Nanotechnologies for the Life Sciences最新文献

{"title":"Quantum Dot–Core Silica Glass–Shell Nanomaterials: Synthesis, Characterization, and Potential Biomedical Applications","authors":"N. Murase","doi":"10.1002/9783527610419.NTLS0201","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0201","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000Historical Overview \u0000Quantum Dots and their Incorporation into Glass Matrices \u0000Single-Particle Spectroscopy and its Application to Biological Systems \u0000 \u0000 \u0000Incorporation of Quantum Dots in Glass Beads for Bioapplications \u0000The Stober Method \u0000Reverse Micelle Method \u0000Bifunctional Glass Beads Derived from the Reverse Micelle Method \u0000Complex Structures Created in Small Glass Beads with Novel Photoluminescent Properties \u0000Emitting Glass Fibers Created by Self-Assembly of the Complex Structured Beads \u0000 \u0000 \u0000Preparation of Cadmium-Free Quantum Dots With Water Dispersibility \u0000Summary and Future Perspective \u0000Acknowledgments \u0000 \u0000 \u0000Keywords: \u0000 \u0000quantum dot; \u0000silica; \u0000glass; \u0000beads; \u0000sol–gel; \u0000photoluminescence; \u0000bioimaging; \u0000biosensing","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123859396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to Synthesis and Characterization of Spherical and Anisometric Metal Oxide Magnetic Nanomaterials","authors":"L. Suber, D. Peddis","doi":"10.1002/9783527610419.NTLS0174","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0174","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000Magnetism in Nanostructured Metal Oxides \u0000Magnetism in Condensed Matter \u0000Magnetic Anisotropy Energy \u0000Magnetism in Small Particles: An Experimental Approach \u0000Zero Field-Cooled and Field-Cooled Magnetization \u0000Thermoremanent Magnetization \u0000 \u0000 \u0000Magnetic Metal Oxides \u0000 \u0000 \u0000Synthesis Methods for Spherical and Anisometric Iron Oxide Nanomaterials \u0000Synthesis of Spherical and Anisometric Nanoparticles \u0000Metal Salt Precipitation in Water \u0000Sol–Gel \u0000Microemulsions \u0000Autocombustion Method \u0000Surfactant-Assisted Hydrothermal Treatment \u0000Surfactant-Assisted Ultrasound Irradiation \u0000 \u0000 \u0000Ferrofluids \u0000Surfactant-Assisted Dehydration \u0000Hydrophobic–Hydrophilic Phase Transfer \u0000 \u0000 \u0000Core–Shell Spherical and Anisometric Particles \u0000Core–Shell Fluorescent Magnetic Iron Oxide–Silica Particles \u0000Synthesis of Anisometric Iron Oxide Nanocapsules \u0000 \u0000 \u0000Maghemite and Magnetite Nanotubes \u0000Solid Nanotube Template \u0000Soluble Nanotube Template \u0000 \u0000 \u0000 \u0000 \u0000Correlations between Synthesis and Magnetic Behavior in Iron Oxide Nanomaterials \u0000Spherical and Anisometric Iron Oxide Particles \u0000Spherical Magnetite (Fe3O4) Nanoparticles \u0000Stable Iron Oxide Spherical Nanoparticle Dispersions (Ferrofluids) \u0000Surfactant Effect \u0000Anisometric Maghemite (γ-Fe2O3) Particles \u0000 \u0000 \u0000Core–Shell Nanoparticles \u0000γ-Fe2O3/Silica Core Coated with Gold Nanoshell \u0000Effect of Particle Size and Particle Size Distribution on the Magnetic Properties of Magnetite/PDMS Nanoparticles \u0000 \u0000 \u0000Nanocomposites \u0000Magnetic Properties of Cobalt Ferrite–Silica Nanocomposites Prepared by a Sol–Gel Autocombustion Technique \u0000Ordered Mesoporous γ-Fe2O3/SiO2 Nanocomposites \u0000Fe3O4/Polymethylmethacrylate \u0000 \u0000 \u0000Iron Oxide Nanowires and Nanotubes \u0000Fe3O4 Nanowires \u0000Fe3O4 Nanowires and γ-Fe2O3 Nanotubes \u0000Fe3O4 and γ-Fe2O3 Tube-in-Tube Nanostructures \u0000 \u0000 \u0000 \u0000 \u0000Conclusions and Perspectives \u0000 \u0000 \u0000Keywords: \u0000 \u0000magnetic iron oxides; \u0000nanoparticle chemical synthesis methods; \u0000iron oxide nanotubes; \u0000iron oxide nanowires; \u0000ferrite composites; \u0000magnetism; \u0000core–shell magnetic particles; \u0000anisometric magnetic particles","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"19 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126980102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplexed Bioimaging Using Quantum Dots","authors":"R. Byers, E. Tholouli","doi":"10.1002/9783527610419.NTLS0193","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0193","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000The Need for Novel Multiplex Imaging Systems \u0000Quantum Dots \u0000Optical Properties \u0000Manufacture \u0000 \u0000 \u0000Bioimaging Applications of Quantum Dots \u0000Quantum Dot Use for Immunohistochemistry \u0000Quantum Dot Use for In Situ Hybridization \u0000Quantum Dot Use in Solid- and Liquid-State Multiplex Detection Platforms \u0000 \u0000 \u0000Translation to Clinical Biomarker Measurement \u0000Quantitation \u0000Imaging Analysis \u0000Combinational Microscopy Methods \u0000Clinical and Mechanistic Biological Applications \u0000Cancer Molecular Profiling \u0000 \u0000 \u0000Summary and Future Perspectives \u0000 \u0000 \u0000Keywords: \u0000 \u0000quantum dots; \u0000in situ hybridization; \u0000immunohistochemistry; \u0000spectral imaging; \u0000bioimaging; \u0000biomarker","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"231 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116194240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Free‐Standing Nanostructured Thin Films","authors":"Izumi Ichinose","doi":"10.1002/9783527610419.NTLS0186","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0186","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000The Roles of Free-Standing Thin Films \u0000Films as Partitions \u0000Nanoseparation Membranes \u0000Biomembranes \u0000 \u0000 \u0000Free-Standing Thin Films with Bilayer Structures \u0000Supported Lipid Bilayers and “Black Lipid Membranes” \u0000Foam Films and Newton Black Films \u0000Dried Foam Film \u0000Foam Films of Ionic Liquids \u0000 \u0000 \u0000Free-Standing Thin Films Prepared with Solid Surfaces \u0000Free-Standing Thin Films of Nanoparticles \u0000Nanofibrous Free-Standing Thin Films \u0000Electrospinning and Filtration Methods \u0000Metal Hydroxide Nanostrands \u0000Nanofibrous Composite Films \u0000Nanoseparation Membranes \u0000 \u0000 \u0000Conclusions \u0000 \u0000 \u0000Keywords: \u0000 \u0000separation membrane; \u0000free-standing; \u0000surfactant' foam film; \u0000nanostrand; \u0000filtration; \u0000nanofibrous film","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"51 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126355944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multiplexed Detection Using Quantum Dots","authors":"Young-Pil Kim, Zuyong Xia, J. Rao","doi":"10.1002/9783527610419.NTLS0194","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0194","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000In Vitro Multiplexed Analysis Using QDs \u0000DNA Hydridization \u0000Immunoassay \u0000Assaying the Activity of Enzymes \u0000FRET-Based Protease Detection with QDs as the Donor \u0000BRET-Based Protease Detection with QDs as Acceptor \u0000 \u0000 \u0000Other In Vitro Multiplexed Detection Systems \u0000 \u0000 \u0000Multiplexed Imaging Using QDs \u0000Multiplexed Cellular Imaging \u0000Multiplexed Imaging in Small Animals \u0000 \u0000 \u0000Summary \u0000 \u0000 \u0000Keywords: \u0000 \u0000multiplexed detection; \u0000quantum dots; \u0000nanosensors; \u0000multiplexed imaging; \u0000DNA hybridization; \u0000immunoassay; \u0000enzyme activity; \u0000energy transfer","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"89 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129013571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Type-I and Type-II Core–Shell Quantum Dots: Synthesis and Characterization","authors":"Dirk Dorfs, S. Hickey, A. Eychmüller","doi":"10.1002/9783527610419.NTLS0199","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0199","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000Core–Shell UV-Vis Nanoparticulate Materials \u0000Type-I Core–Shell Structures \u0000Type-II Core–Shell Structures \u0000Multiple Shell Structures \u0000Nonspherical Nanoheterostructures \u0000 \u0000 \u0000Characterization of Nanoheterostructures \u0000Core-Shell Infrared Nanoparticulate Materials \u0000Type I Core–Shell Infrared Structures \u0000Type II Core–Shell Infrared Structures \u0000Summary and Conclusions \u0000 \u0000 \u0000Keywords: \u0000 \u0000nanocrystal; \u0000semiconductor quantum dot; \u0000core–shell; \u0000type-I structure; \u0000type-II structure; \u0000infrared emitters; \u0000UV-Visible emitters","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127943903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantum Dots for Cancer Imaging","authors":"Yan Xiao, Xiugong Gao","doi":"10.1002/9783527610419.NTLS0191","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0191","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000Cancer \u0000A Primer on Cancer Biology \u0000The Importance of Early Cancer Detection and Diagnosis \u0000The Role of Biomarkers in Cancer Early Detection and Diagnosis \u0000 \u0000 \u0000Quantum Dots: Physics and Chemistry \u0000Photophysical Properties of QDs \u0000Quantum Dot Chemistry \u0000Synthesis \u0000Surface Passivation \u0000Water Solubilization \u0000Bioconjugation \u0000 \u0000 \u0000 \u0000 \u0000Cancer Imaging with QDs \u0000In Vitro Screening and Detection of Cancer Biomarkers Using Microarrays \u0000In Vitro Cellular Labeling of Cancer Biomarkers \u0000Labeling of Fixed Cells and Tissues \u0000Live Cell Imaging in Cancer Cells \u0000 \u0000 \u0000In Vivo Cancer Imaging \u0000In Vivo Tracking of Cancer