Chemical imaging in pharmaceutics for formulation analysis, quality control, and monitoring of formulation interactions with biological tissue

Proceedings of 5th International Electronic Conference on Medicinal Chemistry Pub Date : 2019-10-31 DOI:10.3390/ecmc2019-06351

I. Iermak, Ana Paula Silva, C. Kurachi, V. Bagnato, N. Inada

{"title":"Chemical imaging in pharmaceutics for formulation analysis, quality control, and monitoring of formulation interactions with biological tissue","authors":"I. Iermak, Ana Paula Silva, C. Kurachi, V. Bagnato, N. Inada","doi":"10.3390/ecmc2019-06351","DOIUrl":null,"url":null,"abstract":"Raman microspectroscopy is an elegant and efficient tool for chemical analysis of the samples since it provides information about the structure, conformation, and changes of molecules both in pharmaceutical formulation and in the biological tissue. It is especially useful for samples containing water since water absorption is not dominating the Raman spectrum, as it happens in the case of infrared spectroscopy. Analysis of several formulations for onychomycosis treatment is shown as the example of Raman microspectroscopy application in pharmaceutics. Differences between the formulations are shown to be linked to their efficiency in the infection treatment. Comparison of Raman microspectroscopy as the tool to analyze pharmaceutical formulations, their efficiency and stability is made in relation to the other spectroscopical and microscopical methods and the advantages and disadvantages of several techniques are discussed. The application of the results obtained in this study is demonstrated on further improvement of the formulation in development.","PeriodicalId":312909,"journal":{"name":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","volume":"38 1","pages":"0"},"PeriodicalIF":0.0000,"publicationDate":"2019-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Proceedings of 5th International Electronic Conference on Medicinal Chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3390/ecmc2019-06351","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Raman microspectroscopy is an elegant and efficient tool for chemical analysis of the samples since it provides information about the structure, conformation, and changes of molecules both in pharmaceutical formulation and in the biological tissue. It is especially useful for samples containing water since water absorption is not dominating the Raman spectrum, as it happens in the case of infrared spectroscopy. Analysis of several formulations for onychomycosis treatment is shown as the example of Raman microspectroscopy application in pharmaceutics. Differences between the formulations are shown to be linked to their efficiency in the infection treatment. Comparison of Raman microspectroscopy as the tool to analyze pharmaceutical formulations, their efficiency and stability is made in relation to the other spectroscopical and microscopical methods and the advantages and disadvantages of several techniques are discussed. The application of the results obtained in this study is demonstrated on further improvement of the formulation in development.

查看原文本刊更多论文

药剂学中用于制剂分析、质量控制和制剂与生物组织相互作用监测的化学成像

拉曼微光谱学是一种优雅而高效的样品化学分析工具，因为它提供了药物制剂和生物组织中分子的结构、构象和变化的信息。它对含有水的样品特别有用，因为水的吸收不是拉曼光谱的主要特征，而在红外光谱中则是如此。本文以拉曼光谱技术在医药领域的应用为例，对几种治疗甲癣的制剂进行了分析。配方之间的差异显示与其在感染治疗方面的效率有关。将拉曼显微光谱技术作为分析药物配方的工具，与其他光谱和显微方法进行了效率和稳定性的比较，并讨论了几种技术的优缺点。研究结果在进一步改进配方的开发中得到了应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Proceedings of 5th International Electronic Conference on Medicinal Chemistry

自引率

0.00%

发文量