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Nasal Spray Vaccines – A Breath of Immunity: An Interview with Dr. Marc-André Langlois 鼻喷雾剂疫苗-呼吸免疫:采访马克·安德烈·朗格卢瓦博士
University of Ottawa Journal of Medicine Pub Date : 2021-07-30 DOI: 10.18192/uojm.v11i1.5974
Zacharie Saint-Georges, Omar Dewidar
{"title":"Nasal Spray Vaccines – A Breath of Immunity: An Interview with Dr. Marc-André Langlois","authors":"Zacharie Saint-Georges, Omar Dewidar","doi":"10.18192/uojm.v11i1.5974","DOIUrl":"https://doi.org/10.18192/uojm.v11i1.5974","url":null,"abstract":"Dr. Marc-André Langlois, a cutting-edge virologist, Canada Research Chair in Molecular Virology and Intrinsic Immunity, and Professor in the Department of Biochemistry, Microbiology and Immunology at the University of Ottawa, received 1 million dollars in Canadian Institutes of Health Research (CIHR) funding to develop a nasal spray COVID-19 vaccine. We had the privilege of meeting with him virtually and having a fascinating and informative conversation on the COVID-19 pandemic, vaccines, and its effect on society.","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48528699","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
COVID-19 and Ageism: Has the Pandemic Allowed Prevailing Ageist Attitudes to Go Viral? 新冠肺炎与老年主义：大流行病是否允许流行的老年主义态度传播开来？
University of Ottawa Journal of Medicine Pub Date : 2021-07-30 DOI: 10.18192/uojm.v11i1.5819
Paul Rooprai, Neelam Mistry
{"title":"COVID-19 and Ageism: Has the Pandemic Allowed Prevailing Ageist Attitudes to Go Viral?","authors":"Paul Rooprai, Neelam Mistry","doi":"10.18192/uojm.v11i1.5819","DOIUrl":"https://doi.org/10.18192/uojm.v11i1.5819","url":null,"abstract":"Current perceptions of older adults are often met with prejudice and misconceptions that constitute what has been characterized as ‘ageism’. Rarely are older persons considered indispensable members of the population who deserve our respect and support. While it is unclear if and when this pandemic will end, what is clear is how COVID-19 has unveiled the prevalent ageist attitudes against older people, underscoring an unsettling discourse about age and human worth that has allowed us to easily question the value of older adults. In this commentary, we highlight specific recommendations that can be made to combat ageism during and after the COVID-19 pandemic, with exploration of vaccine administration and inequities across long-term care homes.","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48122031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Introducing the COVID-19 Misinformation Toolkit 介绍新冠肺炎错误信息工具包
University of Ottawa Journal of Medicine Pub Date : 2021-04-21 DOI: 10.18192/UOJM.V11I100.4858
Channarong Intahchomphoo
{"title":"Introducing the COVID-19 Misinformation Toolkit","authors":"Channarong Intahchomphoo","doi":"10.18192/UOJM.V11I100.4858","DOIUrl":"https://doi.org/10.18192/UOJM.V11I100.4858","url":null,"abstract":"This commentary article aims to introduce the University of Ottawa Library’s COVID-19 Misinformation Toolkit which has two objectives. The first is to provide direct links to COVID-19 related library materials. The second is to create open educational resources, including details of the authors’ systematic review on COVID-19 misinformation on social media, and interviews with interdisciplinary experts regarding COVID-19 misinformation.  The toolkit is available on the library website in both English and French. \u0000  \u0000 ","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43262986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protecting Our Healthcare Workers: University of Ottawa Medical Students Secure Personal Protective Equipment and Medical Supplies during COVID-19 Pandemic 保护我们的医护人员:渥太华大学医学生在COVID-19大流行期间确保个人防护设备和医疗用品
University of Ottawa Journal of Medicine Pub Date : 2021-04-21 DOI: 10.18192/UOJM.V11I100.4770
Jonathan Whelan, E. Lin, C. Andronic, K. Alibhai
{"title":"Protecting Our Healthcare Workers: University of Ottawa Medical Students Secure Personal Protective Equipment and Medical Supplies during COVID-19 Pandemic","authors":"Jonathan Whelan, E. Lin, C. Andronic, K. Alibhai","doi":"10.18192/UOJM.V11I100.4770","DOIUrl":"https://doi.org/10.18192/UOJM.V11I100.4770","url":null,"abstract":"“Our family wishes to make our humanitarian contribution in order to assist in the fight of this COVID-19 pandemic. We want to be a part of the University of Ottawa team. Together we can support each other. The following are the details of what we wish to contribute: 980kg of clear plastic film of 0.11mm thickness. This transparent polyester film is usually used on flatbed printers to make signs and other projects but can be used in the making of face shields. Please, do not hesitate to contact us should you be interested. Our preference is to help our local community and thus we are committed to donating all supplies to your group.” - A donor to our University of Ottawa Medical Students Group for Sourcing PPE and Medical Supplies","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42372126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Supporting the Development of Physician-scientists 支持医学科学家的发展
