PH-Sensitive Polymeric Nanoparticles for Targeted Delivery of Doxorubicin

Abstract

In order to improve the targeting of doxorubicin and prolong the action time of the drug, we synthesized a pH-responsive PEG-Schiff-DOX polymer prodrug loaded with nanoparticles. The nanoparticles were prepared by synthesis of PEG-CHO and condensation reaction of PEG-CHO and adriamycin. The release behavior of PEG-Schiff-DOX was tested at different pH. The morphology and particle size of these nanoparticles changed obviously after acid treatment(pH=5.0), and some of them had completely disintegrated. The narrowing of particle size distribution indicates that the heterogeneous nanoparticles disintegrate in the acidic environment of tumor cells, releasing the drug and finally achieving the maximum drug release at pH 5.0. The nanodrugs based on polymeric prodrug had advantages of simple preparation, high drug loading, good storage stability and achieve higher local drug concentration and longer drug action time under the condition of weak acid of tumor microenvironment to keep the curative effect and reduce the side effects. The advantages of offers choices for the development of new drugs and is expected to achieve good application in cancer therapy, has good prospects for development.