Environmental Research最新文献

{"title":"Polystyrene microplastics (PS-MPs) harness copper presence and promote impairments in early zebrafish (Danio rerio) larvae: Developmental, biochemical, transcriptomic approaches and nontargeted metabolomics approaches","authors":"Liqiao Zhang,&nbsp;Dongqiu Guo,&nbsp;Xinrui Dong,&nbsp;Longxiao Liu,&nbsp;Mengqi Jiang,&nbsp;Linlin Song,&nbsp;Xia Wang","doi":"10.1016/j.envres.2025.121213","DOIUrl":"10.1016/j.envres.2025.121213","url":null,"abstract":"<div><div>Due to their large specific surface area and strong hydrophobicity, microplastics (MPs) are highly susceptible to adsorb environmental pollutants, of which heavy metals (HMs) are the most representative inorganic pollutants. However, there is controversy in different studies as to whether the toxic effects of the combined action of MPs and HMs on zebrafish larvae are antagonistic or synergistic. Herein, we firstly evaluated the combined effects of 10 μm polystyrene MPs (PS-MPs) on zebrafish larvae after exposure for 96 h at two different concentrations (5 mg/L, 0.5 mg/L) and Cu²⁺ (0.05 mg/L). Our study primarily showed that the combined exposure of PS-MPs and Cu²⁺ could induce developmental toxicity, oxidative stress, immunotoxicity and neurotoxicity. Furthermore, LC/MS-based nontargeted metabolomics analysis demonstrated that the combined exposure of PS-MPs with Cu²⁺ induced metabolic disturbances. Furthermore, our results showed that the combined exposure of 10 μm PS-MPs with Cu²⁺ exhibited a synergistic effect on the toxicity of zebrafish larvae. In conclusion, this study provides a reference for future research related to combined exposure of PS-MPs and Cu²⁺ on fish.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"273 ","pages":"Article 121213"},"PeriodicalIF":7.7,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143490127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary producers in freshwater ecosystem respond differently to multiple environmental stressors: A mesocosm study","authors":"Jianlin Chen ,&nbsp;Haowu Cheng ,&nbsp;Yifeng Yan ,&nbsp;Jiangqiu Zhu ,&nbsp;Min Zhang ,&nbsp;Songguang Xie ,&nbsp;Jun Xu ,&nbsp;Huan Wang","doi":"10.1016/j.envres.2025.121145","DOIUrl":"10.1016/j.envres.2025.121145","url":null,"abstract":"<div><div>Primary producers play key roles in maintaining a clear-water phase and promoting biodiversity in shallow aquatic ecosystems. Environmental stressors from anthropogenic activities, such as eutrophication and pesticide pollution, individually and in combination, can drive these ecosystems into a turbid state, potentially leading to a regime shift. In this 111-day study, we used 40 mesocosms (200 L) to simulate shallow lakes dominated by two typical macrophytes: the bottom-dwelling densely <em>Vallisneria denseserrulata</em> and the floating <em>Spirodela polyrrhiza</em>, along with associated food web components. We tested the interactive effects of nutrient loading, glyphosate-based herbicides, and imidacloprid insecticides on the growth of aquatic plants, phytoplankton, and periphyton. Our results indicate that meso-eutrophication, glyphosate and imidacloprid directly or indirectly affected aquatic primary producers, with the type of interaction (synergistic, antagonistic and additive) related to the form of the primary producer. Meso-eutrophication alone increased the biomass of all organisms except submerged plants, glyphosate alone decreased the biomass of all organisms except phytoplankton, with particularly strong effects on aquatic plants, and imidacloprid alone affected only aquatic animals. While combinations of multiple stressors generally increased algal biomass and decreased macrophyte biomass, submerged macrophytes consistently helped control algal blooms. These results demonstrate the risk of algal blooms in shallow lakes within agricultural landscapes and emphasize the crucial role of macrophytes in preventing algal blooms and maintaining healthy lake ecosystems.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"272 ","pages":"Article 121145"},"PeriodicalIF":7.