Sports medicine: research and practice最新文献

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Correlation between the intensity of pulse longevity accumulation and the rate of oxygen demand formation and blood lactate accumulation in performing limiting cyclic exercises of different duration 不同持续时间极限循环运动中脉搏寿命积累强度与需氧量形成率和血乳酸积累率的相关性
Sports medicine: research and practice Pub Date : 2023-01-16 DOI: 10.47529/2223-2524.2022.3.2
A. Kozlov, A. N. Bleer, S. Levushkin, V. Sonkin
{"title":"Correlation between the intensity of pulse longevity accumulation and the rate of oxygen demand formation and blood lactate accumulation in performing limiting cyclic exercises of different duration","authors":"A. Kozlov, A. N. Bleer, S. Levushkin, V. Sonkin","doi":"10.47529/2223-2524.2022.3.2","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.3.2","url":null,"abstract":"The purpose of the study was to search for the relationship of Pulse Debt Accumulation Intensity (PDАI) with the rate of formation of oxygen demand and the accumulation of lactate in the blood during the performance of limiting cyclic exercises of various durations.Methods: 14 athletes‑cyclists (1st category, 20 ± 3 years, MОC — 52.9 ± 5.10 ml / min / kg), performed a series of bicycle ergometric exercises of maximum power on different days at a fixed duration of 10, 30, 60, 120, 360 and 1800 s. Based on the pulse sums of the five‑minute recovery (minus the pre‑start HR level) and the exercise time, the intensity of accumulation of pulse debt was calculated for all exercises in each subject. The rate of accumulation of lactate concentration in the blood (SNCL) and the rate of formation of oxygen demand (OCR) were also calculated.Results: SOCS, SNCL and PDАI have a close non‑linear relationship with exercise time (respectively: r2 = 0.84, r2 = 0.91, r2 = 0.96, at p < 0.05), as well as with relative exercise power (respectively: r2 = 0.80, r2 = 0.86, r2 = 0.90, at p < 0.05). INPD has a close relationship with SRCS and SNCL (respectively: r2 = 0.80, r2 = 0.94, p < 0.05).Conclusions: The results of the study make it possible to use the INPD heart rate indicator for a fairly reliable determination of exercise intensity and for predicting the level of lactate accumulation, and on this basis, determining the direction of the exercise and normalizing the training load.","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"171 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"126065553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Features of carnitine metabolism in young athletes 年轻运动员肉碱代谢的特点
Sports medicine: research and practice Pub Date : 2022-12-21 DOI: 10.47529/2223-2524.2022.4.8
A. Samoilov, A. Zholinsky, N. Rylova, I. Bolshakov
{"title":"Features of carnitine metabolism in young athletes","authors":"A. Samoilov, A. Zholinsky, N. Rylova, I. Bolshakov","doi":"10.47529/2223-2524.2022.4.8","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.4.8","url":null,"abstract":"Objective: to study the indicators of carnitine metabolism in young athletes of various specializations.Materials and methods: This study involved 46 people with different levels of physical activity aged 15 to 18 years. The first group consisted of 18 girls professionally involved in field hockey (mean age, 16.17 ± 0.31 years). The second group included 21 swimmers (10 girls and 11 boys, mean age 17.00 ± 0.26 years). The control group included 7 young men with a standard mode of motor activity, not involved in sports (the age of the subjects was 16 years). In the course of the study, the method of liquid tandem chromatography-mass spectrometry with ionization in an electrospray was used. The material for research is capillary blood. As a result of the analysis of the material, the concentrations of bound carnitine (acylcarnitines) and free carnitine were determined in µmol/l.Results: Comparative blood analysis between the three groups showed differences in free carnitine levels. It was shown that the concentration of free carnitine in the blood plasma of field hockey athletes was significantly lower than in the groups of swimmers and non-athletes (p < 0.001). At the same time, the values of indicators of bound carnitine did not differ significantly between all subjects. We also studied that the values of the carnitine coefficient were significantly higher in the group of hockey players compared to other groups (p < 0.001).Conclusion: The decrease in free carnitine levels in the group of hockey players is probably the result of long-term adaptation of the body to conditions in which glucose is the main energy substrate for working muscles. Further studies are needed to clarify the exact mechanisms of development of this phenomenon.","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130149298","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The relationship between reaction to a moving object with concentrations of biogenic amines and kynematic-dynamic parameters of complex coordination movement in elite alpine skiers 优秀高山滑雪运动员对运动物体的反应与生物胺浓度与复杂协调运动动力学参数的关系
