Academic Journal of Medicine & Health Sciences最新文献

Predictive Analysis of Breast Cancer Based on Stacking Algorithm 基于堆叠算法的乳腺癌预测分析

Academic Journal of Medicine & Health Sciences Pub Date : 2021-11-10 DOI: 10.25236/AJMHS.2021.020107

K. Tan, Zhi-yu Luo

引用次数: 0

Reduction-Sensitive Polymeric Micelles for Intracellular Doxorubicin Delivery 细胞内递送阿霉素的还原敏感聚合物胶束

Academic Journal of Medicine & Health Sciences Pub Date : 2021-11-10 DOI: 10.25236/AJMHS.2021.020114

Xiaoyi Zhang, Y. Zhuang, Le-Ping Yang, Yongkang Liu

{"title":"Reduction-Sensitive Polymeric Micelles for Intracellular Doxorubicin Delivery","authors":"Xiaoyi Zhang, Y. Zhuang, Le-Ping Yang, Yongkang Liu","doi":"10.25236/AJMHS.2021.020114","DOIUrl":"https://doi.org/10.25236/AJMHS.2021.020114","url":null,"abstract":"The hazard of cancer is continuously increasing with age, Doxorubicin (DOX) encapsulated by liposomes as an effective formulation is widely used to treat malignancies. To avoid the cardiotoxicity of DOX and increase the half-life and targeting of liposomal drugs, redox-sensitive nanoparticle that improve the delivery of therapeutics to target tissue have become an extensive choice of medical treatment. In this work, we synthesised a kind of redox-sensitive product, PEG-redox-DOX micelles which were made of PEG-SS-COOH coupled with DOX by a reduction-sensitive disulfide bond. This micellar system has a mean diameter of 60nm with acceptable distribution (PDI=0.81) and remained unchanged in phate buffered saline (PBS, pH=7.4) for 24 hours. However, the disulfide bond between DOX and hydrophilic PEG broke readily in the presence of 10 mM DTT imitating intracellular condition. The micelle released more than 75% DOX within 48h at 10 mM DTT, whereas only 12% DOX were released from prodrug at 0 mM DTT. These results suggest that PEG-redox-DOX has expectable efficiency of drug-loading and release. Nowadays, redox-sensitive micelles are more and more taken into considered, demonstrating its developmental potential in cancer therapy categories by providing a new search direction.","PeriodicalId":311994,"journal":{"name":"Academic Journal of Medicine & Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128761281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on nucleic acid detection product design driven by service design in post epidemic Era --Take FengHuangZhou community in Nanchang as an example 后疫情时代服务设计驱动下的核酸检测产品设计研究——以南昌凤凰洲社区为例

Academic Journal of Medicine & Health Sciences Pub Date : 2021-11-10 DOI: 10.25236/AJMHS.2021.020106

W. Yu

{"title":"Research on nucleic acid detection product design driven by service design in post epidemic Era --Take FengHuangZhou community in Nanchang as an example","authors":"W. Yu","doi":"10.25236/AJMHS.2021.020106","DOIUrl":"https://doi.org/10.25236/AJMHS.2021.020106","url":null,"abstract":"Since May 2020, China's epidemic prevention and control has entered a stable stage. The overall trend is that the epidemic situation rises and falls from time to time. It may break out on a small scale at any time, return from foreign countries and have seasonal attacks, which will have a far-reaching impact on all aspects. In this study, the community nucleic acid detection products and service system in such a \"post epidemic era\" as the breakthrough point, through qualitative and quantitative research methods, using issue Map, user interview, data crawler, emotional data analysis and other research tools are used to analyze and integrate the existing community collective nucleic acid detection process, basic user groups, stakeholders and so on. After having a good understanding of the existing service system and products, the outstanding problems of the service system are further optimized, focusing on solving process visualization problems and special crowd services Problems, online product optimization. Build a new stakeholder system, user journey, prototype, and carry out prototype testing to get feedback, in order to provide reference value solutions to deal with large-scale public health problems in the future.","PeriodicalId":311994,"journal":{"name":"Academic Journal of Medicine & Health Sciences","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"132680631","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research on resident Health level and Measurement and Control Model based on Index system and Entropy method 基于指标体系和熵值法的居民健康水平及测控模型研究

Academic Journal of Medicine & Health Sciences Pub Date : 2021-11-10 DOI: 10.25236/AJMHS.2021.020105