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perfluoroalkyl Acids (PFAAs) and their precursors in sediments and adjacent riparian soils from the Three Gorges Reservoir, China: Contamination characteristics, source apportionment and ecological risks.","authors":"Yongxia Hu, Hui Chen, Ying Chen, Yunlong Wang, Yixia Luo, Liubo Sang, Tao Jin, Shengjun Wu","doi":"10.1016/j.envres.2025.121202","DOIUrl":"https://doi.org/10.1016/j.envres.2025.121202","url":null,"abstract":"<p><p>Information on the occurrence and spatial distribution of perfluoroalkyl acids (PFAAs) and their precursors in sediments and adjacent riparian soils of Three Gorges Reservoir (TGR), which is one of the largest reservoirs in the world, is still limited. In this study, The total concentrations of these per- and polyfluoroalkyl substances (PFASs) ranged from 2220 to 19,300 pg/g in sediments and 298 to 9540 pg/g in soils. PFOA was the dominant PFAS in sediments and soils, accounting for 23.4% and 30.7% of the total median cocentrations of PFASs, respectively. PFAA precursors, such as 4:2 fluorotelomer sulfonate (4:2 FTS), 6:2 fluorotelomer sulfonate (6:2 FTS), and perfluorooctane sulfonamide (FOSA), were widely detected in sediments and soils. The distribution of PFASs exhibited distinct spatial variations and was more influenced by anthropogenic activities. Positive matrix factorization (PMF) identified fire-fighting foams (AFFF) and legacy fluoropolymer industry/textile treatment were the dominant sources in sediments (31.5%) and soils (30.8%), respectively. Finally, the ecological risk assessment showed that PFOS exhibited low to medium risks. Our findings indicate that the contamination of PFAA precursors must be considered when developing management measures to protect the TGR region.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"121202"},"PeriodicalIF":7.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Elevation dependence of vegetation growth stages and carbon sequestration dynamics in high mountain ecosystems","authors":"Yunfan Sun,&nbsp;Qingyu Guan,&nbsp;Qinqin Du,&nbsp;Qingzheng Wang,&nbsp;Weiwen Sun","doi":"10.1016/j.envres.2025.121200","DOIUrl":"10.1016/j.envres.2025.121200","url":null,"abstract":"<div><div>Mountain vegetation exhibits unique growth strategies along elevation gradients to adapt to climatic constraints. However, the mechanisms by which temporal allocation of photosynthetic phases and climate change drive elevational differentiation in carbon sequestration dynamics remain poorly quantified. This study adopted a phenology-based method to divide the photosynthetic growing season into distinct stages, revealing vegetation carbon allocation and its elevation-dependent patterns at a finer temporal resolution. In the Qilian Mountains (QLMs), although the maturity period was only 1.2 times longer than the greening period, it contributed fivefold greater gross primary productivity (GPP) during growing season, highlighting its pivotal role in GPP dynamics. Notably, GPP during both the photosynthetic growing season and maturity period exhibited greater relative rates of change at high elevations (&gt;3500 m) than at lower elevations (2500–3500 m). Concurrently, vegetation at higher elevations displayed greater temperature sensitivity. For every 1000 m increase in elevation, the maturity period lengthened by 3.4%, while the greening and senescence periods shortened, maximizing carbon sequestration under colder conditions. Analysis through boosted regression trees and partial least squares regression revealed a dual-control mechanism governing GPP through hydrothermal conditions and growth-stage duration. Temperature dominated GPP during growing season and maturity period, whereas growth-stage duration exerted predominant influence on greening and senescence periods. The observed trend of vegetation homogenization along the elevation gradient in the QLMs could reduce ecosystem resilience and carbon sequestration capacity. Continued monitoring and research are crucial for understanding these impacts and guiding ecosystem management in high-altitude regions.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"273 ","pages":"Article 121200"},"PeriodicalIF":7.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of residential ambient temperature in childhood with mental disorders from childhood into adulthood: A register-based study","authors":"Kaisla Komulainen ,&nbsp;Marko Elovainio ,&nbsp;Mai Gutvilig ,&nbsp;Ripsa Niemi ,&nbsp;Timo Partonen ,&nbsp;Reija Ruuhela ,&nbsp;Marianna Virtanen ,&nbsp;Christian Hakulinen","doi":"10.1016/j.envres.2025.121206","DOIUrl":"10.1016/j.envres.2025.121206","url":null,"abstract":"<div><h3>Background</h3><div>While many environmental exposures in childhood have been associated with later risk of mental disorders, less is known about whether cumulative early-life exposure to ambient temperature could be relevant to later mental health. We combined high-resolution meteorological data with individual-level data from Finnish nationwide registers to investigate associations of childhood ambient temperature exposure with subsequent mental disorders.