Sports medicine: research and practice Pub Date : 2022-12-20 DOI: 10.47529/2223-2524.2022.3.3
A. Kryuchkov, A. M. Fedoseev, S. Missina, G. A. Dudko, E. Myakinchenko
{"title":"The relationship between reaction to a moving object with concentrations of biogenic amines and kynematic-dynamic parameters of complex coordination movement in elite alpine skiers","authors":"A. Kryuchkov, A. M. Fedoseev, S. Missina, G. A. Dudko, E. Myakinchenko","doi":"10.47529/2223-2524.2022.3.3","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.3.3","url":null,"abstract":"Aim of the study: to identify mutual interaction between the reaction to a moving object with functional state of the central nervous system and kinematic-dynamic parameters of complex coordination movement.Materials and methods: 9 elite alpine skiers were participated in this study. Visual-motor coordination variables were assessed by computer complex for psychophysiological testing NS-Psychotest (Neurosoft, Russia). Dynamic parameters of complex coordination movement during counter movement jump were registered on the MuscleLab Force Plate (Ergotest Innovation A.S., Norway). Quantitation of hormones — adrenaline and noradrenaline as well as neurotransmitters — dopamine and serotonin in blood samples was performed using ultra-high performance liquid chromatograph combined with triple quadrupole mass analyzer LCMS-8060 (Shimadzu, Japan).Results: a significant negative relationship between the maximum output of motor efforts during counter movement jump, mean reaction time and the number of negative reactions recorded within visual-motor coordination testing was documented. A reliable positive relationship between excitation processes, jump power and jump time was established. Increases in noradrenaline and serotonin concentrations are positively associated with the number of accurate reactions, whereas dopamine level was positively correlated with jump altitude.Conclusion: the predominance of excitation over inhibition processes in the central nervous system had a positive effect on reducing the time spent on counter moving and increasing the maximum power of movement. As applied to alpine skiers we registered the following relationship: the higher the speeds of signal perception and muscle activation when solving a visual-motor task, the higher the power of working efforts, the shorter the time of the eccentric phase and total time spent on performing counter movement jump.","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"17 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130608740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Shock wave therapy evaluation in the complex treatment of athletes with lateral epicondylitis 冲击波疗法在运动员外上髁炎综合治疗中的评价
Sports medicine: research and practice Pub Date : 2022-12-20 DOI: 10.47529/2223-2524.2022.3.6
M. Ivanov, A. Samoylov, N. R. Zhestyankin
{"title":"Shock wave therapy evaluation in the complex treatment of athletes with lateral epicondylitis","authors":"M. Ivanov, A. Samoylov, N. R. Zhestyankin","doi":"10.47529/2223-2524.2022.3.6","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.3.6","url":null,"abstract":"Objective: to evaluate the effectiveness of shock wave therapy in the complex treatment of athletes with lateral epicondylitis in comparison with standard methods of treatment.Materials and methods: On outpatient treatment in the period from 2019 to 2022. There were 168 athletes diagnosed with Lateral epicondylitis, including 78 women (46.4 %) and 90 men (53.6 %) aged 20 to 45 years. The mean age of the patients was 31.48 ± 6.72 years. The average duration of the disease was 33.68 ± 28.17 days. To achieve the set goals and objectives, a prospective randomized controlled clinical trial was conducted. We used a clinical examination of patients, a study of carpal dynamometry of the affected arm, an assessment of the level of pain and quality of life using the QuickDash and Patient-Rated Tennis Elbow Evaluation (PRTEE) scales, statistical research methods, as well as the use of standard treatment for lateral epicondylitis and radial shock wave therapy with an assessment of effectiveness one month after treatment.Results: shock wave therapy in the complex treatment of athletes with lateral epicondylitis, compared with standard methods of treatment, improved the quality of life and reduced pain three weeks after the start of treatment and has a more pronounced effect in the long term (p < 0.05); allowed to reduce the intensity of the signal from the bone tissue (trabecular edema) according to the results of magnetic resonance imaging.Conclusion: the expediency of using shock wave therapy in the complex treatment of athletes with lateral epicondylitis is substantiated, which makes it possible to recommend its use in practical healthcare.","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115951423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The combination of traditional cardiorespiratory markers during treadmill testing “to failure” in athletes, depending on professional activity 在运动员的跑步机测试中,传统心肺指标的组合“到失败”取决于专业活动
