (CNS). Objectives: This study investigates the HDAC11 potential role in early chicken CNS development by studying its mRNA expression profile which may have unique means in studying human subjects. Materials & Methods: Chicken HDAC11 RNAs were reverse transcribed to cDNAs, and the amount of chHDAC11 transcripts was measured by ΔCT mean calculation using the real-time quantitative PCR method. One-way ANOVA and Duncan’s analysis (SigmaStat software version 4.0) were used to test the statistical significance of the results. The levels of significance were set at P≤0.05. Quantitative data are presented as Mean±SD. Results: The amount of HDAC11 mRNAs gradually increases, at least 2-3 times, from as early as day 14 (E14/HH40) of prenatal cortex formation to day P0 (E20=HH45) and continue to increase to day 40 in both cortical and hippocampal regions of the postnatal chicken brain during development (*P≤0.05). HDAC11 mRNA is not only expressed in the postnatal cortex and hippocampi regions but also—for the first time—in the developing brain during the prenatal period. Conclusion: Our results show a possibly important role for the latest found HDAC11 conserved gene in the development of vertebrates’ embryonic brain, which in turn may have a significant impact on understanding human brain development.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"142 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86244054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

nxiolytic Effect of the Hydro-alcoholic Extract of Anethum Graveolens Seed in Adult Female Wistar Rats: Modulation of GABA Receptors 茴香籽水醇提取物对成年雌性Wistar大鼠的溶血作用:GABA受体的调节

Caspian Journal of Neurological Sciences Pub Date : 2022-01-01 DOI: 10.32598/cjns.8.28.302.1

R. Shahabi, Mohammad Rostampour, B. Khakpour, B. Soltani, F. Saadat

{"title":"nxiolytic Effect of the Hydro-alcoholic Extract of Anethum Graveolens Seed in Adult Female Wistar Rats: Modulation of GABA Receptors","authors":"R. Shahabi, Mohammad Rostampour, B. Khakpour, B. Soltani, F. Saadat","doi":"10.32598/cjns.8.28.302.1","DOIUrl":"https://doi.org/10.32598/cjns.8.28.302.1","url":null,"abstract":"Background: Along with industrial development and the increasing social complexity of societies, anxiety is one of the most prevalent psychological disorders. Medicinal plants are considered as an enrichment source of ingredients with biological activity. Objectives: The aim of this study was to evaluate the anxiolytic effect of Anethum Graveolens seed (AGS) and the possible involvement of Gamma-Aminobutyric Acid (GABA)-ergic system in the AGS effect. Materials & Methods: In the present experimental study, 64 female Wistar rats were divided into eight groups and received various concentrations of hydroalcoholic extract of AGS. To measure the level of anxiety, an elevated plus maze was used in a way that the animal’s head turned to an open arm. Prior to the injections of AGS extract, the GABA receptor antagonist was used. The results were analyzed by one-way analysis of variance using IBM SPSS v. 16. Results: Dose-response experiments showed that the AGS extract significantly decreased the anxiety indices compared to the control group (P<0.05). To analyze locomotor activity, our data showed that AGS extract at 0.1, 1, and 10 mg/kg could significantly increase locomotor activity compared to the control group (P<0.001). Pentylenetetrazol (PTZ (+extract significantly decreased the anxiolytic effect of AGS extract (P<0.01). Conclusion: Considering the anti-anxiety effects of AGS extract and a reduction in this effect caused by PTZ, part of the anti-anxiety effect of extract might be assumed via its interaction with GABA-ergic receptors. Further experimental trials; however, are required for the establishment of the anti-anxiety impact of AGS.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"53 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89932318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Analysis of Soluble Mesenchymal-Epithelial Transition Factor and Hepatocyte Growth Factor Serum Levels in Children With Autism Spectrum Disorder 自闭症谱系障碍儿童血清可溶性间充质上皮转化因子和肝细胞生长因子水平分析

Caspian Journal of Neurological Sciences Pub Date : 2022-01-01 DOI: 10.32598/cjns.8.28.307.1