Cheng Wei

{"title":"Research on resident Health level and Measurement and Control Model based on Index system and Entropy method","authors":"Cheng Wei","doi":"10.25236/AJMHS.2021.020105","DOIUrl":"https://doi.org/10.25236/AJMHS.2021.020105","url":null,"abstract":"In order to thoroughly implement the spirit of the National and Provincial Health and Health Conference, this action plan is formulated according to the outline of the healthy China 2030 Plan and combined with the reality of Shenzhen. In this paper, principal component analysis and mutation series evaluation are mainly used to solve the health problems of Shenzhen residents. First of all, this paper analyzes the factors that affect the health level of residents, determines the corresponding indicators and constructs a three-tier index system, including 21 indicators. As there may be a certain correlation between the indicators in the established index system, and the correlation between the indicators will produce repeated information for the evaluation of residents' health level, so the independent indicators are reduced by principal component analysis. Finally, the catastrophe series method is used to calculate the independent principal components. Then the indicators within the framework are analyzed and screened to determine the index system of population health assessment; finally, the social public health and environment and individual residents are evaluated by entropy method and fuzzy evaluation. Find out the main health problems of Shenzhen residents and analyze the potential influencing factors, and put forward suggestions for health promotion and health intervention.","PeriodicalId":311994,"journal":{"name":"Academic Journal of Medicine & Health Sciences","volume":"107 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126625939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

PH-Sensitive Polymeric Nanoparticles for Targeted Delivery of Doxorubicin 用于靶向递送阿霉素的ph敏感聚合物纳米颗粒

Academic Journal of Medicine & Health Sciences Pub Date : 2021-11-10 DOI: 10.25236/AJMHS.2021.020113

Yuzhe Yuan, Shuyao Geng, Chenxi Li, Jiayuan Yang

{"title":"PH-Sensitive Polymeric Nanoparticles for Targeted Delivery of Doxorubicin","authors":"Yuzhe Yuan, Shuyao Geng, Chenxi Li, Jiayuan Yang","doi":"10.25236/AJMHS.2021.020113","DOIUrl":"https://doi.org/10.25236/AJMHS.2021.020113","url":null,"abstract":"In order to improve the targeting of doxorubicin and prolong the action time of the drug, we synthesized a pH-responsive PEG-Schiff-DOX polymer prodrug loaded with nanoparticles. The nanoparticles were prepared by synthesis of PEG-CHO and condensation reaction of PEG-CHO and adriamycin. The release behavior of PEG-Schiff-DOX was tested at different pH. The morphology and particle size of these nanoparticles changed obviously after acid treatment(pH=5.0), and some of them had completely disintegrated. The narrowing of particle size distribution indicates that the heterogeneous nanoparticles disintegrate in the acidic environment of tumor cells, releasing the drug and finally achieving the maximum drug release at pH 5.0. The nanodrugs based on polymeric prodrug had advantages of simple preparation, high drug loading, good storage stability and achieve higher local drug concentration and longer drug action time under the condition of weak acid of tumor microenvironment to keep the curative effect and reduce the side effects. The advantages of offers choices for the development of new drugs and is expected to achieve good application in cancer therapy, has good prospects for development.","PeriodicalId":311994,"journal":{"name":"Academic Journal of Medicine & Health Sciences","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"133059380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of Eurotium cristatum fermentation on the α-glucosidase inhibitory activity of mulberry leaves alkaloids 鸡冠Eurotium cristum发酵对桑叶生物碱α-葡萄糖苷酶抑制活性的影响

Academic Journal of Medicine & Health Sciences Pub Date : 2021-11-10 DOI: 10.25236/AJMHS.2021.020109

