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Think Beyond Type 1 Diabetes in Children Presenting with High Blood Sugar 考虑高血糖儿童的1型糖尿病以外的问题
Exclusive Real World Evidence Journal Pub Date : 2023-02-20 DOI: 10.54136/erwej-0301-10044
Manisha Gupta, Hitesh Saraogi
{"title":"Think Beyond Type 1 Diabetes in Children Presenting with High Blood Sugar","authors":"Manisha Gupta, Hitesh Saraogi","doi":"10.54136/erwej-0301-10044","DOIUrl":"https://doi.org/10.54136/erwej-0301-10044","url":null,"abstract":"Children presenting with high blood sugar in our clinics are often diagnosed with Type 1 diabetes considering the age of the patient. This case will highlight the need for proper diagnosis in the children to provide them with suitable treatment as per their diagnosis. We report a case of an 8-year-old boy who presented with complaints of weight loss of approximately 2 kg in a span of two months. His height was 134.9 cm and weight was 47 kg with a BMI of 26. His family history of diabetes was positive. To our surprise the patient did not have a simple case of type 1 diabetes as expected, the patient responded well to the diet and lifestyle modification in the beginning, and after a few months, he was started on anti-diabetic treatment as his blood sugar showed a spike. The final diagnosis for this patient was considered as latent autoimmune diabetes of young/ children as the patient’s GAD 65 was highly positive and C-peptide levels were normal. The correct diagnosis of diabetes type in children can help them to prevent the unnecessary psychological burden of multiple injection therapy from a young age and provide them with good quality of life and preserve their beta cells with minimal insulin therapy. Keywords: Latent Autoimmune Diabetes; Auto-antibodies; Diabetes Mellitus; C-peptide","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"205 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-02-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133001603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of Effectiveness, Tolerability, and Compliance of Pharmacotherapies in Patients with Functional Constipation: A Real-World Evidence Study 功能性便秘患者药物治疗的有效性、耐受性和依从性的比较:一项真实世界的证据研究
Exclusive Real World Evidence Journal Pub Date : 2022-11-07 DOI: 10.54136/erwej-0204-10038
S. Gupta, Naresh Bansal, R. S. Bagepally, Dr. Kishalaya
{"title":"Comparison of Effectiveness, Tolerability, and Compliance of Pharmacotherapies in Patients with Functional Constipation: A Real-World Evidence Study","authors":"S. Gupta, Naresh Bansal, R. S. Bagepally, Dr. Kishalaya","doi":"10.54136/erwej-0204-10038","DOIUrl":"https://doi.org/10.54136/erwej-0204-10038","url":null,"abstract":"Background: duphalac® bulk, a combination of bulking agents and an osmotic laxative might prove beneficial in the management of functional constipation (FC) as compared to the existing therapies. Objective: To evaluate and compare the effectiveness, safety, and compliance of duphalac® bulk with other available therapeutic options for the management of constipation. Methods: In this retrospective study, electronic medical records (EMRs) of adult patients suffering from FC who were prescribed various dietary fibers or their combinations between May 2021 to September 2021 and visiting healthcare setups/clinics were reviewed. The patients were divided into four groups (2:1:1:1): Group I-duphalac® bulk; Group II-isabgol alone; Group III-lactitol and isabgol combination; and Group IV-Polyethylene glycol (PEG) and isabgol combination. Effectiveness was determined using the constipation scoring system (CSS). Adverse events and compliance were assessed. Additionally, lipid and glycemic parameters were analyzed. Results: Out of 110 patients screened, 96 met the inclusion criteria and participated in the study. Majority of the patients (42.7%) received duphalac® bulk, followed by lactitol and isabgol combination (19.7%), PEG and isabgol combination (18.7%), and isabgol (18.7%). A significant reduction in overall mean CSS was observed among all the groups; however, the maximum decrease (3.49, p<0.001) was found in Group I as compared to Groups II (3.28, p<0.001), III (2.58, p=0.001), and IV (2.50, p=0.002). All treatments were well tolerated. Improvements in glycemic and lipid parameters were observed in all groups. Conclusion: duphalac® bulk was well tolerated with significant symptomatic improvement in patients suffering from FC. Keywords: Constipation scoring system, Duphalac® bulk, Functional constipation, Glycemic control, Lipid profile","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124294410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approach to Reactive Hypoglycemia 反应性低血糖的治疗方法
Exclusive Real World Evidence Journal Pub Date : 2022-11-07 DOI: 10.54136/erwej-0204-10039
Hitesh Saraogi, Manisha Gupta
{"title":"Approach to Reactive Hypoglycemia","authors":"Hitesh Saraogi, Manisha Gupta","doi":"10.54136/erwej-0204-10039","DOIUrl":"https://doi.org/10.54136/erwej-0204-10039","url":null,"abstract":"Hypoglycemia episodes are a real nightmare for physicians and as well as patients. If clinician comes across non-diabetic patients visiting their clinic with symptoms of an episode of hypoglycemia like tachycardia, cold sweats, hunger, tremor, and other autonomic nervous symptoms after 3 to 4 hours of their meal, and during the event, their random blood sugar is <70mg/dl with all adrenergic and neuroglycopenic symptoms usually following a carbohydrate-rich meal diet. This kind of hypoglycemia is known as Reactive Hypoglycemia (RH) or Postprandial hypoglycemia (PPH). This article will help physicians to better understand reactive hypoglycemia diagnosis, differential diagnosis, and management. The categorization of the patient with hypoglycemia is the key to treating and avoiding future hypoglycemic episodes Keywords: Hypoglycemia, Reactive hypoglycemia, Postprandial hypoglycemia, Diabetes","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130377697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What ails Medical Research in India? 是什么困扰着印度的医学研究?