S. Shabani, S. Talesh Sasani, F. Mashayekhi

{"title":"Analysis of Soluble Mesenchymal-Epithelial Transition Factor and Hepatocyte Growth Factor Serum Levels in Children With Autism Spectrum Disorder","authors":"S. Shabani, S. Talesh Sasani, F. Mashayekhi","doi":"10.32598/cjns.8.28.307.1","DOIUrl":"https://doi.org/10.32598/cjns.8.28.307.1","url":null,"abstract":"Background: Hepatocyte Growth Factor (HGF) and its receptor, Mesothelial-Epithelial Transition (cMet) factor signaling, play an essential role in controlling synaptogenesis. Objectives: Because of the vital role of HGF and Met signaling in synaptogenesis and spatial learning function of the brain’s hippocampal region, we aimed to study the HGF and soluble cMet (s-cMet) serum levels in children with different stages of Autism Spectrum Disorders (ASD). Materials & Methods: A total of 189 ASD patients (mild; n=69, moderate; n=63 and severe; n=57) and 82 control were enrolled in this project. Blood samples were collected from ASD patients referred to Pediatric Neurology Clinic, 17 Shahrivar Hospital, Rasht City, Iran, and serum concentrations of s-cMet and HGF were measured by ELISA. The control children with no clinical characteristics of ASD attended routine blood tests. Results: HGF Mean±SD serum concentration in ASD patients was 239±52.02 pg/mL compared to controls which was 360.04±71.15 pg/mL (P=0.004). Also, the Mean±SD serum concentrations of HGF in mild, moderate, and severe ASD patients were 297.54±69.82, 232.81±56.41, and 189±33.25 ng/mL, respectively, compared to control, which was 360.18±57.40. Besides, the s-cMet Mean±SD serum concentrations in ASD and controls were 143.54±32.50 and 200.25±31.16 pg/mL, respectively (P=0.005). The Mean±SD serum concentrations of s-cMet in the mild, moderate, and severe ASD patients were 172.81±37.69, 129.81±45.55, and 85.18±22.95 ng/mL, respectively, as compared to the control, which was 214.54±34.17 ng/mL. Conclusion: Serum HGF and s-cMet concentration decreased in ASD patients corresponding to disease severity. Also, detecting serum HGF and s-cMet may help classify ASD.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83300952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effectiveness of a School-based Self-injury Prevention Program on Reducing Interpersonal Cognitive Distortion and Fear of Negative Evaluation in Adolescent Girls 校本自伤预防项目对减少少女人际认知扭曲和负面评价恐惧的效果

Caspian Journal of Neurological Sciences Pub Date : 2022-01-01 DOI: 10.32598/cjns.8.28.303.1

Neda Nezhadhamdy, F. Dortaj, E. Sadipour, Kamran Sheivandi Cholicheh, Sajjad Rezaei

{"title":"The Effectiveness of a School-based Self-injury Prevention Program on Reducing Interpersonal Cognitive Distortion and Fear of Negative Evaluation in Adolescent Girls","authors":"Neda Nezhadhamdy, F. Dortaj, E. Sadipour, Kamran Sheivandi Cholicheh, Sajjad Rezaei","doi":"10.32598/cjns.8.28.303.1","DOIUrl":"https://doi.org/10.32598/cjns.8.28.303.1","url":null,"abstract":"Background: Non-Suicidal Self-Injury (NSSI) is a prevalent, harmful, and transdiagnostic behavior that can comprehensively be assessed in daily life studies. Objectives: This study aimed to determine the effectiveness of the student self-injury prevention program in mitigating the Interpersonal Cognitive Distortion (ICD) and the fear of Negative Evaluation (FNE). Materials & Methods: This research is a quasi-experimental study with a pre-test-post-test design, a one-month follow-up, and a control group. The statistical population consisted of all female adolescents studying at the middle schools of Rasht City, Iran, in the 2019–2020 academic years. They must have experienced self-injury at least once. The purposive non-random sampling technique was employed to select 34 self-injuring adolescents, who were then randomly assigned to case and control groups. The interpersonal cognitive distortion scale and the brief fear of negative evaluation scale were adopted to collect data. The case group received 16 sessions of self-injury prevention training for students (twice a week), whereas the control group had no training programs. Analysis of variance and multivariate analysis of variance were then used for data analysis in SPSS v. 25. Results: The results demonstrated the significant effectiveness of the training program in mitigating the ICD (interpersonal rejection: P<0.01; F=21.780, unrealistic relationship expectations: P<0.01; F=51.096, interpersonal misperception: P<0.01; F=20.557), reducing negative meta-emotion, and increasing positive meta-emotion (P<0.05; F=43.591). Conclusion: The student self-injury prevention program effectively reduced the ICD and FNE of female adolescents. Additionally, these two variables have high levels in adolescents struggling with self-injury.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79583395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Small-world Structure in Children’s Featured Semantic Networks 儿童特征语义网络中的小世界结构

