Cellular, Molecular and Biomedical Reports最新文献_第6页

Protective effects of curcumin against naproxen-induced mitochondrial dysfunction in rat kidney tissue 姜黄素对萘普生诱导的大鼠肾组织线粒体功能障碍的保护作用

Cellular, Molecular and Biomedical Reports Pub Date : 2021-06-01 DOI: 10.55705/cmbr.2021.138879.1001

Z. Aziziaram, Ismael Bilal, Yuan Zhong, Azzadin Mahmod, M. Reza Roshandel

引用次数: 70

Cytotoxic effect of diferuloylmethane, a derivative of turmeric on different human glioblastoma cell lines 姜黄衍生物二苯基甲烷对不同人类胶质母细胞瘤细胞系的细胞毒性作用

Cellular, Molecular and Biomedical Reports Pub Date : 2021-06-01 DOI: 10.55705/cmbr.2021.138815.1004

Ismael Bilal, Sijia Xie, Muna S. Elburki, Z. Aziziaram, S. Ahmed, S. J. Jalal Balaky

引用次数: 80

Neonatal Screening for Glucose-6-phosphate dehydrogenase Deficiency in Ardabil Province, Iran, 2018-2019 伊朗阿达比尔省2018-2019年新生儿葡萄糖-6-磷酸脱氢酶缺乏症筛查

Cellular, Molecular and Biomedical Reports Pub Date : 2021-06-01 DOI: 10.55705/cmbr.2021.138793.1000

A. Fathi, M. Barak, M. Damandan, F. Amani, Rouhallah Moradpour, I. Khalilova, M. Valizadeh

{"title":"Neonatal Screening for Glucose-6-phosphate dehydrogenase Deficiency in Ardabil Province, Iran, 2018-2019","authors":"A. Fathi, M. Barak, M. Damandan, F. Amani, Rouhallah Moradpour, I. Khalilova, M. Valizadeh","doi":"10.55705/cmbr.2021.138793.1000","DOIUrl":"https://doi.org/10.55705/cmbr.2021.138793.1000","url":null,"abstract":"Glucose-6-phosphate dehydrogenase (G6PD) is one of the most common genetic deficiencies that affect approximately 400 million people worldwide. This study aimed to identify neonates with G6PD deficiency in Ardabil province during 2017-2018. This cross-sectional study was conducted on all term and preterm newborns in Ardabil Province from April 2018 to April 2019. The sampling method was census and in study duration, 1044 newborns were entered in the study. For each infant, severe hyperbilirubinemia (total serum bilirubin equal or greater than 300 micromol/L) was tested by the diazo method and G6PD was evaluated by Fluorescent Spot Test (FST). Of all infants, 15 (1.4 %) were diagnosed to have G6PD deficiency by FST. The prevalence of G6PD deficiency was significantly in boys higher than in girls (80% vs. 20%, p=0.001). Of all infants, 97 (9.3%) had jaun dice 72 hours after birth that of them 7 neonates (7.2%) had G6PD deficiency. Results showed that the prevalence of G6PD deficiency in this study was less than in other places in Iran that may be because of different ethnicity and demographic features.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"151 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117340905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Insulin-producing cells from bone marrow stem cells versus injectable insulin for the treatment of rats with type I diabetes 骨髓干细胞产生胰岛素的细胞与注射胰岛素治疗1型糖尿病大鼠的比较

Cellular, Molecular and Biomedical Reports Pub Date : 2021-06-01 DOI: 10.55705/cmbr.2021.138888.1006