</div></div><div><h3>Methods</h3><div>The cohort included 578 067 Finnish individuals born in 1990–1999. For each individual, we calculated average daily exposure to ambient temperature from birth to their 10th birthday based on residential history. The individuals were followed from their 10th birthday until a mental disorder diagnosis, death, emigration, or December 2019. Cox proportional hazards models were used to estimate the associations of childhood temperature exposure with subsequent mental disorders while adjusting for individual-level and area-level confounders.</div></div><div><h3>Findings</h3><div>Childhood exposure to warmer climatic conditions was monotonically associated with a greater subsequent risk of a mental disorder (compared to the median of the 10-year temperature exposure, HR = 1.10 (95% CI, 1.08–1.12) at the 95th percentile, HR = 0.88 (95% CI, 0.86–0.90) at the 5th percentile). In disorder-specific analyses, the associations were evident for mood and anxiety disorders, and to a lesser extent for sleep and substance use disorders. No consistent evidence was observed with psychotic or eating disorders.</div></div><div><h3>Interpretation</h3><div>Growing up in warmer climatic conditions was associated with subsequent risk of mental disorders. Further studies in populations residing in different latitudes are needed.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"273 ","pages":"Article 121206"},"PeriodicalIF":7.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between phthalate exposure and metabolic dysfunction-associated steatotic liver disease (MASLD) – Systematic literature review","authors":"Tomasz Gogola ,&nbsp;Sini Pitkänen ,&nbsp;Marjo Huovinen ,&nbsp;Heikki Laitinen ,&nbsp;Jenni Küblbeck","doi":"10.1016/j.envres.2025.121186","DOIUrl":"10.1016/j.envres.2025.121186","url":null,"abstract":"<div><div>The prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) is rising globally. Recent studies have suggested connections between exposure to endocrine disrupting chemicals (EDCs) and the development of MASLD. Phthalates, which are commonly utilized as plasticizers, in building materials and consumer items, exhibit endocrine disrupting effects and have been shown to interfere with lipid metabolism in mechanistic studies. The objective of this systematic review was to examine the association between MASLD and exposure to phthalates in the adult human populations. We searched PubMed, Scopus and Web of Science for studies published from the inception of each database until December 12, 2024. The literature search yielded 10 cross-sectional studies, which were analyzed in detail. The key findings of this study indicate a potential correlation between the prevalence of MASLD and exposure to certain phthalates. Among the phthalates examined, the metabolites of bis(2-ethylhexyl) phthalate (DEHP) – namely MECPP, MEHHP, and MEOHP, demonstrated the strongest and most frequent associations with MASLD. All the current studies followed cross-sectional study designs, which limits the possibility to establish a causal relationship between MASLD and phthalate exposure. Therefore, longitudinal studies are needed to corroborate these findings and shed light on the involvement of phthalate exposure in MASLD.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"273 ","pages":"Article 121186"},"PeriodicalIF":7.