General Internal Medicine and Clinical Innovations最新文献

筛选

英文中文

Intravenous or oral antibiotic therapy: Sophie’s choice? 静脉或口服抗生素治疗:苏菲的选择?

General Internal Medicine and Clinical Innovations Pub Date : 1900-01-01 DOI: 10.15761/gimci.1000176

M. Gajdács

{"title":"Intravenous or oral antibiotic therapy: Sophie’s choice?","authors":"M. Gajdács","doi":"10.15761/gimci.1000176","DOIUrl":"https://doi.org/10.15761/gimci.1000176","url":null,"abstract":"Antibiotics are one of the most important medicines of the 21st century [1]. Due to the emergence and spread of multidrug resistant (MDR) bacteria, the therapy of infectious diseases may be jeopardized, leading to sequelae, decreased quality of life and excess mortality [2]. The spread of MDR pathogens is a major public health issue, which requires global action of an intersectoral nature, involving prudent use and prescribing, development of novel drug candidates, clinical trials and government action and financial support [3]. From the standpoint of antimicrobial drug resistance, the so-called “ESKAPE” pathogens (E: Enterococcus faecium, S: Staphylococcus aureus or recently Stenotrophomonas maltophilia, K: Klebsiella pneumoniae or recently C: Clostridioides difficile, A: Acinetobacter baumannii, P: Pseudomonas aeruginosa, E: Enterobacter spp., or recently Enterobacteriaceae) are the most concerning [4-6]. In the clinical practice, in addition to the susceptibility of the bacteria, other factors also influence the choice of antimicrobial drugs, such as the age (infants, children), pregnancy/ lactation or the general state of the patient [7]. Several drugs may be useful is almost all conditions (e.g., beta-lactams or macrolides if allergy is not detected), while other may not be administered due to their doselimiting side effects or teratogenicity (fluoroquinolones, tetracyclines), further limiting therapeutic options [8]. Another important factor to consider is the administration route of the antimicrobials: this may occur orally (per os) or parenterally (i.v. or i.m.). The possible routes for the administration of the antimicrobials principally depends on the bioavailability of these drugs in vivo.","PeriodicalId":311273,"journal":{"name":"General Internal Medicine and Clinical Innovations","volume":"51 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129213168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

首页上一页