{"title":"Health problems and restrictions of chronic haemodialysis patients","authors":"M. Hreńczuk, W. Kozieł, P. Małkowski","doi":"10.15761/GIMCI.1000172","DOIUrl":"https://doi.org/10.15761/GIMCI.1000172","url":null,"abstract":"It is estimated that chronic kidney diseases affect 1 in every 10 persons worldwide [1]. According to the NATPOL 2011 survey, the incidence of chronic kidney disease (CKD) in Poland amounts to 5.8%. Independent risk factors include age, diabetes and hypertension. In addition, due to the ageing population, the incidence of CKD will increase, and thus, the need for hospitalization and renal replacement therapies will also grow. According to approximate data, kidney damage in various stages may be present in up to 4-5 million people in Poland [2]. Meanwhile, the annual incidence of CKD worldwide amounts to approximately 150/million [1,3].","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"104 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117173791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hepatitis C infection as important risk factor for coronary artery disease: An Egyptian study","authors":"H. E. Mahmoud, M. H. Hassan, E. Meghezel","doi":"10.15761/gimci.1000177","DOIUrl":"https://doi.org/10.15761/gimci.1000177","url":null,"abstract":"Cardiovascular diseases account for more than 17 million deaths worldwide yearly (around 30% of all global deaths); and this number is expected to rise up to around 24 million by the year 2030. 4 Out of each 5 cardiovascular-related deaths occur in low-income and middleincome countries [1]. In 2010, ischemic heart disease alone caused 7 million deaths worldwide, compared to around 5 million in 1990; with a rise of around 35% [2]. Atherosclerosis is the commonest cause of coronary carotid and peripheral arterial diseases [3,4].","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"78 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128492431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Human microbiota and allergy","authors":"G. Alberca, M. Sato, R. Alberca","doi":"10.15761/gimci.1000179","DOIUrl":"https://doi.org/10.15761/gimci.1000179","url":null,"abstract":"The host ́s microbiota is later influenced by sanitary conditions, food, drugs and environmental factors [9]. Therefore, the individual microbiome presents unique characteristics [10,11] and differs in composition according to the site in the human body, such as mouth, skin, gastrointestinal tract, respiratory tract and genitals. This is due to many factors such as: local pH, temperature and nutrients [12].","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"30 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117300390","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tariwari C. N Angaye, Godbless N. Oyinke, O. Ogidi
{"title":"Environmental and health risk assessment of particulate matter associated with sporting activities in Yenagoa metropolis, Nigeria","authors":"Tariwari C. N Angaye, Godbless N. Oyinke, O. Ogidi","doi":"10.15761/gimci.1000180","DOIUrl":"https://doi.org/10.15761/gimci.1000180","url":null,"abstract":"Over the decades there have been problems associated with Particulate Matter (PM) arising from anthropogenic activities. Evaluation and health risk assessment of particulate matter associated with football field was carried out in Yenagoa Metropolis Nigeria. Digital portable AEROCET 513 (Metone instrument) Particulate matter meter was used for evaluation of PM in 5 locations. Results showed that levels of particulate matter for; PM1.0 (13.73–20.18 µg/m 3 ), PM2.5 (19.11–28.83 µg/m 3 ), PM4.0 (24.73–44.63 µg/m 3 ), PM7.0 (41.07–67.04 µg/m 3 ), and PM10 ranging from 65.48–90.82 µg/m 3 . In addition, value of the control station was lowest amongst all recorded values of particulate matter (p<0.05). Based on Air Quality Index football field were predominantly rated as either; unhealthy or very unhealthy, with only few cases of unsafe for sensitive group. This investigation therefore concludes that the emission of particulates matter of the football field are reflection of vehicular emissions and agitated dust particles. Hence mitigable measure must be applied without much ado, in order to ameliorate chronic daily exposure to PM.","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"4 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129736073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Seon-Heui Cha, Eun-A. Kim, Kil-Nam Kim, S. Heo, H. Jun, Y. Jeon
{"title":"Prolonged exposure of marine algal phlorotannins with whitening effect did not cause inflammatory hyperpigmentation in zebrafish larva","authors":"Seon-Heui Cha, Eun-A. Kim, Kil-Nam Kim, S. Heo, H. Jun, Y. Jeon","doi":"10.15761/gimci.1000187","DOIUrl":"https://doi.org/10.15761/gimci.1000187","url":null,"abstract":"The demand for novel melanin synthesis inhibitors is increasing due to the weak effectiveness and unwanted side effects. Thus, marine algae have been studied as sources of inhibitors of melanin synthesis, but it is still unclear whether they will be effective in in vivo . In this study, we investigated whether marine algal phlorotannins including phloroglucinol (PG), ekcol (EK), and dieckol (DK) from Ecklonia cava inhibit melanin synthesis in zebrafish embryos. PG, EK, and DK treatment were