Caspian Journal of Neurological Sciences Pub Date : 2021-10-01 DOI: 10.32598/cjns.7.27.1

S. Hashemikamangar, S. Gharibzadeh, F. Bakouie

{"title":"Small-world Structure in Children’s Featured Semantic Networks","authors":"S. Hashemikamangar, S. Gharibzadeh, F. Bakouie","doi":"10.32598/cjns.7.27.1","DOIUrl":"https://doi.org/10.32598/cjns.7.27.1","url":null,"abstract":"Background: Knowing the development pattern of children’s language is applicable in developmental psychology. Network models of language are helpful for the identification of these patterns. Objectives: We examined the small-world properties of featured semantic networks of developing children. Materials & Methods: In this longitudinal study, the featured semantic networks of children aged 18-30 months were obtained using R software version 3.5.2 and the igraph software package. The data of 2000 English (British)-speaking children, half boy and half girls, were gathered from existing databases of MCDI (between 2000 and 2007) and McRae feature norms. The growth pattern of these networks was illustrated by graph measures. Comparing these measures with those of the reference random networks, the small-world structure can be examined. Results: To have a comparison between path length and clustering coefficient of featured semantic networks with those of random networks, we computed the Q quotient. The results showed that the values of the Q quotient at 18, 22, 26, and 30 months of age were all more than 1, which confirms the small-world characteristic of the networks. Conclusion: Featured semantic networks of children exhibited a small-world structure, in which there was a local structure in the form of clusters of words. For global access, some words act as bridges connecting semantically distant clusters. These networks possess small-world property from the early months of age. The small-world structure cannot be seen in the less dense networks built with a higher cut-off threshold.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"104 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88971387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Exercise Programs on Fear of Falling in Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Clinical Trials 锻炼计划对多发性硬化症患者害怕跌倒的影响:随机临床试验的系统回顾和荟萃分析

Caspian Journal of Neurological Sciences Pub Date : 2021-10-01 DOI: 10.32598/cjns.7.27.7