Sports medicine: research and practice Pub Date : 2022-12-20 DOI: 10.47529/2223-2524.2022.3.5
V. Pustovoyt, E. I. Balakin, A. V. Khan, A. A. Murtazin, N. F. Maksjutov, P. S. Merkulova, K. A. Kubyshev
{"title":"The combination of traditional cardiorespiratory markers during treadmill testing “to failure” in athletes, depending on professional activity","authors":"V. Pustovoyt, E. I. Balakin, A. V. Khan, A. A. Murtazin, N. F. Maksjutov, P. S. Merkulova, K. A. Kubyshev","doi":"10.47529/2223-2524.2022.3.5","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.3.5","url":null,"abstract":"Exercise tolerance test with the use of the spiroergometry technique is a reliable diagnostic method which provides objective information about cardiorespiratory system condition when performing physical activity. Both new and traditional, well-proven cardiorespiratory markers obtained in the process of treadmill testing “to failure”, are described in this article. The nature of the influence of physical exertion on the indicators of cardiorespiratory system functional activity is presented. The interpretation for planning and subsequent monitoring of the training process in athletes of various professional activities is proposed.","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"52 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"128172558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Psychological support of young sportsmen in powerlifting and weightlifting 青少年举重运动员的心理支持
Sports medicine: research and practice Pub Date : 2022-11-29 DOI: 10.47529/2223-2524.2022.3.7
A. Berestyanaya, S. Filippova, A. N. Kornilov, A. P. Oreshkov, V. Gorelik
{"title":"Psychological support of young sportsmen in powerlifting and weightlifting","authors":"A. Berestyanaya, S. Filippova, A. N. Kornilov, A. P. Oreshkov, V. Gorelik","doi":"10.47529/2223-2524.2022.3.7","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.3.7","url":null,"abstract":"The article is a research into psychological and pedagogic support of sportsmen aged 18–25 years old, with taking into account the gender factor, at the stages of training with the strength exercises. It states methods of psychical reserves mobilization of different psychophysical types of sportsmen, aimed at training process efficiency increase in order to reach high results during competitions.Introduction. The article is based at the methodic of classical development of sportsmen’s strength abilities in powerlifting in composition with psychological methods of psychological and pedagogic support (PPS) for increasing of reliability and successfulness of pre-competition training. PPS is considered to be a combination of targets, media, methods and circumstances of planning, realization and control of the process of formation, activation and optimization of sportsmen’s psychological processes, at the stages of preparing for competitions and participating in them. Research target. Theoretical elaboration and experimental substantiation of the methodic of PPS training preparation for the competitions when going in for powerlifting and weightlifting.Materials and methods. The method of control test, pedagogic experiment (PE), fitness tests, anthropometrical methods, psychological development of personality methods, mathematical statistics methods. The research was being performed during five weeks (2020-02-01–2020-03-15). During the pedagogical experiment (PE), strength trainings were based at five-week cycle by B.I. Sheyko, which is equal to one pre-competition mesocycle. Sportsmen aged 18–25 years old formed two groups of 20 persons each: control group (CG) and experimental group (EG), divided [inside] by the gender factor. CG and EG were training with the classical powerlifting methodic, in EG it was supplemented with psychological processes optimization methods.The methodic of PPS preparation for a competition included: learning of goal-setting, forming of readiness for competitions, learning of coping, activation of motivation processes, increase of self-control and of psychoregulation of behavior and sport activity.Results. The authors elaborated five-week mesocycle (medium