S. Azeez, S. Jafar, Z. Aziziaram, Le-kun Fang, A. Mawlood, M. Ercisli

{"title":"Insulin-producing cells from bone marrow stem cells versus injectable insulin for the treatment of rats with type I diabetes","authors":"S. Azeez, S. Jafar, Z. Aziziaram, Le-kun Fang, A. Mawlood, M. Ercisli","doi":"10.55705/cmbr.2021.138888.1006","DOIUrl":"https://doi.org/10.55705/cmbr.2021.138888.1006","url":null,"abstract":"in the of and development of cells. In the study to compare Insulin-producing cells from bone marrow stem cells with injectable insulin in rats with type I diabetes. For this purpose, 40 rats were divided into four groups: the control or healthy group, the diabetic control group, the group that received differentiated insulin-producing cells from bone marrow, and the group that received insulin treatment. To differentiate insulin-producing cells from bone marrow, the femoral bone marrow of rats was extracted using the flushing method. Differentiated cells were evaluated using dithizone-specific dye, anti-insulin-proinsulin antibodies, and anti-insulin beta receptors. Also, the expression of the pdx-I gene, as the specific gene of pancreatic cells, was examined by RT-PCR. The results showed that transplantation of insulin-producing cells could significantly increase blood insulin levels in diabetic rats. This increase intensified in the second stage of transplantation when more cells were injected into rats. Concerning decreasing blood sugar levels, differentiated cells were able to reduce blood sugar levels significantly. Even in the first stage of cell injection, in which the rats received a small number of cells, their blood sugar levels were controlled by these cells. As a result, the present study showed that repeated transplants of insulin-producing cells differentiated from bone marrow could decrease blood sugar and increase insulin levels.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"2 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"129416948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 67

The effect of chickpeas metabolites on human diseases and the application of their valuable nutritional compounds suitable for human consumption 鹰嘴豆代谢产物对人类疾病的影响及其适合人类食用的有价值的营养化合物的应用

Cellular, Molecular and Biomedical Reports Pub Date : 1900-01-01 DOI: 10.55705/cmbr.2023.395591.1153

M. Kakaei, Fazalur Rehman, F. Fazeli

引用次数: 3

New analytical method development and validation for estimation of molnupiravir in bulk and tablet dosage form by RP-HPLC method 反相高效液相色谱法测定莫诺比拉韦原料药和片剂含量的新方法的建立和验证

Cellular, Molecular and Biomedical Reports Pub Date : 1900-01-01 DOI: 10.55705/cmbr.2023.375093.1087

引用次数: 3

In vitro assessment of the Larvicidal activity of Bacillus thuringiensis israelensis (Vectobac 12AS formulation) on Anopheles mosquito larvae 苏云金芽孢杆菌以色列芽孢杆菌(Vectobac 12AS制剂)对按蚊幼虫体外杀虫活性的研究

Cellular, Molecular and Biomedical Reports Pub Date : 1900-01-01 DOI: 10.55705/cmbr.2023.391224.1115

I.W. Muhammad, M. Muhammad, Rejoice Asher, A. Shuaibu

{"title":"In vitro assessment of the Larvicidal activity of Bacillus thuringiensis israelensis (Vectobac 12AS formulation) on Anopheles mosquito larvae","authors":"I.W. Muhammad, M. Muhammad, Rejoice Asher, A. Shuaibu","doi":"10.55705/cmbr.2023.391224.1115","DOIUrl":"https://doi.org/10.55705/cmbr.2023.391224.1115","url":null,"abstract":"This research aimed to evaluate the larvicidal activity of the lower doses of commercially synthetic Bacillus thuringiensis israelensis (Vectobac 12 Aqueous Solution (12AS)) against the fourth instar larva. One hundred and fifty blood-fed female anopheles mosquitoes were collected from different resting sites from Abuja Quarters in June 2022 using an aspirator and allowed to breed until the first instar larva appeared. The larvae were monitored and fed with 10% yeast until the third instar emerged. 240 healthy third instar larvae were selected and grouped into three treatments containing sixty (60) larvae each and replicated three times. The first, second and third treatments were respectively treated with 0.84, 0.42 and 0.21ml/l of Vectobac 12AS. Each treatment has a control containing twenty (20) larvae. Larval mortality was determined using a glass rod at an interval of 15 minutes for 24 hours. ANOVA was used to statistically analysed differences in the larval mortality between the treatment and probit analysis was used to determine the lethal concentration (LC) and the lethal time (LT). Mortality of 1(6.7%) and 3(5.0%) were observed in the first treatment (0.84ml/l) after 15 and 30minute of exposure respectively. The highest mortality of 60(100%) was observed in all the treatments after 24 hours of exposure. Statistically, there was no significant difference (F=0.081, P> 0.05) . 2.35 ml/l, 5.54 ml/l and 8.15 ml/l was determined to be LC 50 , LC 90 and LC 99 respectively and LT 50 , LT 90 and LT 99 were found to be, 1809.29min and 2451.34min respectively. Conclusively vectobac 12AS has demonstrated a high level of efficacy as it revealed 100% larval mortality even at a lower recommended dose. Further research should be carried out to study the impact of other biological and environmental factors on the efficacy of vectobac 12AS.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"58 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121806705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating outbreaks caused by foodborne diseases and determining common bacterial agents that cause them in Kurdistan province 调查库尔德斯坦省由食源性疾病引起的疫情，并确定导致这些疾病的常见细菌病原体