Exclusive Real World Evidence Journal Pub Date : 2022-11-07 DOI: 10.54136/erwej-0204-10037
Prantar Chakrabarti
{"title":"What ails Medical Research in India?","authors":"Prantar Chakrabarti","doi":"10.54136/erwej-0204-10037","DOIUrl":"https://doi.org/10.54136/erwej-0204-10037","url":null,"abstract":"","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"9 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121761427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intra-oral Plasma Cell Granuloma: A Rare Clinico-pathological Entity-Report of Two Cases with Review 口腔内浆细胞肉芽肿:一种罕见的临床病理实体——附2例报告
Exclusive Real World Evidence Journal Pub Date : 2022-11-07 DOI: 10.54136/erwej-0204-10035
Abhishek Ghosh, Sanjeet Kr Das, R. Chatterjee, Snehasish Das
{"title":"Intra-oral Plasma Cell Granuloma: A Rare Clinico-pathological Entity-Report of Two Cases with Review","authors":"Abhishek Ghosh, Sanjeet Kr Das, R. Chatterjee, Snehasish Das","doi":"10.54136/erwej-0204-10035","DOIUrl":"https://doi.org/10.54136/erwej-0204-10035","url":null,"abstract":"Plasma cell granulomas (PCGs) or inflammatory pseudotumors are non-neoplastic lesions that consist of predominantly antibody-producing plasma cells and innate immune cells such as neutrophils, macrophages, and eosinophils. Unlike in multiple myeloma, the plasma cells are polyclonal and proliferate in a fibroblast-rich stromal background. These lesions are predominantly reported in the lungs; however, they may involve other organs too. Very few cases are reported regarding the presence of PCG in the oral cavity and a confirmatory diagnosis is crucial for further management. A critical and careful examination from a pathological point of view is obviously necessary to rule out other plasma cell neoplasms. We present here two cases of intra-oral PCGs; one in the gingiva & another within the jaw; both showing a polyclonal staining pattern in immunohistochemistry confirming a diagnosis of plasma cell granuloma. Keywords: Inflammatory pseudotumor, Plasma cell granuloma, Plasma cells, Polyclonal plasma cells, Lambda and kappa chain","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124022212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Giant Tongue Hemangioma 舌巨血管瘤
Exclusive Real World Evidence Journal Pub Date : 2022-11-07 DOI: 10.54136/erwej-0204-10034
Antonio Gentil da Silva Martins
{"title":"Giant Tongue Hemangioma","authors":"Antonio Gentil da Silva Martins","doi":"10.54136/erwej-0204-10034","DOIUrl":"https://doi.org/10.54136/erwej-0204-10034","url":null,"abstract":"Hemangiomas are benign tumors of infancy and childhood. These tumors are mostly in the neck and head region and occur more commonly in the palate, lips, and tongue. In this case report, we report a case of hemangioma of the body of the tongue, discussing the diagnostic aspects and treatment. A giant tumor malformation of the tongue diagnosed prenatally after birth proved to be a large hemangioma. He required multiple surgeries until the mouth could be closed and the child could eat well and look normal. Keywords: Tongue lesions, Hemangiomas, Congenital malformations, Ultrasonography","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"81 5 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126062693","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Animal Model for Diabetes Co-existing with Metabolic Syndrome 糖尿病合并代谢综合征的动物模型
Exclusive Real World Evidence Journal Pub Date : 2022-11-07 DOI: 10.54136/erwej-0204-10041
R. Suman, Manjusha K. Borde, I. Mohanty, H. Singh
{"title":"Animal Model for Diabetes Co-existing with Metabolic Syndrome","authors":"R. Suman, Manjusha K. Borde, I. Mohanty, H. Singh","doi":"10.54136/erwej-0204-10041","DOIUrl":"https://doi.org/10.54136/erwej-0204-10041","url":null,"abstract":"Metabolic syndrome includes diverse disorders together with truncal obesity, dyslipidemia, high blood pressure, and hyperglycemia. The occurrence of metabolic syndrome is growing globally. The unfavorable results of metabolic syndrome have brought on research efforts to broaden new interventions to reduce the weight of the healthcare system. Because of its multifactorial nature, it may be hard to pick out the best experimental version that high-quality represents the pathophysiology of human metabolic syndrome. Many animal models have evolved and been studied to clarify the molecular mechanisms and useful modifications associated with metabolic sicknesses. Properly characterized and clinically applicable experimental models are taken into consideration as crucial tools for testing new pills and information on their molecular foundation, their pathogenesis, and mechanism of movement. In this review, we collate and discuss the various animal models of metabolic syndrome and the suitability of diabetes co-existing with metabolic syndrome animal models for research also be discussed to provide the readers with a comprehensive overview of the selection of the best animal models to meet their research purpose. Keyword:Animal model, Metabolic syndrome, High fat diet, Rat","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116658451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