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143475917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of compound exposure to snowstorm and cold spell on acute myocardial infarction mortality","authors":"Jihong Hu ,&nbsp;Zhiwei Li ,&nbsp;Jingli Zhu ,&nbsp;Qin He ,&nbsp;Wenjun Cheng ,&nbsp;Qianyao Cheng ,&nbsp;Yinguang Fan ,&nbsp;Hong Su ,&nbsp;Huadong Wang ,&nbsp;Zhongliang Bai ,&nbsp;Xiuya Xing ,&nbsp;Jian Cheng","doi":"10.1016/j.envres.2025.121191","DOIUrl":"10.1016/j.envres.2025.121191","url":null,"abstract":"<div><div>Cold weather events such as cold spell and snowstorm could trigger heart attacks, but the effect of compound exposure to cold weather events remains unknown. This study aimed to estimate and compare the effect of independent and compound exposure to common cold weather events (cold spell and snowstorm) on acute myocardial infarction (AMI) mortality. Daily data on AMI deaths (74,279) and weather conditions were collected in a subtropical-temperate climate transit region of China from 2016 to 2020. We conducted a space-time-stratified case-crossover analysis to fit the association of AMI mortality with cold spell and snowstorm. We observed an increased AMI death risk associated with independent and compound exposure to cold spell or snowstorm. Furthermore, the association of compound exposure to cold spell and snowstorm was greater than the independent exposure but varied by the compound types. A greater risk was observed if the snowstorm and cold spell occurred on the same day [odds ratio (OR): 1.197 (95% confidence interval (CI): 1.153–1.243)] than the scenario that the snowstorm was followed by cold spell [OR: 1.100 (95%CI: 1.079–1.121)] or the cold spell was followed by snowstorm [OR: 1.115 (95%CI: 1.075–1.157)]. This study suggests that compound exposure to cold spell and snowstorm not only has a greater effect on AMI death risk than independent exposure but also differs by the compound types.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"272 ","pages":"Article 121191"},"PeriodicalIF":7.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481920","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessment of Global System for Mobile Communications – Railway (GSM-R) electromagnetic fields exposure along the railway lines in Lanzhou, China","authors":"Yixuan Wang ,&nbsp;Mai Lu","doi":"10.1016/j.envres.2025.121138","DOIUrl":"10.1016/j.envres.2025.121138","url":null,"abstract":"<div><div>The rapid development of high-speed railways, coupled with the swift advancement of related wireless services, has raised public concerns about electromagnetic exposure, particularly for residents along railway lines. While numerous studies have examined radio exposure from mobile operators, broadcasting, and WLAN services, the electromagnetic exposure associated with railway communication services has primarily focused on occupational exposure for relevant personnel, with insufficient attention given to public exposure near railway lines.</div><div>In this study, electromagnetic exposure levels along two railways in Lanzhou, China were assessed at two different dates using both vehicle-mounted data measurement and fixed-location measurement methods.It was observed that the maximum electromagnetic exposure caused by GSM-R occurs at distances of 1200 to 1500 m from the base station. The maximum values, 95 % values and mean values of the electromagnetic exposure for GSM-R were recorded respectively: 0.5755 V/m, 0.2265 V/m and 0.02483 V/m (Lanzhou-Xinjiang railway);0.1376 V/m, 0.1107 V/m and 0.01722 V/m(Lanzhou-Lanzhou New District railway). The data collected at fixed locations during the same time period were 0.0313 V/m, 0.0303 V/m and 0.02517 V/m, respectively. The measurements also exhibited significant spatial variability, yet those taken on different dates showed high reproducibility. Additionally, a phenomenon of channel switching of GSM-R service was noted during the measurements.</div><div>The vehicle-mounted data measurement method is highly efficient for assessing electromagnetic exposure levels over large areas. Integrating additional data, such as GIS(Geographic Information System) and base station information, allows for multi-dimensional analysis, uncovering more exposure-related insights. Our study, utilizing this approach, found that the variability of GSM-R exposure along the railway may be related to the vertical directionality of the antennas. Furthermore, the electromagnetic exposure levels from the GSM-R service were found to comply with ICNIRP guidelines, indicating that these communication services present no significant health risks to the surrounding public.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"272 ","pages":"Article 121138"},"PeriodicalIF":7.