Cellular, Molecular and Biomedical Reports Pub Date : 1900-01-01 DOI: 10.55705/cmbr.2023.384570.1098

M. M. Soltan Dallal, Z. Rajabi, Mohammad Reza Mohammadi, Arezoo Bagheri Sadegi

{"title":"Investigating outbreaks caused by foodborne diseases and determining common bacterial agents that cause them in Kurdistan province","authors":"M. M. Soltan Dallal, Z. Rajabi, Mohammad Reza Mohammadi, Arezoo Bagheri Sadegi","doi":"10.55705/cmbr.2023.384570.1098","DOIUrl":"https://doi.org/10.55705/cmbr.2023.384570.1098","url":null,"abstract":"Foodborne diseases are a global problem that is spreading day by day. These diseases are one of the most common causes of death in children and the elderly. This study was conducted to investigate the prevalence of water and foodborne diseases in Kurdistan province for one year from April to September 2022. Stool samples from patients were collected in the laboratory in a special container containing 10% formalin preservative. 134 stool samples from 28 food outbreaks from Kurdistan province were analyzed for the type of infected bacteria. The research results were analyzed in SPSS-19 software. Among the 28 outbreaks in Kurdistan province during the two seasons of spring and summer, the highest number of outbreaks was in the summer season with 20 and then in the spring season with 8 outbreaks. The dominant age group was children under 10 years (%21) old and people between 20-30 years old, and the dominant gender group was men. The most common clinical symptoms were nausea, vomiting, abdominal cramps, bloody diarrhea and non-bloody diarrhea. It is important to know the type of bacteria that cause water and foodborne diseases in reducing outbreaks and treatment costs and applying necessary measures for control and prevention.","PeriodicalId":304796,"journal":{"name":"Cellular, Molecular and Biomedical Reports","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"1900-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130315371","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Chromoblastomycosis successfully treated with the combination of itraconazole and 5-flucytosine 伊曲康唑联合5-氟胞嘧啶治疗嗜铬菌病成功

Cellular, Molecular and Biomedical Reports Pub Date : 1900-01-01 DOI: 10.55705/cmbr.2023.378135.1092

Reginaldo Gon De Lima-Neto, Mohammad Reza Mohammadi

引用次数: 0

Identification of some Echinophora platyloba miRNAs using computational methods and the effect of these miRNAs in the expression of TLN2 and ZNF521 genes in different human body organs 利用计算方法鉴定一些棘球蚴mirna及其在人体不同器官TLN2和ZNF521基因表达中的影响

Cellular, Molecular and Biomedical Reports Pub Date : 1900-01-01 DOI: 10.55705/cmbr.2023.386145.1100

Sahand Sasani, Sajad Rashidi Monfared, Ali Reza Mirzaei

引用次数: 4