found to inhibit melanin synthesis in zebrafish embryos as similar to arbutin, used as a positive control. Interestingly, PG, EK, and DK treatment showed no toxicity, whereas arbutin treatment showed toxicity for long-term exposure. As well, mRNA expression of pro-inflammatory cytokines, interleukin-1 β (IL-1 β ), tumor necrosis factor- α (TNF- α ), and cyclooxygenase-2 (COX-2) were increased in arbutin treatment, whereas, the mRNA expression were not altered in PG, EK, and DK treatment by long-tern exposure. These findings suggest that PG, EK, and DK from E.cava inhibit melanin synthesis similar to arbutin without inflammatory toxicity. PG, EK, and DK from E. cava could be a potential prevention and/or therapeutic ingredients for hyperpigmentation.","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"61 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128879353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Mosca, Andrea Dello Strologo, M. Sanseviero, Marangio Serena, T. Alterio, S. Zaffina, A. Vania, V. Nobili
{"title":"Vitamin D Deficiency is Associated with High Levels of LDL Cholesterol in NAFL Children","authors":"A. Mosca, Andrea Dello Strologo, M. Sanseviero, Marangio Serena, T. Alterio, S. Zaffina, A. Vania, V. Nobili","doi":"10.15761/gimci.1000175","DOIUrl":"https://doi.org/10.15761/gimci.1000175","url":null,"abstract":"","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"127561160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Monroy, M. Ruiz, Julio Bogueat, Isabel García, J. C. Julian
{"title":"Mapping of the FKSI specific kidney disease measure onto three generic preference-based measures to generate utility values","authors":"M. Monroy, M. Ruiz, Julio Bogueat, Isabel García, J. C. Julian","doi":"10.15761/gimci.1000181","DOIUrl":"https://doi.org/10.15761/gimci.1000181","url":null,"abstract":"Chronic kidney disease (CKD) is a progressive and irreversible loss of renal function, due to different causes (diabetic nephropathy, hypertension, glomerulonephritis, hereditary renal failure, pharmacological poisoning, etc.) that lead to the kidneys losing their ability to eliminate waste, concentrate urine and preserve electrolytes in the blood, progressing towards the total loss of kidney function. At advanced stages, usual treatments are kidney transplantation, hemodialysis and peritoneal dialysis, all of which have a notable impact on daily life and the quality of life of patients.","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128427653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Weimer Le, Cattari G, F. E, Binelli A, Poddighe Af, Sensi F
{"title":"The first year of Sars-Cov-2: Which mutations spread rapidly around the word? Minireview","authors":"Weimer Le, Cattari G, F. E, Binelli A, Poddighe Af, Sensi F","doi":"10.15761/gimci.1000204","DOIUrl":"https://doi.org/10.15761/gimci.1000204","url":null,"abstract":"Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a worldwide crisis with profound effects on both public health and the economy. In order to combat the Sars-Cov-2 pandemic, research groups have shared viral genome sequence data through the Global Initiative on Sharing All Influenza Data (GISAID). SARS-CoV-2 is an RNA virus, which is a family with significant adaptive evolution). Worldwide research groups are generating and sharing SARS-CoV-2 proteome sequence data in a rapid fashion as a global effort to combat the COVID-19 pandemic. The rapid spread of an alternative variant of coronavirus has been blamed for the introduction of strict tier four mixing rules for many people, strict restrictions on mixing at Christmas in England, Scotland and Wales, and other countries placing the United Kingdom on a travel ban. of the virus in","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"46 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128207911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Unlocking innate healing potentials in patients with type 2 diabetes","authors":"Liji Wu, Shaomin Yang","doi":"10.15761/gimci.1000189","DOIUrl":"https://doi.org/10.15761/gimci.1000189","url":null,"abstract":"Type 2 diabetes (T2D) is a systemic degenerative disease and progressively changes leading to inconsistent responses to different medications. None of antihyperglycemic drugs even together with other therapies can cure T2D. The human body inherits innate healing potentials to heal diseases including T2D. Healthy lifestyles and alternative medicine can keep innate healing potentials powerful enough to heal T2D by decreasing or abolishing genetic predisposition. Among them, the regulating shoes for self-healing, also called “Chiyu shoes” restore innate healing potentials in T2D patients by combining herbal medicines and magnetic sheets. Such a combination leads to clinical satisfaction in healing T2D.","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"289 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115766137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The T Lymphocyte","authors":"C. Schultz","doi":"10.15761/gimci.1000207","DOIUrl":"https://doi.org/10.15761/gimci.1000207","url":null,"abstract":"","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"80 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124121491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}