P. Sedaghati, A. Hosseini, H. Zarei

{"title":"Effect of Exercise Programs on Fear of Falling in Multiple Sclerosis: A Systematic Review and Meta-analysis of Randomized Clinical Trials","authors":"P. Sedaghati, A. Hosseini, H. Zarei","doi":"10.32598/cjns.7.27.7","DOIUrl":"https://doi.org/10.32598/cjns.7.27.7","url":null,"abstract":"Background: Multiple Sclerosis (MS) is one of the most common diseases of the Central Nervous System (CNS). Numerous studies have reported Fear of Falling (FOF) among MS patients. FOF is a factor limiting physical activity. Regular physical activity is very important for maintaining good health and preventing the complications of MS patients and can make these people more active and reduce FOF. Objectives: The aim of the present study was to do a meta-analyze about the effect of exercise programs on FOF among MS patients Materials & Methods: Primary sources were obtained from 9 databases including, PubMed, EMBASE, SCOPUS, LILACS, CINAHL, CENTRAL, Web of Science, PEDro, and Google Scholar, from inception until April 2021. Data analysis was carried out using Comprehensive Meta-Analysis ver. 2. Results: Nine studies with 350 participants were included in the review. The results of the meta-analysis showed the effect of exercise programs on the FOF among MS patients. The Hedges’ adjusted Effect Size (ES) regarding the effects of exercise programs on FOF among MS patients was -0.15 (95%CI: -0.52 - 0.22). The results of the meta-analysis showed no significant difference between the effect of exercise programs on FOF among MS patients (p=0.44). Conclusion: It was found that all exercise programs have a significant effect on FOF among MS patients. There was no statistically significant difference between exercise programs regarding which exercise programs led to a higher reduction in FOF among these patients; however, Pilates and virtual reality exercises were more effective than other exercise programs.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"106 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76882014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Psychometric Properties of the Obsessive-compulsive Inventory: The Persian Child Version; a Preliminary Study 强迫量表的心理测量特征:波斯儿童版本初步研究

Caspian Journal of Neurological Sciences Pub Date : 2021-10-01 DOI: 10.32598/cjns.7.27.5

Adele Isanazar, Mahnaz Fallahi-Khesht Masjedi, R. Soleimani, Fatemeh Eslamdoust-Siahestalkhi, M. Kousha

{"title":"Psychometric Properties of the Obsessive-compulsive Inventory: The Persian Child Version; a Preliminary Study","authors":"Adele Isanazar, Mahnaz Fallahi-Khesht Masjedi, R. Soleimani, Fatemeh Eslamdoust-Siahestalkhi, M. Kousha","doi":"10.32598/cjns.7.27.5","DOIUrl":"https://doi.org/10.32598/cjns.7.27.5","url":null,"abstract":"Background: The Obsessive-Compulsive Inventory-Child Version (OCI-CV) is an approved self-report assessment tool that includes various domains of Obsessive-Compulsive Disorder (OCD). Objectives: This study was done to evaluate the psychometric properties of the OCI-CV in a sample of youth with OCD. Materials & Methods: This was a descriptive-analytic study. The subjects were 107 children and adolescents, 7 to 17 years old admitted to the Shafa hospital and Gill psychiatric center in the north of Iran in 2017-2018. The subjects with the diagnosis of OCD based on a diagnostic interview by a youth psychiatrist based on the DSM-5 were included in the study. They were assessed by the OCI-CV, Revised Children’s Manifest Anxiety Scale (RCMAS), and children depression inventory (CDI). Data were analyzed by SPSS v. 22, using Cronbach alpha, Pearson correlation coefficient, and exploratory factor analysis. Results: Youth with the Mean±SD age 11.18±3.1 years participated in the study. Results showed that 51% of the samples were girls. The internal consistency assessed by the Cronbach alpha for the total scale was 0.75, indicating good reliability. The Pearson correlation coefficient between OCI-CV and RCMAS was 0.584 (P=0.01), and between OCI-CV and CDI was 0.232 (P=0.05), showing an excellent concurrent validity. Construct validity showed that all subscales had a high correlation with the total score of the questionnaire and the correlation coefficient was significant (P<0.05). Conclusion: The Persian version of the OCI-CV has good psychometric characteristics in the clinical sample of youth with OCD.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82523937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats 水合儿茶素对大鼠脊髓缺血再灌注损伤的保护作用

Caspian Journal of Neurological Sciences Pub Date : 2021-10-01 DOI: 10.32598/cjns.7.27.4