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patho-physiological effects of environmental relevant concentrations of lufenuron in male Japanese quails.","authors":"Silwat Saeed, Gulnaz Afzal, Hafiz Muhammad Ali, Riaz Hussain, Raheela Jabeen, Shumaila Kiran, Rehana Iqbal, Sana Alam, Amna Jalal, Zaib Un Nisa, Dalia Fouad, Farid Shokry Ataya, Kun Li","doi":"10.1016/j.envres.2025.121203","DOIUrl":"https://doi.org/10.1016/j.envres.2025.121203","url":null,"abstract":"<p><p>The widespread utilization of synthetic chemicals contaminates the land and water environments. The present investigation determined the effects of sub-lethal concentrations of lufenuron in the male Japanese quail. The birds exposed to lufenuron showed the clinical signs of behavioral, digestive, nervous and reproductive upsets. The drug significantly (p<0.05) decreased the feed intake, body weight, absolute and relative weights of visceral organs (kidneys, liver, brain, heart, testes), RBCs count, HCT, Hg concentration, serum proteins and anti-oxidants enzymes (SOD, CAT, LPO, GSH) while concentrations of hepatic, cardiac and renal biomarkers were significantly (p<0.05) increased in the birds treated with higher doses (15mg/kg and 20mg/kg) of lufenuron, in a time and dose dependent manner. Comet assay revealed significantly (p<0.05) increased frequency of DNA damage in the isolated cells of liver, kidneys and intestine along with a significant (p<0.05) increased frequency of micronucleus in the erythrocytes. The visceral organs showed prominent histo-pathological ailments in the birds exposed to higher doses of lufenuron. Our study is the first comprehensive report that demonstrates the significant physio-biochemical health effects of lufenuron on complete clinico-hematological parameters of free ranging fauna (quail) of the natural ecosystem, even at sub-lethal environment relevant concentrations.</p>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":" ","pages":"121203"},"PeriodicalIF":7.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early-life exposure to mixtures of endocrine-disrupting chemicals and a multi-domain health score in preschool children","authors":"Ines Amine ,&nbsp;Alicia Guillien ,&nbsp;Sam Bayat ,&nbsp;Sarah Lyon-Caen ,&nbsp;Marion Ouidir ,&nbsp;Azemira Sabaredzovic ,&nbsp;Amrit K. Sakhi ,&nbsp;Cathrine Thomsen ,&nbsp;Séverine Valmary-Degano ,&nbsp;Claire Philippat ,&nbsp;Valérie Siroux","doi":"10.1016/j.envres.2025.121173","DOIUrl":"10.1016/j.envres.2025.121173","url":null,"abstract":"<div><h3>Background</h3><div>Early-life exposure to endocrine-disrupting chemicals, such as phenols and phthalates, is suspected to impact various dimensions of child health. Using a multi-outcome approach, this study aimed to estimate their cumulative effect on the child cardiometabolic, respiratory and neurodevelopmental health.</div></div><div><h3>Methods</h3><div>In 373 children of 3 years old from the SEPAGES cohort, a multi-domain health score was built from twenty-three health parameters. Fourteen metabolites of parabens, phenols, and phthalate/DINCH were measured several times during pregnancy (trimester 2 and 3) and infancy (2 and 12 months of age). Two mixture models, quantile g computation (q-gcomp) and Bayesian Kernel Machine Regression (BKMR), estimated associations between increased concentration of parabens, phenols, and phthalates/DINCH and the child health score.</div></div><div><h3>Results</h3><div>Q-gcomp showed that the paraben mixture and the phthalate mixture were associated with a poorer health score (β = −0.11, 95% Confidence Interval (CI): −0.22, 0.00; β = −0.14, 95% CI: −0.27, −0.01, respectively), while no significant association was found for the mixture of phenols (β = −0.06, 95% CI: −0.18, 0.06). A trend for an association was observed between the whole mixture (parabens, phenols and phthalates combined) with a poorer health score (β = −0.14, 95% CI: −0.32, 0.04). Similar patterns of association, while subject to large uncertainty, have been observed with BKMR.</div></div><div><h3>Discussion</h3><div>This study provides further evidence for the adverse health effects of early-life exposure to parabens and phthalates. Based on their potential impact on multiple areas of child health, public health policies targeting these chemical compounds are recommended.</div></div>","PeriodicalId":312,"journal":{"name":"Environmental Research","volume":"272 ","pages":"Article 121173"},"PeriodicalIF":7.7,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"环境科学与生态学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}