Acetylcholinesterase and antioxidant evaluation of C18-functionalized ferruginol analogues

One slide, Max 200 words The abietane-type diterpenoids are characterized by a tricyclic ring system and have shown a wide range of chemical diversity and biological activity. Medicinal chemists have studied derivatives of two readily available materials such as dehydroabietic acid and dehydroabietylamine. To date, there is only one commercial drug, Ecabet® [ecabet sodium], based on abietanes, which is used for the treatment of reflux esophagitis and peptic ulcer disease. The simplest phenolic abietane, ferruginol, exhibits anticancer effects in human ovarian cancer and inhibition of cancer cell migration. It also has shown interesting properties in different models of Alzheimer’s disease, researchers have reported neuroprotective effects of ferruginol against amyloid-b (Aβ) oligomers-induced neurodegenerative alterations and butyrylcholinesterase inhibition. In this communication, we present the results of an investigation of several C18ferruginol analogues on anti-acetylcholinesterase activity and antioxidant agents.