Proceedings of 5th International Electronic Conference on Medicinal Chemistry最新文献

{"title":"Antistaphylococcal activity of new salicylamide analogues","authors":"Hana Michnová, A. Imramovský, Pratibha Magar, A. Čížek, J. Jampílek","doi":"10.3390/ecmc2019-06344","DOIUrl":"https://doi.org/10.3390/ecmc2019-06344","url":null,"abstract":": Antimicrobial resistance is still a serious global threat. Staphylococcus aureus is a common cause of severe infections in health facilities and the community. People with methicillin-resistant S. aureus (MRSA) are estimated to be 64% more likely to die than people with a non-resistant form of the infection. For that reason, the research and development of new active compounds is really needed. Salicylamides are anti-infectious agents with a wide range of pharmacological effects, such us antiviral, antibacterial, antifungal and anthelminthic. Thus, derivatives of this group are very promising compounds. A series of newly synthesized complex salicylamide derivatives was tested for their antimicrobial effect against methicillin-resistant Staphylococcus aureus (MRSA). Staphylococcus aureus ATCC 29213 as a control and three isolates of MRSA were used. The activity was assessed by the evaluation of minimum inhibitory concentration. Using the microdilution method with subcultivation of aliquots, the minimum bactericidal concentration was determined too. Ciprofloxacin and ampicillin were used as standard antibacterial drugs. Four most promising compounds from the series were chosen and are demonstrated in this contribution.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115727282","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Food for celiacs with black quinoa (Chenopodium petiolare kunth)","authors":"Juan B Beltramino, M. Mesa, S. Soto","doi":"10.3390/ecmc2019-06347","DOIUrl":"https://doi.org/10.3390/ecmc2019-06347","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115788297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chemical imaging in pharmaceutics for formulation analysis, quality control, and monitoring of formulation interactions with biological tissue","authors":"I. Iermak, Ana Paula Silva, C. Kurachi, V. Bagnato, N. Inada","doi":"10.3390/ecmc2019-06351","DOIUrl":"https://doi.org/10.3390/ecmc2019-06351","url":null,"abstract":"Raman microspectroscopy is an elegant and efficient tool for chemical analysis of the samples since it provides information about the structure, conformation, and changes of molecules both in pharmaceutical formulation and in the biological tissue. It is especially useful for samples containing water since water absorption is not dominating the Raman spectrum, as it happens in the case of infrared spectroscopy. Analysis of several formulations for onychomycosis treatment is shown as the example of Raman microspectroscopy application in pharmaceutics. Differences between the formulations are shown to be linked to their efficiency in the infection treatment. Comparison of Raman microspectroscopy as the tool to analyze pharmaceutical formulations, their efficiency and stability is made in relation to the other spectroscopical and microscopical methods and the advantages and disadvantages of several techniques are discussed. The application of the results obtained in this study is demonstrated on further improvement of the formulation in development.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130638827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In silico studies of bacterial efflux pump inhibition by thioxanthones and their synergistic antibacterial activity","authors":"E. Sousa, Fernando Durães, F. Barbosa, Joana Freitas-Silva, Paulo M. Costa, M. Pinto","doi":"10.3390/ecmc2019-06300","DOIUrl":"https://doi.org/10.3390/ecmc2019-06300","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"49 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123149080","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel synthesis of 3-fluoro- and 3,3-difluoro-substituted β-lactams: evaluation as potential antiproliferative and tubulin destabilizing agents","authors":"Azizah M Malebari, M. Meegan","doi":"10.3390/ecmc2019-06303","DOIUrl":"https://doi.org/10.3390/ecmc2019-06303","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128252441","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acetylcholinesterase and antioxidant evaluation of C18-functionalized ferruginol analogues","authors":"Miguel A. González-Cardenete, A. Yuste, E. García-Martínez, M. Nicolai, R. Zaragozá, P. Rijo","doi":"10.3390/ecmc2019-06313","DOIUrl":"https://doi.org/10.3390/ecmc2019-06313","url":null,"abstract":"One slide, Max 200 words The abietane-type diterpenoids are characterized by a tricyclic ring system and have shown a wide range of chemical diversity and biological activity. Medicinal chemists have studied derivatives of two readily available materials such as dehydroabietic acid and dehydroabietylamine. To date, there is only one commercial drug, Ecabet® [ecabet sodium], based on abietanes, which is used for the treatment of reflux esophagitis and peptic ulcer disease. The simplest phenolic abietane, ferruginol, exhibits anticancer effects in human ovarian cancer and inhibition of cancer cell migration. It also has shown interesting properties in different models of Alzheimer’s disease, researchers have reported neuroprotective effects of ferruginol against amyloid-b (Aβ) oligomers-induced neurodegenerative alterations and butyrylcholinesterase inhibition. In this communication, we present the results of an investigation of several C18ferruginol analogues on anti-acetylcholinesterase activity and antioxidant agents.