University of Ottawa Journal of Medicine Pub Date : 2021-04-17 DOI: 10.18192/UOJM.V10I2.4866
M. Deng
{"title":"Supporting the Development of Physician-scientists","authors":"M. Deng","doi":"10.18192/UOJM.V10I2.4866","DOIUrl":"https://doi.org/10.18192/UOJM.V10I2.4866","url":null,"abstract":"In the last decade, there has been a discrepancy between the increasing recognition for research involvement in medical training and the stagnation in the number physician-scientists. Health research funding cutbacks, inadequate mentorship, heavy schedules, and unfamiliarity with scientific methodology are obstacles that limit research interest amongst junior medical learners and cause attrition of promising physician-scientist in training. This article outlines five strategies to promote and facilitate the development of physician-scientists with the understanding that research is integral to clinical excellence. Some of the ways the undergraduate and postgraduate medical curricula can better lend themselves to producing clinicians with the skillset to address clinical uncertainties through an evidence-based approach are: partnerships between healthcare and academia, increasing admission to MD/PhD and Clinical Investigator programs, establishing fundamentals of scientific thinking, long-term research mentorship, facilitating knowledge translation.","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44813334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Genetics and Medicine Collaborative Effort: Can targeted genetic testing aid in early disease detection and improve patient outcomes? 遗传学和医学合作：有针对性的基因检测是否有助于早期疾病检测并改善患者预后？
University of Ottawa Journal of Medicine Pub Date : 2021-04-17 DOI: 10.18192/UOJM.V10I2.4825
A. A. Rizk, G. Botros, A. Al-Izzi
{"title":"Genetics and Medicine Collaborative Effort: Can targeted genetic testing aid in early disease detection and improve patient outcomes?","authors":"A. A. Rizk, G. Botros, A. Al-Izzi","doi":"10.18192/UOJM.V10I2.4825","DOIUrl":"https://doi.org/10.18192/UOJM.V10I2.4825","url":null,"abstract":"An increasing attention on preventative medicine promises to remodel healthcare by using proactive approaches designed to avert and avoid potential diseases from being introduced to the patient. Genetic screening is a subset of health program measures that is purposely designed to be offered to asymptomatic individuals in favour for providing promising forms of early treatment. Whilst many diseases are multifactorial in nature, an early detection of the disorder can aid in tailoring effective medical interventions to the patient. This article will discuss implementing early genetic screening with the aim to promote greater collaboration between the field of genetics and medicine.","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45155657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of the Effectiveness of Ophthalmology Emergency Clinic Intake Forms 眼科急诊门诊收纳表的有效性评价
University of Ottawa Journal of Medicine Pub Date : 2021-04-17 DOI: 10.18192/UOJM.V10I2.4851
Kaisra Esmail, Keean Nanji, Setareh Ziai
{"title":"Evaluation of the Effectiveness of Ophthalmology Emergency Clinic Intake Forms","authors":"Kaisra Esmail, Keean Nanji, Setareh Ziai","doi":"10.18192/UOJM.V10I2.4851","DOIUrl":"https://doi.org/10.18192/UOJM.V10I2.4851","url":null,"abstract":"Objective: To evaluate the effectiveness of a novel patient intake form in an emergency ophthalmology clinic at a Canadian academic center. Despite the popularity of intake forms, they have not been previously reported in the literature in an emergency ophthalmology clinic setting. \u0000Methods: All new patients at the University of Ottawa emergency ophthalmology clinic were provided with a patient intake form to complete while waiting to be seen. Ophthalmology residents and nurses at the University of Ottawa completed an effectiveness survey evaluating the benefits of these forms after 24 months of use. Emergency ophthalmology clinics at other Canadian academic institutions were questioned regarding their use of patient intake forms.  \u0000Results: Nine residents and two nurses completed the effectiveness survey. The mean (SD) score assessing the use of the form (1=never, 5=every patient encounter) was 3.90 (1.20). The greatest perceived benefit involved improved clinic efficiency (91%). All (100%) of responses indicated that the form should continue to be used in practice. Of the other 14 ophthalmology residency programs in Canada, nine currently do not use an intake form, two have forms completed by nurses and three utilize a form but are dissatisfied with their results. \u0000Conclusions: Our results suggest that there are benefits with respect to clinic efficiency, accuracy of medical information, collaboration between healthcare professionals, and patient satisfaction when utilizing patient intake forms in an emergency ophthalmology setting. The use of similar forms may provide an opportunity to improve clinical practice at other academic institutions within Canada.","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67544397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implications of Striatal Dopamine Signalling for Schizophrenia 纹状体多巴胺信号对精神分裂症的影响