cycle) of training for powerlifters aged 18-25 years old. The forming impact of the complex of PPS methods in EG caused certain growth of strength results in EG at the end of PE: each of CG sportswomen lifted 142.5 kg in the sum of three-lift, CG sportsmen — 215 kg. In EG the result of sportswomen is 190 kg, the result of sportsmen is 250 kg. The growth, when comparing EG and CG, was 57.5 kg for sportswomen and 35 kg for sportsmen in favour of RG with PPS. Psychophysical types of young powerlifters, who need psychological and pedagogic support, were identified, recovery measures for psychological preparation were proposed.Conclusion. PPS in the complex with strength trainings caused certain growth of strength indexes of powerlifters aged 18–25 years old, with taking into ac","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"13 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117007784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Possibilities of echocardiographic screening in athletes. Part 1. Normal values 超声心动图筛查运动员的可能性。第1部分。正常的值
Sports medicine: research and practice Pub Date : 2022-11-15 DOI: 10.47529/2223-2524.2022.3.8
A. Sharykin, V. Badtieva, Iu. M. Ivanova, D. M. Usmanov
{"title":"Possibilities of echocardiographic screening in athletes. Part 1. Normal values","authors":"A. Sharykin, V. Badtieva, Iu. M. Ivanova, D. M. Usmanov","doi":"10.47529/2223-2524.2022.3.8","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.3.8","url":null,"abstract":"Objective: assess the suitability of existing domestic and international recommendations for the use of echocardiography as a screening method for examining athletes; to select standards that characterize the heart in different sports, based on their own research.Materials and methods: a meta‑analysis of 38 domestic and foreign literature sources based on the results of an echocardiographic examination of athletes was carried out. The indicators of 2647 male athletes aged 16 to 45 years old, playing for the national teams of the city of Moscow and having passed an in‑depth medical examination at the Sports Medicine Clinic, were studied.Results: heart sizes in athletes differ slightly from population indicators, however, in 14–45% of cases they go beyond the reference values. In the absence of heart disease, the largest dimensions of the left ventricle (LV) are observed in endurance exercisers. At the same time, high functionality correlates with increased LV volume indexed by BCA (for EDV/BSA and VO2 AT r = 0.52, p < 0.05).Conclusion: echocardiographic screening of athletes allows obtaining sufficient information to identify congenital or pathology that has arisen during excessive training loads. As standards, it is advisable to use population indicators expressed in centile values.","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"26 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124005054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Approaches to the classification of sports disciplines, taking into account their influence on the biochemical profile of an athlete 体育学科分类的方法,考虑到它们对运动员生化特征的影响
Sports medicine: research and practice Pub Date : 2022-11-03 DOI: 10.47529/2223-2524.2022.2.7
A. Zholinsky, Zh. V. Grishina, A. I. Kadykova, G. Makarova, R. Deev
{"title":"Approaches to the classification of sports disciplines, taking into account their influence on the biochemical profile of an athlete","authors":"A. Zholinsky, Zh. V. Grishina, A. I. Kadykova, G. Makarova, R. Deev","doi":"10.47529/2223-2524.2022.2.7","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.2.7","url":null,"abstract":"There are many classifications of sports disciplines, which base on various approaches, which separately take into account the patterns of training activity, physiology, the risk of collision and injury, etc. In our opinion, it most fully reflects the specifics of sports changes that occur in the body of athletes under the influence of intense physical activity, at the level of biochemical processes. The classification of sports disciplines proposed by us takes into account the influence of the nature of the training process, the specifics of sports loads, the leading type of energy supply of sports work on the biochemical profile of an athlete, which makes it possible to identify the key features that occur in the body of an athlete under the influence of a specific load.","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"32 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123942545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Problems of semiotics of diseases of the Achilles tendon in clinical and educational aspects 跟腱疾病的符号学在临床和教育方面的问题
Sports medicine: research and practice Pub Date : 2022-11-03 DOI: 10.47529/2223-2524.2022.2.9