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129689560","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharma-toxicological and phytochemical investigations on Tanacetum parthenium and Salix alba extracts: Focus on potential application as anti-migraine agents","authors":"C. Ferrante","doi":"10.3390/ecmc2019-06282","DOIUrl":"https://doi.org/10.3390/ecmc2019-06282","url":null,"abstract":"Migraine is one of the most common neurological disorder, which has long been related to brain serotonin (5-HT) depletion and neuro-inflammation. Despite many treatment options are available, the frequent occurrence of unacceptable adverse effects further supports the research toward nutraceuticals and herbal preparations, among which Tanacetum parthenium and Salix alba showed promising anti-inflammatory and neuro-modulatory activities. \u0000The impact of extract treatment on astrocyte viability, spontaneous migration and apoptosis was evaluated. Anti-inflammatory/anti-oxidant effects were investigated on isolated rat cortexes exposed to a neurotoxic stimulus. The lactate dehydrogenase (LDH) release, nitrite levels and 5-HT turnover were evaluated, as well. A proteomic analysis was focused on specific neuronal proteins and a fingerprint analysis was carried out on selected phenolic compounds. \u0000Both extracts appeared able to exert in vitro anti-oxidant and anti-apoptotic effects. S. alba and T. parthenium extracts reduced LDH release, nitrite levels and 5-HT turnover induced by neurotoxicity stimulus. The downregulation of selected proteins suggest a neurotoxic, which could be ascribed to an elevate content of gallic acid in both S. alba and T. parthenium extracts. \u0000Concluding, both extracts exert neuroprotective effects, although the downregulation of key proteins involved in neuron physiology suggest caution in their use as food supplements.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"35 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116298076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interactions of zinc(II) complexes with N-donor ligands with 5’-GMP and their cytotoxic activity","authors":"T. Soldatović, Enisa Selimović, Biljana M Šmit, Darko P Ašanin, Nevena S. Planojević, S. Marković, R. Puchta, B. M. Alzoubi","doi":"10.3390/ecmc2019-06286","DOIUrl":"https://doi.org/10.3390/ecmc2019-06286","url":null,"abstract":"Design of novel non-platinum DNA and protein targeting metal-based anticancer agents with potential in vitro toxicity have gained importance in recent years (Bertini, I. et al, Biological Inorganic Chemistry. Structure and Reactivity. University Science Books. Sausalito, CA. 2007. The non-platinum antitumor complexes could be alternatives to platinum-based drugs due to their better characteristics and less negative side effects. (Pessoa, J.C., et al. J. Inorg. Biochem. 2011, 105, 637-644). \u0000The mechanism of substitution from tetrahedral [ZnCl2(en)] and square-pyramidal [ZnCl2(terpy)] complexes (where en = 1,2-diaminoethane or ethylenediamine; terpy= 2,2′:6′,2′′-terpyridine) by guanosine-5’-monophospahate (5’-GMP) have been investigated by 1H NMR spectroscopy. Information about the structures of the final products in solution were obtained from the DFT calculations (B3LYP/6-31G(d)) and experimental 1H NMR data acquired during the course of the reaction. The cytotoxic activity of zinc(II) complexes was tasted on human breast cancer cell line MDA-MB-231, human colon cancer cell line HCT-116 and normal human lung fibroblast cell line MRC-5. Both complexes reduced cell viabilities, while [ZnCl2(terpy)] complex was significantly cytotoxic on MDA-MB-231 after 72 h, and HCT-116 after 24 h without dose dependence. The differences in reactivity toward 5’-GMP and cytotoxic activity of Zn(II) complexes may be attributed to the very stable square-pyramidal geometry of [ZnCl2(terpy)] complex in solution, while weak ligand effect of the en compared to the terpy affected slow interaction of tetrahedral [ZnCl2(en)] complex with the target bio-molecule (Soldatovic, E., et al. J. Coord. Chem. 2019, 72(4), 690-706). \u0000Acknowledgements: T. Soldatovic and E. Selimovic gratefully acknowledge financial support from State University of Novi Pazar, Novi Pazar, Republic of Serbia. R. Puchta would like to thank the Regionales Rechenzentrum Erlangen (RRZE) for a generous allotment of computer time, Prof. Tim Clark for hosting this work at the CCC. B.M. Alzoubi thanks Al-Balqa Applied University for its support. The authors are grateful for the support to the Ministry of Education, Science and Techhnological Development of the Republic of Serbia (Projects No. III41010, OI172016 and OI172036)","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"179 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126072008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Design, synthesis, X-ray structure and evaluation of functionalized hexacyclic carbazoles as new inhibitors of ABCG2 transporter","authors":"A. Bouraiou, G. Valdameri, I. Zanzarini, Esma Lamera, S. Bouacida, I. Zattoni, D. Kita, Z. Bouaziz, V. R. Moure, M. B. Borgne","doi":"10.3390/ecmc2019-06343","DOIUrl":"https://doi.org/10.3390/ecmc2019-06343","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121437941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antioxidant capacity and cholinesterase inhibitory activity of Vulpicida pinastri lichen and its chemical composition","authors":"Isabel Maria Ureña Vacas, Elena González Burgos, M. Gómez-Serranillos","doi":"10.3390/ecmc2019-06317","DOIUrl":"https://doi.org/10.3390/ecmc2019-06317","url":null,"abstract":"","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2019-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117268597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}