Cells \u0000Tumor Vasculature Imaging \u0000Sentinel Lymph Node Mapping and Fluorescence Lymphangiography \u0000In Vivo Whole-Body Tumor Imaging in Animals \u0000 \u0000 \u0000Multimodality Tumor Imaging \u0000Dual-Functionality QDs for Cancer Imaging and Therapy \u0000 \u0000 \u0000Quantum Dot Cytotoxicity and Potential Safety Concerns \u0000Concluding Remarks and Future Perspectives \u0000Acknowledgments \u0000 \u0000 \u0000Keywords: \u0000 \u0000quantum dot; \u0000nanocrystal; \u0000cancer; \u0000tumor; \u0000imaging; \u0000fluorescence; \u0000biomarker; \u0000early detection","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"8 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126407900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic Core–Polymer Shell Nanoparticles: Synthesis and Biomedical Applications","authors":"K. Neoh, L. Tan, E. Kang","doi":"10.1002/9783527610419.NTLS0172","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0172","url":null,"abstract":"Magnetic core–polymer shell nanoparticles, with the core mainly in the form of magnetite (Fe3O4) or maghemite (γ-Fe2O3), offer great opportunities for applications in biomedicine. Such a configuration provides a synergistic combination of the intrinsic properties of the magnetic core with special biochemical functions, achieved through proper tailoring of the polymer shell. Active research and development efforts on the applications of such nanoparticles are ongoing in biomedical areas, such as contrast agents for magnetic resonance imaging to achieve increasingly high spatial resolution, down to the cellular and even molecular level; delivery vehicles of drugs to targeted organs or tumors; and as a heating mediator for cancer thermotherapy (hyperthermia). The controllability of these nanoparticles with respect to their physico-chemical properties, biodistribution and site specificity within the physiological environment, are major challenges which need to be addressed. In this chapter we review the synthetic routes of magnetic core–polymer shell nanoparticles, with emphasis on the tailoring of the polymer shell to confer the nanoparticles with desired properties for biomedical applications. \u0000 \u0000 \u0000Keywords: \u0000 \u0000magnetic nanoparticles; \u0000MRI contrast agent; \u0000cancer targeting; \u0000drug delivery; \u0000polymer coating; \u0000surface functionalization; \u0000encapsulation","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"85 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132367682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to the Synthesis and Characterization of Spherical and Anisotropic Magnetic Alloy Nanomaterials","authors":"M. Wellons, C. Lukehart","doi":"10.1002/9783527610419.NTLS0175","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0175","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000Magnetic Noble Metal Alloy Nanoparticles \u0000Magnetic Early Transition Metal Alloy Nanoparticles \u0000Summary and Future Perspectives \u0000 \u0000 \u0000Keywords: \u0000 \u0000metal alloy; \u0000metal nanoparticles; \u0000magnetic metal nanoparticles; \u0000anisotropic metal nanoparticles","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"43 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121748679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetophoretic Biosensing and Separation Using Magnetic Nanomaterials","authors":"Joo H. Kang, Y. Hahn, Kyu Sung Kim, J. Park","doi":"10.1002/9783527610419.NTLS0165","DOIUrl":"https://doi.org/10.1002/9783527610419.NTLS0165","url":null,"abstract":"The sections in this article are \u0000 \u0000 \u0000Introduction \u0000Theory \u0000Magnetic Properties of a Material \u0000Magnetophoresis \u0000High-Gradient Magnetic Separation \u0000 \u0000 \u0000Magnetophoresis in Microfluidic Devices \u0000Design and Microfabrication Processes \u0000Experimental Set-Up \u0000Measurement and Analysis \u0000 \u0000 \u0000Magnetophoretic Biosensing \u0000Magnetophoretic Sandwich Immunoassay \u0000Highly Sensitive Biosensors Using HGMS \u0000Disease Diagnosis Using Magnetophoretic Assay Systems \u0000Multiplexed Magnetophoretic Immunoassay \u0000 \u0000 \u0000Magnetophoretic Separation \u0000Cell Separation and Analysis \u0000Separation of Nanomaterials \u0000Isomagnetophoresis (IMP) \u0000 \u0000 \u0000Concluding Remarks \u0000Acknowledgments \u0000 \u0000 \u0000Keywords: \u0000 \u0000magnetic nanomaterials; \u0000microfluidic device; \u0000magnetophoresis; \u0000nanobiosensor; \u0000immunoassays; \u0000magnetophoretic separation; \u0000isomagnetophoresis","PeriodicalId":312946,"journal":{"name":"Nanotechnologies for the Life Sciences","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2011-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125547370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}