E. Sorokin, А. P. Sereda, E. Pashkova, N. Konovalchuk, V. Fomichev, D. Chugaev, K. Demyanova, D. Shulepov
{"title":"Problems of semiotics of diseases of the Achilles tendon in clinical and educational aspects","authors":"E. Sorokin, А. P. Sereda, E. Pashkova, N. Konovalchuk, V. Fomichev, D. Chugaev, K. Demyanova, D. Shulepov","doi":"10.47529/2223-2524.2022.2.9","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.2.9","url":null,"abstract":"Achilles tendon disorders are represented by a big group of heterogenous in etiology and pathogenesis conditions, that are quite frequent in patients of various age groups. The diversity of this group of orthopedic disorders and the insufficient information provided on this topic in specialized literature leads to confusion in terminology, which, in turn, leads to misunderstanding the essence of patient’s problem and to mistakes in treatment of such patients.We carried out a content-analysis of contemporary Russian and foreign literature to summarize the existing knowledge and to create the universal nomenclature of the studied pathological conditions for further correct understanding of the problem and creation of classification of disorders and injuries of Achilles tendon.","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"16 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131647007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Comparison of microRNA expression profiles of athletes involved in endurance sports and non-athletic volunteers using a hypoxia signaling pathway panel 使用缺氧信号通路面板比较耐力运动运动员和非运动志愿者的microRNA表达谱
Sports medicine: research and practice Pub Date : 2022-11-03 DOI: 10.47529/2223-2524.2022.2.10
I. Pronina, P. Postnikov, V. I. Pavlov, Z. G. Ordzhonikidze
{"title":"Comparison of microRNA expression profiles of athletes involved in endurance sports and non-athletic volunteers using a hypoxia signaling pathway panel","authors":"I. Pronina, P. Postnikov, V. I. Pavlov, Z. G. Ordzhonikidze","doi":"10.47529/2223-2524.2022.2.10","DOIUrl":"https://doi.org/10.47529/2223-2524.2022.2.10","url":null,"abstract":"In recent years, interest in the search for new potential molecular biomarkers to assess the effectiveness of the training process in elite sports, various pathologies caused by overload, and abuse of prohibited substances has reached an unprecedented level. MicroRNAs that regulate the processes of metabolism, differentiation, proliferation, and apoptosis of cells at the post-transcriptional level are the most valuable candidates for use in this regard. They are found in all biological fluids of the human body, are stable during long-term storage and resistant to changes in environmental conditions. It is known that changes in the miRNA expression profile are closely associated with physical activity, as well as with the administration of recombinant hormones, erythropoiesis-stimulating agents, and other substances and methods that improve sports performance, which are prohibited by the World Anti-Doping Agency (WADA).Objective: In this study, plasma samples from athletes involved in endurance sports (race walking) and non-athletic volunteers were analyzed using a hypoxia signaling pathway panel to identify hypoxia candidate markers.Materials and methods: Expression profiles of plasma circulating miRNAs were assessed by reverse transcription followed by real-time quantitative polymerase chain reaction (RT Q-PCR). The obtained data were subjected to statistical processing using the CFX Manager Software v3.1 program.Results: Three potential microRNA markers were identified: hsa-miR-210-3p, hsa-miR-320a and hsa-miR-935 (increased in athletes by 61.6 times, 51.8 and 41.0 times, respectively) — of physiological response to the training, load, which may be associated with the emergence of hypoxia during endurance training.Conclusion: We have obtained preliminary data on differences in the expression profiles of circulating miRNAs in healthy non-athletic volunteers and professional athletes in the out-of-competition period. In the future, it is planned to expand the sample of studied blood plasma samples and compare the expression profiles of circulating microRNAs in athletes in competition and out-of-competition periods, as well as to compare the expression profiles of circulating microRNAs during aerobic and anaerobic loads. In addition, it is of interest to analyze changes in the expression levels of circulating miRNAs when using hypoxia mimetics applied to improve sports performance.","PeriodicalId":309619,"journal":{"name":"Sports medicine: research and practice","volume":"74 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121579402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
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