Yan-Yu Gao, Rongfa Chen, Yinqiu Zhao

{"title":"Effect of Eurotium cristatum fermentation on the α-glucosidase inhibitory activity of mulberry leaves alkaloids","authors":"Yan-Yu Gao, Rongfa Chen, Yinqiu Zhao","doi":"10.25236/AJMHS.2021.020109","DOIUrl":"https://doi.org/10.25236/AJMHS.2021.020109","url":null,"abstract":"Eurotium cristatum CY-1 was used for the solid-stated fermentation of mulberry leaves (ML) with the purpose of enhancing the alkaloids content and α-glucosidase inhibitory activity of ML through microbial fermentation. The results indicated that Eurotium cristatum CY-1 grown well when cultivated with MLs as substrate. The maximum cell dry weight of 393.32 mg was reached on the 10 d of fermentation. The alkaloids content of ML was increased with the fermentation time, and the maximum value of 8.711 mg/g was obtained at 8 d of fermentation, which was increased by171.96% compared to that extracted from unfermented ML. The α-glucosidase inhibitory efficiency was also improved along with the fermentation time. The IC50 values of alkaloid extracted from 8d-fermented mulberry leaves was 3.94 μg/mL, but 6.82 μg/mL of the alkaloid extracted from the unfermented ML. Therefore, the fermentation of Eurotium cristatum could benefit for enhancing the alkaloid content and α-glucosidase inhibitory efficiency of ML. It would provide a valuable strategy for obtain safe and low-cost α-glucosidase inhibitors from natural herbal medicines.","PeriodicalId":311994,"journal":{"name":"Academic Journal of Medicine & Health Sciences","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130580612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ethical Review Based on Health Care Big Data 基于医疗大数据的伦理审查

Academic Journal of Medicine & Health Sciences Pub Date : 2021-10-10 DOI: 10.25236/AJMHS.2021.020104

Shao-ying Hao

引用次数: 0

Association of miR-1251-5p/miR-6892-5p Expression With Clinicopathological Factors in Premenopausal Endometrial Cancer 绝经前子宫内膜癌中miR-1251-5p/miR-6892-5p表达与临床病理因素的关系

Academic Journal of Medicine & Health Sciences Pub Date : 2021-09-08 DOI: 10.21203/rs.3.rs-877847/v1

Jing Zhang, Bin Li, Liu Yang, Feiqing Wang, Yu Zhang, Lu Gan

{"title":"Association of miR-1251-5p/miR-6892-5p Expression With Clinicopathological Factors in Premenopausal Endometrial Cancer","authors":"Jing Zhang, Bin Li, Liu Yang, Feiqing Wang, Yu Zhang, Lu Gan","doi":"10.21203/rs.3.rs-877847/v1","DOIUrl":"https://doi.org/10.21203/rs.3.rs-877847/v1","url":null,"abstract":"\u0000 Background\u0000\u0000This study is aim to profile the differentially expressed microRNAs (DEMs) of premenopausal endometrial cancer (EC), identify their target genes and understand their roles in carcinogenesis.\u0000Methods\u0000\u0000Next-generation sequencing (NGS) was performed on 3 premenopausal EC and 3 premenopausal normal endometrial tissues. Selection of candidate miRNAs and subsequent validation were performed by qRT-PCR on 20 premenopausal EC, 30 premenopausal normal endometrial and 40 postmenopausal EC samples. The relationship between DEMs and clinical characteristics was analyzed. Moreover, bioinformatic software programs and databases were applied to predict miRNA target genes, molecular functions, and signaling pathways.\u0000Results\u0000\u0000136 upregulated and 131 downregulated DEMs were identified. The expression of miR-1251-5p was highly upregulated in premenopausal EC samples compared with premenopausal normal endometrial samples and significantly downregulated compared with postmenopausal EC samples. The expression of miR-6892-5p was highly upregulated in premenopausal EC samples compared with premenopausal normal endometrial samples and postmenopausal EC samples. In the premenopausal EC group, miR-1251-5p expression was closely correlated with menarche age, number of pregnancies, tumor grading, myometrial infiltration and lymph node metastasis; miR-6892-5p expression was closely correlated with BMI, hypertension, tumor grading, and metastasis.\u0000Conclusions\u0000\u0000miR-1251-5p and miR-6892-5p may play important roles in tumorigenesis progression of premenopausal EC.","PeriodicalId":311994,"journal":{"name":"Academic Journal of Medicine & Health Sciences","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128227490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis of Au@Pt nanoparticles for detection of ascorbic acid 抗坏血酸检测纳米粒子Au@Pt的合成

Academic Journal of Medicine & Health Sciences Pub Date : 2021-05-30 DOI: 10.25236/AJMHS.2021.020103

Shuyi Li

引用次数: 0

Intraspinal schwannoma: a case report 椎管内神经鞘瘤1例

Academic Journal of Medicine & Health Sciences Pub Date : 2021-04-24 DOI: 10.25236/AJMHS.2021.020102

Zhong Yuke, D. Bo, Yao Jie, Yuan Puiwei, Wang Zhankui, K. Wulin

引用次数: 0

Academic Journal of Medicine &amp; Health Sciences最新文献

Academic Journal of Medicine & Health Sciences最新文献