University of Ottawa Journal of Medicine Pub Date : 2021-04-17 DOI: 10.18192/UOJM.V10I2.4876
A. Simmons
{"title":"Implications of Striatal Dopamine Signalling for Schizophrenia","authors":"A. Simmons","doi":"10.18192/UOJM.V10I2.4876","DOIUrl":"https://doi.org/10.18192/UOJM.V10I2.4876","url":null,"abstract":"Our understanding of striatal dopamine (DA) function has come a long way since the inception of the DA hypothesis of schizophrenia. These advances have been facilitated in large part by the technique of optogenetics and they have helped to provide a neural basis for the motivational-salience theory of psychosis. This research has also revealed novel therapeutic targets for the treatment of schizophrenia. Optogenetic studies of striatal DA signalling have proven to be a promising area of research with important implications for our understanding of schizophrenia and its treatment. ","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43440672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Diagnostic Utility of Creatine Kinase in Patients Presenting to the Emergency Department with Chest Pain 肌酸激酶在胸痛急诊患者中的诊断作用
University of Ottawa Journal of Medicine Pub Date : 2021-04-17 DOI: 10.18192/UOJM.V10I2.4826
V. Thiruganasambandamoorthy, B. Lam, H. Chaudry, M. Mukarram, M. Nemnom, Soo-Min Kim, A. Ishimwe, M. Taljaard, R. Beanland, R. Booth, G. Hebert, I. Stiell
{"title":"Diagnostic Utility of Creatine Kinase in Patients Presenting to the Emergency Department with Chest Pain","authors":"V. Thiruganasambandamoorthy, B. Lam, H. Chaudry, M. Mukarram, M. Nemnom, Soo-Min Kim, A. Ishimwe, M. Taljaard, R. Beanland, R. Booth, G. Hebert, I. Stiell","doi":"10.18192/UOJM.V10I2.4826","DOIUrl":"https://doi.org/10.18192/UOJM.V10I2.4826","url":null,"abstract":"Introduction: Creatine Kinase (CK) is routinely performed in some emergency departments (ED) for Non-ST-elevation myocardial infarction (NSTEMI) workup. Its diagnostic utility is not well understood. The objectives of this study were to assess the value of CK in NSTEMI diagnosis in the troponin era and the association between the highest CK/Troponin values and ejection fraction (EF) during NSTEMI follow-up.  \u0000  \u0000Methods: A prospective cohort study conducted at the two EDs of The Ottawa Hospital from March 2014 to March 2016 enrolled adults (≥18 years) for whom troponin I (TnI) and CK were ordered for NSTEMI symptoms. We excluded those with ST-Elevation Myocardial Infarction (STEMI). The primary outcome was a NSTEMI within 30 days. We used descriptive statistics and report test diagnostic characteristics with 95% confidence intervals (CI). We compared the highest median CK/Troponin values using Wilcoxon test. \u0000  \u0000Results: Of the 2,153 patients enrolled, 99 (4.6%) suffered a NSTEMI. The sensitivity and specificity were: CK (cutoff >250U/L) 31.3% (95%CI 22.2, 40.5) and 91.1% (95%CI 89.9, 92.4) respectively; TnI (cutoff >0.045µg/L) 98.0% (95%CI 95.2, 100) and 86.2% (95%CI 84.7, 87.7) respectively. The median CK values were not significantly different between those with normal (n=267) and abnormal EF (n=55) on follow-up (107 U/L and 118 U/L respectively; p=0.31), whereas the median TnI values were significantly different (0.02 µg/L and 0.1 µg/L respectively; p<0.0001). \u0000  \u0000Conclusions: CK measurements do not provide any value in the ED work-up of NSTEMI and is not associated with EF on follow-up. Discontinuing routine CK measurements would improve resource utilization.","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43939245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global Health Disparities: A Pressing Issue and a Student-based Initiative to Help 全球健康差距:一个紧迫的问题和以学生为基础的帮助倡议
University of Ottawa Journal of Medicine Pub Date : 2021-04-17 DOI: 10.18192/UOJM.V10I2.4898
David Ripsman
{"title":"Global Health Disparities: A Pressing Issue and a Student-based Initiative to Help","authors":"David Ripsman","doi":"10.18192/UOJM.V10I2.4898","DOIUrl":"https://doi.org/10.18192/UOJM.V10I2.4898","url":null,"abstract":"Abstract: Developing countries, such as India, suffer profound healthcare disparities compared to developed countries. This commentary explores these healthcare disparities, the barriers to improving healthcare in developing countries, and potential solutions to address these barriers. As an example of a medical student initiative, we highlight a not-for-profit organization that we started with a group of University of Ottawa students, Heart 2 Heart: International Healthcare Relief. Heart 2 Heart provides students at Ontario Universities an opportunity to support the health of low-income individuals in India, Morocco, and Bangladesh.","PeriodicalId":30662,"journal":{"name":"University of Ottawa Journal of Medicine","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-04-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"67544480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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