In Utero Detection and Postnatal Follow-up of a Case of LV Non-compaction 1例左室不压实的宫内检测及产后随访
Exclusive Real World Evidence Journal Pub Date : 2022-11-07 DOI: 10.54136/erwej-0204-10036
M. Ray, V. Kohli
{"title":"In Utero Detection and Postnatal Follow-up of a Case of LV Non-compaction","authors":"M. Ray, V. Kohli","doi":"10.54136/erwej-0204-10036","DOIUrl":"https://doi.org/10.54136/erwej-0204-10036","url":null,"abstract":"22-year-old lady para 1 with a medical history of Diabetes Melitus (recently detected, poorly controled) on insulin Level I ultrasound showed no cardiac abnormality on cardiac screening with normal 4 ch and outflow tracts. Fetal echo at 24 weeks showed the presence of LVNC with LV dysfunction. The patient was counseled and prognosticated. Genetic studies are advised. She continued and was delivered by LUCS. A 3.4 kg, male baby with normal Apgar was born. After an uneventful neonatal period, on folow up the echo confirmed the presence of LVNC. He was put on decongestants and carvedilol. Counseled again and advised to register in a cardiac transplant centre Left ventricular non-compaction (LVNC) is rare congenital cardiomyopathy due to an arrest during fetal development of the myocardium LVNC can be diagnosed at any age and the exact etiology is stil unknown [1-2]. LVNC is being detected & described in fetal life in very few case reports.","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125274562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of Prevailing Awareness on The Psychosocial Impact of The COVID-19 Pandemic Among T1DM Patients from North India 印度北部T1DM患者普遍意识对COVID-19大流行心理社会影响的影响
Exclusive Real World Evidence Journal Pub Date : 2022-08-06 DOI: 10.54136/erwej-0203-10040
Manisha Gupta, Hitesh Saraogi
{"title":"Impact of Prevailing Awareness on The Psychosocial Impact of The COVID-19 Pandemic Among T1DM Patients from North India","authors":"Manisha Gupta, Hitesh Saraogi","doi":"10.54136/erwej-0203-10040","DOIUrl":"https://doi.org/10.54136/erwej-0203-10040","url":null,"abstract":"Background: SARS-CoV-2 has impregnated its effect on the physical and mental status of affected individuals worldwide. The psychosocial impact on individuals with pre-existing medical illnesses is not well documented. Objectives: To evaluate the extent of awareness about COVID-19 and its symptoms, prevention, and quantifying the anxiety among individuals with T1DM during the lockdown in India. Methods: An online survey-based observational study was conducted in two clinics in North India among children and adults with T1DM. A Google form was circulated among the participants and their response was assessed using SPSS version 25. Results:Among 44 study individuals, about 97% had a good extent of knowledge of the COVID-19 symptoms. The mean age of the study population was 20.78±8.35. The male-to-female ratio was 1.2:1. More than half of the individuals were well-versed in diabetic knowledge (carb ratio, correction factor). Around three-fourths of the patients were able to continue their exercise routine during the pandemic. Almost all (97.7%) patients were aware of COVID-19-associated symptoms, preventive care, and ways of transmission. Almost half of them were anxious about the COVID-19 pandemic. This was mainly attributed to better media coverage and communication between each other. Assessment using the COVID-19 anxiety score indicated that less than 50% of the participants experienced anxiety. Conclusion: Dealing with T1DM is a challenge for the healthcare system and it is even more challenging during the pandemic period. Prior knowledge and awareness seem to mitigate anxiety and related issues in individuals with chronic illness, especially T1DM. Keywords: T1DM, COVID-19 pandemic, Mental health, Psychosocial effect, Mental anxiety","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"125158659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Some Extraordinary Cases of Giant Hemangioma in Children 儿童巨大血管瘤的几个特殊病例
Exclusive Real World Evidence Journal Pub Date : 2022-08-05 DOI: 10.54136/erwej-0203-10033
Antonio Gentil da Silva Martins
{"title":"Some Extraordinary Cases of Giant Hemangioma in Children","authors":"Antonio Gentil da Silva Martins","doi":"10.54136/erwej-0203-10033","DOIUrl":"https://doi.org/10.54136/erwej-0203-10033","url":null,"abstract":"Hemangioma is one of the most common tumors in infancy and we aim to show the importance of its spontaneous evolution. They are often present at birth or appear soon after and grow rapidly by endothelial proliferation. Here, we present a series of very extensive and extraordinary hemangiomas, mainly facial, followed for many years in order to be able to evaluate the natural growth and regression of those lesions and allow for a better-based treatment and follow-up. Keywords: Hemangiomas; Spontaneous evolution; Psychology; Extraordinary cases","PeriodicalId":312076,"journal":{"name":"Exclusive Real World Evidence Journal","volume":"18 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123273713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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