Naser Hajizadeh, G. Farjah, M. Karimipour, Bagher Pourheidar

{"title":"Protective Effect of Catechin Hydrate on Spinal Cord Ischemia-reperfusion Injury in Rats","authors":"Naser Hajizadeh, G. Farjah, M. Karimipour, Bagher Pourheidar","doi":"10.32598/cjns.7.27.4","DOIUrl":"https://doi.org/10.32598/cjns.7.27.4","url":null,"abstract":"Background: Aortic artery stenosis leads to Ischemia-Reperfusion (I-R) injury, which can cause certain clinical expressions, such as paraplegia. Objectives: To appraise the effect of Catechin Hydrate (CH) against spinal cord I-R injury. Materials & Methods: A total of 35 male rats (250-300 g) were divided randomly into five groups: intact, sham surgery, dimethyl sulfoxide (I-R+DMSO), low-dose CH (I-R+10 mg/kg CH), and high-dose CH (I-R+20 mg/kg CH). Abdominal aorta clamping was done for 60 min. Seventy-two hours after I-R, animals were evaluated for neurologic function, biochemical analysis, and histology. The data analysis was conducted by SPSS v. 16 using ANOVA and Kruskal-Wallis and Mann-Whitney U tests. Results: The mean Motor Deficit Index (MDI) score and white matter damage in the CH (20 mg/kg) group were lower than in the DMSO group (P=0.032). The mean plasma levels of malondialdehyde (MDA) and superoxide dismutase (SOD) in the CH groups were lower than that of the DMSO group (P<0.05). The plasma level of Total Antioxidant Capacity (TAC) in the CH (20 mg/kg) group was higher than in the DMSO group (P=0.032). In addition, the plasma level of catalase in the CH (20 mg/kg) group was higher than in the DMSO and CH (10 mg/kg) groups (P<0.001). The average number of normal motor neurons in the experimental groups was lower than in the sham surgery group (P<0.001).","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91109329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Coexistence of Gonadal Dysgenesis With Mayer-rokitansky-küster-hauser Syndrome, and Dandy-Walker Variant 性腺发育不良与mayer -rokitansky- k<s:1> ster-hauser综合征和Dandy-Walker变异体共存的研究

Caspian Journal of Neurological Sciences Pub Date : 2021-10-01 DOI: 10.32598/cjns.7.27.3

Shahin Koohmanaee, Amirhossein Tamimi, Soroush Ahmadimacciani, Atena Tamimi, V. Aminzadeh, M. Zarkesh, Seyyedeh Azadeh Hoseini Nouri, Fatemeh Rajaeipoor, Manijeh Tabrizi, Setila Dalili

{"title":"The Coexistence of Gonadal Dysgenesis With Mayer-rokitansky-küster-hauser Syndrome, and Dandy-Walker Variant","authors":"Shahin Koohmanaee, Amirhossein Tamimi, Soroush Ahmadimacciani, Atena Tamimi, V. Aminzadeh, M. Zarkesh, Seyyedeh Azadeh Hoseini Nouri, Fatemeh Rajaeipoor, Manijeh Tabrizi, Setila Dalili","doi":"10.32598/cjns.7.27.3","DOIUrl":"https://doi.org/10.32598/cjns.7.27.3","url":null,"abstract":"Background: Gonadal dysgenesis, the most common cause of primary amenorrhea, is characterized by absent or underdeveloped ovaries. Although the coexistence of gonadal dysgenesis and Mayer-Rokitansky-Küster-Hauser (MRKH) has been reported, it is still quite infrequent. To the extent that authors searched, just one study reported the association between Rokitansky sequence and Dandy-Walker malformation. Clinical Presentation and Intervention: We aimed to report a case with gonadal dysgenesis, MRKH, and the Dandy-Walker variant. In this care report, the authors reported a 15-year-old girl with primary amenorrhea and underdeveloped secondary sexual properties. Her karyotype was 46, XX. The abdominopelvic MRI without contrast demonstrated bilateral ovarian agenesis and no uterus or cervix. Vagina was normal in length. Brain MRI was consistent with the Dandy-Walker variant. Conclusion: Although some affected chromosomal regions have been identified, further genetic analyses should be performed to elucidate the probable association between these anomalies.","PeriodicalId":31302,"journal":{"name":"Caspian Journal of Neurological Sciences","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73542486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0